Author results

6OGE
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CRYO-EM STRUCTURE OF HER2 EXTRACELLULAR DOMAIN-TRASTUZUMAB FAB-PERTUZUMAB FAB COMPLEX
Descriptor:Receptor tyrosine-protein kinase erbB-2, Pertuzumab FAB LIGHT CHAIN, Pertuzumab FAB HEAVY CHAIN, ...
Authors:Hao, Y., Yu, X., Bai, Y., Huang, X.
Deposit date:2019-04-02
Release date:2019-05-15
Method:ELECTRON MICROSCOPY (4.36 Å)
Cite:Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex.
Plos One, 14, 2019
5DLY
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CRYSTAL STRUCTURE OF THE PLANTAZOLICIN METHYLTRANSFERASE BAML IN COMPLEX WITH MONOAZOLIC DESMETHYLPZN ANALOG AND SAH
Descriptor:plantazolicin methyltransferase BamL, prop-2-en-1-yl 2-[(1S)-1-amino-4-carbamimidamidobutyl]-1,3-thiazole-4-carboxylate, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Hao, Y., Nair, S.K.
Deposit date:2015-09-07
Release date:2015-09-30
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicin.
ACS Chem. Biol., 10, 2015
5DM0
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CRYSTAL STRUCTURE OF THE PLANTAZOLICIN METHYLTRANSFERASE BAML IN COMPLEX WITH TRIAZOLIC DESMETHYLPZN ANALOG AND SAH
Descriptor:plantazolicin methyltransferase BamL, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Hao, Y., Nair, S.K.
Deposit date:2015-09-07
Release date:2015-09-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicin.
Acs Chem.Biol., 10, 2015
5DM1
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CRYSTAL STRUCTURE OF THE PLANTAZOLICIN METHYLTRANSFERASE BPUML IN COMPLEX WITH MONOAZOLIC DESMETHYLPZN ANALOG AND SAH
Descriptor:Methyltransferase domain family, prop-2-en-1-yl 2-[(1S)-1-amino-4-carbamimidamidobutyl]-1,3-thiazole-4-carboxylate, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Hao, Y., Nair, S.K.
Deposit date:2015-09-07
Release date:2015-09-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicin.
Acs Chem.Biol., 10, 2015
5DM2
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CRYSTAL STRUCTURE OF THE PLANTAZOLICIN METHYLTRANSFERASE BPUML IN COMPLEX WITH TRIAZOLIC DESMETHYLPZN ANALOG AND SAH
Descriptor:Methyltransferase domain family, S-ADENOSYL-L-HOMOCYSTEINE, ethyl 2-(2-{2-[(1S)-4-carbamimidamido-1-(methylamino)butyl]-1,3-thiazol-4-yl}-5-methyl-1,3-oxazol-4-yl)-1,3-thiazole-4-carboxylate, ...
Authors:Hao, Y., Nair, S.K.
Deposit date:2015-09-07
Release date:2015-09-23
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicin.
Acs Chem.Biol., 10, 2015
5DM4
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CRYSTAL STRUCTURE OF THE PLANTAZOLICIN METHYLTRANSFERASE BPUML IN COMPLEX WITH PENTAZOLIC DESMETHYLPZN ANALOG AND SAH
Descriptor:Methyltransferase domain family, S-ADENOSYL-L-HOMOCYSTEINE, GLYCEROL, ...
Authors:Hao, Y., Nair, S.K.
Deposit date:2015-09-07
Release date:2015-09-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicin.
Acs Chem.Biol., 10, 2015
5I36
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CRYSTAL STRUCTURE OF COLOR DEVICE STATE A
Descriptor:DNA (5'-D(*GP*TP*CP*CP*TP*AP*CP*CP*TP*GP*GP*CP*AP*GP*GP*AP*CP*GP*AP*CP*T)-3'), DNA (26-MER), DNA (5'-D(*TP*CP*TP*GP*AP*TP*GP*TP*GP*GP*TP*AP*GP*G)-3'), ...
Authors:Hao, Y., Kristiansen, M., Sha, R., Birktoft, J., Mao, C., Seeman, N.C.
