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5AEB
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BU of 5aeb by Molmil
Crystal structure of the class B3 di-zinc metallo-beta-lactamase LRA- 12 from an Alaskan soil metagenome.
Descriptor: COBALT (II) ION, LRA-12, SULFATE ION, ...
Authors:Power, P, Herman, R, Kerff, F, Bouillenne, F, Rodriguez, M.M, Galleni, M, Handelsman, J, Gutkind, G, Charlier, P, Sauvage, E.
Deposit date:2015-08-27
Release date:2015-09-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure and kinetic analysis of the class B3 di-zinc metallo-beta-lactamase LRA-12 from an Alaskan soil metagenome.
PLoS ONE, 12, 2017
6BN3
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BU of 6bn3 by Molmil
CTX-M-151 class A extended-spectrum beta-lactamase apo crystal structure at 1.3 Angstrom resolution
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase
Authors:Power, P, Ghiglione, B, Rodriguez, M.M, Gutkind, G, Ishii, Y, Bonomo, R.A, Klinke, S.
Deposit date:2017-11-16
Release date:2018-11-21
Last modified:2022-08-03
Method:X-RAY DIFFRACTION (1.278 Å)
Cite:Structural and Biochemical Characterization of the Novel CTX-M-151 Extended-Spectrum beta-Lactamase and Its Inhibition by Avibactam.
Antimicrob.Agents Chemother., 65, 2021
6BPF
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BU of 6bpf by Molmil
CTX-M-151 class A extended-spectrum beta-lactamase crystal structure in complex with avibactam at 1.32 Angstrom resolution
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase
Authors:Power, P, Ghiglione, B, Rodriguez, M.M, Gutkind, G, Ishii, Y, Bonomo, R.A, Klinke, S.
Deposit date:2017-11-23
Release date:2018-11-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.318 Å)
Cite:Structural and Biochemical Characterization of the Novel CTX-M-151 Extended-Spectrum beta-Lactamase and Its Inhibition by Avibactam.
Antimicrob.Agents Chemother., 65, 2021
8EO5
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BU of 8eo5 by Molmil
Crystal structure of the class A beta-lactamase precursor LRA-5 from an Alaskan soil metagenome at 1.8 Angstrom resolution
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, LRA-5
Authors:Power, P, D'Amico Gonzalez, G, Centron, D, Gutkind, G, Handelsman, J, Klinke, S.
Deposit date:2022-10-02
Release date:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions
to be published
8EO6
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BU of 8eo6 by Molmil
Crystal structure of metagenomic class A beta-lactamase precursor LRA-5 in complex with ceftazidime at 2.35 Angstrom resolution
Descriptor: ACYLATED CEFTAZIDIME, LRA-5
Authors:Power, P, D'Amico Gonzalez, G, Centron, D, Gutkind, G, Handelsman, J, Klinke, S.
Deposit date:2022-10-02
Release date:2023-10-04
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions
to be published
8EO7
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BU of 8eo7 by Molmil
Crystal structure of metagenomic beta-lactamase LRA-5 Y69Q/V166E mutant at 2.15 Angstrom resolution
Descriptor: beta-lactamase
Authors:Power, P, D'Amico Gonzalez, G, Centron, D, Gutkind, G, Handelsman, J, Klinke, S.
Deposit date:2022-10-02
Release date:2023-10-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions
to be published
6D3G
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BU of 6d3g by Molmil
PER-2 class A extended-spectrum beta-lactamase crystal structure in complex with avibactam at 2.4 Angstrom resolution
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, TETRAETHYLENE GLYCOL
Authors:Power, P, Ruggiero, M, Gutkind, G, Bonomo, R, Klinke, S.
Deposit date:2018-04-16
Release date:2019-04-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Structural Insights into the Inhibition of the Extended-Spectrum beta-Lactamase PER-2 by Avibactam.
Antimicrob.Agents Chemother., 63, 2019
6DGU
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BU of 6dgu by Molmil
PER-2 class A extended-spectrum beta-lactamase crystal structure at 2.69 Angstrom resolution
Descriptor: Beta-lactamase
Authors:Power, P, Ruggiero, M, Gutkind, G, Bonomo, R, Klinke, S.
Deposit date:2018-05-18
Release date:2019-05-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.691 Å)
Cite:Structural Insights into the Inhibition of the Extended-Spectrum beta-Lactamase PER-2 by Avibactam.
Antimicrob.Agents Chemother., 63, 2019
8EK9
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BU of 8ek9 by Molmil
Crystal structure of the class A carbapenemase CRH-1 in complex with avibactam at 1.4 Angstrom resolution
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase
Authors:Power, P, Brunetti, F, Ghiglione, B, Guardabassi, L, Gutkind, G, Klinke, S.
Deposit date:2022-09-20
Release date:2023-05-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Biochemical and Structural Characterization of CRH-1, a Carbapenemase from Chromobacterium haemolyticum Related to KPC beta-Lactamases.
