Author results

4U7T
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CRYSTAL STRUCTURE OF DNMT3A-DNMT3L IN COMPLEX WITH HISTONE H3
Descriptor:DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3-like, peptide from Histone H3.3, ...
Authors:Guo, X., Wang, L., Yin, X., Li, J., Xiao, J., He, S., Wang, J., Xu, Y.
Deposit date:2014-07-31
Release date:2014-11-12
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural insight into autoinhibition and histone H3-induced activation of DNMT3A
Nature, 517, 2015
4ADN
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FUSIDIC ACID RESISTANCE PROTEIN FUSB
Descriptor:FAR1, ZINC ION, SODIUM ION, ...
Authors:Guo, X., Peisker, K., Backbro, K., Chen, Y., Kiran, R.K., Sanyal, S., Selmer, M.
Deposit date:2011-12-31
Release date:2012-03-07
Last modified:2012-07-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure and Function of Fusb: An Elongation Factor G-Binding Fusidic Acid Resistance Protein Active in Ribosomal Translocation and Recycling
Open Biol., 2, 2012
4ADO
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FUSIDIC ACID RESISTANCE PROTEIN FUSB
Descriptor:FAR1, ZINC ION
Authors:Guo, X., Peisker, K., Backbro, K., Chen, Y., Kiran, R.K., Sanyal, S., Selmer, M.
Deposit date:2011-12-31
Release date:2012-03-07
Last modified:2012-07-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and Function of Fusb: An Elongation Factor G-Binding Fusidic Acid Resistance Protein Active in Ribosomal Translocation and Recycling
Open Biol., 2, 2012
6FLP
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CRYOEM STRUCTURE OF E.COLI RNA POLYMERASE PAUSED ELONGATION COMPLEX WITHOUT RNA HAIRPIN BOUND TO NUSA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Guo, X., Weixlbaumer, A.
Deposit date:2018-01-26
Release date:2018-03-07
Last modified:2018-03-21
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural Basis for NusA Stabilized Transcriptional Pausing.
Mol. Cell, 69, 2018
6FLQ
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CRYOEM STRUCTURE OF E.COLI RNA POLYMERASE PAUSED ELONGATION COMPLEX BOUND TO NUSA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Guo, X., Weixlbaumer, A.
Deposit date:2018-01-26
Release date:2018-03-21
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural Basis for NusA Stabilized Transcriptional Pausing.
Mol. Cell, 69, 2018
5ABT
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S.ENTERICA HISA MUTANT D7N, G102A, V106M, D176A
Descriptor:1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO) METHYLIDENE AMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE, [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate
Authors:Guo, X., Soderholm, A., Newton, M., Nasvall, J., Andersson, D., Patrick, W., Selmer, M.
Deposit date:2015-08-08
Release date:2016-09-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The Protein Structures, Functions and Dynamics of Adaptive Evolution
To be Published
5G4W
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S. ENTERICA HISA MUTANT D7N, D10G, DUP13-15 (VVR) WITH SUBSTRATE PROFAR
Descriptor:HISA, [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate, GLYCEROL
Authors:Guo, X., Soderholm, A., Newton, M., Nasvall, J., Duarte, F., Andersson, D., Patrick, W., Selmer, M.
Deposit date:2016-05-17
Release date:2017-04-19
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and functional innovations in the real-time evolution of new ( beta alpha )8 barrel enzymes.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4U7P
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CRYSTAL STRUCTURE OF DNMT3A-DNMT3L COMPLEX
Descriptor:DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3-like, ZINC ION, ...
Authors:Wang, L., Guo, X., Li, J., Xiao, J., Yin, X., He, S., Wang, J., Xu, Y.