Deposit date:2016-02-09
Release date:2017-01-18
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (5.123 Å)
Cite:A device that operates within a self-assembled 3D DNA crystal.
Nat Chem, 9, 2017
5I6Q
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CRYSTAL STRUCTURE OF COLOR DEVICE STATE B
Descriptor:DNA (5'-D(*GP*TP*CP*CP*TP*AP*CP*CP*TP*GP*GP*CP*AP*GP*GP*AP*CP*GP*AP*CP*T)-3'), DNA (26-MER), DNA (5'-D(*TP*CP*TP*GP*AP*TP*GP*TP*GP*GP*TP*AP*GP*G)-3'), ...
Authors:Hao, Y., Birktoft, J., Seeman, N.C.
Deposit date:2016-02-16
Release date:2017-01-18
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (4.912 Å)
Cite:A device that operates within a self-assembled 3D DNA crystal.
Nat Chem, 9, 2017
5I6T
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CRYSTAL STRUCTURE OF COLOR DEVICE STATE C
Descriptor:DNA (5'-D(*GP*TP*CP*CP*TP*AP*CP*CP*TP*GP*GP*CP*AP*GP*GP*AP*CP*GP*AP*CP*T)-3'), DNA (26-MER), DNA (5'-D(*TP*CP*TP*GP*AP*TP*GP*TP*GP*GP*TP*AP*GP*G)-3'), ...
Authors:Hao, Y., Birktoft, J., Seeman, N.C.
Deposit date:2016-02-16
Release date:2017-01-18
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (5.283 Å)
Cite:A device that operates within a self-assembled 3D DNA crystal.
Nat Chem, 9, 2017
5TTY
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PAGF PRENYLTRANSFERASE
Descriptor:PagF prenyltransferase, DI(HYDROXYETHYL)ETHER
Authors:Hao, Y., Nair, S.K.
Deposit date:2016-11-04
Release date:2016-11-30
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular basis for the broad substrate selectivity of a peptide prenyltransferase.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5TU4
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PAGF WITH BOC-TYR AND DMSPP
Descriptor:PagF prenyltransferase, DIMETHYLALLYL S-THIOLODIPHOSPHATE, MAGNESIUM ION, ...
Authors:Hao, Y., Nair, S.K.
Deposit date:2016-11-04
Release date:2016-11-30
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular basis for the broad substrate selectivity of a peptide prenyltransferase.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5TU5
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PAGF PRENYLTRANSFERASE WITH TYR-TYR-TYR AND DMSPP
Descriptor:PagF prenyltransferase, TYR-TYR-TYR, DIMETHYLALLYL S-THIOLODIPHOSPHATE, ...
Authors:Hao, Y., Nair, S.K.
Deposit date:2016-11-04
Release date:2016-11-30
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis for the broad substrate selectivity of a peptide prenyltransferase.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5TU6
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PAGF PRENYLTRANSFERASE WITH CYCLIC[INPYLYP] AND DMSPP
Descriptor:PagF prenyltransferase, cyclic[INPYLYP] peptide, MAGNESIUM ION, ...
Authors:Hao, Y., Nair, S.K.
Deposit date:2016-11-04
Release date:2016-11-30
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Molecular basis for the broad substrate selectivity of a peptide prenyltransferase.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
6CZK
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CRYSTAL STRUCTURE OF WILD-TYPE HUMAN PRO-CATHEPSIN H
Descriptor:Pro-cathepsin H, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Huang, X., Hao, Y.
Deposit date:2018-04-09
Release date:2018-08-08
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Crystal structures of human procathepsin H.
PLoS ONE, 13, 2018
6CZS
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CRYSTAL STRUCTURE OF HUMAN PRO-CATHEPSIN H C26S MUTANT
Descriptor:Pro-cathepsin H, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Huang, X., Hao, Y.
Deposit date:2018-04-09
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Crystal structures of human procathepsin H.
PLoS ONE, 13, 2018
4KVZ
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CRYSTAL STRUCTURE OF THE PLANTAZOLICIN METHYLTRANSFERASE BAML IN COMPLEX WITH SAH
Descriptor:BamL, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Hao, Y., Nair, S.K.
