Author results

4GYV
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CRYSTAL STRUCTURE OF THE DH DOMAIN OF FARP2
Descriptor:FERM, RhoGEF and pleckstrin domain-containing protein 2
Authors:He, X., Zhang, X.
Deposit date:2012-09-05
Release date:2013-03-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
Structure, 21, 2013
4GZU
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CRYSTAL STRUCTURE OF THE DH-PH-PH DOMAIN OF FARP2
Descriptor:FERM, RhoGEF and pleckstrin domain-containing protein 2
Authors:He, X., Zhang, X.
Deposit date:2012-09-06
Release date:2013-03-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
Structure, 21, 2013
4H6Y
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CRYSTAL STRUCTURE OF THE DH-PH-PH DOMAIN OF FARP1
Descriptor:FERM, RhoGEF and pleckstrin domain-containing protein 1
Authors:He, X., Zhang, X.
Deposit date:2012-09-19
Release date:2013-03-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (4.09 Å)
Cite:Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
Structure, 21, 2013
3CM8
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A RNA POLYMERASE SUBUNIT STRUCTURE FROM VIRUS
Descriptor:Polymerase acidic protein, peptide from RNA-directed RNA polymerase catalytic subunit
Authors:He, X., Zhou, J., Zeng, Z., Ma, J., Zhang, R., Rao, Z., Liu, Y.
Deposit date:2008-03-21
Release date:2008-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.899 Å)
Cite:Crystal structure of the polymerase PAC-PB1N complex from an avian influenza H5N1 virus
Nature, 454, 2008
1K8D
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CRYSTAL STRUCTURE OF THE NON-CLASSICAL MHC CLASS IB QA-2 COMPLEXED WITH A SELF PEPTIDE
Descriptor:QA-2 antigen, BETA-2-MICROGLOBULIN, 60S RIBOSOMAL PROTEIN
Authors:He, X., Tabaczewski, P., Ho, J., Stroynowski, I., Garcia, K.C.
Deposit date:2001-10-23
Release date:2001-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Promiscuous antigen presentation by the nonclassical MHC Ib Qa-2 is enabled by a shallow, hydrophobic groove and self-stabilized peptide conformation.
Structure, 9, 2001
1Q32
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CRYSTAL STRUCTURE ANALYSIS OF THE YEAST TYROSYL-DNA PHOSPHODIESTERASE
Descriptor:tyrosyl-DNA phosphodiesterase
Authors:He, X., Babaoglu, K., Price, A., Nitiss, K.C., Nitiss, J.L., White, S.W.
Deposit date:2003-07-28
Release date:2004-09-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Mutation of a conserved active site residue converts tyrosyl-DNA phosphodiesterase I into a DNA topoisomerase I-dependent poison
J.Mol.Biol., 372, 2007
2NSD
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ENOYL ACYL CARRIER PROTEIN REDUCTASE INHA IN COMPLEX WITH N-(4-METHYLBENZOYL)-4-BENZYLPIPERIDINE
Descriptor:Enoyl-[acyl-carrier-protein] reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, N-(4-METHYLBENZOYL)-4-BENZYLPIPERIDINE
Authors:He, X., Alian, A., Ortiz de Montellano, P.R.
Deposit date:2006-11-03
Release date:2007-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides.
Bioorg.Med.Chem., 15, 2007
3MKT
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STRUCTURE OF A CATION-BOUND MULTIDRUG AND TOXIN COMPOUND EXTRUSION (MATE) TRANSPORTER
Descriptor:Multi antimicrobial extrusion protein (Na(+)/drug antiporter) MATE-like MDR efflux pump
Authors:He, X., Szewczyk, P., Karyakin, A., Evin, M., Hong, W.-X., Zhang, Q., Chang, G.
Deposit date:2010-04-15
Release date:2010-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Structure of a cation-bound multidrug and toxic compound extrusion transporter.
Nature, 467, 2010
3MKU
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STRUCTURE OF A CATION-BOUND MULTIDRUG AND TOXIN COMPOUND EXTRUSION (MATE) TRANSPORTER
Descriptor:Multi antimicrobial extrusion protein (Na(+)/drug antiporter) MATE-like MDR efflux pump, RUBIDIUM ION
Authors:He, X., Szewczyk, P., Karyakin, A., Evin, M., Hong, W.-X., Zhang, Q., Chang, G.
