Author results

5U96
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CRYSTAL STRUCTURE OF THE COILED-COIL DOMAIN FROM LISTERIA INNOCUA (TETRAGONAL FORM)
Descriptor:Putative integrase
Authors:Gupta, K., Van Duyne, G.D., Sharp, R., Yuan, J.B.
Deposit date:2016-12-15
Release date:2017-05-24
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Coiled-coil interactions mediate serine integrase directionality.
Nucleic Acids Res., 45, 2017
5UAE
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CRYSTAL STRUCTURE OF THE COILED-COIL DOMAIN FROM LISTERIA INNOCUA PHAGE INTEGRASE (TRIGONAL FORM)
Descriptor:Putative integrase, CITRATE ANION
Authors:Gupta, K., Sharp, R., Yuan, J.B., Van Duyne, G.D.
Deposit date:2016-12-19
Release date:2017-05-24
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Coiled-coil interactions mediate serine integrase directionality.
Nucleic Acids Res., 45, 2017
5UDO
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CRYSTAL STRUCTURE OF THE COILED-COIL DOMAIN FROM LISTERIA INNOCUA PHAGE INTEGRASE (TETRAGONAL FORM II)
Descriptor:A118 serine integrase
Authors:Gupta, K., Yuan, J.B., Sharp, R., Van Duyne, G.D.
Deposit date:2016-12-28
Release date:2017-06-07
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.541 Å)
Cite:Coiled-coil interactions mediate serine integrase directionality.
Nucleic Acids Res., 45, 2017
1Q4G
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2.0 ANGSTROM CRYSTAL STRUCTURE OF OVINE PROSTAGLANDIN H2 SYNTHASE-1, IN COMPLEX WITH ALPHA-METHYL-4-BIPHENYLACETIC ACID
Descriptor:Prostaglandin G/H synthase 1, B-OCTYLGLUCOSIDE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Gupta, K., Selinksy, B.S., Kaub, C.J., Katz, A.K., Loll, P.J.
Deposit date:2003-08-03
Release date:2004-01-06
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2.0A Resolution Crystal Structure of Prostaglandin H(2) Synthase-1: Structural Insights into an Unusual Peroxidase
J.Mol.Biol., 335, 2004
2AYL
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2.0 ANGSTROM CRYSTAL STRUCTURE OF MANGANESE PROTOPORPHYRIN IX-RECONSTITUTED OVINE PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH FLURBIPROFEN
Descriptor:Prostaglandin G/H synthase 1, B-OCTYLGLUCOSIDE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Gupta, K., Selinsky, B.S., Loll, P.J.
Deposit date:2005-09-07
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:2.0 angstroms structure of prostaglandin H2 synthase-1 reconstituted with a manganese porphyrin cofactor.
Acta Crystallogr.,Sect.D, 62, 2006
4OJR
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CRYSTAL STRUCTURE OF THE HIV-1 INTEGRASE CATALYTIC DOMAIN WITH GSK1264
Descriptor:HIV-1 Integrase, (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid, CACODYLATE ION, ...
Authors:Gupta, K., Brady, T., Dyer, B., Hwang, Y., Male, F., Nolte, R.T., Wang, L., Velthuisen, E., Jeffrey, J., Van Duyne, G., Bushman, F.D.
Deposit date:2014-01-21
Release date:2014-06-11
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Allosteric Inhibition of Human Immunodeficiency Virus Integrase: LATE BLOCK DURING VIRAL REPLICATION AND ABNORMAL MULTIMERIZATION INVOLVING SPECIFIC PROTEIN DOMAINS.
J.Biol.Chem., 289, 2014
4RG5
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CRYSTAL STRUCTURE OF S. POMBE SMN YG-DIMER
Descriptor:Maltose-binding periplasmic protein, Survival Motor Neuron protein chimera, MALTOSE, ...
Authors:Gupta, K., Martin, R.S., Sarachan, K.L., Sharp, B., Van Duyne, G.D.
Deposit date:2014-09-29
Release date:2015-07-01
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Oligomeric Properties of Survival Motor NeuronGemin2 Complexes.
