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6NAO
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BU of 6nao by Molmil
Discovery of a high affinity inhibitor of cGAS
Descriptor: (1R,2S)-2-[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]cyclohexane-1-carboxylic acid, CYCLIC GMP-AMP SYNTHASE, ZINC ION
Authors:Hall, J.
Deposit date:2018-12-06
Release date:2018-12-19
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
PLoS ONE, 12, 2017
5V8O
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BU of 5v8o by Molmil
Discovery of a high affinity inhibitor of cGAS
Descriptor: 5-phenyltetrazolo[1,5-a]pyrimidin-7-ol, Cyclic GMP-AMP synthase, ZINC ION
Authors:Hall, J.
Deposit date:2017-03-22
Release date:2017-09-27
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
PLoS ONE, 12, 2017
6NFG
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BU of 6nfg by Molmil
CYCLIC GMP-AMP SYNTHASE in complex with compound 16 inhibitor: 7-hydroxy-N-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Descriptor: 7-hydroxy-N-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide, CYCLIC GMP-AMP SYNTHASE, ZINC ION
Authors:Hall, J.
Deposit date:2018-12-20
Release date:2019-01-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Discovery of a high affinity inhibitor of cGAS
to be published
6NFO
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BU of 6nfo by Molmil
CYCLIC GMP-AMP SYNTHASE in complex with compound 20 inhibitor: 7-hydroxy-N-[(2S)-1-hydroxypropan-2-yl]-5-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Descriptor: 7-hydroxy-N-[(2S)-1-hydroxypropan-2-yl]-5-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide, CYCLIC GMP-AMP SYNTHASE, ZINC ION
Authors:Hall, J.
Deposit date:2018-12-20
Release date:2019-01-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Discovery of a high affinity inhibitor of cGAS
to be published
3L9K
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BU of 3l9k by Molmil
Insights into dynein assembly from a dynein intermediate chain-light chain roadblock structure
Descriptor: Dynein intermediate chain, cytosolic, RE64145p
Authors:Hall, J, Karplus, P.A, Barbar, E.
Deposit date:2010-01-05
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Insights into dynein assembly from a dynein intermediate chain-light chain roadblock structure
To be Published
3L7H
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BU of 3l7h by Molmil
Insights into dynein assembly from a dynein intermediate chain light chain Roadblock structure
Descriptor: RE64145p
Authors:Hall, J, Karplus, P.A, Barbar, E.
Deposit date:2009-12-28
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Insights into dynein assembly from a dynein intermediate chain light chain Roadblock structure
To be Published
8PXS
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BU of 8pxs by Molmil
Short RNA binding to peptide amyloids
Descriptor: RNA (5'-R(P*GP*UP*CP*A)-3'), VAL-ALA-GLN-ALA-GLN-ILE-ASN-ILE
Authors:Rout, S.K, Cadalbert, R, Schroder, N, Wiegand, T, Zehnder, J, Gampp, O, Guntert, P, Kringler, D, Kreutz, C, Knorlein, A, Hall, J, Greenwald, J, Riek, R.
Deposit date:2023-07-24
Release date:2023-10-18
Method:SOLID-STATE NMR
Cite:An Analysis of Nucleotide-Amyloid Interactions Reveals Selective Binding to Codon-Sized RNA.
J.Am.Chem.Soc., 145, 2023
6WJG
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BU of 6wjg by Molmil
PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma
Descriptor: DnaJ homolog subfamily B member 1, cAMP-dependent protein kinase catalytic subunit alpha fusion, cAMP-dependent protein kinase type II-beta regulatory subunit
Authors:Lu, T.-W, Aoto, P.C, Weng, J.-H, Nielsen, C, Cash, J.N, Hall, J, Zhang, P, Simon, S.M, Cianfrocco, M.A, Taylor, S.S.
Deposit date:2020-04-13
Release date:2020-12-02
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Structural analyses of the PKA RII beta holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.
Plos Biol., 18, 2020
6WJF
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BU of 6wjf by Molmil
PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma
Descriptor: DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha fusion, cAMP-dependent protein kinase type II-beta regulatory subunit
Authors:Lu, T.-W, Aoto, P.C, Weng, J.-H, Nielsen, C, Cash, J.N, Hall, J, Zhang, P, Simon, S.M, Cianfrocco, M.A, Taylor, S.S.
Deposit date:2020-04-13
Release date:2020-12-02
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (7.5 Å)
Cite:Structural analyses of the PKA RII beta holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.
Plos Biol., 18, 2020
2MXY
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BU of 2mxy by Molmil
Solution structure of hnRNP C RRM in complex with 5'-AUUUUUC-3' RNA
Descriptor: 5'-R(*AP*UP*UP*UP*UP*UP*C)-3', Heterogeneous nuclear ribonucleoproteins C1/C2
Authors:Cienikova, Z, Damberger, F.F, Hall, J, Allain, F.H.-T, Maris, C.
Deposit date:2015-01-19
Release date:2015-02-25
Method:SOLUTION NMR
Cite:Structural and mechanistic insights into poly(uridine) tract recognition by the hnRNP C RNA recognition motif.
J.Am.Chem.Soc., 136, 2014
2MZ1
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BU of 2mz1 by Molmil
Solution structure of hnRNP C RRM in complex with 5'-UUUUC-3' RNA
Descriptor: 5'-R(*UP*UP*UP*UP*C)-3', Heterogeneous nuclear ribonucleoproteins C1/C2
Authors:Cienikova, Z, Damberger, F.F, Hall, J, Allain, F.H.-T, Maris, C.
Deposit date:2015-02-05
Release date:2015-04-08
Method:SOLUTION NMR
Cite:Structural and mechanistic insights into poly(uridine) tract recognition by the hnRNP C RNA recognition motif.
J.Am.Chem.Soc., 136, 2014
5VDR
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BU of 5vdr by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with 3',3'-cdIMP
Descriptor: 3',3'-cdIMP, Cyclic GMP-AMP synthase, ZINC ION
Authors:Byrnes, L.J, Hall, J.D.
Deposit date:2017-04-03
Release date:2017-09-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.042 Å)
Cite:The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
