Author results

6FF4
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HUMAN BACT SPLICEOSOME CORE STRUCTURE
Descriptor:RNA-binding motif protein, X-linked 2, U2 snRNA, ...
Authors:Haselbach, D., Komarov, I., Agafonov, D., Hartmuth, K., Graf, B., Kastner, B., Luehrmann, R., Stark, H.
Deposit date:2018-01-03
Release date:2018-08-29
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure and Conformational Dynamics of the Human Spliceosomal BactComplex.
Cell, 172, 2018
6FF7
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HUMAN BACT SPLICEOSOME CORE STRUCTURE
Descriptor:RNA-binding motif protein, X-linked 2, U2 snRNA, ...
Authors:Haselbach, D., Komarov, I., Agafonov, D., Hartmuth, K., Graf, B., Kastner, B., Luehrmann, R., Stark, H.
Deposit date:2018-01-03
Release date:2019-03-13
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structure and Conformational Dynamics of the Human Spliceosomal BactComplex.
Cell, 172, 2018
5M32
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HUMAN 26S PROTEASOME IN COMPLEX WITH OPROZOMIB
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-4, Proteasome subunit alpha type-7, ...
Authors:Haselbach, D., Schrader, J., Lambrecht, F., Henneberg, F., Chari, A., Stark, H.
Deposit date:2016-10-14
Release date:2017-07-05
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs.
Nat Commun, 8, 2017
6H55
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CORE OF THE HUMAN PYRUVATE DEHYDROGENASE (E2)
Descriptor:Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Authors:Haselbach, D., Prajapati, S., Tittmann, K., Stark, H.
Deposit date:2018-07-23
Release date:2019-06-05
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (6 Å)
Cite:Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.
Structure, 27, 2019
6H60
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PSEUDO-ATOMIC STRUCTURAL MODEL OF THE E3BP COMPONENT OF THE HUMAN PYRUVATE DEHYDROGENASE MULTIENZYME COMPLEX
Descriptor:Pyruvate dehydrogenase protein X component, mitochondrial
Authors:Haselbach, D., Prajapati, S., Tittmann, K., Stark, H.
Deposit date:2018-07-25
Release date:2019-06-05
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (6 Å)
Cite:Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.
Structure, 27, 2019
5L9T
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MODEL OF HUMAN ANAPHASE-PROMOTING COMPLEX/CYCLOSOME (APC/C-CDH1) WITH E2 UBE2S POISED FOR POLYUBIQUITINATION WHERE UBE2S, APC2, AND APC11 ARE MODELED INTO LOW RESOLUTION DENSITY
Descriptor:Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Cell division cycle protein 23 homolog, ...
Authors:Brown, N.G., VanderLinden, R., Dube, P., Haselbach, D., Peters, J.M., Stark, H., Schulman, B.A.
Deposit date:2016-06-11
Release date:2016-10-26
Last modified:2016-11-02
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
5L9U
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MODEL OF HUMAN ANAPHASE-PROMOTING COMPLEX/CYCLOSOME (APC/C-CDH1) WITH A CROSS LINKED UBIQUITIN VARIANT-SUBSTRATE-UBE2C (UBCH10) COMPLEX REPRESENTING KEY FEATURES OF MULTIUBIQUITINATION
Descriptor:Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Cell division cycle protein 23 homolog, ...
Authors:Brown, N.G., VanderLinden, R., Dube, P., Haselbach, D., Peters, J.M., Stark, H., Schulman, B.A.
Deposit date:2016-06-11
Release date:2016-09-14
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
5KHR
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MODEL OF HUMAN ANAPHASE-PROMOTING COMPLEX/CYCLOSOME COMPLEX (APC15 DELETION MUTANT) IN COMPLEX WITH THE E2 UBE2C/UBCH10 POISED FOR UBIQUITIN LIGATION TO SUBSTRATE (APC/C-CDC20-SUBSTRATE-UBE2C)
Descriptor:Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Cell division cycle protein 23 homolog, ...
Authors:VanderLinden, R., Yamaguchi, M., Dube, P., Haselbach, D., Stark, H., Schulman, B.A.
Deposit date:2016-06-15
Release date:2016-08-24
Last modified:2016-08-31
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.
Mol.Cell, 63, 2016
5JG6
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APC11-UBV SHOWS ROLE OF NONCOVALENT RING-UBIQUITIN INTERACTIONS IN PROCESSIVE MULTIUBIQUITINATION AND UBIQUITIN CHAIN ELONGATION BY APC/C
Descriptor:Anaphase-promoting complex subunit 11, Polyubiquitin-B, ZINC ION
Authors:Brown, N.G., Zhang, W., Yu, S., Miller, D.J., Sidhu, S.S., Schulman, B.A.
Deposit date:2016-04-19
Release date:2016-06-15
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.0013 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
4FGV
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CRYSTAL STRUCTURE OF FREE CRM1 (CRYSTAL FORM 1)
Descriptor:Chromosome region maintenance 1 (CRM1) or Exportin 1 (Xpo1)
Authors:Monecke, T., Neumann, P., Dickmanns, A., Ficner, R.
Deposit date:2012-06-05
Release date:2013-01-23
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (2.941 Å)
Cite:Structural basis for cooperativity of CRM1 export complex formation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HZK
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CRYSTAL STRUCTURE OF FREE CRM1 (CRYSTAL FORM 2)
Descriptor:CRM1 Nuclear transport receptor
Authors:Monecke, T., Neumann, P., Dickmanns, A., Ficner, R.
Deposit date:2012-11-15
Release date:2013-01-23
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for cooperativity of CRM1 export complex formation.
Proc.Natl.Acad.Sci.USA, 110, 2013
5KHU
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MODEL OF HUMAN ANAPHASE-PROMOTING COMPLEX/CYCLOSOME (APC15 DELETION MUTANT), IN COMPLEX WITH THE MITOTIC CHECKPOINT COMPLEX (APC/C-CDC20-MCC) BASED ON CRYO EM DATA AT 4.8 ANGSTROM RESOLUTION
Descriptor:Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Cell division cycle protein 23 homolog, ...
Authors:Yamaguchi, M., VanderLinden, R., Dube, P., Stark, H., Schulman, B.
Deposit date:2016-06-15
Release date:2016-09-07
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.
Mol.Cell, 63, 2016
5O9Z
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CRYO-EM STRUCTURE OF A PRE-CATALYTIC HUMAN SPLICEOSOME PRIMED FOR ACTIVATION (B COMPLEX)
Descriptor:Pre-mRNA-processing-splicing factor 8, 116 kDa U5 small nuclear ribonucleoprotein component, U5 small nuclear ribonucleoprotein 200 kDa helicase, ...
Authors:Bertram, K., Kastner, B.
Deposit date:2017-06-20
Release date:2017-08-16
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Cell, 170, 2017
6OB1
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STRUCTURE OF WHB IN COMPLEX WITH UBIQUITIN VARIANT
Descriptor:Ubiquitin, Anaphase-promoting complex subunit 2
Authors:Edmond, R.W., Grace, C.R.
Deposit date:2019-03-19
Release date:2019-08-14
Last modified:2019-09-04
Method:SOLUTION NMR
Cite:Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Proc.Natl.Acad.Sci.USA, 116, 2019