Author results

3T9L
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STRUCTURE OF N-TERMINAL DUSP-UBL DOMAINS OF HUMAN USP15
Descriptor:Ubiquitin carboxyl-terminal hydrolase 15, SULFATE ION
Authors:Harper, S., Besong, T.M.D., Emsley, J., Scott, D.J., Dreveny, I.
Deposit date:2011-08-03
Release date:2011-09-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of the USP15 N-Terminal Domains: A beta-Hairpin Mediates Close Association between the DUSP and UBL Domains
Biochemistry, 50, 2011
4MEL
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CRYSTAL STRUCTURE OF THE HUMAN USP11 DUSP-UBL DOMAINS
Descriptor:Ubiquitin carboxyl-terminal hydrolase 11
Authors:Harper, S., Gratton, H.E., Cornaciu, I., Oberer, M., Scott, D.J., Emsley, J., Dreveny, I.
Deposit date:2013-08-27
Release date:2014-05-07
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.899 Å)
Cite:Structure and Catalytic Regulatory Function of Ubiquitin Specific Protease 11 N-Terminal and Ubiquitin-like Domains.
Biochemistry, 53, 2014
4MEM
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CRYSTAL STRUCTURE OF THE RAT USP11 DUSP-UBL DOMAINS
Descriptor:Ubiquitin carboxyl-terminal hydrolase 11
Authors:Harper, S., Gratton, H.E., Cornaciu, I., Oberer, M., Scott, D.J., Emsley, J., Dreveny, I.
Deposit date:2013-08-27
Release date:2014-05-07
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structure and Catalytic Regulatory Function of Ubiquitin Specific Protease 11 N-Terminal and Ubiquitin-like Domains.
Biochemistry, 53, 2014
4L4R
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STRUCTURAL CHARACTERISATION OF THE APO-FORM OF HUMAN LACTATE DEHYDROGENASE M ISOZYME
Descriptor:L-lactate dehydrogenase A chain
Authors:Dempster, S., Harper, S., Moses, J.E., Dreveny, I.
Deposit date:2013-06-09
Release date:2014-04-30
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase.
Acta Crystallogr.,Sect.D, 70, 2014
4L4S
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STRUCTURAL CHARACTERISATION OF THE NADH BINARY COMPLEX OF HUMAN LACTATE DEHYDROGENASE M ISOZYME
Descriptor:L-lactate dehydrogenase A chain, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE
Authors:Dempster, S., Harper, S., Moses, J.E., Dreveny, I.
Deposit date:2013-06-09
Release date:2014-04-30
Last modified:2014-06-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase.
Acta Crystallogr.,Sect.D, 70, 2014
1MJ9
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CRYSTAL STRUCTURE OF YEAST ESA1(C304S) MUTANT COMPLEXED WITH COENZYME A
Descriptor:ESA1 PROTEIN, SODIUM ION, COENZYME A
Authors:Yan, Y., Harper, S., Speicher, D., Marmorstein, R.
Deposit date:2002-08-27
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate.
Nat.Struct.Biol., 9, 2002
1MJA
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CRYSTAL STRUCTURE OF YEAST ESA1 HISTONE ACETYLTRANSFERASE DOMAIN COMPLEXED WITH ACETYL COENZYME A
Descriptor:Esa1 protein, COENZYME A
Authors:Yan, Y., Harper, S., Speicher, D., Marmorstein, R.
Deposit date:2002-08-27
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate.
Nat.Struct.Biol., 9, 2002
1MJB
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CRYSTAL STRUCTURE OF YEAST ESA1 HISTONE ACETYLTRANSFERASE E338Q MUTANT COMPLEXED WITH ACETYL COENZYME A
Descriptor:Esa1 protein, ACETYL COENZYME *A
Authors:Yan, Y., Harper, S., Speicher, D., Marmorstein, R.
Deposit date:2002-08-27
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate.
Nat.Struct.Biol., 9, 2002
3COQ
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STRUCTURAL BASIS FOR DIMERIZATION IN DNA RECOGNITION BY GAL4
Descriptor:DNA (5'-D(*DAP*DCP*DCP*DGP*DGP*DAP*DGP*DGP*DAP*DCP*DAP*DGP*DTP*DCP*DCP*DTP*DCP*DCP*DGP*DG)-3'), DNA (5'-D(*DTP*DCP*DCP*DGP*DGP*DAP*DGP*DGP*DAP*DCP*DTP*DGP*DTP*DCP*DCP*DTP*DCP*DCP*DGP*DG)-3'), Regulatory protein GAL4, ...
Authors:Hong, M., Fitzgerald, M.X., Harper, S., Luo, C., Speicher, D.W.
