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2EWS
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CRYSTAL STRUCTURE OF S.AUREUS PANTOTHENATE KINASE
分子名称:Pantothenate kinase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Hong, B.S., Park, H.W., Structural Genomics Consortium (SGC)
登録日2005-11-06
公開日2006-09-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Prokaryotic Type II and Type III Pantothenate Kinases: The Same Monomer Fold Creates Dimers with Distinct Catalytic Properties.
Structure, 14, 2006
2I7N
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CRYSTAL STRUCTURE OF HUMAN PANK1 ALPHA: THE CATALYTIC CORE DOMAIN IN COMPLEX WITH ACCOA
分子名称:Pantothenate kinase 1, ACETYL COENZYME *A
著者Hong, B.S., Wang, L., Tempel, W., Loppnau, P., Allali-Hassani, A., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H.W.
登録日2006-08-31
公開日2006-12-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
J.Biol.Chem., 282, 2007
2I7P
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CRYSTAL STRUCTURE OF HUMAN PANK3 IN COMPLEX WITH ACCOA
分子名称:Pantothenate kinase 3, ACETYL COENZYME *A
著者Hong, B.S., Wang, L., Shen, L., Tempel, W., Loppnau, P., Finerty, P., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
登録日2006-08-31
公開日2006-12-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
J.Biol.Chem., 282, 2007
3FEG
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CRYSTAL STRUCTURE OF HUMAN CHOLINE KINASE BETA IN COMPLEX WITH PHOSPHORYLATED HEMICHOLINIUM-3 AND ADENOSINE NUCLEOTIDE
分子名称:Choline/ethanolamine kinase, (2S)-2-[4'-({dimethyl[2-(phosphonooxy)ethyl]ammonio}acetyl)biphenyl-4-yl]-2-hydroxy-4,4-dimethylmorpholin-4-ium, SULFATE ION, ...
著者Hong, B.S., Tempel, W., Rabeh, W.M., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
登録日2008-11-29
公開日2008-12-23
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.302 Å)
主引用文献Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
J.Biol.Chem., 285, 2010
3G15
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CRYSTAL STRUCTURE OF HUMAN CHOLINE KINASE ALPHA IN COMPLEX WITH HEMICHOLINIUM-3 AND ADP
分子名称:Choline kinase alpha, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Hong, B.S., Tempel, W., Rabeh, W.M., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
登録日2009-01-29
公開日2009-02-10
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
J.Biol.Chem., 285, 2010
3LQ3
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CRYSTAL STRUCTURE OF HUMAN CHOLINE KINASE BETA IN COMPLEX WITH PHOSPHORYLATED HEMICHOLINIUM-3 AND ADENOSINE NUCLEOTIDE
分子名称:Choline/ethanolamine kinase, (2S)-2-[4'-({dimethyl[2-(phosphonooxy)ethyl]ammonio}acetyl)biphenyl-4-yl]-2-hydroxy-4,4-dimethylmorpholin-4-ium, MAGNESIUM ION, ...
著者Hong, B.S., Tempel, W., Rabeh, W.M., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
登録日2010-02-08
公開日2010-05-05
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
J.Biol.Chem., 285, 2010
4MTL
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HUMAN METHYLTRANSFERASE-LIKE PROTEIN 21C
分子名称:Protein-lysine methyltransferase METTL21C, S-ADENOSYL-L-HOMOCYSTEINE, UNKNOWN ATOM OR ION
著者Hong, B.S., Tempel, W., Dong, A., Li, Y., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
登録日2013-09-19
公開日2013-10-23
最終更新日2015-07-08
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Human Methyltransferase-Like Protein 21C
To be Published
2OSA
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THE RHO-GAP DOMAIN OF HUMAN N-CHIMAERIN
分子名称:N-chimaerin
著者Walker, J.R., Hong, B.S., Shen, L., Arrowsmith, C.H., Sundstrom, M., Weigelt, J., Edwards, A.M., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
登録日2007-02-05
公開日2007-03-06
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of the Rho-GAP domain from human N-chimaerin
To be Published
2ZXX
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CRYSTAL STRUCTURE OF CDT1/GEMININ COMPLEX
分子名称:Geminin, DNA replication factor Cdt1
著者Cho, Y., Lee, C., Hong, B.S., Choi, J.M.
