Author results

1FMU
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STRUCTURE OF NATIVE PROTEINASE A IN P3221 SPACE GROUP.
Descriptor:SACCHAROPEPSIN, ALPHA-D-MANNOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Gustchina, A., Li, M., Phylip, L.H., Lees, W.E., Kay, J., Wlodawer, A.
Deposit date:2000-08-18
Release date:2002-07-31
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae.
Biochem.Biophys.Res.Commun., 295, 2002
1FMX
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STRUCTURE OF NATIVE PROTEINASE A IN THE SPACE GROUP P21
Descriptor:SACCHAROPEPSIN, BETA-D-MANNOSE, N-ACETYL-D-GLUCOSAMINE
Authors:Gustchina, A., Li, M., Phylip, L.H., Lees, W.E., Kay, J., Wlodawer, A.
Deposit date:2000-08-18
Release date:2002-07-31
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae.
Biochem.Biophys.Res.Commun., 295, 2002
1B11
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STRUCTURE OF FELINE IMMUNODEFICIENCY VIRUS PROTEASE COMPLEXED WITH TL-3-093
Descriptor:PROTEIN (Feline Immunodeficiency Virus PROTEASE), SULFATE ION, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Gustchina, A., Li, M., Wlodawer, A.
Deposit date:1998-11-25
Release date:1998-12-02
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
1FMB
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EIAV PROTEASE COMPLEXED WITH THE INHIBITOR HBY-793
Descriptor:EIAV PROTEASE, [2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYL-VALINYL]-PHENYLALANINOL
Authors:Wlodawer, A., Gustchina, A., Zdanov, A., Kervinen, J.
Deposit date:1996-02-27
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of equine infectious anemia virus proteinase complexed with an inhibitor.
Protein Sci., 5, 1996
1YG9
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THE STRUCTURE OF MUTANT (N93Q) OF BLA G 2
Descriptor:Aspartic protease Bla g 2, N-ACETYL-D-GLUCOSAMINE, ZINC ION
Authors:Li, M., Gustchina, A., Wuenschmann, S., Pomes, A., Wlodawer, A.
Deposit date:2005-01-04
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition.
J.Mol.Biol., 348, 2005
3MA9
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CRYSTAL STRUCTURE OF GP41 DERIVED PROTEIN COMPLEXED WITH FAB 8066
Descriptor:Transmembrane glycoprotein, Fab8066 FAB ANTIBODY FRAGMENT, Heavy Chain, ...
Authors:Li, M., Gustchina, E., Louis, J., Gustchina, A., Wlodawer, A., Clore, M.
Deposit date:2010-03-23
Release date:2010-12-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41.
Plos Pathog., 6, 2010
3MAC
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CRYSTAL STRUCTURE OF GP41-DERIVED PROTEIN COMPLEXED WITH FAB 8062
Descriptor:Transmembrane glycoprotein, Fab8062
Authors:Li, M., Gustchina, E., Louis, J., Gustchina, A., Wlodawer, A., Clore, M.
Deposit date:2010-03-23
Release date:2010-12-08
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41.
Plos Pathog., 6, 2010
4KHT
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TRIPLE HELIX BUNDLE OF GP41 COMPLEXED WITH FAB 8066
Descriptor:Gp41 helix, 8066 heavy chain, 8066 light chain
Authors:Li, M., Gustchina, A., Wlodawer, A.
Deposit date:2013-05-01
Release date:2014-03-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.817 Å)
Cite:Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41.
Plos One, 8, 2013
4KHX
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CRYSTAL STRUCTURE OF GP41 HELIX COMPLEXED WITH ANTIBODY 8062
Descriptor:gp41 helix, 8062 heavy chain, 8062 light chain
Authors:Li, M., Gustchina, A., Wlodawer, A.
Deposit date:2013-05-01
Release date:2014-03-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.921 Å)
Cite:Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41.
Plos One, 8, 2013
1G0V
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THE STRUCTURE OF PROTEINASE A COMPLEXED WITH A IA3 MUTANT, MVV
Descriptor:PROTEINASE A, PROTEASE A INHIBITOR 3, BETA-D-MANNOSE, ...