Deposit date:2008-03-29
Release date:2008-07-01
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for dimerization in DNA recognition by gal4.
Structure, 16, 2008
3NWS
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF THE YEAST TELOMERE-BINDING AND TELOMERASE REGULATORY PROTEIN CDC13
Descriptor:Cell division control protein 13
Authors:Mitchell, M.T., Smith, J.S., Mason, M., Harper, S., Speicher, D.W., Johnson, F.B., Skordalakes, E.
Deposit date:2010-07-10
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation.
Mol.Cell.Biol., 30, 2010
3NWT
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF THE YEAST TELOMERE-BINDING AND TELOMERASE REGULATORY PROTEIN CDC13
Descriptor:Cell division control protein 13
Authors:Mitchell, M.T., Smith, J.S., Mason, M., Harper, S., Speicher, D.W., Johnson, F.B., Skordalakes, E.
Deposit date:2010-07-10
Release date:2010-09-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation.
Mol.Cell.Biol., 30, 2010
4HCE
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CRYSTAL STRUCTURE OF THE TELOMERIC SACCHAROMYCES CEREVISIAE CDC13 OB2 DOMAIN
Descriptor:Cell division control protein 13
Authors:Mason, M., Wannat, J.J., Harper, S., Schultz, D.C., Speicher, D.W., Johnson, F.B., Skordalakes, E.
Deposit date:2012-09-29
Release date:2012-11-28
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cdc13 OB2 Dimerization Required for Productive Stn1 Binding and Efficient Telomere Maintenance.
Structure, 21, 2013
5JPZ
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CRYSTAL STRUCTURE OF HAT DOMAIN OF HUMAN SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNIZED BY T CELLS 3, SART3 (TIP110)
Descriptor:Squamous cell carcinoma antigen recognized by T-cells 3
Authors:Grazette, A., Harper, S., Emsley, J., Layfield, R., Dreveny, I.
Deposit date:2016-05-04
Release date:2016-05-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.045 Å)
Cite:unpublished
To Be Published
1W3C
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CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS3 PROTEASE IN COMPLEX WITH A PEPTIDOMIMETIC INHIBITOR
Descriptor:PROTEASE/HELICASE NS3 (P70), NONSTRUCTURAL PROTEIN NS4A (P4), 3-({(2S)-2-[({(1R)-1-[({(1R)-1-[(R)-CARBOXY(HYDROXY)METHYL]-3,3-DIFLUOROPROPYL}AMINO)CARBONYL]-3-METHYLBUTYL}AMINO)CARBONYL]-2,3-DIHYDRO-1H-INDOL-2-YL}METHYL)THIOPHENE-2-CARBOXYLIC ACID, ...
Authors:Di Marco, S., Volpari, C.
Deposit date:2004-07-14
Release date:2004-12-09
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Design and Enzyme-Bound Crystal Structure of Indoline Based Peptidomimetic Inhibitors of Hepatitis C Virus Ns3 Protease
J.Med.Chem., 47, 2004
2BRK
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CRYSTAL STRUCTURE OF HEPATITIS C VIRUS POLYMERASE IN COMPLEX WITH AN ALLOSTERIC INHIBITOR (COMPOUND 1)
Descriptor:RNA-DIRECTED RNA POLYMERASE, MANGANESE (II) ION, 3-CYCLOHEXYL-1-(2-MORPHOLIN-4-YL-2-OXOETHYL)-2-PHENYL-1H-INDOLE-6-CARBOXYLIC ACID
Authors:Di Marco, S., Volpari, C., Carfi, A.
Deposit date:2005-05-06
Release date:2005-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small-Molecule Inhibitors Bound to a Novel Allosteric Site
J.Biol.Chem., 280, 2005
2BRL
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CRYSTAL STRUCTURE OF HEPATITIS C VIRUS POLYMERASE IN COMPLEX WITH AN ALLOSTERIC INHIBITOR (COMPOUND 2)
Descriptor:RNA-DIRECTED RNA POLYMERASE, MANGANESE (II) ION, 3-CYCLOHEXYL-1-(2-{METHYL[(1-METHYLPIPERIDIN-3-YL)METHYL]AMINO}-2-OXOETHYL)-2-PHENYL-1H-INDOLE-6-CARBOXYLIC ACID
Authors:Di Marco, S., Volpari, C., Carfi, A.
Deposit date:2005-05-06
Release date:2005-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small-Molecule Inhibitors Bound to a Novel Allosteric Site
J.Biol.Chem., 280, 2005
4CDC
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HUMAN DPP1 IN COMPLEX WITH (2S)-2-AMINO-N-((1S)-1-CYANO-2-(4- PHENYLPHENYL)ETHYL)BUTANAMIDE
Descriptor:DIPEPTIDYL PEPTIDASE 1 EXCLUSION DOMAIN CHAIN, DIPEPTIDYL PEPTIDASE 1 HEAVY CHAIN, DIPEPTIDYL PEPTIDASE 1 LIGHT CHAIN, ...
