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1VJ5
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BU of 1vj5 by Molmil
Human soluble Epoxide Hydrolase- N-cyclohexyl-N'-(4-iodophenyl)urea complex
Descriptor: HEXAETHYLENE GLYCOL, MAGNESIUM ION, N-CYCLOHEXYL-N'-(4-IODOPHENYL)UREA, ...
Authors:Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
Deposit date:2004-02-03
Release date:2004-04-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis
Biochemistry, 43, 2004
1S8O
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BU of 1s8o by Molmil
Human soluble Epoxide Hydrolase
Descriptor: HEXAETHYLENE GLYCOL, epoxide hydrolase 2, cytoplasmic
Authors:Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
Deposit date:2004-02-03
Release date:2004-04-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis
Biochemistry, 43, 2004
1CQZ
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BU of 1cqz by Molmil
CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE.
Descriptor: EPOXIDE HYDROLASE
Authors:Argiriadi, M.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
Deposit date:1999-08-12
Release date:1999-11-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase.
Proc.Natl.Acad.Sci.USA, 96, 1999
1CR6
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BU of 1cr6 by Molmil
CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CPU INHIBITOR
Descriptor: EPOXIDE HYDROLASE, N-CYCLOHEXYL-N'-(PROPYL)PHENYL UREA
Authors:Argiriadi, M.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
Deposit date:1999-08-13
Release date:1999-11-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase.
Proc.Natl.Acad.Sci.USA, 96, 1999
1EK1
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BU of 1ek1 by Molmil
CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CIU INHIBITOR
Descriptor: EPOXIDE HYDROLASE, N-CYCLOHEXYL-N'-(4-IODOPHENYL)UREA
Authors:Argiriadi, M.A, Morisseau, C, Goodrow, M.H, Dowdy, D.L, Hammock, B.D, Christianson, D.W.
Deposit date:2000-03-06
Release date:2000-05-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation.
J.Biol.Chem., 275, 2000
1EK2
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BU of 1ek2 by Molmil
CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CDU INHIBITOR
Descriptor: EPOXIDE HYDROLASE, N-CYCLOHEXYL-N'-DECYLUREA
Authors:Argiriadi, M.A, Morisseau, C, Goodrow, M.H, Dowdy, D.L, Hammock, B.D, Christianson, D.W.
Deposit date:2000-03-06
Release date:2000-05-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation.
J.Biol.Chem., 275, 2000
4Q3I
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BU of 4q3i by Molmil
Structure of the OsSERK2 leucine rich repeat extracellular domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, OsSERK2 D128N
Authors:McAndrew, R.P, Pruitt, R.N, Kamita, S.G, Pereira, J.H, Majumder, D, Hammock, B.D, Adams, P.D, Ronald, P.C.
Deposit date:2014-04-11
Release date:2014-11-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of the OsSERK2 leucine-rich repeat extracellular domain.
Acta Crystallogr.,Sect.D, 70, 2014
4Q3G
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BU of 4q3g by Molmil
Structure of the OsSERK2 leucine rich repeat extracellular domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, OsSERK2
Authors:McAndrew, R.P, Pruitt, R.N, Kamita, S.G, Pereira, J.H, Majumder, D, Hammock, B.D, Adams, P.D, Ronald, P.C.
Deposit date:2014-04-11
Release date:2014-11-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.787 Å)
Cite:Structure of the OsSERK2 leucine-rich repeat extracellular domain.
Acta Crystallogr.,Sect.D, 70, 2014
1ZD3
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BU of 1zd3 by Molmil
Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-butyric acid complex
Descriptor: 4-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACID, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
Deposit date:2005-04-14
Release date:2006-03-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
Protein Sci., 15, 2006
1ZD5
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BU of 1zd5 by Molmil
Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-heptanoic acid complex
Descriptor: 7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACID, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
Deposit date:2005-04-14
Release date:2006-03-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
Protein Sci., 15, 2006
1ZD4
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BU of 1zd4 by Molmil
Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-hexanoic acid complex
Descriptor: 6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACID, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
Deposit date:2005-04-14
Release date:2006-03-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
Protein Sci., 15, 2006
1ZD2
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BU of 1zd2 by Molmil
Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-ethanoic acid complex
Descriptor: MAGNESIUM ION, N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINE, PHOSPHATE ION, ...
Authors:Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
Deposit date:2005-04-14
Release date:2006-03-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
Protein Sci., 15, 2006
4HAI
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BU of 4hai by Molmil
Crystal structure of human soluble epoxide hydrolase complexed with N-cycloheptyl-1-(mesitylsulfonyl)piperidine-4-carboxamide.
Descriptor: Bifunctional epoxide hydrolase 2, MAGNESIUM ION, N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide, ...
Authors:Pecic, S, Pakhomova, S, Newcomer, M.E, Morisseau, C, Hammock, B.D, Zhu, Z, Deng, S.
Deposit date:2012-09-26
Release date:2012-12-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4J03
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BU of 4j03 by Molmil
Crystal structure of human soluble epoxide hydrolase complexed with fulvestrant
Descriptor: (7beta,9beta,13alpha,17beta)-7-{9-[(R)-(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1(10),2,4-triene-3,17-diol, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ...
Authors:Morisseau, C, Pakhomova, S, Hwang, S.H, Newcomer, M.E, Hammock, B.D.
Deposit date:2013-01-30
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides.
Bioorg.Med.Chem.Lett., 23, 2013
4OCZ
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BU of 4ocz by Molmil
Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea
Descriptor: 1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ...
