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5NO2
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RSGA-GDPNP BOUND TO THE 30S RIBOSOMAL SUBUNIT (RSGA ASSEMBLY INTERMEDIATE)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S4, 30S ribosomal protein S5, ...
Authors:Lopez-Alonso, J.P., Kaminishi, T., Kikuchi, T., Hirata, Y., Iturrioz, I., Dhimole, N., Schedlbauer, A., Hase, Y., Goto, S., Kurita, D., Muto, A., Zhou, S., Naoe, C., Mills, D.J., Gil-Carton, D., Takemoto, C., Himeno, H., Fucini, P., Connell, S.R.
Deposit date:2017-04-10
Release date:2017-05-24
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (5.16 Å)
Cite:RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket.
Nucleic Acids Res., 45, 2017
5NO3
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RSGA-GDPNP BOUND TO THE 30S RIBOSOMAL SUBUNIT (RSGA ASSEMBLY INTERMEDIATE WITHOUT US3)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S4, ...
Authors:Lopez-Alonso, J.P., Kaminishi, T., Kikuchi, T., Hirata, Y., Iturrioz, I., Dhimole, N., Schedlbauer, A., Hase, Y., Goto, S., Kurita, D., Muto, A., Zhou, S., Naoe, C., Mills, D.J., Gil-Carton, D., Takemoto, C., Himeno, H., Fucini, P., Connell, S.R.
Deposit date:2017-04-10
Release date:2017-05-31
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (5.16 Å)
Cite:RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket.
Nucleic Acids Res., 45, 2017
5NO4
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RSGA-GDPNP BOUND TO THE 30S RIBOSOMAL SUBUNIT (RSGA ASSEMBLY INTERMEDIATE WITH US3)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Lopez-Alonso, J.P., Kaminishi, T., Kikuchi, T., Hirata, Y., Iturrioz, I., Dhimole, N., Schedlbauer, A., Hase, Y., Goto, S., Kurita, D., Muto, A., Zhou, S., Naoe, C., Mills, D.J., Gil-Carton, D., Takemoto, C., Himeno, H., Fucini, P., Connell, S.R.
Deposit date:2017-04-10
Release date:2017-05-31
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (5.16 Å)
Cite:RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket.
Nucleic Acids Res., 45, 2017
5AYG
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CRYSTAL STRUCTURE OF THE HUMAN ROR GAMMA LIGAND BINDING DOMAIN WITH 3G
Descriptor:Nuclear receptor ROR-gamma, 3-[5-(2-cyclohexylethyl)-4-ethyl-1,2,4-triazol-3-yl]-N-naphthalen-1-yl-propanamide
Authors:Noguchi, M., Doi, S., Nomura, A., Kikuwaka, M., Murase, K., Hirata, K., Kamada, M., Adachi, T.
Deposit date:2015-08-20
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR gamma Inhibitor
Acs Med.Chem.Lett., 7, 2016
6IVX
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DISCOVERY OF THE SECOND GENERATION ROR GAMMA INHIBITORS COMPOSED OF AN AZOLE SCAFFOLD.
Descriptor:Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2, (4S)-4-[4'-cyclopropyl-5-(2,2-dimethylpropyl)[3,5'-bi-1,2-oxazol]-3'-yl]-6-[(2,4-dichlorophenyl)amino]-6-oxohexanoic acid
Authors:Noguchi, M., Nomura, A., Doi, S., Adachi, T.
Deposit date:2018-12-04
Release date:2019-03-06
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Discovery of Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold.
J. Med. Chem., 62, 2019
2DXS
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CRYSTAL STRUCTURE OF HCV NS5B RNA POLYMERASE COMPLEXED WITH A TETRACYCLIC INHIBITOR
Descriptor:Genome polyprotein, N-[(13-CYCLOHEXYL-6,7-DIHYDROINDOLO[1,2-D][1,4]BENZOXAZEPIN-10-YL)CARBONYL]-2-METHYL-L-ALANINE
Authors:Adachi, T., Tsuruha, J., Doi, S., Murase, K., Ikegashira, K., Watanabe, S., Uehara, K., Orita, T., Nomura, A., Kamada, M.
Deposit date:2006-08-30
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of Conformationally Constrained Tetracyclic Compounds as Potent Hepatitis C Virus NS5B RNA Polymerase Inhibitors
J.Med.Chem., 49, 2006
6IG8
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CRYSTAL STRUCTURE OF CSF-1R KINASE DOMAIN WITH A SMALL MOLECULAR INHIBITOR, JTE-952
Descriptor:Macrophage colony-stimulating factor 1 receptor, MAGNESIUM ION, GLYCEROL, ...
Authors:Doi, S., Adachi, T.
Deposit date:2018-09-25
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of a novel azetidine scaffold for colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors by the use of docking models.
Bioorg.Med.Chem.Lett., 29, 2019