Authors:Debreczeni, J., Edman, K., Furber, M., Tiden, A., Gardiner, P., Mete, T., Ford, R., Millichip, I., Stein, L., Mather, A., Kinchin, E., Luckhurst, C., Cage, P., Sanghanee, H., Breed, J., Wissler, L.
Deposit date:2013-10-31
Release date:2014-03-19
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate.
J.Med.Chem., 57, 2014
4CDD
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HUMAN DPP1 IN COMPLEX WITH (2S)-N-((1S)-1-CYANO-2-(4-(4-CYANOPHENYL) PHENYL)ETHYL)PIPERIDINE-2-CARBOXAMIDE
Descriptor:DIPEPTIDYL PEPTIDASE 1 EXCLUSION DOMAIN CHAIN, DIPEPTIDYL PEPTIDASE 1 HEAVY CHAIN, DIPEPTIDYL PEPTIDASE 1 LIGHT CHAIN, ...
Authors:Debreczeni, J., Edman, K., Furber, M., Tiden, A., Gardiner, P., Mete, T., Ford, R., Millichip, I., Stein, L., Mather, A., Kinchin, E., Luckhurst, C., Cage, P., Sanghanee, H., Breed, J., Wissler, L.
Deposit date:2013-10-31
Release date:2014-03-19
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate.
J.Med.Chem., 57, 2014
4CDE
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HUMAN DPP1 IN COMPLEX WITH 4-AMINO-N-((1S)-1-CYANO-2-(4-(4- CYANOPHENYL)PHENYL)ETHYL)TETRAHYDROPYRAN-4-CARBOXAMIDE
Descriptor:DIPEPTIDYL PEPTIDASE 1 EXCLUSION DOMAIN CHAIN, DIPEPTIDYL PEPTIDASE 1 HEAVY CHAIN, DIPEPTIDYL PEPTIDASE 1 LIGHT CHAIN, ...
Authors:Debreczeni, J., Edman, K., Furber, M., Tiden, A., Gardiner, P., Mete, T., Ford, R., Millichip, I., Stein, L., Mather, A., Kinchin, E., Luckhurst, C., Cage, P., Sanghanee, H., Breed, J., Wissler, L.
Deposit date:2013-10-31
Release date:2014-03-19
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate.
J.Med.Chem., 57, 2014
4CDF
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HUMAN DPP1 IN COMPLEX WITH (2S,4S)-N-((1S)-1-CYANO-2-(4-(4- CYANOPHENYL)PHENYL)ETHYL)-4-HYDROXY-PIPERIDINE-2-CARBOXAMIDE
Descriptor:DIPEPTIDYL PEPTIDASE 1 EXCLUSION DOMAIN CHAIN, DIPEPTIDYL PEPTIDASE 1 HEAVY CHAIN, DIPEPTIDYL PEPTIDASE 1 LIGHT CHAIN, ...
Authors:Debreczeni, J., Edman, K., Furber, M., Tiden, A., Gardiner, P., Mete, T., Ford, R., Millichip, I., Stein, L., Mather, A., Kinchin, E., Luckhurst, C., Cage, P., Sanghanee, H., Breed, J., Wissler, L.
Deposit date:2013-10-31
Release date:2014-03-19
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate.
J.Med.Chem., 57, 2014
2WCX
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CRYSTAL STRUCTURE OF HEPATITIS C VIRUS NS5B POLYMERASE IN COMPLEX WITH THIENOPYRROLE-BASED FINGER-LOOP INHIBITORS
Descriptor:RNA-DIRECTED RNA POLYMERASE, MANGANESE (II) ION, 6-CYCLOHEXYL-4-METHYL-5-PHENYL-4H-THIENO[3,2-B]PYRROLE-2-CARBOXYLIC ACID
Authors:Di Marco, S.
Deposit date:2009-03-17
Release date:2009-08-18
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Optimization of Thienopyrrole-Based Finger-Loop Inhibitors of the Hepatitis C Virus Ns5B Polymerase.
Chemmedchem, 4, 2009
5OK6
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UBIQUITIN SPECIFIC PROTEASE 11 USP11 - PEPTIDE F COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 11, ALA-GLU-GLY-GLU-PHE-TYR-LYS-LEU-LYS-ILE-ARG-THR-PRO-AAR, GLYCEROL, ...
Authors:Spiliotopoulos, A., Dreveny, I.
Deposit date:2017-07-25
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Ubiquitin specific protease 11 USP11 - peptide F complex
to be published