Deposit date:2014-07-31
Release date:2014-11-12
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (3.821 Å)
Cite:Structural insight into autoinhibition and histone H3-induced activation of DNMT3A
Nature, 517, 2015
5AB3
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S.ENTERICA HISA MUTANT D7N, D10G, DUP13-15, Q24L, G102A
Descriptor:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, [(2R,3S,4R,5R)-5-[4-AMINOCARBONYL-5-[[(Z)-[(3R,4R)-3,4-DIHYDROXY-2-OXO-5-PHOSPHONOOXY-PENTYL]IMINOMETHYL]AMINO]IMIDAZOL-1-YL]-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL DIHYDROGEN PHOSPHATE, SODIUM ION
Authors:Guo, X., Soderholm, A., Newton, M., Nasvall, J., Andersson, D., Patrick, W., Selmer, M.
Deposit date:2015-07-31
Release date:2016-09-28
Last modified:2018-06-06
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Structural and functional innovations in the real-time evolution of new ( beta alpha )8 barrel enzymes.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5AC6
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S.ENTERICA HISA MUTANT D10G, DUP13-15, Q24L, G102A
Descriptor:SULFATE ION
Authors:Guo, X., Soderholm, A., Newton, M., Nasvall, J., Andersson, D., Patrick, W., Selmer, M.
Deposit date:2015-08-12
Release date:2016-09-28
Method:X-RAY DIFFRACTION (1.993 Å)
Cite:The Protein Structures, Functions and Dynamics of Adaptive Evolution
To be Published
5G1T
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S. ENTERICA HISA MUTANT DUP13-15, D10G
Descriptor:PHOSPHATE ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Guo, X., Soderholm, A., Newton, M., Nasvall, J., Andersson, D., Patrick, W., Selmer, M.
Deposit date:2016-03-30
Release date:2017-04-19
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and functional innovations in the real-time evolution of new ( beta alpha )8 barrel enzymes.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5G1Y
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S. ENTERICA HISA MUTANT D10G, DUP13-15,V14:2M, Q24L, G102
Descriptor:SULFATE ION, GLYCEROL
Authors:Guo, X., Soderholm, A., Newton, M., Nasvall, J., Andersson, D., Patrick, W., Selmer, M.
Deposit date:2016-04-01
Release date:2017-04-12
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Structural and functional innovations in the real-time evolution of new ( beta alpha )8 barrel enzymes.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5G2I
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S. ENTERICA HISA MUTANT DUP13-15(VVR)
Descriptor:PHOSPHATE ION, SODIUM ION
Authors:Guo, X., Soderholm, A., Newton, M., Nasvall, J., Duarte, F., Andersson, D., Patrick, W., Selmer, M.
Deposit date:2016-04-08
Release date:2017-04-19
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Structural and functional innovations in the real-time evolution of new ( beta alpha )8 barrel enzymes.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5G2W
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S. ENTERICA HISA MUTANT D10G, G102A
Descriptor:SULFATE ION
Authors:Guo, X., Soderholm, A., Newton, M., Nasvall, J., Andersson, D., Patrick, W., Selmer, M.
Deposit date:2016-04-14
Release date:2017-04-19
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Structural and functional innovations in the real-time evolution of new ( beta alpha )8 barrel enzymes.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5G5I
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S. ENTERICA HISA MUTANT D10G
Descriptor:PHOSPHATE ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Guo, X., Soderholm, A., Newton, M., Nasvall, J., Andersson, D., Patrick, W., Selmer, M.
Deposit date:2016-05-25
Release date:2017-04-19
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structural and functional innovations in the real-time evolution of new ( beta alpha )8 barrel enzymes.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5L6U
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S. ENTERICA HISA MUTANT - D10G, DUP13-15, Q24L, G102A
Descriptor:HisA, SULFATE ION
Authors:Guo, X., Soderholm, A., Selmer, M.
Deposit date:2016-05-31
Release date:2017-04-19
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and functional innovations in the real-time evolution of new ( beta alpha )8 barrel enzymes.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5L9F
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S. ENTERICA HISA MUTANT - D10G, G11D, DUP13-15, G44E, G102A
Descriptor:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, SODIUM ION, SULFATE ION
Authors:Guo, X., Soderholm, A., Selmer, M.
