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6WQU
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BU of 6wqu by Molmil
CSL (RBPJ) bound to Notch3 RAM and DNA
Descriptor: DNA (5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*AP*CP*CP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3'), Neurogenic locus notch homolog protein 3, ...
Authors:Kovall, R.A, Gagliani, E, Hall, D.
Deposit date:2020-04-29
Release date:2021-03-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion.
J.Biol.Chem., 296, 2021
7RTE
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BU of 7rte by Molmil
X-ray structure of wild type RBPJ-L3MBTL3-DNA complex
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*AP*CP*CP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3'), ...
Authors:Hall, D.P, Kovall, R.A, Yuan, Z.
Deposit date:2021-08-13
Release date:2022-08-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3.
Nucleic Acids Res., 50, 2022
7RTI
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BU of 7rti by Molmil
X-ray structure of RBPJ-L3MBTL3(dT62)-DNA complex
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*AP*CP*CP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3'), ...
Authors:Hall, D.P, Kovall, R.A, Yuan, Z.
Deposit date:2021-08-13
Release date:2022-08-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3.
Nucleic Acids Res., 50, 2022
6YB7
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BU of 6yb7 by Molmil
SARS-CoV-2 main protease with unliganded active site (2019-nCoV, coronavirus disease 2019, COVID-19).
Descriptor: 3C-like proteinase, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE
Authors:Owen, C.D, Lukacik, P, Strain-Damerell, C.M, Douangamath, A, Powell, A.J, Fearon, D, Brandao-Neto, J, Crawshaw, A.D, Aragao, D, Williams, M, Flaig, R, Hall, D.R, McAuley, K.E, Mazzorana, M, Stuart, D.I, von Delft, F, Walsh, M.A.
Deposit date:2020-03-16
Release date:2020-03-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:COVID-19 main protease with unliganded active site
To Be Published
6Y84
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BU of 6y84 by Molmil
SARS-CoV-2 main protease with unliganded active site (2019-nCoV, coronavirus disease 2019, COVID-19)
Descriptor: 3C-like proteinase nsp5, DIMETHYL SULFOXIDE
Authors:Owen, C.D, Lukacik, P, Strain-Damerell, C.M, Douangamath, A, Powell, A.J, Fearon, D, Brandao-Neto, J, Crawshaw, A.D, Aragao, D, Williams, M, Flaig, R, Hall, D.R, McAuley, K.E, Mazzorana, M, Stuart, D.I, von Delft, F, Walsh, M.A.
Deposit date:2020-03-03
Release date:2020-03-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:COVID-19 main protease with unliganded active site
To Be Published
4UOB
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BU of 4uob by Molmil
Crystal structure of Deinococcus radiodurans Endonuclease III-3
Descriptor: ACETATE ION, COBALT (II) ION, ENDONUCLEASE III-3, ...
Authors:Sarre, A, Okvist, M, Klar, T, Hall, D, Smalas, A.O, McSweeney, S, Timmins, J, Moe, E.
Deposit date:2014-06-02
Release date:2015-06-10
Last modified:2015-08-12
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Structural and Functional Characterization of Two Unusual Endonuclease III Enzymes from Deinococcus Radiodurans.
J.Struct.Biol., 191, 2015
4UNF
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BU of 4unf by Molmil
Crystal structure of Deinococcus radiodurans Endonuclease III-1
Descriptor: ACETATE ION, ENDONUCLEASE III-1, IRON/SULFUR CLUSTER, ...
Authors:Sarre, A, Okvist, M, Klar, T, Hall, D, Smalas, A.O, McSweeney, S, Timmins, J, Moe, E.
Deposit date:2014-05-28
Release date:2015-06-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural and Functional Characterization of Two Unusual Endonuclease III Enzymes from Deinococcus Radiodurans.
J.Struct.Biol., 191, 2015
6B97
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BU of 6b97 by Molmil
Crystal structure of PDE2 in complex with complex 9
Descriptor: 1,2-ETHANEDIOL, 6-chloro-1-methyl-N-{(1R)-1-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine, MAGNESIUM ION, ...
Authors:Lu, J.
Deposit date:2017-10-10
Release date:2017-11-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design.
Bioorg. Med. Chem. Lett., 27, 2017
6B98
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BU of 6b98 by Molmil
PDE2 in complex with compound 1
Descriptor: 6-chloro-N,1-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine, MAGNESIUM ION, ZINC ION, ...
Authors:Lu, J.
Deposit date:2017-10-10
Release date:2017-11-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design.
Bioorg. Med. Chem. Lett., 27, 2017
6B96
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BU of 6b96 by Molmil
Crystal Structure of PDE2 in complex with compound 16
Descriptor: 1,2-ETHANEDIOL, 6-chloro-N-{1-[4-(trifluoromethyl)phenyl]cyclopropyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine, MAGNESIUM ION, ...
Authors:Lu, J.
Deposit date:2017-10-10
Release date:2017-11-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design.
Bioorg. Med. Chem. Lett., 27, 2017
4YBI
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BU of 4ybi by Molmil
Crystal structure of BACE with amino thiazine inhibitor LY2811376
Descriptor: (4S)-4-[2,4-difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine, Beta-secretase 1, GLYCEROL
Authors:Timm, D.E.
Deposit date:2015-02-18
Release date:2015-04-01
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Robust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor.
J.Neurosci., 31, 2011

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PDB entries from 2024-03-27

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