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2AVH
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G4T3G4 DIMERIC QUADRUPLEX STRUCTURE
Descriptor:5'-D(*GP*GP*GP*GP*TP*TP*TP*GP*GP*GP*G)-3', POTASSIUM ION
Authors:Hazel, P., Parkinson, G.N., Neidle, S.
Deposit date:2005-08-30
Release date:2006-03-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex.
J.Am.Chem.Soc., 128, 2006
2AVJ
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G4(BR)UTTG4 DIMERIC QUADRUPLEX
Descriptor:5'-D(*GP*GP*GP*GP*(BRU)P*TP*TP*GP*GP*GP*G)-3', POTASSIUM ION, CACODYLATE ION
Authors:Hazel, P., Parkinson, G.N., Neidle, S.
Deposit date:2005-08-30
Release date:2006-03-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex.
J.Am.Chem.Soc., 128, 2006
5JQ5
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CRYSTAL STRUCTURE OF CDK2 IN COMPLEX WITH INHIBITOR ICEC0942
Descriptor:Cyclin-dependent kinase 2, ACETATE ION, (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol
Authors:Hazel, P., Freemont, P.S.
Deposit date:2016-05-04
Release date:2017-02-08
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study.
ChemMedChem, 12, 2017
5JQ8
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CRYSTAL STRUCTURE OF CDK2 IN COMPLEX WITH INHIBITOR ICEC0943
Descriptor:Cyclin-dependent kinase 2, (3S,4S)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol
Authors:Hazel, P., Freemont, P.S.
Deposit date:2016-05-04
Release date:2017-02-08
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study.
ChemMedChem, 12, 2017
3NS9
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CRYSTAL STRUCTURE OF CDK2 IN COMPLEX WITH INHIBITOR BS-194
Descriptor:Cell division protein kinase 2, (2S,3S)-3-{[7-(benzylamino)-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino}butane-1,2,4-triol
Authors:Hazel, P., Freemont, P.S.
Deposit date:2010-07-01
Release date:2010-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:A Novel Pyrazolo[1,5-a]pyrimidine Is a Potent Inhibitor of Cyclin-Dependent Protein Kinases 1, 2, and 9, Which Demonstrates Antitumor Effects in Human Tumor Xenografts Following Oral Administration.
J.Med.Chem., 53, 2010
2GW0
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A D(TGGGGT)- SODIUM AND CALCIUM COMPLEX.
Descriptor:5'-D(*TP*GP*GP*GP*GP*T)-3', SODIUM ION, CALCIUM ION
Authors:Lee, M.P.H., Parkinson, G.N., Neidle, S.
Deposit date:2006-05-03
Release date:2007-05-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel.
J.Am.Chem.Soc., 129, 2007