Deposit date:2016-06-10
Release date:2017-04-19
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (2.594 Å)
Cite:Structural and functional innovations in the real-time evolution of new ( beta alpha )8 barrel enzymes.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5A5W
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CRYSTAL STRUCTURE OF SALMONELLA ENTERICA HISA D7N D176A WITH PROFAR
Descriptor:[(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate
Authors:Soderholm, A., Guo, X., Newton, M.S., Evans, G.B., Nasvall, J., Patrick, W.M., Selmer, M.
Deposit date:2015-06-23
Release date:2015-09-02
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Two-Step Ligand Binding in a Beta/Alpha8 Barrel Enzyme -Substrate-Bound Structures Shed New Light on the Catalytic Cycle of Hisa
J.Biol.Chem., 290, 2015
5AHF
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CRYSTAL STRUCTURE OF SALMONELLA ENTERICA HISA D7N WITH PROFAR
Descriptor:[(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate, GLYCEROL
Authors:Soderholm, A., Guo, X., Newton, M.S., Evans, G.B., Nasvall, J., Patrick, W.M., Selmer, M.
Deposit date:2015-02-05
Release date:2015-09-02
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:Two-Step Ligand Binding in a Beta/Alpha8 Barrel Enzyme -Substrate-Bound Structures Shed New Light on the Catalytic Cycle of Hisa
J.Biol.Chem., 290, 2015
5AHI
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CRYSTAL STRUCTURE OF SALMONALLA ENTERICA HISA MUTANT D7N WITH PROFAR
Descriptor:1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO) METHYLIDENE AMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE, GLYCEROL, [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate, ...
Authors:Soderholm, A., Guo, X., Newton, M.S., Evans, G.B., Nasvall, J., Patrick, W.M., Selmer, M.
Deposit date:2015-02-06
Release date:2016-03-02
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Structure and Mechanism of Hisa from Salmonella Enterica
To be Published
5GNS
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STRUCTURES OF HUMAN MITOFUSIN 1 PROVIDE INSIGHT INTO MITOCHONDRIAL TETHERING
Descriptor:Mitofusin-1, GUANOSINE-5'-TRIPHOSPHATE
Authors:Qi, Y., Yan, L., Yu, C., Guo, X., Zhou, X., Hu, X., Huang, X., Rao, Z., Lou, Z., Hu, J.
Deposit date:2016-07-24
Release date:2016-12-07
Method:X-RAY DIFFRACTION (2.702 Å)
Cite:Structures of human Mitofusin 1 provide insight into mitochondrial tethering
To Be Published
4FLA
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CRYSTAL STRUCTURE OF HUMAN RPRD1B, CARBOXY-TERMINAL DOMAIN
Descriptor:Regulation of nuclear pre-mRNA domain-containing protein 1B, UNKNOWN ATOM OR ION
Authors:Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Guo, X., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)
Deposit date:2012-06-14
Release date:2012-08-22
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Nat.Struct.Mol.Biol., 21, 2014
4FLB
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CID OF HUMAN RPRD2
Descriptor:Regulation of nuclear pre-mRNA domain-containing protein 2, SULFATE ION, PRASEODYMIUM ION, ...
Authors:Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Guo, X., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)
Deposit date:2012-06-14
Release date:2012-08-15
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Nat.Struct.Mol.Biol., 21, 2014
4JXT
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CID OF HUMAN RPRD1A IN COMPLEX WITH A PHOSPHORYLATED PEPTIDE FROM RPB1-CTD
Descriptor:Regulation of nuclear pre-mRNA domain-containing protein 1A, DNA-directed RNA polymerase II subunit RPB1, UNKNOWN ATOM OR ION
Authors:Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Guo, X., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)
Deposit date:2013-03-28
Release date:2013-11-13
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Nat.Struct.Mol.Biol., 21, 2014
4Q96
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CID OF HUMAN RPRD1B IN COMPLEX WITH AN UNMODIFIED CTD PEPTIDE
Descriptor:Regulation of nuclear pre-mRNA domain-containing protein 1B, RPB1-CTD, UNKNOWN ATOM OR ION, ...
Authors:Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Guo, X., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)
Deposit date:2014-04-29
Release date:2014-06-04
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Nat.Struct.Mol.Biol., 21, 2014