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7QG0
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BU of 7qg0 by Molmil
Inhibitor-induced hSARM1 duplex
Descriptor: NAD(+) hydrolase SARM1
Authors:Zalk, R, Kahzma, T, Guez-Haddad, J.
Deposit date:2021-12-07
Release date:2022-12-21
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (4.02 Å)
Cite:A duplex structure of SARM1 octamers stabilized by a new inhibitor.
Cell.Mol.Life Sci., 80, 2022
6ZFX
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BU of 6zfx by Molmil
hSARM1 GraFix-ed
Descriptor: (~{E})-4-methylnon-4-enedial, NAD(+) hydrolase SARM1
Authors:Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Dessau, M, Mim, C, Isupov, M.N, Zalk, R, Hons, M, Opatowsky, Y.
Deposit date:2020-06-18
Release date:2020-11-18
Last modified:2022-11-09
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
6ZG1
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BU of 6zg1 by Molmil
SARM1 SAM1-2 domains
Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Dessau, M, Mim, C, Isupov, M.N, Zalk, R, Hons, M, Opatowsky, Y.
Deposit date:2020-06-18
Release date:2020-11-11
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (3.77 Å)
Cite:Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
7ANW
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BU of 7anw by Molmil
hSARM1 NAD+ complex
Descriptor: NAD(+) hydrolase SARM1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Mim, C, Isupov, M.N, Zalk, R, Dessau, M, Hons, M, Opatowsky, Y.
Deposit date:2020-10-13
Release date:2020-11-11
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (2.68 Å)
Cite:Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
5I6J
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BU of 5i6j by Molmil
Crystal Structure of SRGAP2 F-BARx
Descriptor: SLIT-ROBO Rho GTPase-activating protein 2
Authors:Sporny, M, Guez-Haddad, J, Isupov, M.N, Opatowsky, Y.
Deposit date:2016-02-16
Release date:2017-03-08
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural History of Human SRGAP2 Proteins.
Mol. Biol. Evol., 34, 2017
5I7D
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BU of 5i7d by Molmil
Crystal Structure of srGAP2 F-BARx WT Form-2
Descriptor: SLIT-ROBO Rho GTPase-activating protein 2
Authors:Sporny, M, Guez-Haddad, J, Isupov, M.N, Opatowsky, Y.
Deposit date:2016-02-17
Release date:2017-08-30
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:Structural Basis for srGAP2 Membrane Interactions, and Antagonism by the Human Specific Paralog srGAP2C
To Be Published
5I6R
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BU of 5i6r by Molmil
Crystal Structure of srGAP2 F-BARx WT Form-1
Descriptor: ACETATE ION, D-MALATE, SLIT-ROBO Rho GTPase-activating protein 2, ...
Authors:Sporny, M, Guez-Haddad, J, Isupov, M.N, Opatowsky, Y.
Deposit date:2016-02-16
Release date:2017-08-30
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Basis for srGAP2 Membrane Interactions, and Antagonism by the Human Specific Paralog srGAP2C
To Be Published
6ZG0
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BU of 6zg0 by Molmil
SARM1 SAM1-2 domains
Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Dessau, M, Mim, C, Isupov, M.N, Zalk, R, Hons, M, Opatowsky, Y.
Deposit date:2020-06-18
Release date:2020-11-11
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (7.7 Å)
Cite:Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
2F4S
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BU of 2f4s by Molmil
A-site RNA in complex with neamine
Descriptor: (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, 5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3'
Authors:Murray, J.B, Meroueh, S.O, Russell, R.J, Lentzen, G, Haddad, J, Mobashery, S.
Deposit date:2005-11-24
Release date:2006-05-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site
Chem.Biol., 13, 2006
2F4T
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BU of 2f4t by Molmil
Asite RNA + designer antibiotic
Descriptor: (2R)-4-AMINO-N-{(1R,2S,3R,4R,5S)-5-AMINO-2-{2-[(2-AMINOETHYL)AMINO]ETHOXY}-4-[(2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-3-HYDROXYCYCLOHEXYL}-2-HYDROXYBUTANAMIDE, 5'-R(*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', 5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3'
Authors:Murray, J.B, Meroueh, S.O, Russell, R.J, Lentzen, G, Haddad, J, Mobashery, S.
Deposit date:2005-11-24
Release date:2006-05-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site
Chem.Biol., 13, 2006
2F4U
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BU of 2f4u by Molmil
Asite RNA + designer antibiotic
Descriptor: (2R)-4-AMINO-N-((1R,2S,3R,4R,5S)-5-AMINO-4-[(2-AMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-{2-[(3-AMINOPROPYL)AMINO]ETHOXY}-3-HYDROXYCYCLOHEXYL)-2-HYDROXYBUTANAMIDE, 5'-R(*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3'
Authors:Murray, J.B, Meroueh, S.O, Russell, R.J, Lentzen, G, Haddad, J, Mobashery, S.
