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1QIV
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BU of 1qiv by Molmil
CALMODULIN COMPLEXED WITH N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE (DPD), 1:2 COMPLEX
Descriptor: CALCIUM ION, CALMODULIN, N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(2 3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE
Authors:Harmat, V, Bocskei, Z.S, Vertessy, B.G, Naray-Szabo, G, Ovadi, J.
Deposit date:1999-06-17
Release date:2000-03-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:A New Potent Calmodulin Antagonist with Arylalkylamine Structure: Crystallographic, Spectroscopic and Functional Studies
J.Mol.Biol., 297, 2000
1Q3X
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BU of 1q3x by Molmil
Crystal structure of the catalytic region of human MASP-2
Descriptor: GLYCEROL, Mannan-binding lectin serine protease 2, SODIUM ION
Authors:Harmat, V, Gal, P, Kardos, J, Szilagyi, K, Ambrus, G, Naray-Szabo, G, Zavodszky, P.
Deposit date:2003-08-01
Release date:2004-08-03
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions
J.Mol.Biol., 342, 2004
1QIW
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BU of 1qiw by Molmil
Calmodulin complexed with N-(3,3,-diphenylpropyl)-N'-[1-R-(3,4-bis-butoxyphenyl)-ethyl]-propylenediamine (DPD)
Descriptor: CALCIUM ION, CALMODULIN, N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(2 3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE
Authors:Harmat, V, Bocskei, Z.S, Vertessy, B.G, Ovadi, J, Naray-Szabo, G.
Deposit date:1999-06-17
Release date:2000-03-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A New Potent Calmodulin Antagonist with Arylalkylamine Structure: Crystallographic, Spectroscopic and Functional Studies
J.Mol.Biol., 297, 2000
3O4H
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BU of 3o4h by Molmil
Structure and Catalysis of Acylaminoacyl Peptidase
Descriptor: Acylamino-acid-releasing enzyme, GLYCEROL, SODIUM ION
Authors:Harmat, V, Domokos, K, Menyhard, D.K, Pallo, A, Szeltner, Z, Szamosi, I, Beke-Somfai, T, Naray-Szabo, G, Polgar, L.
Deposit date:2010-07-27
Release date:2010-11-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structure and Catalysis of Acylaminoacyl Peptidase: CLOSED AND OPEN SUBUNITS OF A DIMER OLIGOPEPTIDASE.
J.Biol.Chem., 286, 2011
3O4J
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BU of 3o4j by Molmil
Structure and Catalysis of Acylaminoacyl Peptidase
Descriptor: Acylamino-acid-releasing enzyme, CHLORIDE ION, GLYCEROL, ...
Authors:Harmat, V, Domokos, K, Menyhard, D.K, Pallo, A, Szeltner, Z, Szamosi, I, Beke-Somfai, T, Naray-Szabo, G, Polgar, L.
Deposit date:2010-07-27
Release date:2010-11-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and Catalysis of Acylaminoacyl Peptidase: CLOSED AND OPEN SUBUNITS OF A DIMER OLIGOPEPTIDASE.
J.Biol.Chem., 286, 2011
3O4I
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BU of 3o4i by Molmil
Structure and Catalysis of Acylaminoacyl Peptidase
Descriptor: Acylamino-acid-releasing enzyme, CHLORIDE ION, GLYCEROL
Authors:Harmat, V, Domokos, K, Menyhard, D.K, Pallo, A, Szeltner, Z, Szamosi, I, Beke-Somfai, T, Naray-Szabo, G, Polgar, L.
Deposit date:2010-07-27
Release date:2010-11-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and Catalysis of Acylaminoacyl Peptidase: CLOSED AND OPEN SUBUNITS OF A DIMER OLIGOPEPTIDASE.
J.Biol.Chem., 286, 2011
3O4G
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BU of 3o4g by Molmil
Structure and Catalysis of Acylaminoacyl Peptidase
Descriptor: Acylamino-acid-releasing enzyme, GLYCEROL
Authors:Harmat, V, Domokos, K, Menyhard, D.K, Pallo, A, Szeltner, Z, Szamosi, I, Beke-Somfai, T, Naray-Szabo, G, Polgar, L.
Deposit date:2010-07-27
Release date:2010-11-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and Catalysis of Acylaminoacyl Peptidase: CLOSED AND OPEN SUBUNITS OF A DIMER OLIGOPEPTIDASE.
J.Biol.Chem., 286, 2011
7PQN
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BU of 7pqn by Molmil
Catalytic fragment of MASP-2 in complex with ecotin
Descriptor: Ecotin, GLYCEROL, Mannan-binding lectin serine protease 2 A chain, ...