Authors:Phylip, L.H., Lees, W., Brownsey, B.G., Bur, D., Dunn, B.M., Winther, J., Gustchina, A., Li, M., Copeland, T., Wlodawer, A., Kay, J.
Deposit date:2000-10-09
Release date:2001-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae.
J.Biol.Chem., 276, 2001
1ZVJ
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STRUCTURE OF KUMAMOLISIN-AS MUTANT, D164N
Descriptor:kumamolisin-As, CALCIUM ION, SULFATE ION
Authors:Li, M., Wlodawer, A., Gustchina, A., Nakayama, T.
Deposit date:2005-06-02
Release date:2006-05-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Processing, catalytic activity and crystal structures of kumamolisin-As with an engineered active site.
Febs J., 273, 2006
1ZVK
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STRUCTURE OF DOUBLE MUTANT, D164N, E78H OF KUMAMOLISIN-AS
Descriptor:kumamolisin-As, CALCIUM ION
Authors:Li, M., Wlodawer, A., Gustchina, A., Nakayama, T.
Deposit date:2005-06-02
Release date:2006-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Processing, catalytic activity and crystal structures of kumamolisin-As with an engineered active site.
Febs J., 273, 2006
2FIV
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CRYSTAL STRUCTURE OF FELINE IMMUNODEFICIENCY VIRUS PROTEASE COMPLEXED WITH A SUBSTRATE
Descriptor:FELINE IMMUNODEFICIENCY VIRUS PROTEASE, ACE-ALN-VAL-STA-GLU-ALN-NH2, SULFATE ION
Authors:Schalk-Hihi, C., Lubkowski, J., Zdanov, A., Wlodawer, A., Gustchina, A.
Deposit date:1997-07-21
Release date:1997-11-12
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor.
Biochemistry, 36, 1997
3FIV
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CRYSTAL STRUCTURE OF FELINE IMMUNODEFICIENCY VIRUS PROTEASE COMPLEXED WITH A SUBSTRATE
Descriptor:FELINE IMMUNODEFICIENCY VIRUS PROTEASE, ACE-ALN-VAL-LEU-ALA-GLU-ALN-NH2, SULFATE ION
Authors:Schalk-Hihi, C., Lubkowski, J., Zdanov, A., Wlodawer, A., Gustchina, A.
Deposit date:1997-07-09
Release date:1997-11-12
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor.
Biochemistry, 36, 1997
3TLH
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STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITHAN EFFICIENT INHIBITOR OF FIV PR
Descriptor:PROTEIN (PROTEASE), benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Li, M., Lee, T., Morris, G., Laco, G., Wong, C., Olson, A., Elder, J., Wlodawer, A., Gustchina, A.
Deposit date:1998-12-03
Release date:1998-12-09
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
5FIV
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STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITH AN EFFICIENT INHIBITOR OF FIV PR
Descriptor:RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Li, M., Lee, T., Morris, G., Laco, G., Wong, C., Olson, A., Elder, J., Wlodawer, A., Gustchina, A.
Deposit date:1998-12-02
Release date:1998-12-09
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
6FIV
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STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITH AN EFFICIENT INHIBITOR OF FIV PR
Descriptor:RETROPEPSIN, SULFATE ION, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Li, M., Lee, T., Morris, G., Laco, G., Wong, C., Olson, A., Elder, J., Wlodawer, A., Gustchina, A.
Deposit date:1998-12-02
Release date:1998-12-09
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
1FIV
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STRUCTURE OF AN INHIBITOR COMPLEX OF PROTEINASE FROM FELINE IMMUNODEFICIENCY VIRUS
Descriptor:FIV PROTEASE, FIV PROTEASE INHIBITOR ACE-ALN-VAL-STA-GLU-ALN-NH2
Authors:Wlodawer, A., Gustchina, A., Reshetnikova, L., Lubkowski, J., Zdanov, A.
Deposit date:1995-05-04
Release date:1995-07-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of an inhibitor complex of the proteinase from feline immunodeficiency virus.
Nat.Struct.Biol., 2, 1995
1GA4
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CRYSTAL STRUCTURE ANALYSIS OF PSCP (PSEUDOMONAS SERINE-CARBOXYL PROTEINASE) COMPLEXED WITH INHIBITOR PSEUDOIODOTYROSTATIN (THIS ENZYME RENAMED "SEDOLISIN" IN 2003)
Descriptor:SERINE-CARBOXYL PROTEINASE, PSEUDOIODOTYROSTATIN, CALCIUM ION, ...
