Author results

1ZCM
  • Download 1zcm
  • View 1zcm
Molmil generated image of 1zcm
HUMAN CALPAIN PROTEASE CORE INHIBITED BY ZLLYCH2F
分子名称:Calpain 1, large [catalytic] subunit, CALCIUM ION, ...
著者Li, Q., Hanzlik, R.P., Weaver, R.F., Schonbrunn, E.
登録日2005-04-12
公開日2006-01-31
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core
Biochemistry, 45, 2006
3IEP
  • Download 3iep
  • View 3iep
Molmil generated image of 3iep
FIREFLY LUCIFERASE APO STRUCTURE (P41 FORM)
分子名称:Luciferin 4-monooxygenase
著者Lovell, S., Battaile, K.P., Auld, D.S., Thorne, N., Lea, W.A., Maloney, D.J., Shen, M., Raj, G., Thomas, C.J., Simeonov, A., Hanzlik, R.P., Inglese, J.
登録日2009-07-23
公開日2010-02-16
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.
Proc.Natl.Acad.Sci.USA, 107, 2010
3IER
  • Download 3ier
  • View 3ier
Molmil generated image of 3ier
FIREFLY LUCIFERASE APO STRUCTURE (P41 FORM) WITH PEG 400 BOUND
分子名称:Luciferin 4-monooxygenase, TETRAETHYLENE GLYCOL
著者Lovell, S., Battaile, K.P., Auld, D.S., Thorne, N., Lea, W.A., Maloney, D.J., Shen, M., Raj, G., Thomas, C.J., Simeonov, A., Hanzlik, R.P., Inglese, J.
登録日2009-07-23
公開日2010-02-16
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.
Proc.Natl.Acad.Sci.USA, 107, 2010
3IES
  • Download 3ies
  • View 3ies
Molmil generated image of 3ies
FIREFLY LUCIFERASE INHIBITOR COMPLEX
分子名称:Luciferin 4-monooxygenase, 5'-O-[(R)-[({3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]phenyl}carbonyl)oxy](hydroxy)phosphoryl]adenosine
著者Lovell, S., Battaile, K.P., Auld, D.S., Thorne, N., Lea, W.A., Maloney, D.J., Shen, M., Raj, G., Thomas, C.J., Simeonov, A., Hanzlik, R.P., Inglese, J.
登録日2009-07-23
公開日2010-02-16
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.
Proc.Natl.Acad.Sci.USA, 107, 2010
6AW4
  • Download 6aw4
  • View 6aw4
Molmil generated image of 6aw4
1.50A RESOLUTION STRUCTURE OF CATECHOL O-METHYLTRANSFERASE (COMT) FROM NANNOSPALAX GALILI
分子名称:Catechol O-methyltransferase, GLYCEROL, SODIUM ION, ...
著者Lovell, S., Mehzabeen, N., Battaile, K.P., Deng, Y., Hanzlik, R.P., Shams, I., Moskovitz, J.
登録日2017-09-05
公開日2018-09-12
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structure of the catechol-o-methyl transferase (COMT) enzyme of the subterranean mole rat (Spalax) and the effect of L136M substitution
To be published
6AW5
  • Download 6aw5
  • View 6aw5
Molmil generated image of 6aw5
1.90A RESOLUTION STRUCTURE OF CATECHOL O-METHYLTRANSFERASE (COMT) L136M (HEXAGONAL FORM) FROM NANNOSPALAX GALILI
分子名称:Catechol O-methyltransferase, SODIUM ION, CHLORIDE ION, ...
著者Lovell, S., Mehzabeen, N., Battaile, K.P., Deng, Y., Hanzlik, R.P., Shams, I., Moskovitz, J.
登録日2017-09-05
公開日2018-09-12
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the catechol-o-methyl transferase (COMT) enzyme of the subterranean mole rat (Spalax) and the effect of L136M substitution
To be published
6AW6
  • Download 6aw6
  • View 6aw6
Molmil generated image of 6aw6
1.70A RESOLUTION STRUCTURE OF CATECHOL O-METHYLTRANSFERASE (COMT) L136M (RHOMBOHEDRAL FORM) FROM NANNOSPALAX GALILI
分子名称:Catechol O-methyltransferase, SULFATE ION
著者Lovell, S., Mehzabeen, N., Battaile, K.P., Deng, Y., Hanzlik, R.P., Shams, I., Moskovitz, J.