J.Biol.Chem., 290, 2015
5HOT
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STRUCTURAL BASIS FOR INHIBITOR-INDUCED AGGREGATION OF HIV-1 INTEGRASE
Descriptor:Integrase, (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid
Authors:Gupta, K., Turkki, V., Sherrill-Mix, S., Hwang, Y., Eilers, G., Taylor, L., McDanal, C., Wang, P., Temelkoff, D., Nolte, R., Velthuisen, E., Jeffrey, J., Van Duyne, G.D., Bushman, F.D.
Deposit date:2016-01-19
Release date:2016-12-14
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016
5M4S
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TRANSCRIPTION FACTOR TFIIA AS A SINGLE CHAIN PROTEIN
Descriptor:Transcription initiation factor IIA subunit 2,Transcription initiation factor IIA subunit 1,Transcription initiation factor IIA subunit 1
Authors:Kandiah, E., Gupta, K.
Deposit date:2016-10-19
Release date:2017-11-29
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Architecture of TAF11/TAF13/TBP complex suggests novel regulation properties of general transcription factor TFIID.
Elife, 6, 2017
3MGV
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CRE RECOMBINASE-DNA TRANSITION STATE
Descriptor:Recombinase cre, DNA (5'-D(*TP*AP*TP*AP*AP*CP*TP*TP*CP*GP*TP*AP*TP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*AP*TP*GP*CP*TP*AP*TP*AP*CP*GP*AP*AP*GP*TP*TP*AP*T)-3'), ...
Authors:Gibb, B.P., Gupta, K., Ghosh, K., Sharp, R., Chen, J., Van Duyne, G.D.
Deposit date:2010-04-07
Release date:2010-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Requirements for catalysis in the Cre recombinase active site.
Nucleic Acids Res., 38, 2010
6DNW
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SEQUENCE REQUIREMENTS OF THE LISTERIA INNOCUA PROPHAGE ATTP SITE
Descriptor:Putative integrase [Bacteriophage A118], DNA (26-MER), ZINC ION
Authors:Li, H., Sharp, R., Rutherford, K., Gupta, K., Van Duyne, G.D.
Deposit date:2018-06-08
Release date:2018-10-03
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.849 Å)
Cite:Serine Integrase attP Binding and Specificity.
J. Mol. Biol., 430, 2018
2LEH
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SOLUTION STRUCTURE OF THE CORE SMN-GEMIN2 COMPLEX
Descriptor:Survival of motor neuron protein-interacting protein 1, Survival motor neuron protein
Authors:Sarachan, K.L., Valentine, K., Gupta, K., Moorman, V., Gledhill, J., Bernens, M., Tommos, C., Wand, A.J., Van Duyne, G.
Deposit date:2011-06-15
Release date:2012-06-27
Last modified:2012-07-11
Method:SOLUTION NMR
Cite:Solution structure of the core SMN-Gemin2 complex.
Biochem.J., 445, 2012
1EQG
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THE 2.6 ANGSTROM MODEL OF OVINE COX-1 COMPLEXED WITH IBUPROFEN
Descriptor:PROSTAGLANDIN H2 SYNTHASE-1, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Loll, P.J., Selinsky, B.S., Gupta, K., Sharkey, C.T.
Deposit date:2000-04-04
Release date:2001-04-11
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.
Biochemistry, 40, 2001
1EQH
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THE 2.7 ANGSTROM MODEL OF OVINE COX-1 COMPLEXED WITH FLURBIPROFEN
Descriptor:PROSTAGLANDIN H2 SYNTHASE-1, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Loll, P.J., Selinsky, B.S., Gupta, K., Sharkey, C.T.
Deposit date:2000-04-04
Release date:2001-04-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.
Biochemistry, 40, 2001
1HT5
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THE 2.75 ANGSTROM RESOLUTION MODEL OF OVINE COX-1 COMPLEXED WITH METHYL ESTER FLURBIPROFEN
Descriptor:PROSTAGLANDIN H2 SYNTHASE-1, B-OCTYLGLUCOSIDE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Selinsky, B.S., Gupta, K., Sharkey, C.T., Loll, P.J.
Deposit date:2000-12-28
Release date:2001-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.
