Author results

3D1Z
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CRYSTAL STRUCTURE OF HIV-1 MUTANT I54M AND INHIBITOR DARUNAVIR
Descriptor:HIV-1 Protease, CHLORIDE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ...
Authors:Liu, F., Kovalesky, A.Y., Tie, Y., Ghosh, A.K., Harrison, R.W., Weber, I.T.
Deposit date:2008-05-07
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.
J.Mol.Biol., 381, 2008
3D20
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CRYSTAL STRUCTURE OF HIV-1 MUTANT I54V AND INHIBITOR DARUNAVIA
Descriptor:HIV-1 Protease, SODIUM ION, CHLORIDE ION, ...
Authors:Liu, F., Kovalesky, A.Y., Tie, Y., Ghosh, A.K., Harrison, R.W., Weber, I.T.
Deposit date:2008-05-07
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.
J.Mol.Biol., 381, 2008
1A8M
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TUMOR NECROSIS FACTOR ALPHA, R31D MUTANT
Descriptor:TUMOR NECROSIS FACTOR ALPHA
Authors:Reed, C., Fu, Z.-Q., Wu, J., Xue, Y.-N., Harrison, R.W., Chen, M.-J., Weber, I.T.
Deposit date:1998-03-27
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2.
Protein Eng., 10, 1997
1JRS
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HEMIACETAL COMPLEX BETWEEN LEUPEPTIN AND TRYPSIN
Descriptor:TRYPSIN, Leupeptin, CALCIUM ION
Authors:Kurinov, I.V., Harrison, R.W.
Deposit date:1996-02-07
Release date:1996-10-14
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Two crystal structures of the leupeptin-trypsin complex.
Protein Sci., 5, 1996
1JRT
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HEMIACETAL COMPLEX BETWEEN LEUPEPTIN AND TRYPSIN
Descriptor:TRYPSIN, LEUPEPTIN, CALCIUM ION
Authors:Kurinov, I.V., Harrison, R.W.
Deposit date:1996-02-07
Release date:1996-10-14
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Two crystal structures of the leupeptin-trypsin complex.
Protein Sci., 5, 1996
2IEN
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE WITH A POTENT NON-PEPTIDE INHIBITOR (UIC-94017)
Descriptor:Protease, SODIUM ION, CHLORIDE ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Manna, D., Hussain, A.K., Leshchenko, S., Ghosh, A.K., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2006-09-19
Release date:2006-10-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-Peptide Inhibitor (Uic-94017) Active Against Multi-Drug-Resistant Clinical Strains.
J.Mol.Biol., 338, 2004
1A1X
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CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES
Descriptor:HMTCP-1
Authors:Fu, Z.Q., Dubois, G.C., Song, S.P., Kulikovskaya, I., Virgilio, L., Rothstein, J., Croce, C.M., Weber, I.T., Harrison, R.W.
Deposit date:1997-12-18
Release date:1998-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies.
Proc.Natl.Acad.Sci.USA, 95, 1998
1A8K
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CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES
Descriptor:HIV PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Weber, I.T., Wu, J., Adomat, J., Harrison, R.W., Kimmel, A.R., Wondrak, E.M., Louis, J.M.
Deposit date:1998-03-27
Release date:1999-01-13
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates.
Eur.J.Biochem., 249, 1997
1A94
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STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES
Descriptor:PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Wu, J., Adomat, J.M., Ridky, T.W., Louis, J.M., Leis, J., Harrison, R.W., Weber, I.T.
Deposit date:1998-04-16
Release date:1999-01-13
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for specificity of retroviral proteases.
Biochemistry, 37, 1998
1BAI
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CRYSTAL STRUCTURE OF ROUS SARCOMA VIRUS PROTEASE IN COMPLEX WITH INHIBITOR
Descriptor:PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Wu, J., Adomat, J.M., Ridky, T.W., Louis, J.M., Leis, J., Harrison, R.W., Weber, I.T.
Deposit date:1998-04-17
Release date:1999-01-13
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for specificity of retroviral proteases.