登録日2017-09-05
公開日2018-09-12
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of the catechol-o-methyl transferase (COMT) enzyme of the subterranean mole rat (Spalax) and the effect of L136M substitution
To be published
6AW7
  • Download 6aw7
  • View 6aw7
Molmil generated image of 6aw7
2.15A RESOLUTION STRUCTURE OF SAH BOUND CATECHOL O-METHYLTRANSFERASE (COMT) FROM NANNOSPALAX GALILI
分子名称:Catechol O-methyltransferase, CALCIUM ION, S-ADENOSYL-L-HOMOCYSTEINE
著者Lovell, S., Mehzabeen, N., Battaile, K.P., Deng, Y., Hanzlik, R.P., Shams, I., Moskovitz, J.
登録日2017-09-05
公開日2018-09-12
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal structure of the catechol-o-methyl transferase (COMT) enzyme of the subterranean mole rat (Spalax) and the effect of L136M substitution
To be published
6AW8
  • Download 6aw8
  • View 6aw8
Molmil generated image of 6aw8
2.25A RESOLUTION DOMAIN SWAPPED DIMER STRUCTURE OF SAH BOUND CATECHOL O-METHYLTRANSFERASE (COMT) FROM NANNOSPALAX GALILI
分子名称:Catechol O-methyltransferase, CALCIUM ION, S-ADENOSYL-L-HOMOCYSTEINE
著者Lovell, S., Mehzabeen, N., Battaile, K.P., Deng, Y., Hanzlik, R.P., Shams, I., Moskovitz, J.
登録日2017-09-05
公開日2018-09-12
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal structure of the catechol-o-methyl transferase (COMT) enzyme of the subterranean mole rat (Spalax) and the effect of L136M substitution
To be published
6AW9
  • Download 6aw9
  • View 6aw9
Molmil generated image of 6aw9
2.55A RESOLUTION STRUCTURE OF SAH BOUND CATECHOL O-METHYLTRANSFERASE (COMT) L136M FROM NANNOSPALAX GALILI
分子名称:Catechol O-methyltransferase, CALCIUM ION, S-ADENOSYL-L-HOMOCYSTEINE
著者Lovell, S., Mehzabeen, N., Battaile, K.P., Deng, Y., Hanzlik, R.P., Shams, I., Moskovitz, J.
登録日2017-09-05
公開日2018-09-12
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal structure of the catechol-o-methyl transferase (COMT) enzyme of the subterranean mole rat (Spalax) and the effect of L136M substitution
To be published
6C8U
  • Download 6c8u
  • View 6c8u
Molmil generated image of 6c8u
SOLUTION STRUCTURE OF MUSASHI2 RRM1
分子名称:RNA-binding protein Musashi homolog 2
著者Xing, M., Lan, L., Douglas, J.T., Gao, P., Hanzlik, R.P., Xu, L.
登録日2018-01-25
公開日2019-01-30
最終更新日2019-02-20
実験手法SOLUTION NMR
主引用文献Solution structure of Musashi2 RRM1
To be Published
2BB7
  • Download 2bb7
  • View 2bb7
Molmil generated image of 2bb7
MN FORM OF E. COLI METHIONINE AMINOPEPTIDASE IN COMPLEX WITH A QUINOLINYL SULFONAMIDE INHIBITOR
分子名称:Methionine aminopeptidase, MANGANESE (II) ION, SODIUM ION, ...
著者Ye, Q.Z.
登録日2005-10-17
公開日2006-01-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Metal mediated inhibition of methionine aminopeptidase by quinolinyl sulfonamides
Biochem.Biophys.Res.Commun., 339, 2006
2EVC
  • Download 2evc
  • View 2evc
Molmil generated image of 2evc
CRYSTAL STRUCTURE OF E. COLI. METHIONINE AMINO PEPTIDASE IN COMPLEX WITH 5-(2-(TRIFLUOROMETHYL)PHENYL)FURAN-2-CARBOXYLIC ACID
分子名称:Methionine aminopeptidase, MANGANESE (II) ION, SODIUM ION, ...
著者Huang, W.-J.
登録日2005-10-31
公開日2006-03-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural analysis of metalloform-selective inhibition of methionine aminopeptidase.
