Author results

6CXZ
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RNA OCTAMER CONTAINING 2'-F, 4'-CALPHA-ME U.
分子名称:RNA (5'-R(*CP*GP*AP*AP*(U4M)P*UP*CP*G)-3'), CACODYLATE ION, COBALT HEXAMMINE(III)
著者Harp, J.M., Egli, M.
登録日2018-04-04
公開日2018-08-29
最終更新日2018-10-03
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY0
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RNA OCTAMER CONTAINING 2'-F, 4'-CBETA-OME U.
分子名称:RNA (5'-R(*(CBV)P*GP*AP*AP*(UFB)P*UP*CP*G)-3')
著者Harp, J.M., Egli, M.
登録日2018-04-04
公開日2018-08-29
最終更新日2018-10-03
実験手法X-RAY DIFFRACTION (2.398 Å)
主引用文献Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY2
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RNA OCTAMER CONTAINING 2'-OME, 4'CALPHA-OME U.
分子名称:RNA (5'-R(*(CBV)P*GP*AP*AP*(UOA)P*UP*CP*G)-3')
著者Harp, J.M., Egli, M.
登録日2018-04-04
公開日2018-08-29
最終更新日2018-10-03
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY4
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RNA OCTAMER CONTAINING 2'-OME, 4'- CBETA-OME U.
分子名称:RNA (5'-R(*(CBV)P*GP*AP*AP*(UOB)P*UP*CP*G)-3')
著者Harp, J.M., Egli, M.
登録日2018-04-04
公開日2018-08-29
最終更新日2018-10-03
実験手法X-RAY DIFFRACTION (1.851 Å)
主引用文献Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
1EQZ
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X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION
分子名称:146 NUCLEOTIDES LONG DNA, PROTEIN (HISTONE H2A), PROTEIN (HISTONE H2B), ...
著者Hanson, B.L., Harp, J.M., Timm, D.E., Bunick, G.J.
登録日2000-04-06
公開日2000-04-17
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Asymmetries in the nucleosome core particle at 2.5 A resolution.
Acta Crystallogr.,Sect.D, 56, 2000
1MT6
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STRUCTURE OF HISTONE H3 K4-SPECIFIC METHYLTRANSFERASE SET7/9 WITH ADOHCY
分子名称:SET9, S-ADENOSYL-L-HOMOCYSTEINE
著者Jacobs, S.A., Harp, J.M., Devarakonda, S., Kim, Y., Rastinejad, F., Khorasanizadeh, S.
登録日2002-09-20
公開日2002-11-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The active site of the SET domain is constructed on a knot
Nat.Struct.Biol., 9, 2002
1MUF
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STRUCTURE OF HISTONE H3 K4-SPECIFIC METHYLTRANSFERASE SET7/9
分子名称:SET9
著者Jacobs, S.A., Harp, J.M., Devarakonda, S., Kim, Y., Rastinejad, F., Khorasanizadeh, S.
登録日2002-09-23
公開日2002-11-06
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献The active site of the SET domain is constructed on a knot
Nat.Struct.Biol., 9, 2002
1OSV
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STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCLEAR RECEPTOR FXR
分子名称:Bile acid receptor, Nuclear receptor coactivator 2, 6-ETHYL-CHENODEOXYCHOLIC ACID
著者Mi, L.Z., Devarakonda, S., Harp, J.M., Han, Q., Pellicciari, R., Willson, T.M., Khorasanizadeh, S., Rastinejad, F.
登録日2003-03-20
公開日2004-03-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR
Mol.Cell, 11, 2003
1OT7
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STRUCTURAL BASIS FOR 3-DEOXY-CDCA BINDING AND ACTIVATION OF FXR
分子名称:Bile Acid Receptor, dodecamer peptide fragment of RPGR-interacting protein 1, 6-ETHYL-CHENODEOXYCHOLIC ACID, ...
著者Mi, L.Z., Devarakonda, S., Harp, J.M., Han, Q., Pellicciari, R., Willson, T.M., Khorasanizadeh, S., Rastinejad, F.
登録日2003-03-21
公開日2004-03-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR
Mol.Cell, 11, 2003
1QCN
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CRYSTAL STRUCTURE OF FUMARYLACETOACETATE HYDROLASE
分子名称:FUMARYLACETOACETATE HYDROLASE, CALCIUM ION, ACETATE ION, ...
著者Timm, D.E., Mueller, H.A., Bhanumoorthy, P., Harp, J.M., Bunick, G.J.
登録日1999-05-14
公開日2000-06-07
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure and mechanism of a carbon-carbon bond hydrolase.
Structure Fold.Des., 7, 1999
1QCO
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CRYSTAL STRUCTURE OF FUMARYLACETOACETATE HYDROLASE COMPLEXED WITH FUMARATE AND ACETOACETATE
分子名称:FUMARYLACETOACETATE HYDROLASE, CALCIUM ION, NICKEL (II) ION, ...
著者Timm, D.E., Mueller, H.A., Bhanumoorthy, P., Harp, J.M., Bunick, G.J.
登録日1999-05-17
公開日2000-06-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure and mechanism of a carbon-carbon bond hydrolase.
Structure Fold.Des., 7, 1999
1QQJ
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CRYSTAL STRUCTURE OF MOUSE FUMARYLACETOACETATE HYDROLASE REFINED AT 1.55 ANGSTROM RESOLUTION
分子名称:FUMARYLACETOACETATE HYDROLASE, CALCIUM ION, ACETATE ION, ...