登録日2009-01-08
公開日2009-02-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
Nature, 430, 2004
4PWY
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CRYSTAL STRUCTURE OF A CALMODULIN-LYSINE N-METHYLTRANSFERASE FRAGMENT
分子名称:Calmodulin-lysine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, GLYCEROL, ...
著者Tempel, W., Hong, B.S., Walker, J.R., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
登録日2014-03-21
公開日2014-04-16
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of a Calmodulin-lysine N-methyltransferase fragment
TO BE PUBLISHED
4QPN
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CRYSTAL STRUCTURE OF HUMAN METHYLTRANSFERASE-LIKE PROTEIN 21B
分子名称:Protein-lysine methyltransferase METTL21B, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
著者Tempel, W., Hong, B.S., Seitova, A., He, H., Li, Y., Graslund, S., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
登録日2014-06-24
公開日2014-07-09
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Crystal Structure of Human Methyltransferase-Like Protein 21B
TO BE PUBLISHED
4RFQ
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HUMAN METHYLTRANSFERASE-LIKE 18
分子名称:Histidine protein methyltransferase 1 homolog, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION
著者Tempel, W., Ravichandran, M., Li, Y., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Hong, B.S., Structural Genomics Consortium (SGC)
登録日2014-09-26
公開日2014-10-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Human Methyltransferase-Like 18
TO BE PUBLISHED
5E26
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CRYSTAL STRUCTURE OF HUMAN PANK2: THE CATALYTIC CORE DOMAIN IN COMPLEX WITH PANTOTHENATE AND ADENOSINE DIPHOSPHATE
分子名称:Pantothenate kinase 2, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ...
著者DONG, A., LOPPNAU, P., RAVICHANDRAN, M., CHENG, C., TEMPEL, W., SEITOVA, A., HUTCHINSON, A., HONG, B.S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., Structural Genomics Consortium (SGC)
登録日2015-09-30
公開日2015-10-21
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate
to be published
2F9T
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STRUCTURE OF THE TYPE III COAA FROM PSEUDOMONAS AERUGINOSA
分子名称:Pantothenate Kinase
著者Leonardi, R., Yun, M.K., Chohnan, S., White, S.W., Rock, C.O., Jackowski, S.
登録日2005-12-06
公開日2006-08-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Prokaryotic Type II and Type III Pantothenate Kinases: The Same Monomer Fold Creates Dimers with Distinct Catalytic Properties.
Structure, 14, 2006
2F9W
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STRUCTURE OF THE TYPE III COAA FROM PSEUDOMONAS AERUGINOSA
分子名称:Pantothenate Kinase, PANTOTHENOIC ACID, 1,2-ETHANEDIOL, ...
著者Leonardi, R., Yun, M.K., Chohnan, S., White, S.W., Rock, C.O., Jackowski, S.
登録日2005-12-06
公開日2006-08-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Prokaryotic Type II and Type III Pantothenate Kinases: The Same Monomer Fold Creates Dimers with Distinct Catalytic Properties.
Structure, 14, 2006
4FK7
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CRYSTAL STRUCTURE OF CERTHRAX CATALYTIC DOMAIN
分子名称:Putative ADP-ribosyltransferase Certhrax, N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE, CHLORIDE ION, ...
著者Hong, B.S., Dimov, S., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Park, H., Structural Genomics Consortium (SGC)
登録日2012-06-12
公開日2012-09-26
最終更新日2012-12-26
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus.
J.Biol.Chem., 287, 2012
4GF1
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CRYSTAL STRUCTURE OF CERTHRAX
分子名称:Putative ADP-ribosyltransferase Certhrax, UNKNOWN ATOM OR ION
著者Hong, B.S., Dimov, S., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Park, H., Structural Genomics Consortium (SGC)
登録日2012-08-02
公開日2012-09-26
最終更新日2013-01-02
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus.
