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6CND
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BU of 6cnd by Molmil
Yeast RNA polymerase III natural open complex (nOC)
Descriptor: DNA (71-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ...
Authors:Han, Y, He, Y.
Deposit date:2018-03-08
Release date:2018-08-22
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structural visualization of RNA polymerase III transcription machineries.
Cell Discov, 4, 2018
6CNB
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BU of 6cnb by Molmil
Yeast RNA polymerase III initial transcribing complex
Descriptor: DNA (71-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ...
Authors:Han, Y, He, Y.
Deposit date:2018-03-08
Release date:2018-08-22
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural visualization of RNA polymerase III transcription machineries.
Cell Discov, 4, 2018
6CNC
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BU of 6cnc by Molmil
Yeast RNA polymerase III open complex
Descriptor: DNA (71-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ...
Authors:Han, Y, He, Y.
Deposit date:2018-03-08
Release date:2018-08-22
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural visualization of RNA polymerase III transcription machineries.
Cell Discov, 4, 2018
6CNF
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BU of 6cnf by Molmil
Yeast RNA polymerase III elongation complex
Descriptor: DNA (79-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ...
Authors:Han, Y, He, Y.
Deposit date:2018-03-08
Release date:2018-08-22
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural visualization of RNA polymerase III transcription machineries.
Cell Discov, 4, 2018
5W5Y
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BU of 5w5y by Molmil
RNA polymerase I Initial Transcribing Complex
Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ...
Authors:Han, Y, He, Y.
Deposit date:2017-06-16
Release date:2017-07-26
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.
Elife, 6, 2017
5W66
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BU of 5w66 by Molmil
RNA polymerase I Initial Transcribing Complex State 3
Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ...
Authors:Han, Y, He, Y.
Deposit date:2017-06-16
Release date:2017-07-26
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.
Elife, 6, 2017
5W65
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BU of 5w65 by Molmil
RNA polymerase I Initial Transcribing Complex State 2
Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ...
Authors:Han, Y, He, Y.
Deposit date:2017-06-16
Release date:2017-08-02
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.
Elife, 6, 2017
5W64
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BU of 5w64 by Molmil
RNA Polymerase I Initial Transcribing Complex State 1
Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ...
Authors:Han, Y, He, Y.
Deposit date:2017-06-16
Release date:2017-07-26
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.
Elife, 6, 2017
4G8K
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BU of 4g8k by Molmil
Intact sensor domain of human RNase L in the inactive signaling state
Descriptor: 2-5A-dependent ribonuclease
Authors:Han, Y, Whitney, G, Donovan, J, Korennykh, A.
Deposit date:2012-07-23
Release date:2012-10-31
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Innate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes.
Cell Rep, 2, 2012
4G8L
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BU of 4g8l by Molmil
Active state of intact sensor domain of human RNase L with 2-5A bound
Descriptor: 2-5A-dependent ribonuclease, 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE
Authors:Han, Y, Whitney, G, Donovan, J, Korennykh, A.
Deposit date:2012-07-23
Release date:2012-10-31
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Innate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes.
Cell Rep, 2, 2012
4OAV
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BU of 4oav by Molmil
Complete human RNase L in complex with 2-5A (5'-ppp heptamer), AMPPCP and RNA substrate.
Descriptor: (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-({[(S)-hydroxy{[(2R,3S,4S)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]oxy}phosphoryl]oxy}methyl)tetrahydrofuran-3-yl dihydrogen phosphate, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Han, Y, Donovan, J, Rath, S, Whitney, G, Chitrakar, A, Korennykh, A.
Deposit date:2014-01-06
Release date:2014-03-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response.
Science, 343, 2014
4OAU
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BU of 4oau by Molmil
Complete human RNase L in complex with biological activators.
Descriptor: 2-5A-dependent ribonuclease, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Han, Y, Donovan, J, Rath, S, Whitney, G, Chitrakar, A, Korennykh, A.
Deposit date:2014-01-06
Release date:2014-03-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response.
Science, 343, 2014
6UXW
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BU of 6uxw by Molmil
SWI/SNF nucleosome complex with ADP-BeFx
Descriptor: 601 sequence bottom strand, 601 sequence top strand, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:He, Y, Han, Y.
Deposit date:2019-11-08
Release date:2020-03-18
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (8.96 Å)
Cite:Cryo-EM structure of SWI/SNF complex bound to a nucleosome.
Nature, 579, 2020
6UXV
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BU of 6uxv by Molmil
SWI/SNF Body Module
Descriptor: SWI/SNF chromatin-remodeling complex subunit SNF5, SWI/SNF chromatin-remodeling complex subunit SWI1, SWI/SNF complex subunit SWI3, ...
Authors:He, Y, Han, Y.
