3E33
| Protein farnesyltransferase complexed with FPP and ethylenediamine scaffold inhibitor 7 | Descriptor: | FARNESYL DIPHOSPHATE, N-benzyl-N-(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)-2-methylbenzenesulfonamide, Protein farnesyltransferase subunit beta, ... | Authors: | Hast, M.A, Beese, L.S. | Deposit date: | 2008-08-06 | Release date: | 2009-03-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem.Biol., 16, 2009
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3E37
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3E32
| Protein farnesyltransferase complexed with FPP and ethylenediamine scaffold inhibitor 2 | Descriptor: | FARNESYL DIPHOSPHATE, N-benzyl-N-(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)-1-methyl-1H-imidazole-4-sulfonamide, Protein farnesyltransferase subunit beta, ... | Authors: | Hast, M.A, Beese, L.S. | Deposit date: | 2008-08-06 | Release date: | 2009-03-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem.Biol., 16, 2009
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3E34
| Protein farnesyltransferase complexed with FPP and ethylenediamine-scaffold inhibitor 10 | Descriptor: | 3-{2'-[{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)sulfamoyl]biphenyl-3-yl}propanoic acid, FARNESYL DIPHOSPHATE, Protein farnesyltransferase subunit beta, ... | Authors: | Hast, M.A, Beese, L.S. | Deposit date: | 2008-08-06 | Release date: | 2009-03-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem.Biol., 16, 2009
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3E30
| Protein farnesyltransferase complexed with FPP and ethylene diamine inhibitor 4 | Descriptor: | FARNESYL DIPHOSPHATE, Protein farnesyltransferase subunit beta, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, ... | Authors: | Hast, M.A, Beese, L.S. | Deposit date: | 2008-08-06 | Release date: | 2009-03-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem.Biol., 16, 2009
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3DRA
| Candida albicans protein geranylgeranyltransferase-I complexed with GGPP | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GERANYLGERANYL DIPHOSPHATE, Geranylgeranyltransferase type I beta subunit, ... | Authors: | Hast, M.A, Beese, L.S. | Deposit date: | 2008-07-10 | Release date: | 2008-09-30 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of protein geranylgeranyltransferase-I from the human pathogen Candida albicans complexed with a lipid substrate. J.Biol.Chem., 283, 2008
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3Q79
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3Q7A
| Cryptococcus neoformans protein farnesyltransferase in complex with FPP and L-778,123 | Descriptor: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE, FARNESYL DIPHOSPHATE, ... | Authors: | Hast, M.A, Beese, L.S. | Deposit date: | 2011-01-04 | Release date: | 2011-08-03 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens. J.Biol.Chem., 286, 2011
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3Q78
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3Q73
| Cryptococcus neoformans protein farnesyltransferase, apo enzyme | Descriptor: | (2S)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, Farnesyltransferase, alpha subunit, ... | Authors: | Hast, M.A, Beese, L.S. | Deposit date: | 2011-01-04 | Release date: | 2011-08-03 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens. J.Biol.Chem., 286, 2011
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3Q75
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3Q7F
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3SFX
| Cryptococcus neoformans protein farnesyltransferase in complex with FPT-II and tipifarnib | Descriptor: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE, Cryptococcus neoformans protein farnesyltransferase alpha subunit, ... | Authors: | Hast, M.A, Beese, L.S. | Deposit date: | 2011-06-14 | Release date: | 2011-08-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens. J.Biol.Chem., 286, 2011
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3SFY
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2IEJ
| Human Protein Farnesyltransferase Complexed with Inhibitor Compound STN-48 And FPP Analog at 1.8A Resolution | Descriptor: | ACETATE ION, METHYL N-{(3S)-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-6-PHENYL-1,2,3,4-TETRAHYDROQUINOLIN-3-YL}-N-[(1-METHYL-1H-IMIDAZOL-4-YL)SULFONYL]GLYCINATE, Protein farnesyltransferase subunit beta, ... | Authors: | Hast, M.A, Beese, L.S. | Deposit date: | 2006-09-19 | Release date: | 2007-01-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. Mol.Biochem.Parasitol., 152, 2007
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3DPY
