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4ONS
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BU of 4ons by Molmil
Structural and thermodynamic characterization of cadherin-beta-catenin-alpha-catenin complex formation
Descriptor: Catenin alpha-2, Catenin beta-1
Authors:Pokutta, S, Choi, H.-J, Ahlsen, G, Hansen, S.D, Weis, W.I.
Deposit date:2014-01-29
Release date:2014-04-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and Thermodynamic Characterization of Cadherin beta-Catenin alpha-Catenin Complex Formation.
J.Biol.Chem., 289, 2014
8AJ8
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BU of 8aj8 by Molmil
Structure of p110 gamma bound to the p84 regulatory subunit
Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Phosphoinositide 3-kinase regulatory subunit 6
Authors:Burke, J.E, Williams, R.L, Zhang, X.
Deposit date:2022-07-27
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (8.5 Å)
Cite:Molecular basis for differential activation of p101 and p84 complexes of PI3K gamma by Ras and GPCRs.
Cell Rep, 42, 2023
8DP0
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BU of 8dp0 by Molmil
Structure of p110 gamma bound to the Ras inhibitory nanobody NB7
Descriptor: Nanobody NB7, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Authors:Burke, J.E, Nam, S.E, Rathinaswamy, M.K, Yip, C.K.
Deposit date:2022-07-14
Release date:2023-07-19
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Allosteric activation or inhibition of PI3K gamma mediated through conformational changes in the p110 gamma helical domain.
Elife, 12, 2023
7MEZ
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BU of 7mez by Molmil
Structure of the phosphoinositide 3-kinase p110 gamma (PIK3CG) p101 (PIK3R5) complex
Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Phosphoinositide 3-kinase regulatory subunit 5
Authors:Burke, J.E, Dalwadi, U, Rathinaswamy, M.K, Yip, C.K.
Deposit date:2021-04-08
Release date:2021-07-14
Last modified:2022-04-06
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Structure of the phosphoinositide 3-kinase (PI3K) p110 gamma-p101 complex reveals molecular mechanism of GPCR activation.
Sci Adv, 7, 2021

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