Authors:Harmat, V, Fodor, K, Heja, D.
Deposit date:2021-09-17
Release date:2022-05-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.400015 Å)
Cite:Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.
J.Biol.Chem., 298, 2022
7PQO
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BU of 7pqo by Molmil
Catalytic fragment of MASP-1 in complex with P1 site mutant ecotin
Descriptor: Ecotin, GLYCEROL, Mannan-binding lectin serine protease 1, ...
Authors:Harmat, V, Fodor, K, Heja, D.
Deposit date:2021-09-17
Release date:2022-05-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.39 Å)
Cite:Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.
J.Biol.Chem., 298, 2022
2OAY
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BU of 2oay by Molmil
Crystal structure of latent human C1-inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Plasma protease C1 inhibitor
Authors:Harmat, V, Beinrohr, L, Gal, P, Dobo, J.
Deposit date:2006-12-18
Release date:2007-05-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease
J.Biol.Chem., 282, 2007
2QR5
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BU of 2qr5 by Molmil
Aeropyrum pernix acylaminoacyl peptidase, H367A mutant
Descriptor: Acylamino-acid-releasing enzyme
Authors:Harmat, V, Pallo, A, Kiss, A.L, Polgar, L.
Deposit date:2007-07-27
Release date:2008-05-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and kinetic contributions of the oxyanion binding site to the catalytic activity of acylaminoacyl peptidase
J.Struct.Biol., 162, 2008
3GOV
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BU of 3gov by Molmil
Crystal structure of the catalytic region of human MASP-1
Descriptor: GLYCEROL, MASP-1
Authors:Harmat, V, Dobo, J, Beinrohr, L, Sebestyen, E, Zavodszky, P, Gal, P.
Deposit date:2009-03-20
Release date:2009-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity.
J.Immunol., 183, 2009
4IGD
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BU of 4igd by Molmil
Crystal structure of the zymogen catalytic region of Human MASP-1
Descriptor: GLYCEROL, Mannan-binding lectin serine protease 1
Authors:Harmat, V, Megyeri, M, Vegh, A, Dobo, J.
Deposit date:2012-12-17
Release date:2013-02-13
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway
J.Biol.Chem., 288, 2013
1A29
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BU of 1a29 by Molmil
CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:2 COMPLEX)
Descriptor: 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE, CALCIUM ION, CALMODULIN
Authors:Bocskei, Zs, Harmat, V, Vertessy, B.G, Ovadi, J, Naray-Szabo, G.
Deposit date:1998-01-19
Release date:1998-09-16
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Simultaneous binding of drugs with different chemical structures to Ca2+-calmodulin: crystallographic and spectroscopic studies.
Biochemistry, 37, 1998
1XA5
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BU of 1xa5 by Molmil
Structure of Calmodulin in complex with KAR-2, a bis-indol alkaloid
Descriptor: 3"-(BETA-CHLOROETHYL)-2",4"-DIOXO-3, 5"-SPIRO-OXAZOLIDINO-4-DEACETOXY-VINBLASTINE, CALCIUM ION, ...
Authors:Horvath, I, Harmat, V, Hlavanda, E, Naray-Szabo, G, Ovadi, J.
Deposit date:2004-08-25
Release date:2004-12-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:The structure of the complex of calmodulin with KAR-2: a novel mode of binding explains the unique pharmacology of the drug
J.Biol.Chem., 280, 2005
7ARX
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BU of 7arx by Molmil
Crystal structure of the catalytic fragment of masp-1 in complex with SFMI1
Descriptor: DI(HYDROXYETHYL)ETHER, Mannan-binding lectin serine protease 1, SFMI1 - Sunflower MASP1 inhibitor
Authors:Durvanger, Z, Harmat, V, Dobo, J, Megyeri, M.
Deposit date:2020-10-26
Release date:2021-11-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides.
Acs Chem.Biol., 17, 2022
8AHT
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BU of 8aht by Molmil
Crystal structure of Plasmodium falciparum Ca2+/Calmodulin in complex with melittin
Descriptor: CALCIUM ION, Calmodulin, Melittin
Authors:Durvanger, Z, Harmat, V.
Deposit date:2022-07-22
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of calmodulin-melittin complexes show multiple binding modes lacking classical anchoring interactions.
J.Biol.Chem., 299, 2023
8AHS
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BU of 8ahs by Molmil
Crystal structure of human Ca2+/Calmodulin in complex with melittin
Descriptor: CALCIUM ION, Calmodulin-1, Melittin
Authors:Durvanger, Z, Harmat, V.
