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7Z74
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BU of 7z74 by Molmil
PI3KC2a core in complex with PITCOIN2
Descriptor: 1,2-ETHANEDIOL, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, ~{N}-[4-(3-hydroxyphenyl)-1,3-thiazol-2-yl]-2-[4-oxidanylidene-3-(2-phenylethyl)pteridin-2-yl]sulfanyl-ethanamide
Authors:Lo, W.T, Roske, Y, Daumke, O, Haucke, V.
Deposit date:2022-03-15
Release date:2022-08-31
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Development of selective inhibitors of phosphatidylinositol 3-kinase C2 alpha.
Nat.Chem.Biol., 19, 2023
7Z75
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BU of 7z75 by Molmil
PI3KC2a core in complex with PITCOIN3
Descriptor: 1,2-ETHANEDIOL, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, SULFATE ION, ...
Authors:Lo, W.T, Roske, Y, Daumke, O, Haucke, V.
Deposit date:2022-03-15
Release date:2022-08-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Development of selective inhibitors of phosphatidylinositol 3-kinase C2 alpha.
Nat.Chem.Biol., 19, 2023
8A9I
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BU of 8a9i by Molmil
PI3KC2a core in complex with PITCOIN1
Descriptor: 1,2-ETHANEDIOL, 2-[4-oxidanylidene-3-(2-phenylethyl)pteridin-2-yl]sulfanyl-~{N}-(1,3-thiazol-2-yl)ethanamide, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, ...
Authors:Lo, W.T, Roske, Y, Daumke, O, Haucke, V.
Deposit date:2022-06-28
Release date:2022-08-31
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Development of selective inhibitors of phosphatidylinositol 3-kinase C2 alpha.
Nat.Chem.Biol., 19, 2023
2PR9
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BU of 2pr9 by Molmil
Mu2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with GABAA receptor-gamma2 subunit-derived internalization peptide DEEYGYECL
Descriptor: AP-2 complex subunit mu-1, GABA(A) receptor subunit gamma-2 peptide
Authors:Vahedi-Faridi, A, Haucke, V, Kittler, J.T, Kukhtina, V, Moss, S.J, Saenger, W, Chen, G.-J, Tretter, V, Smith, K, Yan, Z, McAinsh, K, Arancibia-Carcamo, L.
Deposit date:2007-05-04
Release date:2008-03-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit.
Proc.Natl.Acad.Sci.Usa, 105, 2008
6E4L
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BU of 6e4l by Molmil
The structure of the N-terminal domain of human clathrin heavy chain 1 (nTD) in complex with ES9
Descriptor: 1,2-ETHANEDIOL, 5-bromo-N-(4-nitrophenyl)thiophene-2-sulfonamide, ACETATE ION, ...
Authors:Dejonghe, W, Sharma, I, Denoo, B, Munck, S.D, Bulut, H, Mylle, E, Vasileva, M, Lu, Q, Savatin, D.V, Mishev, K, Nerinckx, W, Staes, A, Drozdzecki, A, Audenaert, D, Madder, A, Friml, J, Damme, D.V, Gevaert, K, Haucke, V, Savvides, S, Winne, J, Russinova, E.
Deposit date:2018-07-17
Release date:2019-04-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Disruption of endocytosis through chemical inhibition of clathrin heavy chain function.
Nat.Chem.Biol., 15, 2019
4G55
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BU of 4g55 by Molmil
Clathrin terminal domain complexed with pitstop 2
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Clathrin heavy chain 1, ...
Authors:Bulut, H, Von Kleist, L, Saenger, W, Haucke, V.
Deposit date:2012-07-17
Release date:2012-08-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.
Cell(Cambridge,Mass.), 146, 2011
2JXC
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BU of 2jxc by Molmil
Structure of the EPS15-EH2 Stonin2 Complex
Descriptor: CALCIUM ION, Epidermal growth factor receptor substrate 15, Stonin-2
Authors:Rumpf, J, Simon, B, Jung, N, Maritzen, T, Haucke, V, Sattler, M, Groemping, Y.
Deposit date:2007-11-12
Release date:2008-01-08
Last modified:2013-06-19
Method:SOLUTION NMR
Cite:Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity.
Embo J., 27, 2008
5A3F
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BU of 5a3f by Molmil
Crystal structure of the dynamin tetramer
Descriptor: DYNAMIN 3
Authors:Reubold, T.F, Faelber, K, Plattner, N, Posor, Y, Branz, K, Curth, U, Schlegel, J, Anand, R, Manstein, D.J, Noe, F, Haucke, V, Daumke, O, Eschenburg, S.
Deposit date:2015-05-29
Release date:2015-08-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Crystal Structure of the Dynamin Tetramer
Nature, 525, 2015
3H1Z
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BU of 3h1z by Molmil
Molecular basis for the association of PIPKIgamma -p90 with the clathrin adaptor AP-2
Descriptor: AP-2 complex subunit beta-1, Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
Authors:Vahedi-Faridi, A, Kahlfeldt, N, Schaefer, J.G, Krainer, G, Keller, S, Saenger, W, Krauss, M, Haucke, V.
Deposit date:2009-04-14
Release date:2009-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2.
J.Biol.Chem., 285, 2010
3H85
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BU of 3h85 by Molmil
Molecular basis for the association of PIPKI gamma-p90 with the clathrin adaptor AP-2
Descriptor: AP-2 complex subunit mu-1, NICKEL (II) ION, Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
Authors:Vahedi-Faridi, A, Kahlfeldt, N, Schaefer, J.G, Haucke, V.
Deposit date:2009-04-28
Release date:2009-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2.