Deposit date:2010-04-15
Release date:2010-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structure of a cation-bound multidrug and toxic compound extrusion transporter.
Nature, 467, 2010
3UPU
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CRYSTAL STRUCTURE OF THE T4 PHAGE SF1B HELICASE DDA
Descriptor:ATP-dependent DNA helicase dda, 5'-D(*TP*TP*TP*TP*TP*TP*TP*T)-3'
Authors:He, X., Yun, M.K., Pemble IV, C.W., Kreuzer, K.N., Raney, K.D., White, S.W.
Deposit date:2011-11-18
Release date:2012-06-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.299 Å)
Cite:The T4 Phage SF1B Helicase Dda Is Structurally Optimized to Perform DNA Strand Separation.
Structure, 20, 2012
4TRJ
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE (INHA) COMPLEXED WITH N-(3-BROMOPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE, REFINED WITH NEW LIGAND RESTRAINTS
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-N-(3-BROMOPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
Authors:He, X., Alian, A., Stroud, R.M., Ortiz de Montellano, P.R.
Deposit date:2014-06-17
Release date:2014-08-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Med. Chem., 2006
4TZK
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE (INHA) COMPLEXED WITH 1-CYCLOHEXYL-N-(3,5-DICHLOROPHENYL)-5-OXOPYRROLIDINE-3-CARBOXAMIDE
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-1-CYCLOHEXYL-N-(3,5-DICHLOROPHENYL)-5-OXOPYRROLIDINE-3-CARBOXAMIDE
Authors:He, X., Alian, A., Stroud, R.M., Ortiz de Montellano, P.R.
Deposit date:2014-07-10
Release date:2014-08-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Med. Chem., 2006
4TZT
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE (INHA) COMPLEXED WITH N-(3-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL- 5-OXOPYRROLIDINE-3-CARBOXAMIDE
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-N-(3-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
Authors:He, X., Alian, A., Stroud, R.M., Ortiz de Montellano, P.R.
Deposit date:2014-07-10
Release date:2014-08-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Med. Chem., 2006
4U0J
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE (INHA) COMPLEXED WITH 1-CYCLOHEXYL-5-OXO-N-PHENYLPYRROLIDINE-3-CARBOXAMIDE, REFINED WITH NEW LIGAND RESTRAINTS
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-1-CYCLOHEXYL-5-OXO-N-PHENYLPYRROLIDINE-3-CARBOXAMIDE
Authors:He, X., Alian, A., Stroud, R.M., Ortiz de Montellano, P.R.
Deposit date:2014-07-11
Release date:2014-07-30
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Med. Chem., 2006
4U0K
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE COMPLEXED WITH N-(5-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-N-(5-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
Authors:He, X., Alian, A., Stroud, R.M., Ortiz de Montellano, P.R.
Deposit date:2014-07-11
Release date:2014-07-30
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Med. Chem., 2006
6D2K
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CRYSTAL STRUCTURE OF THE FERM DOMAIN OF MOUSE FARP2
Descriptor:FERM, ARHGEF and pleckstrin domain-containing protein 2
Authors:He, X., Zhang, X.
Deposit date:2018-04-13
Release date:2018-07-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural analyses of FERM domain-mediated membrane localization of FARP1.
Sci Rep, 8, 2018
4FA8
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MULTI-PRONGED MODULATION OF CYTOKINE SIGNALING
Descriptor:Secreted protein BARF1, Macrophage colony-stimulating factor 1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:He, X., Shim, A.H.
Deposit date:2012-05-21
Release date:2012-08-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.
Proc.Natl.Acad.Sci.USA, 109, 2012
2IFG
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STRUCTURE OF THE EXTRACELLULAR SEGMENT OF HUMAN TRKA IN COMPLEX WITH NERVE GROWTH FACTOR
Descriptor:High affinity nerve growth factor receptor, Beta-nerve growth factor, N-ACETYL-D-GLUCOSAMINE, ...
Authors:He, X., Garcia, K.C.
Deposit date:2006-09-20
Release date:2007-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors.
