Author results

4JNM
  • Download 4jnm
  • View 4jnm
Molmil generated image of 4jnm
DISCOVERY OF POTENT AND EFFICACIOUS UREA-CONTAINING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) INHIBITORS WITH REDUCED CYP2C9 INHIBITION PROPERTIES
分子名称:Nicotinamide phosphoribosyltransferase, 1-[(6-aminopyridin-3-yl)methyl]-3-[4-(phenylsulfonyl)phenyl]urea, PHOSPHATE ION, ...
著者Gunzner-Toste, J., Zhao, G., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Fu, B., Han, B., Ho, Y., Kley, N., Liederer, B., Lin, J., Mukadam, S., O'Brien, T., Reynolds, D.J., Sharma, G., Skelton, N., Smith, C.C., Oh, A., Wang, W., Wang, Z., Xiao, Y., Yuen, P., Zak, M., Zhang, L., Zheng, X., Bair, K.W., Dragovich, P.S.
登録日2013-03-15
公開日2013-05-29
最終更新日2013-06-05
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.
Bioorg.Med.Chem.Lett., 23, 2013
4GQB
  • Download 4gqb
  • View 4gqb
Molmil generated image of 4gqb
CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX
分子名称:Protein arginine N-methyltransferase 5, Methylosome protein 50, Histone H4 peptide, ...
著者Antonysamy, S., Bonday, Z., Campbell, R., Doyle, B., Druzina, Z., Gheyi, T., Han, B., Jungheim, L.N., Qian, Y., Rauch, C., Russell, M., Sauder, J.M., Wasserman, S.R., Weichert, K., Willard, F.S., Zhang, A., Emtage, S.
登録日2012-08-22
公開日2012-10-17
最終更新日2018-11-21
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Crystal structure of the human PRMT5:MEP50 complex.
Proc.Natl.Acad.Sci.USA, 109, 2012
4JR5
  • Download 4jr5
  • View 4jr5
Molmil generated image of 4jr5
STRUCTURE-BASED IDENTIFICATION OF UREAS AS NOVEL NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) INHIBITORS
分子名称:Nicotinamide phosphoribosyltransferase, 1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea, PHOSPHATE ION, ...
著者Zheng, X., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y., Kley, N., Lin, J., Reynolds, D.J., Sharma, G., Smith, C.C., Wang, Z., Dragovich, P.S., Oh, A., Wang, W., Zak, M., Gunzner-Toste, J., Zhao, G., Yuen, P., Bair, K.W.
登録日2013-03-21
公開日2013-05-08
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (1.906 Å)
主引用文献Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors.
J.Med.Chem., 56, 2013
4KFN
  • Download 4kfn
  • View 4kfn
Molmil generated image of 4kfn
STRUCTURE-BASED DISCOVERY OF NOVEL AMIDE-CONTAINING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) INHIBITORS
分子名称:Nicotinamide phosphoribosyltransferase, N-[4-(piperidin-1-ylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide, PHOSPHATE ION, ...
著者Zheng, X., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y., Kley, N., Lin, J., Reynolds, D.J., Sharma, G., Smith, C.C., Wang, Z., Dragovich, P.S., Gunzner-Toste, J., Liederer, B.M., Ly, J., O'Brien, T., Oh, A., Wang, L., Wang, W., Xiao, Y., Zak, M., Zhao, G., Yuen, P., Bair, K.W.
登録日2013-04-27
公開日2013-05-08
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors.
J.Med.Chem., 56, 2013
4KFO
  • Download 4kfo
  • View 4kfo
Molmil generated image of 4kfo
STRUCTURE-BASED DISCOVERY OF NOVEL AMIDE-CONTAINING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) INHIBITORS
分子名称:Nicotinamide phosphoribosyltransferase, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}imidazo[1,2-a]pyridine-6-carboxamide, PHOSPHATE ION, ...
