Author results

1AMN
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TRANSITION STATE ANALOG: ACETYLCHOLINESTERASE COMPLEXED WITH M-(N,N,N-TRIMETHYLAMMONIO)TRIFLUOROACETOPHENONE
Descriptor:ACETYLCHOLINESTERASE, SULFATE ION, M-(N,N,N-TRIMETHYLAMMONIO)-2,2,2-TRIFLUORO-1,1-DIHYDROXYETHYLBENZENE
Authors:Harel, M., Silman, I., Sussman, J.L.
Deposit date:1996-02-13
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase.
J.Am.Chem.Soc., 118, 1996
1FSS
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ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH FASCICULIN-II
Descriptor:ACETYLCHOLINESTERASE, FASCICULIN II, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Harel, M., Kleywegt, G.J., Silman, I., Sussman, J.L.
Deposit date:1995-10-25
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target.
Structure, 3, 1995
1GCD
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REFINED CRYSTAL STRUCTURE OF "AGED" AND "NON-AGED" ORGANOPHOSPHORYL CONJUGATES OF GAMMA-CHYMOTRYPSIN
Descriptor:GAMMA-CHYMOTRYPSIN, SULFATE ION, DIETHYL PHOSPHONATE
Authors:Harel, M., Sussman, J.L., Silman, I.
Deposit date:1994-05-05
Release date:1994-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Refined crystal structures of "aged" and "non-aged" organophosphoryl conjugates of gamma-chymotrypsin.
J.Mol.Biol., 221, 1991
1GMH
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REFINED CRYSTAL STRUCTURE OF "AGED" AND "NON-AGED" ORGANOPHOSPHORYL CONJUGATES OF GAMMA-CHYMOTRYPSIN
Descriptor:GAMMA-CHYMOTRYPSIN A, SULFATE ION, PHOSPHORYLISOPROPANE
Authors:Harel, M., Sussman, J.L., Silman, I.
Deposit date:1994-07-01
Release date:1994-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Refined crystal structures of "aged" and "non-aged" organophosphoryl conjugates of gamma-chymotrypsin.
J.Mol.Biol., 221, 1991
1HC9
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ALPHA-BUNGAROTOXIN COMPLEXED WITH HIGH AFFINITY PEPTIDE
Descriptor:ALPHA-BUNGAROTOXIN ISOFORM V31, ALPHA-BUNGAROTOXIN ISOFORM A31, PEPTIDE INHIBITOR, ...
Authors:Harel, M., Kasher, R., Sussman, J.L.
Deposit date:2001-05-02
Release date:2001-11-10
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Binding Site of Acetylcholine Receptor as Visualized in the X-Ray Structure of a Complex between Alpha-Bungarotoxin and a Mimotope Peptide.
Neuron, 32, 2001
1DX4
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ACHE FROM DROSOPHILA MELANOGASTER COMPLEX WITH TACRINE DERIVATIVE 9-(3-PHENYLMETHYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE
Descriptor:ACETYLCHOLINESTERASE, SULFATE ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Harel, M., Silman, I., Sussman, J.L.
Deposit date:1999-12-20
Release date:2000-07-21
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Three-Dimensional Structures of Drosophila Melanogaster Acetylcholinesterase and of its Complexes with Two Potent Inhibitors
Protein Sci., 9, 2000
1QO9
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NATIVE ACETYLCHOLINESTERASE FROM DROSOPHILA MELANOGASTER
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE
Authors:Harel, M., Silman, I., Sussman, J.L.
Deposit date:1999-11-08
Release date:2000-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Three-Dimensional Structures of Drosophila Melanogaster Acetylcholinesterase and of its Complexes with Two Potent Inhibitors
Protein Sci., 9, 2000
1QON
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ACHE FROM DROSOPHILA MELANOGASTER COMPLEX WITH TACRINE DERIVATIVE 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE
Descriptor:ACETYLCHOLINESTERASE, SULFATE ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Harel, M., Silman, I., Sussman, J.L.