J.Biol.Chem., 287, 2012
3CPF
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CRYSTAL STRUCTURE OF HUMAN EUKARYOTIC TRANSLATION INITIATION FACTOR EIF5A
分子名称:Eukaryotic translation initiation factor 5A-1, UNKNOWN ATOM OR ION
著者Nedyalkova, L., Tong, Y., Tempel, W., Hong, B., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2008-03-31
公開日2008-04-15
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of human eIF5A1: insight into functional similarity of human eIF5A1 and eIF5A2.
Proteins, 75, 2009
3ME3
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
分子名称:Pyruvate kinase isozymes M1/M2, 3-{[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl}aniline, BETA-FRUCTOSE-1,6-DIPHOSPHATE, ...
著者Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
登録日2010-03-31
公開日2010-04-28
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat.Chem.Biol., 8, 2012
3U2Z
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
分子名称:Pyruvate kinase isozymes M1/M2, BETA-FRUCTOSE-1,6-DIPHOSPHATE, UNKNOWN ATOM OR ION, ...
著者Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
登録日2011-10-04
公開日2012-09-12
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat.Chem.Biol., 8, 2012
4M7X
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STAPHYLOCOCCUS AUREUS TYPE II PANTOTHENATE KINASE IN COMPLEX WITH A PANTOTHENATE ANALOG
分子名称:Type II pantothenate kinase, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Mottaghi, K., Hong, B., Tempel, W., Park, H.
登録日2013-08-12
公開日2014-09-03
最終更新日2016-12-28
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product.
ACS Infect Dis, 2, 2016
4M7Y
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STAPHYLOCOCCUS AUREUS TYPE II PANTOTHENATE KINASE IN COMPLEX WITH A PANTOTHENATE ANALOG
分子名称:Type II pantothenate kinase, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-pentyl-beta-alaninamide, ADENOSINE-5'-DIPHOSPHATE, ...
著者Mottaghi, K., Hong, B., Tempel, W., Park, H., Structural Genomics Consortium (SGC)
登録日2013-08-12
公開日2014-09-03
最終更新日2016-12-28
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product.
ACS Infect Dis, 2, 2016
5ELZ
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STAPHYLOCOCCUS AUREUS TYPE II PANTOTHENATE KINASE IN COMPLEX WITH A PANTOTHENATE ANALOG
分子名称:Type II pantothenate kinase, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Mottaghi, K., Hughes, S.J., Tempel, W., Hong, B., Park, H., Structural Genomics Consortium (SGC)
登録日2015-11-05
公開日2016-08-10
最終更新日2016-11-09
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product.
Acs Infect Dis., 2, 2016
2PZ9
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CRYSTAL STRUCTURE OF PUTATIVE TRANSCRIPTIONAL REGULATOR SCO4942 FROM STREPTOMYCES COELICOLOR
分子名称:Putative regulatory protein, SULFATE ION
著者Filippova, E.V., Chruszcz, M., Xu, X., Zheng, H., Cymborowski, M., Savchenko, A., Edwards, A., Joachimiak, A., Minor, W., Midwest Center for Structural Genomics (MCSG)
登録日2007-05-17
公開日2007-06-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献In situ proteolysis for protein crystallization and structure determination.
Nat.Methods, 4, 2007
4F7W
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CRYSTAL STRUCTURE OF KLEBSIELLA PNEUMONIAE PANTOTHENATE KINASE IN COMPLEX WITH N-PENTYLPANTOTHENAMIDE
分子名称:Pantothenate kinase, ADENOSINE-5'-DIPHOSPHATE, (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pentylamino)propyl]butanamide, ...
著者Li, B., Tempel, W., Smil, D., Bolshan, Y., Hong, B.S., Park, H.W., Structural Genomics Consortium (SGC)
登録日2012-05-16
公開日2013-04-10
最終更新日2013-08-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N-substituted pantothenamides.
Proteins, 81, 2013
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