Biochemistry, 37, 1998
1D53
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CRYSTAL STRUCTURE AT 1.5 ANGSTROMS RESOLUTION OF D(CGCICICG), AN OCTANUCLEOTIDE CONTAINING INOSINE, AND ITS COMPARISON WITH D(CGCG) AND D(CGCGCG) STRUCTURES
Descriptor:DNA (5'-D(*CP*GP*CP*IP*CP*IP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*G)-3')
Authors:Kumar, V.D., Harrison, R.W., Andrews, L.C., Weber, I.T.
Deposit date:1992-11-05
Release date:1993-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure at 1.5-A resolution of d(CGCICICG), an octanucleotide containing inosine, and its comparison with d(CGCG) and d(CGCGCG) structures.
Biochemistry, 31, 1992
1DAZ
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STRUCTURAL AND KINETIC ANALYSIS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE (RETROPEPSIN), N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Louis, J.M., Reed, C.C., Adomat, J.M., Krouse, J., Wang, Y.F., Harrison, R.W., Weber, I.T.
Deposit date:1999-11-01
Release date:2000-05-03
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.
Eur.J.Biochem., 263, 1999
1DW6
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STRUCTURAL AND KINETIC ANALYSIS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Louis, J.M., Reed, C.C., Adomat, J.M., Krouse, J., Wang, Y.F., Harrison, R.W., Weber, I.T.
Deposit date:2000-01-24
Release date:2000-07-26
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.
Eur.J.Biochem., 263, 1999
1EBK
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STRUCTURAL AND KINETIC ANALYSIS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Louis, J.M., Reed, C.C., Adomat, J.M., Krouse, J., Wang, Y.F., Harrison, R.W., Weber, I.T.
Deposit date:2000-01-24
Release date:2000-07-26
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.
Eur.J.Biochem., 263, 1999
1FEJ
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:PROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-21
Release date:2001-06-01
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FF0
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES.
Descriptor:PROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-24
Release date:2001-06-01
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FFF
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE : HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES.
Descriptor:PROTEASE RETROPEPSIN, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-25
Release date:2001-06-01
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FFI
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:PROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-25
Release date:2001-06-01
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FG6
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:PROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-25
Release date:2001-06-01
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FG8
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:PROTEASE RETROPEPSIN, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-25
Release date:2001-06-01
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FGC
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:PROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-28
Release date:2001-06-01
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1JNP
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CRYSTAL STRUCTURE OF MURINE TCL1 AT 2.5 RESOLUTION
Descriptor:T-CELL LEUKEMIA/LYMPHOMA PROTEIN 1A
Authors:Petock, J.M., Torshin, I.Y., Wang, Y.F., DuBois, G.C., Croce, C.M., Harrison, R.W., Weber, I.T.
Deposit date:2001-07-24
Release date:2001-11-07
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family.
Acta Crystallogr.,Sect.D, 57, 2001
1K1T
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COMBINING MUTATIONS IN HIV-1 PROTEASE TO UNDERSTAND MECHANISMS OF RESISTANCE
Descriptor:PROTEASE RETROPEPSIN, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, SULFATE ION
Authors:Mahalingam, B., Boross, P., Wang, Y.-F., Louis, J.M., Fischer, C., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2001-09-25
Release date:2002-07-10
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Combining mutations in HIV-1 protease to understand mechanisms of resistance.
Proteins, 48, 2002
1LSA
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THE INFLUENCE OF TEMPERATURE ON LYSOZYME CRYSTALS. STRUCTURE AND DYNAMICS OF PROTEIN AND WATER
Descriptor:HEN EGG WHITE LYSOZYME
Authors:Kurinov, I., Harrison, R.W.
Deposit date:1994-07-05
Release date:1994-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The influence of temperature on lysozyme crystals. Structure and dynamics of protein and water.
Acta Crystallogr.,Sect.D, 51, 1995
1LSB
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THE INFLUENCE OF TEMPERATURE ON LYSOZYME CRYSTALS. STRUCTURE AND DYNAMICS OF PROTEIN AND WATER
Descriptor:HEN EGG WHITE LYSOZYME
Authors:Kurinov, I., Harrison, R.W.
Deposit date:1994-07-05
Release date:1994-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The influence of temperature on lysozyme crystals. Structure and dynamics of protein and water.
Acta Crystallogr.,Sect.D, 51, 1995