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6W5D
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BU of 6w5d by Molmil
Crystal Structure of Fab RSB1
Descriptor: RSB1 Fab Heavy Chain, RSB1 Fab Light Chain
Authors:Harshbarger, W, Chandramouli, S, Malito, M.
Deposit date:2020-03-13
Release date:2020-11-11
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Convergent structural features of respiratory syncytial virus neutralizing antibodies and plasticity of the site V epitope on prefusion F.
Plos Pathog., 16, 2020
5J41
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BU of 5j41 by Molmil
Glutathione S-transferase bound with hydrolyzed Piperlongumine
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-(3,4,5-trimethoxyphenyl)propanoic acid, GLUTATHIONE, ...
Authors:Harshbarger, W, Gondi, S, Ficarro, S, Hunter, J, Udayakumar, D, Gurbani, D, Marto, J, Westover, K.
Deposit date:2016-03-31
Release date:2016-11-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.19035351 Å)
Cite:Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine.
J. Biol. Chem., 292, 2017
7MMN
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BU of 7mmn by Molmil
Crystal Structure of the Prefusion RSV F Glycoprotein bound by human antibody AM14
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, AM14 Fab Heavy Chain, AM14 Fab Light Chain, ...
Authors:Harshbarger, W, Malito, E.
Deposit date:2021-04-29
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.57 Å)
Cite:Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein.
Mabs, 13, 2021
6W52
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BU of 6w52 by Molmil
Prefusion RSV F bound by neutralizing antibody RSB1
Descriptor: Fusion glycoprotein F0, Fusion glycoprotein F1 fused with Fibritin trimerization domain, RSB1 Fab Heavy Chain, ...
Authors:Harshbarger, W, Chandramouli, S, Malito, M.
Deposit date:2020-03-12
Release date:2020-11-11
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.74 Å)
Cite:Convergent structural features of respiratory syncytial virus neutralizing antibodies and plasticity of the site V epitope on prefusion F.
Plos Pathog., 16, 2020
3QJ7
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BU of 3qj7 by Molmil
Crystal Structure of the Mycobacterium tuberculosis Thymidylate synthase (ThyA) bound to dUMP
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, SPERMINE, Thymidylate synthase
Authors:Reddy, M.C.M, Bruning, J.B, Harshbarger, W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-01-28
Release date:2011-06-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.504 Å)
Cite:Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: insights into the selectivity and mode of inhibition
To be Published
4FOX
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BU of 4fox by Molmil
Crystal Structure of Mtb ThyA in complex with dUMP and Raltitrexed
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, Thymidylate synthase
Authors:Reddy, M.C.M, Bruning, J.B, Sacchettini, J.C, Harshbarger, W, TB Structural Genomics Consortium (TBSGC)
Deposit date:2012-06-21
Release date:2013-08-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: Insights into the selectivity and mode of inhibition
To be Published
4FQS
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BU of 4fqs by Molmil
Crystal Structure of Mycobacterium tuberculosis ThyA in complex with UMP and Pemetrexed
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, Thymidylate synthase
Authors:Reddy, M.C.M, Bruning, J.B, Harshbarger, W, Sacchettini, J.C.
Deposit date:2012-06-25
Release date:2013-08-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: insights into the selectivity and mode of inhibition
To be Published
4R67
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BU of 4r67 by Molmil
Human constitutive 20S proteasome in complex with carfilzomib
Descriptor: N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-phenylalaninamide, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ...
Authors:Sacchettini, J.C, Harshbarger, W.H.
Deposit date:2014-08-22
Release date:2015-02-11
Last modified:2015-02-18
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Crystal Structure of the Human 20S Proteasome in Complex with Carfilzomib.
Structure, 23, 2015
4R3O
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BU of 4r3o by Molmil
Human Constitutive 20S Proteasome
Descriptor: Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ...
Authors:Sacchettini, J.C, Harshbarger, W.H.
Deposit date:2014-08-16
Release date:2015-01-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Human 20S Proteasome in Complex with Carfilzomib.
Structure, 23, 2015
7MPG
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BU of 7mpg by Molmil
Cryo-EM structure of Prefusion-stabilized RSV F (DS-Cav1) in complex with Fab AM14
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, AM14 Fab Heavy Chain, AM14 Fab Light Chain, ...
Authors:Abeyrathne, P.D, Malito, E, Harshbarger, W.D.
Deposit date:2021-05-04
Release date:2021-09-08
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein.
Mabs, 13
8EPN
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BU of 8epn by Molmil
Cryo-EM structure of SARS-CoV-2 Spike trimer S2D14 in the 3-RBD Down conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Williams, J.A, Harshbarger, W.
Deposit date:2022-10-06
Release date:2023-06-21
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural and computational design of a SARS-CoV-2 spike antigen with improved expression and immunogenicity.
Sci Adv, 9, 2023
8EPQ
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BU of 8epq by Molmil
Cryo-EM structure of SARS-CoV-2 Spike trimer S2D14 with two RBDs exposed
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Williams, J.A, Harshbarger, W.
Deposit date:2022-10-06
Release date:2023-06-21
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural and computational design of a SARS-CoV-2 spike antigen with improved expression and immunogenicity.
Sci Adv, 9, 2023
8EPP
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BU of 8epp by Molmil
Cryo-EM structure of SARS-CoV-2 Spike trimer S2D14 with two RBDs in the open conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Williams, J.A, Harshbarger, W.
Deposit date:2022-10-06
Release date:2023-06-21
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural and computational design of a SARS-CoV-2 spike antigen with improved expression and immunogenicity.
Sci Adv, 9, 2023
4FOG
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BU of 4fog by Molmil
Crystal Structure of Mtb ThyA in Complex with 5-Fluoro-dUMP and 5-methyltetrahydrofolic acid
Descriptor: 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, Thymidylate synthase
Authors:Reddy, M.C.M, Bruning, J.B, Harshbarger, W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2012-06-20
Release date:2013-08-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: Insights into the selectivity and mode of inhibition
To be Published

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PDB entries from 2024-03-27

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