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3NMQ
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HSP90B N-TERMINAL DOMAIN IN COMPLEX WITH EC44, A PYRROLO-PYRIMIDINE METHOXYPYRIDINE INHIBITOR
Descriptor:Heat shock protein HSP 90-beta, 5-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylpent-4-yn-2-ol
Authors:Arndt, J.W., Yun, T.J., Harning, E.K., Giza, K., Rabah, D., Li, P., Luchetti, D., Shi, J., Manning, A., Kehry, M.R.
Deposit date:2010-06-22
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:EC144, a Synthetic Inhibitor of Heat Shock Protein 90, Blocks Innate and Adaptive Immune Responses in Models of Inflammation and Autoimmunity.
J.Immunol., 186, 2011
3QDD
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HSP90A N-TERMINAL DOMAIN IN COMPLEX WITH BIIB021
Descriptor:Heat shock protein HSP 90-alpha, 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine
Authors:Arndt, J.W., Biamonte, M.A.
Deposit date:2011-01-18
Release date:2012-07-18
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:EC144 Is a Potent Inhibitor of the Heat Shock Protein 90.
J.Med.Chem., 55, 2012