Authors:Lee, K.S.S, Liu, J, Wagner, K.M, Pakhomova, S, Dong, H, Morriseau, C, Fu, S.H, Yang, J, Wang, P, Ulu, A, Mate, C, Nguyen, L, Wullf, H, Eldin, M.L, Mara, A.A, Newcomer, M.E, Zeldin, D.C, Hammock, B.D.
Deposit date:2014-01-09
Release date:2014-09-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.
J.Med.Chem., 57, 2014
4OD0
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BU of 4od0 by Molmil
Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea
Descriptor: 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ...
Authors:Lee, K.S.S, Liu, J, Wagner, K.M, Pakhomova, S, Dong, H, Morisseau, C, Fu, S.H, Yang, J, Wang, P, Ulu, A, Mate, C, Nguyen, L, Wullf, H, Eldin, M.L, Mara, A.A, Newcomer, M.E, Zeldin, D.C, Hammock, B.D.
Deposit date:2014-01-09
Release date:2014-09-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.
J.Med.Chem., 57, 2014
6N3Z
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BU of 6n3z by Molmil
Crystal structure of an epoxide hydrolase from Trichoderma reesei in complex with inhibitor 4
Descriptor: Epoxide hydrolase TrEH, N-methyl-4-{[trans-4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)cyclohexyl]oxy}benzamide
Authors:de Oliveira, G.S, Adriani, P.P, Ribeiro, J.A, Morisseau, C, Hammock, B.D, Dias, M.V, Chambergo, F.S.
Deposit date:2018-11-16
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.238 Å)
Cite:The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors.
Int. J. Biol. Macromol., 129, 2019
6N5H
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BU of 6n5h by Molmil
Crystal structure of an epoxide hydrolase from Trichoderma reesei in complex with inhibitor 5
Descriptor: 4-[(trans-4-{[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-ylcarbamoyl]amino}cyclohexyl)oxy]benzoic acid, Epoxide hydrolase TrEH
Authors:Oliveira, G.S, Adriano, P.P, Ribeiro, J.A, Morisseau, C, Hammock, B.D, Dias, M.V, Chambergo, F.S.
Deposit date:2018-11-21
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.717 Å)
Cite:The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors
Int. J. Biol. Macromol., 129, 2019
6N5F
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BU of 6n5f by Molmil
Crystal structure of an epoxide hydrolase from Trichoderma reesei in complex with inhibitor 3
Descriptor: Epoxide hydrolase TrEH, N-(8-amino-8-oxooctyl)nonanamide
Authors:Oliveira, G.S, Adriani, P.P, Ribeiro, J.A, Morisseau, C, Hammock, B.D, Dias, M.V, Chambergo, F.S.
Deposit date:2018-11-21
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors.
Int. J. Biol. Macromol., 129, 2019
6N5G
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BU of 6n5g by Molmil
Crystal structure of an epoxide hydrolase from Trichoderma reesei in complex with inhibitor 2
Descriptor: 4-[(quinolin-3-yl)methyl]-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide, Epoxide hydrolase TrEH
Authors:Oliveira, G.S, Adriani, P.P, Ribeiro, J.A, Morisseau, C, Hammock, B.D, Dias, M.V, Chambergo, F.S.
Deposit date:2018-11-21
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors.
Int. J. Biol. Macromol., 129, 2019
6N3K
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BU of 6n3k by Molmil
Crystal structure of an epoxide hydrolase from Trichoderma reesei in complex with inhibitor 1
Descriptor: Epoxide hydrolase, N-{cis-4-[(2,6-difluorophenyl)methoxy]cyclohexyl}-N'-(3-phenylpropyl)urea
Authors:de Oliveira, G.S, Adriani, P.P, Ribeiro, J.A, Morisseau, C, Hammock, B.D, Dias, M.V, Chambergo, F.S.
Deposit date:2018-11-15
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors.
Int. J. Biol. Macromol., 129, 2019
5JYC
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BU of 5jyc by Molmil
Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 14,15-EET hydrolysis intermediate
Descriptor: (5~{Z},11~{Z},14~{R},15~{R})-14,15-bis(oxidanyl)icosa-5,8,11-trienoic acid, CFTR inhibitory factor
Authors:Hvorecny, K.L, Madden, D.R.
Deposit date:2016-05-13
Release date:2017-01-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6AUM
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BU of 6aum by Molmil
Crystal structure of human soluble epoxide hydrolase complexed with trans-4-[4-(3-trifluoromethoxyphenyl-l-ureido)-cyclohexyloxy]-benzoic acid.
Descriptor: 4-{[trans-4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)cyclohexyl]oxy}benzoic acid, Bifunctional epoxide hydrolase 2, CHLORIDE ION, ...
Authors:Kodani, S.D, Bahkta, S, Hwang, S.H, Pakhomova, S, Newcomer, M.E, Morisseau, C, Hammock, B.
Deposit date:2017-09-01
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.
Bioorg. Med. Chem. Lett., 28, 2018
4YX9
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BU of 4yx9 by Molmil
Crystal structure of the CFTR inhibitory factor Cif bound to tiratricol
Descriptor: CFTR inhibitory factor, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID
Authors:Bahl, C.D, Madden, D.R.
Deposit date:2015-03-22
Release date:2015-07-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR.
Angew.Chem.Int.Ed.Engl., 54, 2015
2ZJF
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BU of 2zjf by Molmil
Crystal structure of Mycobacterium tuberculosis epoxide hydrolase B complexed with an inhibitor
Descriptor: 1,3-DIPHENYLUREA, ACETATE ION, Probable epoxide hydrolase ephB
Authors:Biswal, B.K, TB Structural Genomics Consortium (TBSGC)
Deposit date:2008-03-07
Release date:2008-04-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor.
J.Mol.Biol., 381, 2008

 

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