Neuron, 53, 2007
3HX3
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CRYSTAL STRUCTURE OF CRALBP MUTANT R234W
Descriptor:Retinaldehyde-binding protein 1, RETINAL
Authors:Stocker, A., He, X., Lobsiger, J.
Deposit date:2009-06-19
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Bothnia dystrophy is caused by domino-like rearrangements in cellular retinaldehyde-binding protein mutant R234W.
Proc.Natl.Acad.Sci.USA, 106, 2009
3HY5
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CRYSTAL STRUCTURE OF CRALBP
Descriptor:Retinaldehyde-binding protein 1, RETINAL, L(+)-TARTARIC ACID
Authors:Stocker, A., He, X., Lobsiger, J.
Deposit date:2009-06-22
Release date:2009-10-20
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Bothnia dystrophy is caused by domino-like rearrangements in cellular retinaldehyde-binding protein mutant R234W.
Proc.Natl.Acad.Sci.USA, 106, 2009
5ZMM
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STRUCTURE OF THE TYPE IV PHOSPHOROTHIOATION-DEPENDENT RESTRICTION ENDONUCLEASE SCOMCRA
Descriptor:Uncharacterized protein McrA, ZINC ION, SULFATE ION
Authors:Liu, G., Fu, W., Zhang, Z., He, Y., Yu, H., Zhao, Y., Deng, Z., Wu, G., He, X.
Deposit date:2018-04-04
Release date:2018-09-26
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural basis for the recognition of sulfur in phosphorothioated DNA.
Nat Commun, 9, 2018
5ZMN
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SULFUR BINDING DOMAIN AND SRA DOMAIN OF SCOMCRA COMPLEXED WITH PHOSPHOROTHIOATED DNA
Descriptor:Uncharacterized protein McrA, DNA (5'-D(*CP*CP*CP*GP*(GS)P*CP*CP*GP*GP*G)-3'), SULFATE ION
Authors:Liu, G., Fu, W., Zhang, Z., He, Y., Yu, H., Zhao, Y., Deng, Z., Wu, G., He, X.
Deposit date:2018-04-04
Release date:2018-09-26
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:Structural basis for the recognition of sulfur in phosphorothioated DNA.
Nat Commun, 9, 2018
5ZMO
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SULFUR BINDING DOMAIN OF SCOMCRA COMPLEXED WITH PHOSPHOROTHIOATED DNA
Descriptor:Uncharacterized protein McrA, DNA (5'-D(P*CP*CP*GP*(GS)P*CP*CP*GP*G)-3'), PHOSPHATE ION
Authors:Liu, G., Fu, W., Zhang, Z., He, Y., Yu, H., Zhao, Y., Deng, Z., Wu, G., He, X.
Deposit date:2018-04-04
Release date:2018-09-26
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural basis for the recognition of sulfur in phosphorothioated DNA.
Nat Commun, 9, 2018
1S17
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IDENTIFICATION OF NOVEL POTENT BICYCLIC PEPTIDE DEFORMYLASE INHIBITORS
Descriptor:Peptide deformylase, NICKEL (II) ION, 2-(3,4-DIHYDRO-3-OXO-2H-BENZO[B][1,4]THIAZIN-2-YL)-N-HYDROXYACETAMIDE, ...
Authors:Molteni, V., He, X., Nabakka, J., Yang, K., Kreusch, A., Gordon, P., Bursulaya, B., Ryder, N.S., Goldberg, R., He, Y.
Deposit date:2004-01-05
Release date:2004-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Identification of novel potent bicyclic peptide deformylase inhibitors
Bioorg.Med.Chem.Lett., 14, 2004
5YYC
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CRYSTAL STRUCTURE OF ALANINE RACEMASE FROM BACILLUS PSEUDOFIRMUS (OF4)
Descriptor:Alanine racemase, PYRIDOXAL-5'-PHOSPHATE
Authors:Dong, H., Hu, T.T., He, G.Z., Lu, D.R., Qi, J.X., Dou, Y.S., Long, W., He, X., Su, D., Ju, J.S.
Deposit date:2017-12-08
Release date:2019-01-02
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Structural features and kinetic characterization of alanine racemase from Bacillus pseudofirmus OF4.
Biochem. Biophys. Res. Commun., 497, 2018