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1HGD
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BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY
Descriptor:HEMAGGLUTININ, CHAIN HA1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Sauter, N.K., Hanson, J.E., Glick, G.D., Brown, J.H., Crowther, R.L., Park, S.-J., Skehel, J.J., Wiley, D.C.
Deposit date:1991-11-01
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Biochemistry, 31, 1992
1HGE
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BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY
Descriptor:HEMAGGLUTININ, (G135R), HA1 CHAIN, ...
Authors:Sauter, N.K., Hanson, J.E., Glick, G.D., Brown, J.H., Crowther, R.L., Park, S.-J., Skehel, J.J., Wiley, D.C.
Deposit date:1991-11-01
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Biochemistry, 31, 1992
1HGF
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BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY
Descriptor:HEMAGGLUTININ, CHAIN HA1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Sauter, N.K., Hanson, J.E., Glick, G.D., Brown, J.H., Crowther, R.L., Park, S.-J., Skehel, J.J., Wiley, D.C.
Deposit date:1991-11-01
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Biochemistry, 31, 1992
1HGG
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BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY
Descriptor:HEMAGGLUTININ, CHAIN HA1, CHAIN HA2, ...
Authors:Sauter, N.K., Hanson, J.E., Glick, G.D., Brown, J.H., Crowther, R.L., Park, S.-J., Skehel, J.J., Wiley, D.C.
Deposit date:1991-11-01
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Biochemistry, 31, 1992
1HGH
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BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY
Descriptor:HEMAGGLUTININ, CHAIN HA1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Sauter, N.K., Hanson, J.E., Glick, G.D., Brown, J.H., Crowther, R.L., Park, S.-J., Skehel, J.J., Wiley, D.C.
Deposit date:1991-11-01
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Biochemistry, 31, 1992
1HGI
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BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY
Descriptor:HEMAGGLUTININ, CHAIN HA1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Sauter, N.K., Hanson, J.E., Glick, G.D., Brown, J.H., Crowther, R.L., Park, S.-J., Skehel, J.J., Wiley, D.C.
Deposit date:1991-11-01
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Biochemistry, 31, 1992
1HGJ
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BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY
Descriptor:HEMAGGLUTININ, CHAIN HA1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Sauter, N.K., Hanson, J.E., Glick, G.D., Brown, J.H., Crowther, R.L., Park, S.-J., Skehel, J.J., Wiley, D.C.
Deposit date:1991-11-01
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Biochemistry, 31, 1992
1QRP
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HUMAN PEPSIN 3A IN COMPLEX WITH A PHOSPHONATE INHIBITOR IVA-VAL-VAL-LEU(P)-(O)PHE-ALA-ALA-OME
Descriptor:PEPSIN 3A, methyl N-[(2S)-2-({(S)-hydroxy[(1R)-3-methyl-1-{[N-(3-methylbutanoyl)-L-valyl-L-valyl]amino}butyl]phosphoryl}oxy)-3-phenylpropanoyl]-L-alanyl-L-alaninate
Authors:Fujinaga, M., Cherney, M.M., Tarasova, N.I., Bartlett, P.A., Hanson, J.E., James, M.N.G.
Deposit date:1999-06-15
Release date:1999-06-18
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structural study of the complex between human pepsin and a phosphorus-containing peptidic -transition-state analog.
Acta Crystallogr.,Sect.D, 56, 2000
1PPK
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CRYSTALLOGRAPHIC ANALYSIS OF TRANSITION STATE MIMICS BOUND TO PENICILLOPEPSIN: PHOSPHOROUS-CONTAINING PEPTIDE ANALOGUES
Descriptor:PENICILLOPEPSIN, N-(3-methylbutanoyl)-L-valyl-N-{(1R)-1-[(R)-(2-ethoxy-2-oxoethyl)(hydroxy)phosphoryl]-3-methylbutyl}-L-valinamide, ALPHA-D-MANNOSE, ...
Authors:Strynadka, N.C.J., James, M.N.G.