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4L9P
| Crystal structure of Aspergillus fumigatus protein farnesyltransferase complexed with the FII analog, FPT-II, and the KCVVM peptide | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, CaaX farnesyltransferase alpha subunit Ram2, ... | Authors: | Mabanglo, M.F, Hast, M.A, Beese, L.S. | Deposit date: | 2013-06-18 | Release date: | 2014-01-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Sci., 23, 2014
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4LNG
| Aspergillus fumigatus protein farnesyltransferase complex with farnesyldiphosphate and tipifarnib | Descriptor: | 1,2-ETHANEDIOL, 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE, CaaX farnesyltransferase alpha subunit Ram2, ... | Authors: | Mabanglo, M.F, Hast, M.A, Beese, L.S. | Deposit date: | 2013-07-11 | Release date: | 2014-01-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.905 Å) | Cite: | Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Sci., 23, 2014
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4LNB
| Aspergillus fumigatus protein farnesyltransferase ternary complex with farnesyldiphosphate and ethylenediamine scaffold inhibitor 5 | Descriptor: | 1,2-ETHANEDIOL, CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, ... | Authors: | Mabanglo, M.F, Hast, M.A, Beese, L.S. | Deposit date: | 2013-07-11 | Release date: | 2014-01-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.752 Å) | Cite: | Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Sci., 23, 2014
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4MBG
| Crystal structure of Aspergillus fumigatus protein farnesyltransferase binary complex with farnesyldiphosphate | Descriptor: | 1,2-ETHANEDIOL, CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, ... | Authors: | Mabanglo, M.F, Hast, M.A, Beese, L.S. | Deposit date: | 2013-08-19 | Release date: | 2014-01-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Sci., 23, 2014
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4YDE
| CRYSTAL STRUCTURE OF CANDIDA ALBICANS PROTEIN FARNESYLTRANSFERASE BINARY COMPLEX WITH THE ISOPRENOID FARNESYLDIPHOSPHATE | Descriptor: | (3R,7S)-3,7,11-trimethyldodecyl trihydrogen diphosphate, 1,2-ETHANEDIOL, Protein farnesyltransferase/geranylgeranyltransferase type-1 Subunit beta, ... | Authors: | Kumar, S, Mabanglo, M.F, Hast, M.A, Shi, Y, Beese, L.S. | Deposit date: | 2015-02-22 | Release date: | 2016-07-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.701 Å) | Cite: | CRYSTAL STRUCTURE OF CANDIDA ALBICANS PROTEIN FARNESYLTRANSFERASE BINARY COMPLEX WITH THE ISOPRENOID FARNESYLDIPHOSPHATE To Be Published
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4YDO
| CRYSTAL STRUCTURE OF CANDIDA ALBICANS PROTEIN FARNESYLTRANSFERASE IN APO FORM | Descriptor: | CALCIUM ION, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Uncharacterized protein, ... | Authors: | Kumar, S, Mabanglo, M.F, Hast, M.A, Shi, Y, Beese, L.S. | Deposit date: | 2015-02-22 | Release date: | 2016-07-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | CRYSTAL STRUCTURE OF CANDIDA ALBICANS PROTEIN FARNESYLTRANSFERASE IN APO FORM To Be Published
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3QEA
| Crystal structure of human exonuclease 1 Exo1 (WT) in complex with DNA (complex II) | Descriptor: | BARIUM ION, DNA (5'-D(P*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ... | Authors: | Orans, J, McSweeney, E.A, Iyer, R.R, Hast, M.A, Hellinga, H.W, Modrich, P, Beese, L.S. | Deposit date: | 2011-01-20 | Release date: | 2011-04-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. Cell(Cambridge,Mass.), 145, 2011
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3QE9
| Crystal structure of human exonuclease 1 Exo1 (D173A) in complex with DNA (complex I) | Descriptor: | CALCIUM ION, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ... | Authors: | Orans, J, McSweeney, E.A, Iyer, R.R, Hast, M.A, Hellinga, H.W, Modrich, P, Beese, L.S. | Deposit date: | 2011-01-20 | Release date: | 2011-04-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. Cell(Cambridge,Mass.), 145, 2011
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3QEB
| Crystal structure of human exonuclease 1 Exo1 (WT) in complex with DNA and Mn2+ (complex III) | Descriptor: | DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), Exonuclease 1, ... | Authors: | Orans, J, McSweeney, E.A, Iyer, R.R, Hast, M.A, Hellinga, H.W, Modrich, P, Beese, L.S. | Deposit date: | 2011-01-20 | Release date: | 2011-04-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. Cell(Cambridge,Mass.), 145, 2011
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