Author results

4DD8
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ADAM-8 METALLOPROTEINASE DOMAIN WITH BOUND BATIMASTAT
Descriptor:Disintegrin and metalloproteinase domain-containing protein 8, 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, CALCIUM ION, ...
Authors:Hall, T., Shieh, H.S., Day, J.E., Caspers, N., Chrencik, J.E., Williams, J.M., Pegg, L.E., Pauley, A.M., Moon, A.F., Krahn, J.M., Fischer, D.H., Kiefer, J.R., Tomasselli, A.G., Zack, M.D.
Deposit date:2012-01-18
Release date:2012-06-06
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of human ADAM-8 catalytic domain complexed with batimastat.
Acta Crystallogr.,Sect.F, 68, 2012
5E8N
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THE STRUCTURE OF THE TEIPP ASSOCIATED TRH4 PEPTIDE IN COMPLEX WITH H-2D(B)
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
Authors:Hafstrand, I., Doorduijn, E., Duru, A.D., Buratto, J., Oliveira, C.C., Sandalova, T., van Hall, T., Achour, A.
Deposit date:2015-10-14
Release date:2016-02-03
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer.
J Immunol., 196, 2016
5E8O
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THE STRUCTURE OF THE TEIPP ASSOCIATED ALTERED PEPTIDE LIGAND TRH4-P2ABU IN COMPLEX WITH H-2D(B)
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Ceramide synthase 5, ...
Authors:Hafstrand, I., Doorduijn, E., Duru, A.D., Buratto, J., Oliveira, C.C., Sandalova, T., van Hall, T., Achour, A.
Deposit date:2015-10-14
Release date:2016-02-03
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer.
J Immunol., 196, 2016
5E8P
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THE STRUCTURE OF THE TEIPP ASSOCIATED ALTERED PEPTIDE LIGAND TRH4-P5NLE IN COMPLEX WITH H-2D(B)
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
Authors:Hafstrand, I., Doorduijn, E., Duru, A.D., Buratto, J., Oliveira, C.C., Sandalova, T., van Hall, T., Achour, A.
Deposit date:2015-10-14
Release date:2016-02-03
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer.
J Immunol., 196, 2016
2KHX
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DROSHA DOUBLE-STRANDED RNA BINDING MOTIF
Descriptor:Ribonuclease 3
Authors:Mueller, G.A., Miller, M., Ghosh, M., DeRose, E.F., London, R.E., Hall, T.
Deposit date:2009-04-13
Release date:2010-02-23
Last modified:2012-03-21
Method:SOLUTION NMR
Cite:Solution structure of the Drosha double-stranded RNA-binding domain.
Silence, 1, 2010
5SVD
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NOP9, A NEW PUF-LIKE PROTEIN, PREVENTS PREMATURE PRE-RRNA CLEAVAGE TO CORRECTLY PROCESS MATURE 18S RRNA
Descriptor:Nucleolar protein 9
Authors:Zhang, J., Qiu, C., Hall, T.
Deposit date:2016-08-05
Release date:2016-10-26
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Nop9 is a PUF-like protein that prevents premature cleavage to correctly process pre-18S rRNA.
Nat Commun, 7, 2016
2XR9
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CRYSTAL STRUCTURE OF AUTOTAXIN (ENPP2)
Descriptor:ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Kamtekar, S., Hausmann, J., Day, J.E., Christodoulou, E., Perrakis, A.
Deposit date:2010-09-13
Release date:2011-01-19
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis of substrate discrimination and integrin binding by autotaxin.
Nat. Struct. Mol. Biol., 18, 2011
5MZM
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STRUCTURE OF H-2DB IN COMPLEX WITH TEIPP APL TRH4 P3P
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
Authors:Hafstrand, I., Achour, A., Sandalova, T.
Deposit date:2017-02-01
Release date:2018-03-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability.
J. Immunol., 200, 2018
2XRG
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CRYSTAL STRUCTURE OF AUTOTAXIN (ENPP2) IN COMPLEX WITH THE HA155 BORONIC ACID INHIBITOR
Descriptor:ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Hausmann, J., Albers, H.M.H.G., Perrakis, A.
Deposit date:2010-09-14
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis of Substrate Discrimination and Integrin Binding by Autotaxin.