Deposit date:1994-01-20
Release date:1994-05-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystallographic analysis of transition-state mimics bound to penicillopepsin: phosphorus-containing peptide analogues.
Biochemistry, 31, 1992
1PPL
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CRYSTALLOGRAPHIC ANALYSIS OF TRANSITION-STATE MIMICS BOUND TO PENICILLOPEPSIN: PHOSPHORUS-CONTAINING PEPTIDE ANALOGUES
Descriptor:PENICILLOPEPSIN, N-(3-methylbutanoyl)-L-valyl-N-{(1S)-1-[(R)-[(1R)-1-benzyl-2-methoxy-2-oxoethoxy](hydroxy)phosphoryl]-3-methylbutyl}-L-valinamide, ALPHA-D-MANNOSE, ...
Authors:Fraser, M.E., James, M.N.G.
Deposit date:1992-06-01
Release date:1993-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystallographic analysis of transition-state mimics bound to penicillopepsin: phosphorus-containing peptide analogues.
Biochemistry, 31, 1992
1PPM
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CRYSTALLOGRAPHIC ANALYSIS OF TRANSITION-STATE MIMICS BOUND TO PENICILLOPEPSIN: PHOSPHORUS-CONTAINING PEPTIDE ANALOGUES
Descriptor:PENICILLOPEPSIN, N-[(benzyloxy)carbonyl]-L-alanyl-N-{(1S)-1-[(R)-[(1R)-1-benzyl-2-methoxy-2-oxoethoxy](hydroxy)phosphoryl]-3-methylbutyl}-L-alaninamide, ALPHA-D-MANNOSE, ...
Authors:Fraser, M.E., James, M.N.G.
Deposit date:1992-06-01
Release date:1993-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystallographic analysis of transition-state mimics bound to penicillopepsin: phosphorus-containing peptide analogues.
Biochemistry, 31, 1992
5H8F
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STRUCTURE OF THE APO HUMAN GLUN1/GLUN2A LBD
Descriptor:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
Authors:Wallweber, H.J.A., Lupardus, P.J.
Deposit date:2015-12-23
Release date:2016-02-24
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
Neuron, 89, 2016
5H8H
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH GNE3419
Descriptor:Glutamate receptor ionotropic, NMDA 2A,Glutamate receptor ionotropic, NMDA 2A, ...
Authors:Wallweber, H.J.A., Lupardus, P.J.
Deposit date:2015-12-23
Release date:2016-02-24
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
Neuron, 89, 2016
5H8N
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH NAM
Descriptor:Glutamate receptor ionotropic, NMDA 2A,Glutamate receptor ionotropic, NMDA 2A, ...
Authors:Wallweber, H.J.A., Lupardus, P.J.
Deposit date:2015-12-23
Release date:2016-02-24
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
Neuron, 89, 2016
5H8Q
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH GNE8324
Descriptor:Glutamate receptor ionotropic, NMDA 2A,Glutamate receptor ionotropic, NMDA 2A, ...
Authors:Wallweber, H.J.A., Lupardus, P.J.
Deposit date:2015-12-23
Release date:2016-02-24
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
Neuron, 89, 2016
5H8S
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STRUCTURE OF THE HUMAN GLUA2 LBD IN COMPLEX WITH GNE3419
Descriptor:Glutamate receptor 2,Glutamate receptor 2, GLUTAMIC ACID, 7-[[ethyl(phenyl)amino]methyl]-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, ...
Authors:Wallweber, H.J.A., Lupardus, P.J.
Deposit date:2015-12-23
Release date:2016-02-24
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.703 Å)
Cite:Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
Neuron, 89, 2016
5I2K
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH 7-{[ETHYL(4-FLUOROPHENYL)AMINO]METHYL}-N,2-DIMETHYL-5-OXO-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDINE-3-CARBOXAMIDE (COMPOUND 19)
Descriptor:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
Authors:Wallweber, H.J.A., Lupardus, P.J.