Antimicrob.Agents Chemother., 67, 2023
8EHU
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BU of 8ehu by Molmil
Crystal structure of the environmental CRH-1 class A carbapenemase at 1.1 Angstrom resolution
Descriptor: Beta-lactamase
Authors:Power, P, Brunetti, F, Ghiglione, B, Guardabassi, L, Gutkind, G, Klinke, S.
Deposit date:2022-09-14
Release date:2023-05-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Biochemical and Structural Characterization of CRH-1, a Carbapenemase from Chromobacterium haemolyticum Related to KPC beta-Lactamases.
Antimicrob.Agents Chemother., 67, 2023
8EHH
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BU of 8ehh by Molmil
Crystal structure of the class A extended-spectrum beta-lactamase CTX-M-96 in complex with relebactam at 1.03 Angstrom resolution
Descriptor: (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase
Authors:Power, P, Ghiglione, B, Bonomo, R.A, Rodriguez, M.M, Gutkind, G, Klinke, S.
Deposit date:2022-09-14
Release date:2023-09-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:Biochemical and structural evidences of the activity of relebactam as inhibitor of the extended-spectrum beta-lactamase CTX-M-96.
To be published
3ZNY
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BU of 3zny by Molmil
Crystal structure of the class A extended-spectrum beta-lactamase CTX- M-96, a natural D240G mutant derived from CTX-M-12
Descriptor: CTX-M-12A ENZYME
Authors:Power, P, Herman, R, Bouillenne, F, Ghiglione, B, Rodriguez, M.M, Galleni, M, Gutkind, G, Charlier, P, Sauvage, E.
Deposit date:2013-02-18
Release date:2014-01-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural and Kinetic Insights Into the "Ceftazidimase" Behavior of the Extended-Spectrum Beta-Lactamase Ctx-M-96.
Biochemistry, 54, 2015
4D2O
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BU of 4d2o by Molmil
Crystal structure of the class A extended-spectrum beta-lactamase PER- 2
Descriptor: PER-2 BETA-LACTAMASE
Authors:Power, P, Herman, R, Ruggiero, M, Kerff, F, Galleni, M, Gutkind, G, Charlier, P, Sauvage, E.
Deposit date:2014-05-12
Release date:2014-05-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the Extended-Spectrum Beta-Lactamase Per- 2 and Insights Into the Role of Specific Residues in the Interaction with Beta-Lactams and Beta-Lactamase Inhibitors.
Antimicrob.Agents Chemother., 58, 2014
2Y91
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BU of 2y91 by Molmil
Crystal structure of class A beta-lactamase from Bacillus licheniformis BS3 with clavulanic acid
Descriptor: 5-HYDROXY-3-OXOPENTANOIC ACID, BETA-LACTAMASE, CITRIC ACID, ...
Authors:Power, P, Sauvage, E, Herman, R, Kerff, F, Charlier, P.
Deposit date:2011-02-11
Release date:2012-02-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Novel Fragments of Clavulanate Observed in the Structure of the Class a Beta-Lactamase from Bacillus Licheniformis Bs3.
J.Antimicrob.Chemother., 67, 2012
7UTB
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BU of 7utb by Molmil
KPC-2 CARBAPENEMASE IN COMPLEX WITH THE BORONIC ACID INHIBITOR MB_076
Descriptor: Carbapenem-hydrolyzing beta-lactamase KPC, [(1~{R})-1-[2-[(5-azanyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanoylamino]-2-(4-carboxy-1,2,3-triazol-1-yl)ethyl]-$l^{3}-oxidanyl-bis(oxidanyl)boron
Authors:van den Akker, F, Alsenani, T.A.
Deposit date:2022-04-26
Release date:2022-12-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M beta-Lactamases: Biochemical and Structural Analyses.
Antimicrob.Agents Chemother., 67, 2023
3ZNT
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BU of 3znt by Molmil
Crystal structure of OXA-24 class D beta-lactamase with tazobactam
Descriptor: BETA-LACTAMASE, SULFATE ION, TAZOBACTAM INTERMEDIATE
Authors:Power, P, Sauvage, E, Herman, R, Kerff, F, Charlier, P.
Deposit date:2013-02-18
Release date:2014-01-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of Oxa-24 Beta-Lactamase Inhibited by Tazobactam
To be Published
4A5R
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BU of 4a5r by Molmil
Crystal structure of class A beta-lactamase from Bacillus licheniformis BS3 with tazobactam
Descriptor: BETA-LACTAMASE, CARBON DIOXIDE, CITRIC ACID, ...
Authors:Power, P, Sauvage, E, Herman, R, Kerff, F, Charlier, P.
Deposit date:2011-10-28
Release date:2012-10-10
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Class a Beta-Lactamase from Bacillus Licheniformis Inhibited by Tazobactam
To be Published

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PDB entries from 2024-03-27

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