Deposit date:2013-05-23
Release date:2013-07-24
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KWC
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STRUCTURE OF THE PLANTAZOLICIN METHYLTRANSFERASE BPUML IN COMPLEX WITH SAH
Descriptor:BpumL, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Hao, Y., Nair, S.K.
Deposit date:2013-05-23
Release date:2013-07-24
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis.
Proc.Natl.Acad.Sci.USA, 110, 2013
4WD9
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CRYSTAL STRUCTURE OF TRNA-DEPENDENT LANTIBIOTIC DEHYDRATASE NISB IN COMPLEX WITH NISA LEADER PEPTIDE
Descriptor:Nisin biosynthesis protein NisB
Authors:Hao, Y., Nair, S.K.
Deposit date:2014-09-08
Release date:2014-10-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB.
Nature, 517, 2015
5EHK
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CRYSTAL STRUCTURE OF TRNA DEPENDENT LANTIBIOTIC DEHYDRATASE MIBB FROM MICROBISPORA SP. 107891
Descriptor:Lantibiotic dehydratase
Authors:Hao, Y., Nair, S.K.
Deposit date:2015-10-28
Release date:2016-03-02
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.708 Å)
Cite:Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis.
Cell Chem Biol, 23, 2016
3OFT
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CRYSTAL STRUCTURE OF CYTOCHROME P450 CYP101C1
Descriptor:Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, (2R,5R)-hexane-2,5-diol
Authors:Zhou, W., Ma, M., Bell, S.G., Yang, W., Hao, Y., Rees, N.H., Bartlam, M., Wong, L.-L., Rao, Z.
Deposit date:2010-08-16
Release date:2011-07-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Analysis of CYP101C1 from Novosphingobium aromaticivorans DSM12444.
Chembiochem, 12, 2011
3OFU
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CRYSTAL STRUCTURE OF CYTOCHROME P450 CYP101C1
Descriptor:Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, (3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one
Authors:Zhou, W., Ma, M., Bell, S.G., Yang, W., Hao, Y., Rees, N.H., Bartlam, M., Wong, L.-L., Rao, Z.
Deposit date:2010-08-16
Release date:2011-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Analysis of CYP101C1 from Novosphingobium aromaticivorans DSM12444.
Chembiochem, 12, 2011
6PGM
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PIRF GERANYLTRANSFERASE
Descriptor:PirF Geranyltransferase
Authors:Nair, S.K., Hao, Y., Estrada, P.
Deposit date:2019-06-24
Release date:2019-07-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A Single Amino Acid Switch Alters the Isoprene Donor Specificity in Ribosomally Synthesized and Post-Translationally Modified Peptide Prenyltransferases.
J.Am.Chem.Soc., 140, 2018
6PGN
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PAGF SINGLE MUTANT WITH GPP
Descriptor:PagF, MAGNESIUM ION, GERANYL DIPHOSPHATE
Authors:Nair, S.K., Hao, Y., Estrada, P.
Deposit date:2019-06-24
Release date:2019-07-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A Single Amino Acid Switch Alters the Isoprene Donor Specificity in Ribosomally Synthesized and Post-Translationally Modified Peptide Prenyltransferases
J. Am. Chem. Soc., 140, 2018
5CD3
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STRUCTURE OF IMMATURE VRC01-CLASS ANTIBODY DRVIA7
Descriptor:DRVIA7 Heavy Chain, DRVIA7 Light Chain
Authors:Kong, L., Wilson, I.A.
Deposit date:2015-07-02
Release date:2016-04-06
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.
Immunity, 44, 2016
5CD5
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CRYSTAL STRUCTURE OF AN IMMATURE VRC01-CLASS ANTIBODY DRVIA7 FROM A CHINESE DONOR BOUND TO CLADE A/E HIV-1 GP120 CORE
Descriptor:93TH057 HIV-1 gp120 core, DRVIA7 Fab Heavy Chain, DRVIA7 Fab Light Chain, ...
Authors:Kong, L., Wilson, I.A.
Deposit date:2015-07-03
Release date:2016-04-06
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.396 Å)
Cite:Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.
Immunity, 44, 2016
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