Author results

6T6B
  • Download 6t6b
  • View 6t6b
Molmil generated image of 6t6b
CRYSTAL STRUCTURE OF PPARGAMMA IN COMPLEX WITH COMPOUND 16 (MF27)
Descriptor:Peroxisome proliferator-activated receptor gamma, (2~{R})-2-[[6-[(2,4-dichlorophenyl)sulfonylamino]-1,3-benzothiazol-2-yl]sulfanyl]octanoic acid
Authors:Chaikuad, A., Ni, X., Hanke, T., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Merk, D., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2019-10-18
Release date:2019-12-11
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A Selective Modulator of Peroxisome Proliferator-Activated Receptor gamma with an Unprecedented Binding Mode.
J.Med.Chem., 63, 2020
6Y3U
  • Download 6y3u
  • View 6y3u
Molmil generated image of 6y3u
CRYSTAL STRUCTURE OF PPARGAMMA IN COMPLEX WITH COMPOUND (R)-16
Descriptor:Peroxisome proliferator-activated receptor gamma, (2~{R})-2-[[6-[(2,4-dichlorophenyl)sulfonylamino]-1,3-benzothiazol-2-yl]sulfanyl]octanoic acid
Authors:Chaikuad, A., Hanke, T., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Merk, D., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2020-02-18
Release date:2020-04-22
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:A Selective Modulator of Peroxisome Proliferator-Activated Receptor gamma with an Unprecedented Binding Mode.
J.Med.Chem., 63, 2020
5NXD
  • Download 5nxd
  • View 5nxd
Molmil generated image of 5nxd
LIM DOMAIN KINASE 2 (LIMK2) IN COMPLEX WITH TH-300
Descriptor:LIM domain kinase 2, 4-[(3-chlorophenyl)sulfamoyl]-~{N}-(phenylmethyl)-~{N}-propyl-benzamide, 1,2-ETHANEDIOL
Authors:Mathea, S., Salah, E., Hanke, T., Newman, J.A., Oerum, S., Wang, D., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N., Knapp, S.
Deposit date:2017-05-10
Release date:2017-05-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:LIM Domain Kinase 2 (LIMK2)In Complex With TH-300
To Be Published
6YUL
  • Download 6yul
  • View 6yul
Molmil generated image of 6yul
CK2 ALPHA BOUND TO MACROCYCLE
Descriptor:Casein kinase II subunit alpha, SULFATE ION, 7,10-Dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxylic acid
Authors:Kraemer, A., Hanke, T., Kurz, C., Celik, I., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2020-04-27
Release date:2020-07-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:CK2 alpha bound to Macrocycle
To Be Published
6YUM
  • Download 6yum
  • View 6yum
Molmil generated image of 6yum
CK2 ALPHA BOUND TO UNCLOSED MACROCYCLE
Descriptor:Casein kinase II subunit alpha, SULFATE ION, 4-[5-[2-(2-hydroxyethyloxy)ethyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pyrazolo[1,5-a]pyrimidin-3-yl]-2-oxidanyl-benzoic acid
Authors:Kraemer, A., Hanke, T., Kurz, C., Celik, I., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2020-04-27
Release date:2020-07-01
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:CK2 alpha bound to unclosed Macrocycle
To Be Published
1YJD
  • Download 1yjd
  • View 1yjd
Molmil generated image of 1yjd
CRYSTAL STRUCTURE OF HUMAN CD28 IN COMPLEX WITH THE FAB FRAGMENT OF A MITOGENIC ANTIBODY (5.11A1)
Descriptor:Fab fragment of 5.11A1 antibody light chain, Fab fragment of 5.11A1 antibody heavy chain, T-cell-specific surface glycoprotein CD28, ...
Authors:Evans, E.J., Esnouf, R.M., Manso-Sancho, R., Gilbert, R.J.C., James, J.R., Sorensen, P., Stuart, D.I., Davis, S.J.
Deposit date:2005-01-14
Release date:2005-02-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a soluble CD28-Fab complex
Nat.Immunol., 6, 2005