Authors:Wlodawer, A., Li, M., Dauter, Z., Gustchina, A., Uchida, K.
Deposit date:2000-11-29
Release date:2000-12-13
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Carboxyl proteinase from Pseudomonas defines a novel family of subtilisin-like enzymes.
Nat.Struct.Biol., 8, 2001
1GA6
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CRYSTAL STRUCTURE ANALYSIS OF PSCP (PSEUDOMONAS SERINE-CARBOXYL PROTEINASE) COMPLEXED WITH A FRAGMENT OF TYROSTATIN (THIS ENZYME RENAMED "SEDOLISIN" IN 2003)
Descriptor:SERINE-CARBOXYL PROTEINASE, FRAGMENT OF TYROSTATIN, CALCIUM ION, ...
Authors:Wlodawer, A., Li, M., Dauter, Z., Gustchina, A., Uchida, K.
Deposit date:2000-11-29
Release date:2000-12-13
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1 Å)
Cite:Carboxyl proteinase from Pseudomonas defines a novel family of subtilisin-like enzymes.
Nat.Struct.Biol., 8, 2001
1ILK
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INTERLEUKIN-10 CRYSTAL STRUCTURE REVEALS THE FUNCTIONAL DIMER WITH AN UNEXPECTED TOPOLOGICAL SIMILARITY TO INTERFERON GAMMA
Descriptor:INTERLEUKIN-10
Authors:Zdanov, A., Schalk-Hihi, C., Gustchina, A., Wlodawer, A.
Deposit date:1995-04-21
Release date:1995-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma.
Structure, 3, 1995
1NLU
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PSEUDOMONAS SEDOLISIN (SERINE-CARBOXYL PROTEINASE) COMPLEXED WITH TWO MOLECULES OF PSEUDO-IODOTYROSTATIN
Descriptor:SEDOLISIN, PSEUDO-IODOTYROSTATIN, CALCIUM ION
Authors:Wlodawer, A., Li, M., Gustchina, A., Dauter, Z., Uchida, K., Oyama, H., Glodfarb, N.E., Dunn, B.M., Oda, K.
Deposit date:2003-01-07
Release date:2004-01-20
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Two inhibitor molecules bound in the active site of Pseudomonas sedolisin: a model for the bi-product complex following cleavage of a peptide substrate.
Biochem.Biophys.Res.Commun., 314, 2004
1ODY
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HIV-1 PROTEASE COMPLEXED WITH AN INHIBITOR LP-130
Descriptor:HIV-1 PROTEASE, 4-[2-(2-ACETYLAMINO-3-NAPHTALEN-1-YL-PROPIONYLAMINO)-4-METHYL-PENTANOYLAMINO]-3-HYDROXY-6-METHYL-HEPTANOIC ACID [1-(1-CARBAMOYL-2-NAPHTHALEN-1-YL-ETHYLCARBAMOYL)-PROPYL]-AMIDE
Authors:Kervinen, J., Lubkowski, J., Zdanov, A., Wlodawer, A., Gustchina, A.
Deposit date:1998-07-13
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV.
Protein Sci., 7, 1998
1QZM
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ALPHA-DOMAIN OF ATPASE
Descriptor:ATP-dependent protease La
Authors:Botos, I., Melnikov, E.E., Cherry, S., Khalatova, A.G., Rasulova, F.S., Tropea, J.E., Maurizi, M.R., Rotanova, T.V., Gustchina, A., Wlodawer, A.
Deposit date:2003-09-17
Release date:2004-05-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the AAA+ alpha domain of E. coli Lon protease at 1.9A resolution.
J.Struct.Biol., 146
1RCB
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CRYSTAL STRUCTURE OF HUMAN RECOMBINANT INTERLEUKIN-4 AT 2.25 ANGSTROMS RESOLUTION
Descriptor:INTERLEUKIN-4
Authors:Wlodawer, A., Pavlovsky, A., Gustchina, A.
Deposit date:1992-08-26
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of human recombinant interleukin-4 at 2.25 A resolution.
FEBS Lett., 309, 1992