著者Zheng, X., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y., Kley, N., Lin, J., Reynolds, D.J., Sharma, G., Smith, C.C., Wang, Z., Dragovich, P.S., Gunzner-Tosteb, J., Liederer, B.M., Ly, J., O'Brien, T., Oh, A., Wang, L., Wang, W., Xiao, Y., Zak, M., Zhao, G., Yuen, P., Bair, K.W.
登録日2013-04-27
公開日2013-05-08
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors.
J.Med.Chem., 56, 2013
4LTS
  • Download 4lts
  • View 4lts
Molmil generated image of 4lts
DISCOVERY OF POTENT AND EFFICACIOUS CYANOGUANIDINE-CONTAINING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) INHIBITORS
分子名称:Nicotinamide phosphoribosyltransferase, 2-cyano-1-pyridin-4-yl-3-(4-{[3-(trifluoromethoxy)phenyl]sulfonyl}benzyl)guanidine, PHOSPHATE ION, ...
著者Zheng, X., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y., Kley, N., Lin, J., Reynoids, D.J., Sharma, G., Smith, C.C., Wang, Z., Dragovich, P.S., Oh, A., Wang, W., Zak, M., Wang, L., Yuen, P., Bair, K.W.
登録日2013-07-23
公開日2013-12-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.692 Å)
主引用文献Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
Bioorg.Med.Chem.Lett., 24, 2014
4LWW
  • Download 4lww
  • View 4lww
Molmil generated image of 4lww
DISCOVERY OF POTENT AND EFFICACIOUS CYANOGUANIDINE-CONTAINING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) INHIBITORS
分子名称:Nicotinamide phosphoribosyltransferase, N-(4-(phenylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide, PHOSPHATE ION, ...
著者Zheng, X., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y., Kley, N., Lin, J., Reynoids, D.J., Sharma, G., Smith, C.C., Wang, Z., Dragovich, P.S., Oh, A., Wang, W., Zak, M., Wang, L., Yuen, P., Bair, K.W.
登録日2013-07-28
公開日2013-12-25
最終更新日2014-01-15
実験手法X-RAY DIFFRACTION (1.641 Å)
主引用文献Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
Bioorg.Med.Chem.Lett., 24, 2014
4QWP
  • Download 4qwp
  • View 4qwp
Molmil generated image of 4qwp
CO-CRYSTAL STRUCTURE OF CHITOSANASE OU01 WITH SUBSTRATE
分子名称:Chitosanase, D-GLUCOSAMINE, ACETATE ION, ...
著者Lyu, Q., Liu, W., Han, B.
登録日2014-07-17
公開日2015-07-22
最終更新日2015-07-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural and biochemical insights into the degradation mechanism of chitosan by chitosanase OU01.
Biochim.Biophys.Acta, 1850, 2015
4OLT
  • Download 4olt
  • View 4olt
Molmil generated image of 4olt
CHITOSANASE COMPLEX STRUCTURE
分子名称:Chitosanase, D-GLUCOSAMINE, GLYCEROL
著者Liu, W.Z., Lyu, Q.Q., Han, B.Q.
登録日2014-01-25
公開日2014-04-30
最終更新日2014-08-06
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Structural insights into the substrate-binding mechanism for a novel chitosanase.
Biochem.J., 461, 2014
4LV9
  • Download 4lv9
  • View 4lv9
Molmil generated image of 4lv9
FRAGMENT-BASED IDENTIFICATION OF AMIDES DERIVED FROM TRANS-2-(PYRIDIN-3-YL)CYCLOPROPANECARBOXYLIC ACID AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide, PHOSPHATE ION, ...
著者Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
登録日2013-07-26
公開日2013-09-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.807 Å)
主引用文献Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4LVA
  • Download 4lva
  • View 4lva
Molmil generated image of 4lva
FRAGMENT-BASED IDENTIFICATION OF AMIDES DERIVED FROM TRANS-2-(PYRIDIN-3-YL)CYCLOPROPANECARBOXYLIC ACID AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, N-(4-{[4-(pyrrolidin-1-yl)piperidin-1-yl]sulfonyl}benzyl)-2H-pyrido[4,3-e][1,2,4]thiadiazin-3-amine 1,1-dioxide, PHOSPHATE ION, ...