J.Biol.Chem., 285, 2010
3HS8
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BU of 3hs8 by Molmil
Intersectin 1-peptide-AP2 alpha ear complex
Descriptor: Adaptor protein complex AP-2, alpha 2 subunit, peptide from Intersectin-1, ...
Authors:Vahedi-Faridi, A, Pechstein, A, Schaefer, J.G, Saenger, W, Haucke, V.
Deposit date:2009-06-10
Release date:2010-02-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Regulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2.
Proc.Natl.Acad.Sci.USA, 107, 2010
3HS9
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BU of 3hs9 by Molmil
Intersectin 1-peptide-AP2 beta ear complex
Descriptor: AP-2 complex subunit beta-1, peptide from Intersectin-1, residues 841-851
Authors:Vahedi-Faridi, A, Pechstein, A, Schaefer, J.G, Saenger, W, Haucke, V.
Deposit date:2009-06-10
Release date:2010-02-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Regulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2.
Proc.Natl.Acad.Sci.USA, 107, 2010
7BI2
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BU of 7bi2 by Molmil
PI3KC2aDeltaN and DeltaC-C2
Descriptor: 1,2-ETHANEDIOL, 9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1H)-one, IODIDE ION, ...
Authors:Lo, W.T, Roske, Y, Daumke, O, Haucke, V.
Deposit date:2021-01-12
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural basis of phosphatidylinositol 3-kinase C2 alpha function.
Nat.Struct.Mol.Biol., 29, 2022
7BI6
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BU of 7bi6 by Molmil
PI3KC2a core in complex with ATP
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Lo, W.T, Roske, Y, Daumke, O, Haucke, V.
Deposit date:2021-01-12
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis of phosphatidylinositol 3-kinase C2 alpha function.
Nat.Struct.Mol.Biol., 29, 2022
7BI4
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BU of 7bi4 by Molmil
PI3KC2a core apo
Descriptor: 1,2-ETHANEDIOL, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha,Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, SULFATE ION
Authors:Lo, W.T, Roske, Y, Daumke, O, Haucke, V.
Deposit date:2021-01-12
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural basis of phosphatidylinositol 3-kinase C2 alpha function.
Nat.Struct.Mol.Biol., 29, 2022
7BI9
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BU of 7bi9 by Molmil
PI3KC2a core in complex with PIK90
Descriptor: 1,2-ETHANEDIOL, N-(2,3-DIHYDRO-7,8-DIMETHOXYIMIDAZO[1,2-C] QUINAZOLIN-5-YL)NICOTINAMIDE, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha,Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
Authors:Lo, W.T, Roske, Y, Daumke, O, Haucke, V.
Deposit date:2021-01-12
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis of phosphatidylinositol 3-kinase C2 alpha function.
Nat.Struct.Mol.Biol., 29, 2022
2X3V
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BU of 2x3v by Molmil
Structure of The F-BAR Domain of Mouse Syndapin I
Descriptor: PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1
Authors:Ma, Q, Rao, Y, Vahedi-Faridi, A, Saenger, W, Haucke, V.
Deposit date:2010-01-27
Release date:2010-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Molecular Basis for SH3 Domain Regulation of F-Bar-Mediated Membrane Deformation.
Proc.Natl.Acad.Sci.USA, 107, 2010
2X3W
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BU of 2x3w by Molmil
structure of mouse syndapin I (crystal form 2)
Descriptor: PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1
Authors:Ma, Q, Rao, Y, Saenger, W, Haucke, V.
Deposit date:2010-01-28
Release date:2010-04-07
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Molecular Basis for SH3 Domain Regulation of F-Bar-Mediated Membrane Deformation.
Proc.Natl.Acad.Sci.USA, 107, 2010
2X3X
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BU of 2x3x by Molmil
structure of mouse syndapin I (crystal form 1)
Descriptor: PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1
Authors:Ma, Q, Rao, Y, Vahedi-Faridi, A, Saenger, W, Haucke, V.
Deposit date:2010-01-28
Release date:2010-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Molecular Basis for SH3 Domain Regulation of F-Bar-Mediated Membrane Deformation.
Proc.Natl.Acad.Sci.USA, 107, 2010
2XZG
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BU of 2xzg by Molmil
Clathrin Terminal Domain Complexed with Pitstop 1
Descriptor: 2-(4-AMINOBENZYL)-1,3-DIOXO-2,3-DIHYDRO-1H-BENZO[DE]ISOQUINOLINE-5-SULFONATE, ACETATE ION, CLATHRIN HEAVY CHAIN 1, ...
Authors:Bulut, H, Von Kleist, L, Saenger, W, Haucke, V.
Deposit date:2010-11-25
Release date:2011-08-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition.
Cell(Cambridge,Mass.), 146, 2011
8OMI
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BU of 8omi by Molmil
Crystal structure of the inositol hexakisphosphate kinase EhIP6KA M85 variant in complex with ATP and Mg2+
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Schuetz, A, Aguirre, T, Fiedler, D.
Deposit date:2023-03-31
Release date:2024-01-10
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor.
Elife, 12, 2023
6H5T
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BU of 6h5t by Molmil
Intersectin SH3A short isoform
Descriptor: 2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL, ACETATE ION, CHLORIDE ION, ...
Authors:Driller, J.H, Gerth, F, Freund, C, Wahl, M.C, Loll, B.
Deposit date:2018-07-25
Release date:2019-02-27
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (1.689 Å)
Cite:Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain.
Structure, 27, 2019
3SNH
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BU of 3snh by Molmil
Crystal structure of nucleotide-free human dynamin1
Descriptor: Dynamin-1
Authors:Faelber, K, Daumke, O.
Deposit date:2011-06-29
Release date:2011-09-21
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Crystal structure of nucleotide-free dynamin.
Nature, 477, 2011

217705

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