Biochemistry, 40, 2001
1HT8
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THE 2.7 ANGSTROM RESOLUTION MODEL OF OVINE COX-1 COMPLEXED WITH ALCLOFENAC
Descriptor:PROSTAGLANDIN H2 SYNTHASE-1, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Selinsky, B.S., Gupta, K., Sharkey, C.T., Loll, P.J.
Deposit date:2000-12-29
Release date:2001-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.
Biochemistry, 40, 2001
2M61
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NMR AND MASS SPECTROMETRIC STUDIES OF M-2 BRANCH MINI-M CONOTOXINS FROM INDIAN CONE SNAILS
Descriptor:Conotoxin Ar1446
Authors:Sarma, S.P., Rajesh, R.P., Kumar, G.S., Sudarslal, S., Sabareesh, V., Gowd, K.H., Gupta, K., Krishnan, K.S., Balaram, P.
Deposit date:2013-03-18
Release date:2014-04-16
Method:SOLUTION NMR
Cite:NMR and Mass Spectrometric Studies of M-2 Branch Mini-M Conotoxins from Indian Cone Snails
To be Published
4OT9
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF P100/NF-KB2
Descriptor:Nuclear factor NF-kappa-B p100 subunit, SULFATE ION
Authors:Tao, Z.H., Huang, D.B., Fusco, A., Gupta, K., Ware, C.F., Duynne, G.V.
Deposit date:2014-02-13
Release date:2015-01-14
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:p100/I kappa B delta sequesters and inhibits NF-kappa B through kappaBsome formation.
Proc.Natl.Acad.Sci.USA, 111, 2014
5HRN
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HIV INTEGRASE CATALYTIC DOMAIN CONTAINING F185K MUTATION COMPLEXED WITH GSK0002
Descriptor:Integrase, CACODYLATE ION, SULFATE ION, ...
Authors:Nolte, R.T.
Deposit date:2016-01-23
Release date:2016-12-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016
5HRP
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HIV INTEGRASE CATALYTIC DOMAIN CONTAINING F185K + A124T MUTATIONS COMPLEXED WITH GSK0002
Descriptor:Integrase, CACODYLATE ION, SULFATE ION, ...
Authors:Nolte, R.T.
Deposit date:2016-01-24
Release date:2016-12-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016
5HRR
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HIV INTEGRASE CATALYTIC DOMAIN CONTAINING F185K + A124N + T125S MUTATIONS COMPLEXED WITH GSK0002
Descriptor:Integrase, CACODYLATE ION, SULFATE ION, ...
Authors:Nolte, R.T.
Deposit date:2016-01-24
Release date:2016-12-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016
5HRS
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HIV INTEGRASE CATALYTIC DOMAIN CONTAINING F185K + A124N + T125A MUTATIONS COMPLEXED WITH GSK0002
Descriptor:Integrase, CACODYLATE ION, SULFATE ION, ...
Authors:Nolte, R.T.
Deposit date:2016-01-24
Release date:2016-12-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016
4GLI
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CRYSTAL STRUCTURE OF HUMAN SMN YG-DIMER
Descriptor:Maltose-binding periplasmic protein, Survival motor neuron protein chimera
Authors:Martin, R.S., Perry, K., Van Duyne, G.D.
Deposit date:2012-08-14
Release date:2012-10-17
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:The survival motor neuron protein forms soluble glycine zipper oligomers.
Structure, 20, 2012
2LO9
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NMR SOLUTION STRUCTURE OF MU-CONTOXIN BUIIIB
Descriptor:Mu-conotoxin BuIIIB
Authors:Kuang, Z.
Deposit date:2012-01-20
Release date:2013-01-23
Last modified:2014-02-19
Method:SOLUTION NMR
Cite:Mammalian neuronal sodium channel blocker mu-conotoxin BuIIIB has a structured N-terminus that influences potency.
Acs Chem.Biol., 8, 2013
2LOC
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CONOTOXIN ANALOGUE [D-ALA2]BUIIIB
Descriptor:Mu-conotoxin BuIIIB
Authors:Kuang, Z.
Deposit date:2012-01-21
Release date:2013-01-23
Last modified:2014-02-19
Method:SOLUTION NMR
Cite:Mammalian neuronal sodium channel blocker mu-conotoxin BuIIIB has a structured N-terminus that influences potency.
Acs Chem.Biol., 8, 2013
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