Deposit date:1999-11-15
Release date:2000-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Three-Dimensional Structures of Drosophila Melanogaster Acetylcholinesterase and of its Complexes with Two Potent Inhibitors
Protein Sci., 9, 2000
1U65
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ACHE W. CPT-11
Descriptor:Acetylcholinesterase, BETA-L-FUCOSE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Harel, M., Hyatt, J.L., Brumshtein, B., Morton, C.L., Wadkins, R.W., Silman, I., Sussman, J.L., Potter, P.M., Israel Structural Proteomics Center (ISPC)
Deposit date:2004-07-29
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action
Mol.Pharmacol., 67, 2005
1V04
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SERUM PARAOXONASE BY DIRECTED EVOLUTION
Descriptor:SERUM PARAOXONASE/ARYLESTERASE 1, CALCIUM ION, PHOSPHATE ION
Authors:Harel, M., Aharoni, A., Gaidukov, L., Brumshtein, B., Khersonsky, O., Yagur, S., Meged, R., Dvir, H., Ravelli, R.B.G., McCarthy, A., Toker, L., Silman, I., Sussman, J.L., Tawfik, D.S.
Deposit date:2004-03-22
Release date:2004-04-23
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and Evolution of the Serum Paraoxonase Family of Detoxifying and Anti-Atherosclerotic Enzymes
Nat.Struct.Mol.Biol., 11, 2004
2J3D
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NATIVE MONOCLINIC FORM OF TORPEDO ACETYLCHOLINESTERASE
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, MAGNESIUM ION
Authors:Harel, M., Sussman, J.L.
Deposit date:2006-08-20
Release date:2008-06-24
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Native Monoclinic Form of Torpedo Acetylcholinesterase
To be Published
2J3Q
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TORPEDO ACETYLCHOLINESTERASE COMPLEXED WITH FLUOROPHORE THIOFLAVIN T
Descriptor:ACETYLCHOLINESTERASE, 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Harel, M., Cusack, B., Johnson, J.L., Silman, I., Sussman, J.L., Rosenberry, T.L.
Deposit date:2006-08-23
Release date:2007-09-04
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site.
J. Am. Chem. Soc., 130, 2008
2VQ6
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TORPEDO CALIFORNICA ACETYLCHOLINESTERASE COMPLEXED WITH 2-PAM
Descriptor:ACETYLCHOLINESTERASE, N-hydroxy-1-(1-methylpyridin-2(1H)-ylidene)methanamine, SULFATE ION, ...
Authors:Harel, M., Silman, I., Sussman, J.L.
Deposit date:2008-03-11
Release date:2008-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:The Structure of Torpedo Californica Acetylcholinesterase Complexed with 2-Pam
To be Published
8GCH
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GAMMA-CHYMOTRYPSIN IS A COMPLEX OF ALPHA-CHYMOTRYPSIN WITH ITS OWN AUTOLYSIS PRODUCTS
Descriptor:GAMMA-CHYMOTRYPSIN A, GLY ALA TRP PEPTIDE, SULFATE ION
Authors:Harel, M., Sussman, J.L., Silman, I.
Deposit date:1991-03-27
Release date:1992-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Gamma-chymotrypsin is a complex of alpha-chymotrypsin with its own autolysis products.
Biochemistry, 30, 1991
1EA5
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NATIVE ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA AT 1.8A RESOLUTION
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE
Authors:Harel, M., Weik, M., Silman, I., Sussman, J.L.
Deposit date:2000-11-06
Release date:2000-11-08
Last modified:2011-09-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-Ray Structures of Torpedo Californica Acetylcholinesterase Complexed with (+)-Huperzine a and (-)-Huperzine B: Structural Evidence for an Active Site Rearrangement
Biochemistry, 41, 2002
2ACE
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NATIVE ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA
Descriptor:ACETYLCHOLINESTERASE, ACETYLCHOLINE
Authors:Harel, M., Raves, M.L., Silman, I., Sussman, J.L.
Deposit date:1996-06-23
Release date:1996-11-08
Last modified:2016-06-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.