5VDP
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BU of 5vdp by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with 2',3'-cGAMP
Descriptor: Cyclic GMP-AMP synthase, SULFATE ION, ZINC ION, ...
Authors:Byrnes, L.J, Hall, J.D.
Deposit date:2017-04-03
Release date:2017-09-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
5VDO
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BU of 5vdo by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with 2',2'-cGAMP
Descriptor: 2-amino-9-[(1R,3R,6R,8R,9R,11S,14R,16R,17R,18R)-16-(6-amino-9H-purin-9-yl)-3,11,17,18-tetrahydroxy-3,11-dioxido-2,4,7,10,12,15-hexaoxa-3,11-diphosphatricyclo[12.2.1.1~6,9~]octadec-8-yl]-1,9-dihydro-6H-purin-6-one, Cyclic GMP-AMP synthase, ZINC ION
Authors:Byrnes, L.J, Hall, J.D.
Deposit date:2017-04-03
Release date:2017-09-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.218 Å)
Cite:The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
5VDU
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BU of 5vdu by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with Compound F2
Descriptor: 2-(pyridin-2-yl)pyrimidine, Cyclic GMP-AMP synthase, ZINC ION
Authors:Byrnes, L.J, Hall, J.D.
Deposit date:2017-04-03
Release date:2017-09-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.729 Å)
Cite:The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
5VDV
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BU of 5vdv by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with Compound F3
Descriptor: Cyclic GMP-AMP synthase, SULFATE ION, ZINC ION, ...
Authors:Byrnes, L.J, Hall, J.D.
Deposit date:2017-04-03
Release date:2017-09-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.998 Å)
Cite:The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
5VDT
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BU of 5vdt by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with 3',3'-cGAMP
Descriptor: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, Cyclic GMP-AMP synthase, ZINC ION
Authors:Byrnes, L.J, Hall, J.D.
Deposit date:2017-04-03
Release date:2017-09-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.576 Å)
Cite:The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
5VDW
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BU of 5vdw by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with Compound F1
Descriptor: Cyclic GMP-AMP synthase, ZINC ION, [2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetic acid
Authors:Byrnes, L.J, Hall, J.D.
Deposit date:2017-04-03
Release date:2017-09-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.711 Å)
Cite:The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
5VDS
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BU of 5vds by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with 3',3'-cdUMP
Descriptor: 3',3'-cdUMP, Cyclic GMP-AMP synthase, ZINC ION
Authors:Byrnes, L.J, Hall, J.D.
Deposit date:2017-04-03
Release date:2017-09-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.766 Å)
Cite:The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
5VDQ
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BU of 5vdq by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with 2',5'-GpAp
Descriptor: 2',5'-GpAp, Cyclic GMP-AMP synthase, ZINC ION
Authors:Byrnes, L.J, Hall, J.D.
Deposit date:2017-04-03
Release date:2017-09-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.246 Å)
Cite:The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
3GLW
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BU of 3glw by Molmil
Quaternary Structure of Drosophila melanogaster IC/Tctex-1/LC8; Allosteric Interactions of Dynein Light Chains with Dynein Intermediate Chain
Descriptor: Dynein intermediate Chain, Dynein light chain 1, cytoplasmic
Authors:Hall, J.D, Karplus, P.A, Barbar, E.J.
Deposit date:2009-03-12
Release date:2009-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Multivalency in the assembly of intrinsically disordered Dynein intermediate chain.
J.Biol.Chem., 284, 2009
3FM7
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BU of 3fm7 by Molmil
Quaternary Structure of Drosophila melanogaster IC/Tctex-1/LC8; Allosteric Interactions of Dynein Light Chains with Dynein Intermediate Chain
Descriptor: Dynein intermediate chain, cytosolic, Dynein light chain 1, ...
Authors:Hall, J.D, Karplus, P.A, Barbar, E.J.
Deposit date:2008-12-19
Release date:2009-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Multivalency in the assembly of intrinsically disordered Dynein intermediate chain.
J.Biol.Chem., 284, 2009
6G64
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BU of 6g64 by Molmil
MamM CTD H264A-E289A
Descriptor: BETA-MERCAPTOETHANOL, Magnetosome protein MamM, SULFATE ION
Authors:Barber-Zucker, S, Zarivach, R.
Deposit date:2018-04-01
Release date:2018-10-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Metal binding to the dynamic cytoplasmic domain of the cation diffusion facilitator (CDF) protein MamM induces a 'locked-in' configuration.
Febs J., 286, 2019
6G6I
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BU of 6g6i by Molmil
MamM CTD W247A
Descriptor: BETA-MERCAPTOETHANOL, Magnetosome protein MamM
Authors:Barber-Zucker, S, Zarivach, R.
Deposit date:2018-04-01
Release date:2018-10-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Metal binding to the dynamic cytoplasmic domain of the cation diffusion facilitator (CDF) protein MamM induces a 'locked-in' configuration.
Febs J., 286, 2019
4WZ6
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BU of 4wz6 by Molmil
Human CFTR aa389-678 (NBD1), deltaF508 with three solubilizing mutations, bound ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION
Authors:Byrnes, L.J, Hall, J.
Deposit date:2014-11-18
Release date:2015-11-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy.
Protein Sci., 25, 2016

 

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PDB entries from 2024-03-27

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