4ZID
| Dimeric Hydrogenobacter thermophilus cytochrome c552 obtained from Escherichia coli | Descriptor: | Cytochrome c-552, HEME C | Authors: | Hayashi, Y, Yamanaka, M, Nagao, S, Komori, H, Higuchi, Y, Hirota, S. | Deposit date: | 2015-04-28 | Release date: | 2016-02-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Domain swapping oligomerization of thermostable c-type cytochrome in E. coli cells Sci Rep, 6, 2016
|
|
3VYM
| Dimeric Hydrogenobacter thermophilus cytochrome c552 | Descriptor: | Cytochrome c-552, HEME C | Authors: | Hayashi, Y, Nagao, S, Osuka, H, Komori, H, Higuchi, Y, Hirota, S. | Deposit date: | 2012-09-28 | Release date: | 2012-11-07 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Domain Swapping of the Heme and N-Terminal alpha-Helix in Hydrogenobacter thermophilus Cytochrome c(552) Dimer Biochemistry, 51, 2012
|
|
2E9L
| Crystal Structure of human Cytosolic Neutral beta-Glycosylceramidase (Klotho-related Prote:KLrP) complex with Glucose and fatty acids | Descriptor: | Cytosolic beta-glucosidase, GLYCEROL, OLEIC ACID, ... | Authors: | Kakuta, Y, Hayashi, Y, Okino, N, Ito, M. | Deposit date: | 2007-01-25 | Release date: | 2007-09-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase. J.Biol.Chem., 282, 2007
|
|
2E9M
| Crystal Structure of human Cytosolic Neutral beta-Glycosylceramidase (Klotho-related Prote:KLrP) complex with Galactose and fatty acids | Descriptor: | Cytosolic beta-glucosidase, OLEIC ACID, PALMITIC ACID, ... | Authors: | Kakuta, Y, Hayashi, Y, Okino, N, Ito, M. | Deposit date: | 2007-01-25 | Release date: | 2007-09-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase. J.Biol.Chem., 282, 2007
|
|
3CVF
| Crystal Structure of the carboxy terminus of Homer3 | Descriptor: | Homer protein homolog 3 | Authors: | Hayashi, M.K, Stearns, M.H, Giannini, V, Xu, R.-M, Sala, C, Hayashi, Y. | Deposit date: | 2008-04-18 | Release date: | 2009-03-31 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The postsynaptic density proteins Homer and Shank form a polymeric network structure. Cell(Cambridge,Mass.), 137, 2009
|
|
3CVE
| Crystal Structure of the carboxy terminus of Homer1 | Descriptor: | Homer protein homolog 1 | Authors: | Hayashi, M.K, Stearns, M.H, Giannini, V, Xu, R.-M, Sala, C, Hayashi, Y. | Deposit date: | 2008-04-18 | Release date: | 2009-03-31 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | The postsynaptic density proteins Homer and Shank form a polymeric network structure. Cell(Cambridge,Mass.), 137, 2009
|
|
4EBW
| Structure of Focal Adhesion Kinase catalytic domain in complex with novel allosteric inhibitor | Descriptor: | 1-ethyl-8-(4-ethylphenyl)-5-methyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazine 4,4-dioxide, Focal adhesion kinase 1 | Authors: | Iwatani, M, Iwata, H, Okabe, A, Skene, R.J, Tomita, N, Hayashi, Y, Aramaki, Y, Hosfield, D.J, Hori, A, Baba, A, Miki, H. | Deposit date: | 2012-03-25 | Release date: | 2012-07-25 | Last modified: | 2013-03-27 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Discovery and characterization of novel allosteric FAK inhibitors. Eur.J.Med.Chem., 61, 2013
|
|
4XFP
| Crystal Structure of Highly Active Mutant of Bacillus sp. TB-90 Urate Oxidase | Descriptor: | 8-AZAXANTHINE, CHLORIDE ION, SULFATE ION, ... | Authors: | Hibi, T, Hayashi, Y, Kawamura, A, Itoh, T. | Deposit date: | 2014-12-28 | Release date: | 2016-01-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Glycine Substitution of Surface Proline 287 Involves Entropic Enhancement of Bacillus sp. TB-90 Uricase Activity To be published
|
|
2ZOX