Nat.Struct.Biol., 4, 1997
1ACJ
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QUATERNARY LIGAND BINDING TO AROMATIC RESIDUES IN THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE
Descriptor:ACETYLCHOLINESTERASE, TACRINE
Authors:Sussman, J.L., Harel, M., Silman, I.
Deposit date:1993-08-18
Release date:1994-08-31
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.
Proc.Natl.Acad.Sci.USA, 90, 1993
1ACL
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QUATERNARY LIGAND BINDING TO AROMATIC RESIDUES IN THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE
Descriptor:ACETYLCHOLINESTERASE, DECAMETHONIUM ION
Authors:Sussman, J.L., Harel, M., Silman, I.
Deposit date:1993-08-18
Release date:1994-08-31
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.
Proc.Natl.Acad.Sci.USA, 90, 1993
1AX9
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ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, LAUE DATA
Descriptor:ACETYLCHOLINESTERASE, EDROPHONIUM ION
Authors:Raves, M.L., Ravelli, R.B.G., Sussman, J.L., Harel, M., Silman, I.
Deposit date:1997-11-03
Release date:1998-02-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Static Laue diffraction studies on acetylcholinesterase.
Acta Crystallogr.,Sect.D, 54, 1998
1DOI
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2FE-2S FERREDOXIN FROM HALOARCULA MARISMORTUI
Descriptor:2FE-2S FERREDOXIN, POTASSIUM ION, FE2/S2 (INORGANIC) CLUSTER
Authors:Frolow, F., Harel, M., Sussman, J.L., Shoham, M.
Deposit date:1996-04-08
Release date:1996-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights into protein adaptation to a saturated salt environment from the crystal structure of a halophilic 2Fe-2S ferredoxin.
Nat.Struct.Biol., 3, 1996
2ACK
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ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, MONOCHROMATIC DATA
Descriptor:ACETYLCHOLINESTERASE, EDROPHONIUM ION
Authors:Raves, M.L., Sussman, J.L., Harel, M., Silman, I.
Deposit date:1997-10-29
Release date:1998-02-11
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Static Laue diffraction studies on acetylcholinesterase.
Acta Crystallogr.,Sect.D, 54, 1998
1B41
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HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH FASCICULIN-II, GLYCOSYLATED PROTEIN
Descriptor:ACETYLCHOLINESTERASE, FASCICULIN-2, ALPHA-L-FUCOSE, ...
Authors:Kryger, G., Harel, M., Shafferman, A., Silman, I., Sussman, J.L.
Deposit date:1999-01-05
Release date:2001-01-17
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.
Acta Crystallogr.,Sect.D, 56, 2000
1E3Q
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TORPEDO CALIFORNICA ACETYLCHOLINESTERASE COMPLEXED WITH BW284C51
Descriptor:ACETYLCHOLINESTERASE, 4-(5-{4-[DIMETHYL(PROP-2-ENYL)AMMONIO]PHENYL}-3-OXOPENTYL)-N,N-DIMETHYL-N-PROP-2-ENYLBENZENAMINIUM, SULFATE ION, ...
Authors:Felder, C.E., Harel, M., Silman, I., Sussman, J.L.
Deposit date:2000-06-21
Release date:2000-07-03
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure of a Complex of the Potent and Specific Inhibitor Bw284C51 with Torpedo Californica Acetylcholinesterase
Acta Crystallogr.,Sect.D, 58, 2002
1GQR
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ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH RIVASTIGMINE
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, 3-[(1S)-1-(DIMETHYLAMINO)ETHYL]PHENOL, ...
Authors:Raves, M.L., Harel, M., Silman, I., Sussman, J.L.
Deposit date:2001-12-04
Release date:2002-03-15
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine
Biochemistry, 41, 2002
1GQS
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ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH NAP
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, 3-[(1S)-1-(DIMETHYLAMINO)ETHYL]PHENOL
Authors:Bar-on, P., Millard, C.B., Harel, M., Dvir, H., Enz, A., Sussman, J.L., Silman, I.
Deposit date:2001-12-04
Release date:2002-03-15
Last modified:2011-09-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine
Biochemistry, 41, 2002