著者Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
登録日2013-07-26
公開日2013-09-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4LVB
  • Download 4lvb
  • View 4lvb
Molmil generated image of 4lvb
FRAGMENT-BASED IDENTIFICATION OF AMIDES DERIVED FROM TRANS-2-(PYRIDIN-3-YL)CYCLOPROPANECARBOXYLIC ACID AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, N-[4-(acetylamino)phenyl]cyclopropanecarboxamide, PHOSPHATE ION, ...
著者Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
登録日2013-07-26
公開日2013-09-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.836 Å)
主引用文献Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4LVD
  • Download 4lvd
  • View 4lvd
Molmil generated image of 4lvd
FRAGMENT-BASED IDENTIFICATION OF AMIDES DERIVED FROM TRANS-2-(PYRIDIN-3-YL)CYCLOPROPANECARBOXYLIC ACID AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, N-(4-nitrophenyl)cyclopropanecarboxamide, ...
著者Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
登録日2013-07-26
公開日2013-09-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4LVF
  • Download 4lvf
  • View 4lvf
Molmil generated image of 4lvf
FRAGMENT-BASED IDENTIFICATION OF AMIDES DERIVED FROM TRANS-2-(PYRIDIN-3-YL)CYCLOPROPANECARBOXYLIC ACID AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, (1S,2S)-2-phenyl-N-(pyridin-4-yl)cyclopropanecarboxamide, PHOSPHATE ION, ...
著者Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
登録日2013-07-26
公開日2013-09-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4LVG
  • Download 4lvg
  • View 4lvg
Molmil generated image of 4lvg
FRAGMENT-BASED IDENTIFICATION OF AMIDES DERIVED FROM TRANS-2-(PYRIDIN-3-YL)CYCLOPROPANECARBOXYLIC ACID AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, (1S,2S)-N-[4-(phenylsulfonyl)phenyl]-2-(pyridin-3-yl)cyclopropanecarboxamide, PHOSPHATE ION, ...
著者Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
登録日2013-07-26
公開日2013-09-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.702 Å)
主引用文献Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4M6P
  • Download 4m6p
  • View 4m6p
Molmil generated image of 4m6p
IDENTIFICATION OF AMIDES DERIVED FROM 1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, N-[4-(phenylsulfonyl)benzyl]-2H-pyrazolo[3,4-b]pyridine-5-carboxamide, PHOSPHATE ION
著者Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
登録日2013-08-10
公開日2013-09-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4M6Q
  • Download 4m6q
  • View 4m6q
Molmil generated image of 4m6q
IDENTIFICATION OF AMIDES DERIVED FROM 1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, 1-(5-O-phosphono-beta-D-ribofuranosyl)-N-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide, PYROPHOSPHATE 2-, ...
著者Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
登録日2013-08-10
公開日2013-09-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.406 Å)
主引用文献Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4WQ6
  • Download 4wq6
  • View 4wq6
Molmil generated image of 4wq6
THE CRYSTAL STRUCTURE OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) IN COMPLEX WITH N-(4-{(S)-[1-(2-METHYLPROPYL)PIPERIDIN-4-YL]SULFINYL}BENZYL)FURO[2,3-C]PYRIDINE-2-CARBOXAMIDE INHIBITOR (COMPOUND 21)
分子名称:Nicotinamide phosphoribosyltransferase, N-(4-{(S)-[1-(2-methylpropyl)piperidin-4-yl]sulfinyl}benzyl)furo[2,3-c]pyridine-2-carboxamide, PHOSPHATE ION, ...
著者Li, D., Wang, W.