| Crystal Structure of the Covalent Intermediate of Human Cytosolic beta-Glucosidase | Descriptor: | 4-nitrophenyl alpha-D-glucopyranoside, Cytosolic beta-glucosidase, GLYCEROL, ... | Authors: | Noguchi, J, Hayashi, Y, Baba, Y, Okino, N, Kimura, M, Ito, M, Kakuta, Y. | Deposit date: | 2008-06-17 | Release date: | 2008-09-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the covalent intermediate of human cytosolic beta-glucosidase Biochem.Biophys.Res.Commun., 374, 2008
|
|
7E18
| Crystal structure of SAR-CoV-2 3CL protease complex with inhibitor YH-53 | Descriptor: | 1,2-ETHANEDIOL, N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methoxy-1H-indole-2-carboxamide, Replicase polyprotein 1ab | Authors: | Senda, M, Konno, S, Hayashi, Y, Senda, T. | Deposit date: | 2021-02-01 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents. J.Med.Chem., 65, 2022
|
|
7E19
| Crystal structure of SAR-CoV-2 3CL protease complex with inhibitor SH-5 | Descriptor: | (phenylmethyl) N-[(2S)-1-[[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]amino]-3-methyl-1-oxidanylidene-butan-2-yl]carbamate, 3C-like proteinase | Authors: | Senda, M, Konno, S, Hayashi, Y, Senda, T. | Deposit date: | 2021-02-01 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents. J.Med.Chem., 65, 2022
|
|
1K5O
| CPI-17(35-120) deletion mutant | Descriptor: | CPI-17 | Authors: | Ohki, S, Eto, M, Kariya, E, Hayano, T, Hayashi, Y, Yazawa, M, Brautigan, D, Kainosho, M. | Deposit date: | 2001-10-11 | Release date: | 2002-10-11 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of the Myosin Phosphatase Inhibitor Protein CPI-17 Shows Phosphorylation-induced Conformational Changes Responsible for Activation J.Mol.Biol., 314, 2001
|
|
5Y7F
| Crystal structure of catalytic domain of UGGT (UDP-bound form) from Thermomyces dupontii | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, UGGT, ... | Authors: | Satoh, T, Song, C, Zhu, T, Toshimori, T, Murata, K, Hayashi, Y, Kamikubo, H, Uchihashi, T, Kato, K. | Deposit date: | 2017-08-17 | Release date: | 2017-09-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Visualisation of a flexible modular structure of the ER folding-sensor enzyme UGGT. Sci Rep, 7, 2017
|
|
5Y7O
| Crystal structure of folding sensor region of UGGT from Thermomyces dupontii | Descriptor: | UGGT | Authors: | Satoh, T, Song, C, Zhu, T, Toshimori, T, Murata, K, Hayashi, Y, Kamikubo, H, Uchihashi, T, Kato, K. | Deposit date: | 2017-08-17 | Release date: | 2017-09-27 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Visualisation of a flexible modular structure of the ER folding-sensor enzyme UGGT. Sci Rep, 7, 2017
|
|
3VKK
| Crystal Structure Of The Covalent Intermediate Of Human Cytosolic Beta-Glucosidase-mannose complex | Descriptor: | CHLORIDE ION, Cytosolic beta-glucosidase, GLYCEROL, ... | Authors: | Noguchi, J, Hayashi, Y, Okino, N, Ito, M, Kimura, M, Kakuta, Y. | Deposit date: | 2011-11-17 | Release date: | 2012-11-21 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for inhibition mechanism of human cytosolic beta-glucosidase by monnoside To be Published
|
|
3WLV
| Thermostable urate oxidase from Bacillus sp. TB-90 | Descriptor: | 8-AZAXANTHINE, CHLORIDE ION, POTASSIUM ION, ... | Authors: | Hibi, T, Hayashi, Y, Itoh, T. | Deposit date: | 2013-11-14 | Release date: | 2014-06-18 | Last modified: | 2022-08-24 | Method: | X-RAY DIFFRACTION (1.747 Å) | Cite: | Intersubunit salt bridges with a sulfate anion control subunit dissociation and thermal stabilization of Bacillus sp. TB-90 urate oxidase. Biochemistry, 53, 2014
|
|
5ZC6