Deposit date:2005-11-24
Release date:2006-05-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site
Chem.Biol., 13, 2006
2F4V
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BU of 2f4v by Molmil
30S ribosome + designer antibiotic
Descriptor: (2R)-4-AMINO-N-{(1R,2S,3R,4R,5S)-5-AMINO-2-{2-[(2-AMINOETHYL)AMINO]ETHOXY}-4-[(2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-3-HYDROXYCYCLOHEXYL}-2-HYDROXYBUTANAMIDE, (2S,4S,4AR,5AS,6S,11R,11AS,12R,12AR)-7-CHLORO-4-(DIMETHYLAMINO)-6,10,11,12-TETRAHYDROXY-1,3-DIOXO-1,2,3,4,4A,5,5A,6,11,11A,12,12A-DODECAHYDROTETRACENE-2-CARBOXAMIDE, 16S ribosomal RNA, ...
Authors:Murray, J.B, Meroueh, S.O, Russell, R.J, Lentzen, G, Haddad, J, Mobashery, S.
Deposit date:2005-11-24
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Interactions of designer antibiotics and the bacterial ribosome aminoacyl-tRNA site
Chem.Biol., 13, 2006
5NOI
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BU of 5noi by Molmil
human Robo2 extracellular domains 4-5
Descriptor: Roundabout homolog 2
Authors:Opatowsky, Y, Barak, R.
Deposit date:2017-04-12
Release date:2017-10-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Robo Ig4 Is a Dimerization Domain.
J. Mol. Biol., 429, 2017
4RTT
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BU of 4rtt by Molmil
Cyrstal structure of SLIT-ROBO Rho GTPase-activating protein 2 fragment
Descriptor: SLIT-ROBO Rho GTPase-activating protein 2, SULFATE ION
Authors:Opatowsky, Y, Guez-Hadad, J.
Deposit date:2014-11-16
Release date:2015-11-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The Neuronal Migration Factor srGAP2 Achieves Specificity in Ligand Binding through a Two-Component Molecular Mechanism.
Structure, 23, 2015
4RUG
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BU of 4rug by Molmil
Cyrstal structure of SLIT-ROBO Rho GTPase-activating protein 2 fragment
Descriptor: SLIT-ROBO Rho GTPase-activating protein 2
Authors:Opatowsky, Y, Guez-Hadad, J.
Deposit date:2014-11-19
Release date:2015-11-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:The Neuronal Migration Factor srGAP2 Achieves Specificity in Ligand Binding through a Two-Component Molecular Mechanism.
Structure, 23, 2015
6QWV
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BU of 6qwv by Molmil
SARM1 SAM1-2 domains
Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Sporny, M, Isupov, N.M, Opatowsky, Y.
Deposit date:2019-03-06
Release date:2019-07-03
Last modified:2019-09-18
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Structural Evidence for an Octameric Ring Arrangement of SARM1.
J.Mol.Biol., 431, 2019
1O9M
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BU of 1o9m by Molmil
The Complex of a novel antibiotic with the Aminoacyl Site of the Bacterial Ribosome Revealed by X-Ray Crystallography.
Descriptor: 1-(AMINOETHYL)AMINO-4-AMINOBUTANE, 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranose, 4-AMINO-2-HYDROXYBUTANOIC ACID, ...
Authors:Russell, R, Murray, J.B.
Deposit date:2002-12-17
Release date:2003-03-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Complex of a Designer Antibiotic with a Model Aminoacyl Site of the 30S Ribosomal Subunit Revealed by X-Ray Crystallography
J.Am.Chem.Soc., 125, 2003
8P2M
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BU of 8p2m by Molmil
C. elegans TIR-1 protein.
Descriptor: NAD(+) hydrolase tir-1
Authors:Isupov, M.N, Opatowsky, Y.
Deposit date:2023-05-16
Release date:2023-09-06
Method:ELECTRON MICROSCOPY (3.82 Å)
Cite:Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans.
Cell Rep, 42, 2023
8P2L
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BU of 8p2l by Molmil
A CHIMERA construct containing human SARM1 ARM and SAM domains and C. elegans TIR domain.
Descriptor: NAD(+) hydrolase SARM1,NAD(+) hydrolase tir-1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Isupov, M.N, Opatowsky, Y.
Deposit date:2023-05-16
Release date:2023-09-06
Method:ELECTRON MICROSCOPY (2.68 Å)
Cite:Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans.
Cell Rep, 42, 2023
6I9S
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BU of 6i9s by Molmil
hRobo2 Extracellular Domains 2-3
Descriptor: Roundabout homolog 2, SODIUM ION
Authors:Barak, R, Isupov, N.M, Opatowsky, Y.
Deposit date:2018-11-25
Release date:2019-03-13
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Structural Principles in Robo Activation and Auto-inhibition.
Cell, 177, 2019
6IAA
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BU of 6iaa by Molmil
hRobo2 ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Roundabout homolog 2, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Barak, R, Isupov, N.M, Opatowsky, Y.
Deposit date:2018-11-26
Release date:2019-03-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural Principles in Robo Activation and Auto-inhibition.
Cell, 177, 2019

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