Acta Crystallogr.,Sect.D, 62, 2006
2EVM
  • Download 2evm
  • View 2evm
Molmil generated image of 2evm
CRYSTAL STRUCTURE OF METHIONINE AMINOPEPTIDASE IN COMPLEX WITH 5-(2,5-DICHLOROPHENYL)FURAN-2-CARBOXYLIC ACID
分子名称:Methionine aminopeptidase, MANGANESE (II) ION, SODIUM ION, ...
著者Huang, W.-J.
登録日2005-10-31
公開日2006-03-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural analysis of metalloform-selective inhibition of methionine aminopeptidase.
Acta Crystallogr.,Sect.D, 62, 2006
2EVO
  • Download 2evo
  • View 2evo
Molmil generated image of 2evo
CRYSTAL STRUCTURE OF METHIONINE AMINO PEPTIDASE IN COMPLEX WITH N-CYCLOPENTYL-N-(THIAZOL-2-YL)OXALAMIDE
分子名称:Methionine aminopeptidase, COBALT (II) ION, N1-CYCLOPENTYL-N2-(THIAZOL-2-YL)OXALAMIDE
著者Huang, W.-J.
登録日2005-10-31
公開日2006-03-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural analysis of metalloform-selective inhibition of methionine aminopeptidase.
Acta Crystallogr.,Sect.D, 62, 2006
2GTX
  • Download 2gtx
  • View 2gtx
Molmil generated image of 2gtx
STRUCTURAL BASIS OF CATALYSIS BY MONONUCLEAR METHIONINE AMINOPEPTIDASE
分子名称:Methionine aminopeptidase, MANGANESE (II) ION, SODIUM ION, ...
著者Ye, Q.Z.
登録日2006-04-28
公開日2006-07-04
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis of catalysis by monometalated methionine aminopeptidase.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2GU4
  • Download 2gu4
  • View 2gu4
Molmil generated image of 2gu4
E. COLI METHIONINE AMINOPEPTIDASE IN COMPLEX WITH NLEP, 1: 0.5, DI-METALATED
分子名称:Methionine aminopeptidase, MANGANESE (II) ION, SODIUM ION, ...
著者Ye, Q.Z.
登録日2006-04-28
公開日2006-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis of catalysis by monometalated methionine aminopeptidase.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2GU5
  • Download 2gu5
  • View 2gu5
Molmil generated image of 2gu5
E. COLI METHIONINE AMINOPEPTIDASE IN COMPLEX WITH NLEP, 1: 1, DI-METALATED
分子名称:Methionine aminopeptidase, MANGANESE (II) ION, SODIUM ION, ...
著者Ye, Q.Z.
登録日2006-04-28
公開日2006-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural basis of catalysis by monometalated methionine aminopeptidase.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2GU6
  • Download 2gu6
  • View 2gu6
Molmil generated image of 2gu6
E. COLI METHIONINE AMINOPEPTIDASE IN COMPLEX WITH NLEP, 1: 2, DI-METALATED
分子名称:Methionine aminopeptidase, MANGANESE (II) ION, SODIUM ION, ...
著者Ye, Q.Z.
登録日2006-04-28
公開日2006-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis of catalysis by monometalated methionine aminopeptidase.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2GU7
  • Download 2gu7
  • View 2gu7
Molmil generated image of 2gu7
E. COLI METHIONINE AMINOPEPTIDASE UNLIGANDED, 1:0.5
分子名称:Methionine aminopeptidase, MANGANESE (II) ION, SODIUM ION
著者Ye, Q.Z.
登録日2006-04-28
公開日2006-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis of catalysis by monometalated methionine aminopeptidase.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2RG3
  • Download 2rg3
  • View 2rg3
Molmil generated image of 2rg3
COVALENT COMPLEX STRUCTURE OF ELASTASE
分子名称:Leukocyte elastase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
著者Huang, W., Yamamoto, Y.
登録日2007-10-02
公開日2008-07-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives.
J.Med.Chem., 51, 2008
3BEN
  • Download 3ben
  • View 3ben
Molmil generated image of 3ben
STRUCTURE OF N-(12-IMIDAZOLYL-DODECANOYL)-L-LEUCINE INHIBITOR BOUND TO THE HEME DOMAIN OF CYTOCHROME P450-BM3
分子名称:Cytochrome P450 102, PROTOPORPHYRIN IX CONTAINING FE, N-[12-(1H-imidazol-1-yl)dodecanoyl]-L-leucine, ...
著者Tomchick, D.R.
登録日2007-11-19
公開日2008-09-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel.
Biochemistry, 47, 2008