| Solution structure of H-RasT35S mutant protein in complex with KBFM123 | Descriptor: | 3-oxidanyl-~{N}-[[(2~{R})-oxolan-2-yl]methyl]naphthalene-2-carboxamide, GTPase HRas, MAGNESIUM ION, ... | Authors: | Matsumoto, S, Hayashi, Y, Hiraga, T, Matsuo, K, Kataoka, T. | Deposit date: | 2018-02-15 | Release date: | 2018-09-12 | Last modified: | 2018-09-26 | Method: | SOLUTION NMR | Cite: | Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring Biochemistry, 57, 2018
|
|
3AAD
| Structure of the histone chaperone CIA/ASF1-double bromodomain complex linking histone modifications and site-specific histone eviction | Descriptor: | Histone chaperone ASF1A, SULFATE ION, Transcription initiation factor TFIID subunit 1 | Authors: | Akai, Y, Adachi, N, Hayashi, Y, Eitoku, M, Sano, N, Natsume, R, Kudo, N, Tanokura, M, Senda, T, Horikoshi, M. | Deposit date: | 2009-11-16 | Release date: | 2010-04-28 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure of the histone chaperone CIA/ASF1-double bromodomain complex linking histone modifications and site-specific histone eviction Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
2ANL
| X-ray crystal structure of the aspartic protease plasmepsin 4 from the malarial parasite plasmodium malariae bound to an allophenylnorstatine based inhibitor | Descriptor: | (4R)-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide, plasmepsin IV | Authors: | Clemente, J.C, Govindasamy, L, Madabushi, A, Fisher, S.Z, Moose, R.E, Yowell, C.A, Hidaka, K, Kimura, T, Hayashi, Y, Kiso, Y, Agbandje-McKenna, M, Dame, J.B, Dunn, B.M, McKenna, R. | Deposit date: | 2005-08-11 | Release date: | 2006-04-04 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor. Acta Crystallogr.,Sect.D, 62, 2006
|
|
4RBO
| |
3WJT
| Crystal structure of the L68D variant of mLolB | Descriptor: | CHLORIDE ION, Outer-membrane lipoprotein LolB, SULFATE ION | Authors: | Takeda, K, Tokuda, H, Miki, K. | Deposit date: | 2013-10-16 | Release date: | 2014-03-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Roles of the Protruding Loop of Factor B Essential for the Localization of Lipoproteins (LolB) in the Anchoring of Bacterial Triacylated Proteins to the Outer Membran J.Biol.Chem., 289, 2014
|
|
3WJU
| |
3WJV
| Crystal structure of the L68E variant of mLolB | Descriptor: | Outer-membrane lipoprotein LolB, SULFATE ION | Authors: | Takeda, K, Tokuda, H, Miki, K. | Deposit date: | 2013-10-16 | Release date: | 2014-03-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Roles of the Protruding Loop of Factor B Essential for the Localization of Lipoproteins (LolB) in the Anchoring of Bacterial Triacylated Proteins to the Outer Membran J.Biol.Chem., 289, 2014
|
|
6YTU
| Atomic-resolution structure of the coiled-coil dimerisation domain of human Arc | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Activity-regulated cytoskeleton-associated protein, CHLORIDE ION | Authors: | Hallin, E.I, Touma, C, Bramham, C.R, Kursula, P. | Deposit date: | 2020-04-24 | Release date: | 2021-03-03 | Last modified: | 2021-05-12 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif. Febs J., 288, 2021
|
|
3FX5
| Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by High Resolution X-ray Crystallography | Descriptor: | (4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide, GLYCEROL, protease | Authors: | Adachi, M, Ohhara, T, Tamada, T, Okazaki, N, Kuroki, R. | Deposit date: | 2009-01-20 | Release date: | 2009-03-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (0.93 Å) | Cite: | Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography. Proc.Natl.Acad.Sci.USA, 2009
|
|