Deposit date:2022-07-22
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Structures of calmodulin-melittin complexes show multiple binding modes lacking classical anchoring interactions.
J.Biol.Chem., 299, 2023
3TVJ
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BU of 3tvj by Molmil
Catalytic fragment of MASP-2 in complex with its specific inhibitor developed by directed evolution on SGCI scaffold
Descriptor: Mannan-binding lectin serine protease 2 A chain, Mannan-binding lectin serine protease 2 B chain, Protease inhibitor SGPI-2, ...
Authors:Heja, D, Harmat, V, Dobo, J, Szasz, R, Kekesi, K.A, Zavodszky, P, Gal, P, Pal, G.
Deposit date:2011-09-20
Release date:2012-04-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2.
J.Biol.Chem., 287, 2012
7QUN
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BU of 7qun by Molmil
CryoEM structure of mammalian AAP in complex with Meropenem
Descriptor: (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Acylamino-acid-releasing enzyme
Authors:Kiss-Szeman, A.J, Harmat, V, Straner, P, Jakli, I, Menyhard, K.D, Masiulis, S, Perczel, A.
Deposit date:2022-01-18
Release date:2022-11-16
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:A carbapenem antibiotic inhibiting a mammalian serine protease: structure of the acylaminoacyl peptidase-meropenem complex.
Chem Sci, 13, 2022
4RE6
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BU of 4re6 by Molmil
Acylaminoacyl peptidase complexed with a chloromethylketone inhibitor
Descriptor: Acylamino-acid-releasing enzyme, CHLORIDE ION, N-[(benzyloxy)carbonyl]glycyl-N-[(2S,3R)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]glycinamide
Authors:Menyhard, D.K, Orgovan, Z, Szeltner, Z, Szamosi, I, Harmat, V.
Deposit date:2014-09-22
Release date:2015-01-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Catalytically distinct states captured in a crystal lattice: the substrate-bound and scavenger states of acylaminoacyl peptidase and their implications for functionality.
Acta Crystallogr.,Sect.D, 71, 2015
4RE5
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BU of 4re5 by Molmil
Acylaminoacyl peptidase complexed with a chloromethylketone inhibitor
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, Acylamino-acid-releasing enzyme, ...
Authors:Menyhard, D.K, Orgovan, Z, Szeltner, Z, Szamosi, I, Harmat, V.
Deposit date:2014-09-22
Release date:2015-01-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Catalytically distinct states captured in a crystal lattice: the substrate-bound and scavenger states of acylaminoacyl peptidase and their implications for functionality.
Acta Crystallogr.,Sect.D, 71, 2015
2XQQ
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BU of 2xqq by Molmil
Human dynein light chain (DYNLL2) in complex with an in vitro evolved peptide (Ac-SRGTQTE).
Descriptor: ACETATE ION, DYNEIN LIGHT CHAIN 2, CYTOPLASMIC, ...
Authors:Rapali, P, Radnai, L, Suveges, D, Hetenyi, C, Harmat, V, Tolgyesi, F, Wahlgren, W.Y, Katona, G, Nyitray, L, Pal, G.
Deposit date:2010-09-07
Release date:2011-05-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Directed Evolution Reveals the Binding Motif Preference of the Lc8/Dynll Hub Protein and Predicts Large Numbers of Novel Binders in the Human Proteome
Plos One, 6, 2011
4DJZ
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BU of 4djz by Molmil
Catalytic fragment of masp-1 in complex with its specific inhibitor developed by directed evolution on sgci scaffold
Descriptor: Mannan-binding lectin serine protease 1 heavy chain, Mannan-binding lectin serine protease 1 light chain, Protease inhibitor SGPI-2
Authors:Heja, D, Harmat, V, Fodor, K, Wilmanns, M, Dobo, J, Kekesi, K.A, Zavodszky, P, Gal, P, Pal, G.
Deposit date:2012-02-03
Release date:2012-04-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2.
J.Biol.Chem., 287, 2012
4GV8
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DUTPase from phage phi11 of S.aureus: visualization of the species-specific insert
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, DUTPase, MAGNESIUM ION
Authors:Leveles, I, Harmat, V, Nemeth, V, Bendes, A, Szabo, J, Kadar, V, Zagyva, I, Rona, G, Toth, J, Vertessy, B.G.
Deposit date:2012-08-30
Release date:2013-09-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and enzymatic mechanism of a moonlighting dUTPase
Acta Crystallogr.,Sect.D, 69, 2013

 

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