Nat.Struct.Mol.Biol., 18, 2011
4IHO
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CRYSTAL STRUCTURE OF H-2DB Y159F IN COMPLEX WITH CHIMERIC GP100
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
Authors:Uchtenhagen, H., Stahl, E., Achour, A.
Deposit date:2012-12-19
Release date:2013-09-11
Last modified:2013-12-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Proline substitution independently enhances H-2D(b) complex stabilization and TCR recognition of melanoma-associated peptides
Eur.J.Immunol., 43, 2013
3CC5
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H-2DB COMPLEX WITH HUMAN GP100
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
Authors:Badia-Martinez, D., Achour, A.
Deposit date:2008-02-24
Release date:2009-03-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Design of agonistic altered peptides for the robust induction of CTL directed towards H-2Db in complex with the melanoma-associated epitope gp100.
Cancer Res., 69, 2009
3CCH
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H-2DB COMPLEX WITH MURINE GP100
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
Authors:Badia-Martinez, D., Achour, A.
Deposit date:2008-02-25
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Design of agonistic altered peptides for the robust induction of CTL directed towards H-2Db in complex with the melanoma-associated epitope gp100.
Cancer Res., 69, 2009
3CH1
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CRYSTAL STRUCTURE OF H-2DB IN COMPLEX WITH CHIMERIC GP100
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
Authors:Badia-Martinez, D., Achour, A.
Deposit date:2008-03-06
Release date:2009-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design of agonistic altered peptides for the robust induction of CTL directed towards H-2Db in complex with the melanoma-associated epitope gp100.
Cancer Res., 69, 2009
3LXK
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STRUCTURAL AND THERMODYNAMIC CHARACTERIZATION OF THE TYK2 AND JAK3 KINASE DOMAINS IN COMPLEX WITH CP-690550 AND CMP-6
Descriptor:Tyrosine-protein kinase JAK3, 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile
Authors:Chrencik, J.E., Patny, A., Leung, I.K., Korniski, B., Emmons, T.L., Benson, T.E.
Deposit date:2010-02-25
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
J.Mol.Biol., 400, 2010
3LXL
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STRUCTURAL AND THERMODYNAMIC CHARACTERIZATION OF THE TYK2 AND JAK3 KINASE DOMAINS IN COMPLEX WITH CP-690550 AND CMP-6
Descriptor:Tyrosine-protein kinase JAK3, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE
Authors:Chrencik, J.E., Benson, T.E.
Deposit date:2010-02-25
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
J.Mol.Biol., 400, 2010
3LXN
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STRUCTURAL AND THERMODYNAMIC CHARACTERIZATION OF THE TYK2 AND JAK3 KINASE DOMAINS IN COMPLEX WITH CP-690550 AND CMP-6
Descriptor:Non-receptor tyrosine-protein kinase TYK2, 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile
Authors:Chrencik, J.E., Benson, T.E.
Deposit date:2010-02-25
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
J.Mol.Biol., 400, 2010
3LXP
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STRUCTURAL AND THERMODYNAMIC CHARACTERIZATION OF THE TYK2 AND JAK3 KINASE DOMAINS IN COMPLEX WITH CP-690550 AND CMP-6
Descriptor:Non-receptor tyrosine-protein kinase TYK2, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE
Authors:Chrencik, J.E., Benson, T.E.
Deposit date:2010-02-25
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
J.Mol.Biol., 400, 2010
4EJN
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CRYSTAL STRUCTURE OF AUTOINHIBITED FORM OF AKT1 IN COMPLEX WITH N-(4-(5-(3-ACETAMIDOPHENYL)-2-(2-AMINOPYRIDIN-3-YL)-3H-IMIDAZO[4,5-B]PYRIDIN-3-YL)BENZYL)-3-FLUOROBENZAMIDE
Descriptor:RAC-alpha serine/threonine-protein kinase, N-(4-{5-[3-(acetylamino)phenyl]-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl}benzyl)-3-fluorobenzamide, 2-BUTANOL, ...
Authors:Eathiraj, S.
Deposit date:2012-04-06
Release date:2012-05-23
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors.
J.Med.Chem., 55, 2012