Deposit date:2019-11-08
Release date:2020-03-18
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Cryo-EM structure of SWI/SNF complex bound to a nucleosome.
Nature, 579, 2020
6CB7
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BU of 6cb7 by Molmil
CRYSTAL STRUCTURE OF VACCINIA VIRUS A6 N-TERMINUS (SPACE GROUP C2)
Descriptor: NICKEL (II) ION, Protein A6
Authors:Han, Y, Zhang, B, Deng, J.
Deposit date:2018-02-02
Release date:2018-12-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CB6
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BU of 6cb6 by Molmil
CRYSTAL STRUCTURE OF VACCINIA VIRUS A6 N-TERMINUS (SPACE GROUP C2)
Descriptor: Protein A6
Authors:Han, Y, Zhang, B, Deng, J.
Deposit date:2018-02-02
Release date:2018-12-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
2YYF
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BU of 2yyf by Molmil
Purification and structural characterization of a D-amino acid containing conopeptide, marmophine, from Conus marmoreus
Descriptor: M-conotoxin mr12
Authors:Huang, F, Du, W, Han, Y, Wang, C.
Deposit date:2007-04-29
Release date:2008-04-08
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Purification and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus.
Febs J., 275, 2008
2JQC
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BU of 2jqc by Molmil
A L-amino acid mutant of a D-amino acid containing conopeptide
Descriptor: L-mr12
Authors:Huang, F, Du, W, Han, Y, Wang, C, Chi, C.
Deposit date:2007-05-31
Release date:2008-04-15
Last modified:2023-12-20
Method:SOLUTION NMR
Cite:Purification and structural characterization of a d-amino acid-containing conopeptide, conomarphin, from Conus marmoreus
Febs J., 275, 2008
3CWE
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BU of 3cwe by Molmil
PTP1B in complex with a phosphonic acid inhibitor
Descriptor: MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1, [{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid
Authors:Scapin, G, Han, Y, Kennedy, B.P.
Deposit date:2008-04-21
Release date:2008-06-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor
Bioorg.Med.Chem.Lett., 18, 2008
3QH2
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BU of 3qh2 by Molmil
Crystal structure of TenI from Bacillus subtilis complexed with product cThz-P
Descriptor: 4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazole-2-carboxylic acid, Regulatory protein tenI, SULFATE ION
Authors:Han, Y, Zhang, Y, Hazra, A, Chatterjee, A, Lai, R, Begley, T.P, Ealick, S.E.
Deposit date:2011-01-25
Release date:2011-05-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.231 Å)
Cite:A Missing Enzyme in Thiamin Thiazole Biosynthesis: Identification of TenI as a Thiazole Tautomerase.
J.Am.Chem.Soc., 133, 2011
7RH9
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BU of 7rh9 by Molmil
Cryo-EM structure of human rod CNGA1/B1 channel in apo state
Descriptor: Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1
Authors:Xue, J, Han, Y, Jiang, Y.
Deposit date:2021-07-16
Release date:2021-11-03
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (2.61 Å)
Cite:Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel.
Neuron, 110, 2022
8BWU
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BU of 8bwu by Molmil
Crystal structure of SARS-CoV-2 nsp14 methyltransferase domain in complex with the SS148 inhibitor
Descriptor: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Transcription factor ETV6,Proofreading exoribonuclease nsp14, ZINC ION
Authors:Konkolova, E, Klima, M, Boura, E, Jin, J, Kaniskan, H.U, Han, Y, Vedadi, M.
Deposit date:2022-12-07
Release date:2023-10-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors.
Biorxiv, 2024
8FYF
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BU of 8fyf by Molmil
Human TMEM175-LAMP1 transmembrane domain only complex
Descriptor: Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1
Authors:Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X.
Deposit date:2023-01-26
Release date:2023-06-28
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Mol.Cell, 83, 2023
8FY5
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BU of 8fy5 by Molmil
Human TMEM175-LAMP1 full-length complex
Descriptor: Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1
Authors:Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X.
Deposit date:2023-01-25
Release date:2023-06-28
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Mol.Cell, 83, 2023
6VP0
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BU of 6vp0 by Molmil
Human Diacylglycerol Acyltransferase 1 in complex with oleoyl-CoA
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Diacylglycerol O-acyltransferase 1, Lauryl Maltose Neopentyl Glycol, ...
Authors:Wang, L, Qian, H, Han, Y, Nian, Y, Ren, Z, Zhang, H, Hu, L, Prasad, B.V.V, Yan, N, Zhou, M.
Deposit date:2020-02-01
Release date:2020-05-13
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure and mechanism of human diacylglycerol O-acyltransferase 1.
Nature, 581, 2020

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PDB entries from 2024-03-27

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