著者Timm, D.E., Mueller, H.A., Bhanumoorthy, P., Harp, J.M., Bunick, G.J.
登録日1999-06-07
公開日2000-06-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Crystal structure and mechanism of a carbon-carbon bond hydrolase.
Structure Fold.Des., 7, 1999
1R0N
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CRYSTAL STRUCTURE OF HETERODIMERIC ECDSYONE RECEPTOR DNA BINDING COMPLEX
分子名称:Ecdsyone Response Element, Ecdysone Response Element, Retinoic acid receptor RXR-alpha, ...
著者Devarakonda, S., Harp, J.M., Kim, Y., Ozyhar, A., Rastinejad, F.
登録日2003-09-22
公開日2003-10-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of the heterodimeric Ecdysone Receptor DNA-binding complex
Embo J., 22, 2003
1R0O
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CRYSTAL STRUCTURE OF THE HETERODIMERIC ECDYSONE RECEPTOR DNA-BINDING COMPLEX
分子名称:Ecdysone Response Element, Ultraspiracle protein, Ecdysone receptor, ...
著者Devarakonda, S., Harp, J.M., Kim, Y., Ozyhar, A., Rastinejad, F.
登録日2003-09-22
公開日2003-10-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex
Embo J., 22, 2003
3GX0
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CRYSTAL STRUCTURE OF GSH-DEPENDENT DISULFIDE BOND OXIDOREDUCTASE
分子名称:GST-like protein yfcG, OXIDIZED GLUTATHIONE DISULFIDE
著者Ladner, J.E., Harp, J.M., Wadington, M.C., Armstrong, R.N.
登録日2009-04-01
公開日2009-07-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Analysis of the structure and function of YfcG from Escherichia coli reveals an efficient and unique disulfide bond reductase.
Biochemistry, 48, 2009
3MF6
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COMPUTATIONALLY DESIGNED ENDO-1,4-BETA-XYLANASE
分子名称:Endo-1,4-beta-xylanase, SULFATE ION
著者Morin, A., Harp, J.M.
登録日2010-04-01
公開日2010-11-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
3MF9
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COMPUTATIONALLY DESIGNED ENDO-1,4-BETA-XYLANASE
分子名称:Endo-1,4-beta-xylanase, SULFATE ION
著者Morin, A., Harp, J.M.
登録日2010-04-01
公開日2010-11-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
3MFA
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COMPUTATIONALLY DESIGNED ENDO-1,4-BETA-XYLANASE
分子名称:Endo-1,4-beta-xylanase, SULFATE ION
著者Morin, A., Harp, J.M.
登録日2010-04-01
公開日2010-11-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
3MFC
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COMPUTATIONALLY DESIGNED END0-1,4-BETA,XYLANASE
分子名称:Endo-1,4-beta-xylanase, SULFATE ION
著者Morin, A., Harp, J.M.
登録日2010-04-01
公開日2010-11-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
3NT1
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HIGH RESOLUTION STRUCTURE OF NAPROXEN:COX-2 COMPLEX.
分子名称:Prostaglandin-endoperoxide synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
著者Duggan, K.C., Musee, J., Walters, M.J., Harp, J.M., Kiefer, J.R., Oates, J.A., Marnett, L.J.
登録日2010-07-02
公開日2010-09-01
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.
J.Biol.Chem., 285, 2010
3NTB
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STRUCTURE OF 6-METHYLTHIO NAPROXEN ANALOG BOUND TO MCOX-2.
分子名称:Prostaglandin-endoperoxide synthase 2, PROTOPORPHYRIN IX CONTAINING FE, N-ACETYL-D-GLUCOSAMINE, ...
著者Duggan, K.C., Musee, J., Walters, M.J., Harp, J.M., Kiefer, J.R., Oates, J.A., Marnett, L.J.
登録日2010-07-03
公開日2010-09-01
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.
J.Biol.Chem., 285, 2010
3R3E
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THE GLUTATHIONE BOUND STRUCTURE OF YQJG, A GLUTATHIONE TRANSFERASE HOMOLOG FROM ESCHERICHIA COLI K-12
分子名称:Uncharacterized protein yqjG, GLUTATHIONE, SULFATE ION
著者Branch, M.C., Cook, P.D., Harp, J.M., Armstrong, R.N.
登録日2011-03-15
公開日2012-03-14
実験手法X-RAY DIFFRACTION (2.205 Å)
主引用文献Crystal Structure Analysis of yqjG from Escherichia Coli K-12
To be Published
4YP3
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MUTANT HUMAN DNA POLYMERASE ETA Q38A/R61A INSERTING DCTP OPPOSITE AN 8-OXOGUANINE LESION
分子名称:DNA polymerase eta, DNA (5'-D(*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P.
登録日2015-03-12
公開日2015-05-13
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
4YQW
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MUTANT HUMAN DNA POLYMERASE ETA Q38A/R61A INSERTING DCTP OPPOSITE TEMPLATE G
分子名称:DNA polymerase eta, DNA (5'-D(*AP*TP*GP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P.
登録日2015-03-13
公開日2015-05-13
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.064 Å)
主引用文献Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
4YR0
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MUTANT HUMAN DNA POLYMERASE ETA R61M INSERTING DCTP OPPOSITE AN 8-OXOGUANINE LESION
分子名称:DNA polymerase eta, DNA (5'-D(P*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P.
登録日2015-03-13
公開日2015-05-13
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
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