登録日2014-10-21
公開日2015-02-11
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Bioorg.Med.Chem.Lett., 25, 2015
5MW2
  • Download 5mw2
  • View 5mw2
Molmil generated image of 5mw2
CRYSTAL STRUCTURE OF BCL-6 BTB-DOMAIN WITH BI-3802
分子名称:B-cell lymphoma 6 protein, 2-[6-[[5-chloranyl-2-[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl]amino]-1-methyl-2-oxidanylidene-quinolin-3-yl]oxy-~{N}-methyl-ethanamide
著者Bader, G., Flotzinger, G., Weiss-Puxbaum, A., Zoephel, A.
登録日2017-01-18
公開日2017-10-04
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.
Cell Rep, 20, 2017
5MW6
  • Download 5mw6
  • View 5mw6
Molmil generated image of 5mw6
CRYSTAL STRUCTURE OF THE BCL6 BTB-DOMAIN WITH COMPOUND 1
分子名称:B-cell lymphoma 6 protein, 5-chloranyl-~{N}-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-amine
著者Davies, D.R., Kessler, D.
登録日2017-01-18
公開日2017-10-04
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.
Cell Rep, 20, 2017
5MWD
  • Download 5mwd
  • View 5mwd
Molmil generated image of 5mwd
CRYSTAL STRUCTURE OF THE BCL6 BTB-DOMAIN WITH COMPOUND 2
分子名称:B-cell lymphoma 6 protein, 5-[[5-chloranyl-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]amino]-1,3-dihydroindol-2-one
著者Bader, G., Flotzinger, G., Weiss-Puxbaum, A., Zoephel, A.
登録日2017-01-18
公開日2017-10-04
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.
Cell Rep, 20, 2017
6C2R
  • Download 6c2r
  • View 6c2r
Molmil generated image of 6c2r
AURORA A LIGAND COMPLEX
分子名称:Aurora kinase A, SULFATE ION, (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-({3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridin-2-yl}methyl)-2-methylpiperidine-4-carboxylic acid
著者Antonysamy, S., Pustilnik, A., Manglicmot, D., Froning, K., Weichert, K., Wasserman, S.
登録日2018-01-08
公開日2019-01-23
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of theRB1Tumor Suppressor Gene.
Cancer Discov, 9, 2019
6C2T
  • Download 6c2t
  • View 6c2t
Molmil generated image of 6c2t
AURORA A LIGAND COMPLEX
分子名称:Aurora kinase A, (2S,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-2-methyl-4-({3-[(1,3-thiazol-2-yl)amino]isoquinolin-1-yl}methyl)piperidine-4-carboxylic acid, DIMETHYL SULFOXIDE, ...
著者Antonysamy, S., Pustilnik, A., Manglicmot, D., Froning, K., Weichert, K., Wasserman, S.
登録日2018-01-08
公開日2019-01-23
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of theRB1Tumor Suppressor Gene.
Cancer Discov, 9, 2019
6KKR
  • Download 6kkr
  • View 6kkr
Molmil generated image of 6kkr
HUMAN KCC1 STRUCTURE DETERMINED IN KCL AND DETERGENT GDN
分子名称:Solute carrier family 12 member 4, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
著者Liu, S., Chang, S., Ye, S., Bai, X., Guo, J.
登録日2019-07-27
公開日2019-10-23
最終更新日2019-11-13
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Cryo-EM structures of the human cation-chloride cotransporter KCC1.
Science, 366, 2019
6KKT
  • Download 6kkt
  • View 6kkt
Molmil generated image of 6kkt
HUMAN KCC1 STRUCTURE DETERMINED IN KCL AND LIPID NANODISC
分子名称:Solute carrier family 12 member 4, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
著者Liu, S., Chang, S., Ye, S., Bai, X., Guo, J.
登録日2019-07-27
公開日2019-10-23
最終更新日2019-11-13
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Cryo-EM structures of the human cation-chloride cotransporter KCC1.
Science, 366, 2019
<12>