Deposit date:2016-02-09
Release date:2016-03-16
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
J.Med.Chem., 59, 2016
5I2N
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH N-ETHYL-7-{[2-FLUORO-3-(TRIFLUOROMETHYL)PHENYL]METHYL}-2-METHYL-5-OXO-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDINE-3-CARBOXAMIDE (COMPOUND 29)
Descriptor:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
Authors:Wallweber, H.J.A., Lupardus, P.J.
Deposit date:2016-02-09
Release date:2016-03-16
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
J.Med.Chem., 59, 2016
5KCJ
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH GNE6901
Descriptor:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
Authors:Wallweber, H.J.A., Lupardus, P.J.
Deposit date:2016-06-06
Release date:2016-07-13
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
Neuron, 89, 2016
5KDT
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH GNE0723
Descriptor:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
Authors:Wallweber, H.J.A., Lupardus, P.J.
Deposit date:2016-06-08
Release date:2016-07-13
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
J. Med. Chem., 59, 2016
5TP9
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH COMPOUND 2 (GNE9178)
Descriptor:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
Authors:Wallweber, H.J.A., Lupardus, P.J.
Deposit date:2016-10-20
Release date:2016-11-30
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
ACS Med Chem Lett, 8, 2017
5TPA
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH COMPOUND 9 (GNE3500)
Descriptor:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
Authors:Wallweber, H.J.A., Lupardus, P.J.
Deposit date:2016-10-20
Release date:2016-11-30
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
ACS Med Chem Lett, 8, 2017
2WEA
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ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE INHIBITOR: METHYL[CYCLO-7[(2R)-((N-VALYL) AMINO)-2-(HYDROXYL-(1S)-1-METHYOXYCARBONYL-2-PHENYLETHOXY) PHOSPHINYLOXY-ETHYL]-1-NAPHTHALENEACETAMIDE], SODIUM SALT
Descriptor:PENICILLOPEPSIN, ALPHA-D-MANNOSE, SULFATE ION, ...
Authors:Ding, J., Fraser, M.E., James, M.N.G.
Deposit date:1998-02-03
Release date:1998-05-27
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Macrocyclic Inhibitors of Penicillopepsin. II. X-Ray Crystallographic Analyses of Penicillopepsin Complexed with a P3-P1 Macrocyclic Peptidyl Inhibitor and with its Two Acyclic Analogues
J.Am.Chem.Soc., 120, 1998
2WEB
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ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE INHIBITOR: METHYL(2S)-[1-(((N-FORMYL)-L-VALYL)AMINO-2-(2-NAPHTHYL)ETHYL)HYDROXYPHOSPHINYLOXY]-3-PHENYLPROPANOATE, SODIUM SALT
Descriptor:PENICILLOPEPSIN, ALPHA-D-MANNOSE, SULFATE ION, ...
Authors:Ding, J., Fraser, M.E., James, M.N.G.
Deposit date:1998-02-03
Release date:1998-05-27
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Macrocyclic Inhibitors of Penicillopepsin. II. X-Ray Crystallographic Analyses of Penicillopepsin Complexed with a P3-P1 Macrocyclic Peptidyl Inhibitor and with its Two Acyclic Analogues
J.Am.Chem.Soc., 120, 1998
2WEC
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ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE INHIBITOR: METHYL(2S)-[1-(((N-(1-NAPHTHALENEACETYL))-L-VALYL)AMINOMETHYL)HYDROXY PHOSPHINYLOXY]-3-PHENYLPROPANOATE, SODIUM SALT
Descriptor:PENICILLOPEPSIN, ALPHA-D-MANNOSE, SULFATE ION, ...
Authors:Ding, J., Fraser, M.E., James, M.N.G.
Deposit date:1998-02-03
Release date:1998-05-27
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Macrocyclic Inhibitors of Penicillopepsin. II. X-Ray Crystallographic Analyses of Penicillopepsin Complexed with a P3-P1 Macrocyclic Peptidyl Inhibitor and with its Two Acyclic Analogues
J.Am.Chem.Soc., 120, 1998
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