Author results

6IUT
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS H5 HEMAGGLUTININ GLOBULAR HEAD IN COMPLEX WITH THE FAB OF ANTIBODY AVFLUIGG01
Descriptor:AVFluIgG01 Heavy Chain, AVFluIgG01 Light Chain, Hemagglutinin, ...
Authors:Wang, P., Zuo, Y., Sun, J., Zhang, L., Wang, X.
Deposit date:2018-11-30
Release date:2019-01-16
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1.
J. Biol. Chem., 294, 2019
6IUV
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS H5 HEMAGGLUTININ GLOBULAR HEAD IN COMPLEX WITH THE FAB OF ANTIBODY 3C11
Descriptor:Hemagglutinin, 3C11 Light Chain, 3C11 Heavy Chain, ...
Authors:Wang, P., Zuo, Y., Sun, J., Zhang, L., Wang, X.
Deposit date:2018-11-30
Release date:2019-01-16
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.332 Å)
Cite:Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1.
J. Biol. Chem., 294, 2019
6A67
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS H5 HEMAGGLUTININ GLOBULAR HEAD IN COMPLEX WITH THE FAB OF ANTIBODY FLD21.140
Descriptor:FLD21.140 Heavy Chain, FLD21.140 Light Chain, Hemagglutinin, ...
Authors:Wang, P., Zuo, Y., Sun, J., Zhang, L., Wang, X.
Deposit date:2018-06-26
Release date:2018-08-29
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Complementary recognition of the receptor-binding site of highly pathogenic H5N1 influenza viruses by two human neutralizing antibodies.
J. Biol. Chem., 293, 2018
6DDA
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NURR1 COVALENTLY MODIFIED BY A DOPAMINE METABOLITE
Descriptor:Nuclear receptor subfamily 4 group A member 2, POTASSIUM ION, 5-hydroxy-1,2-dihydro-6H-indol-6-one, ...
Authors:Bruning, J.M., Wang, Y., Otrabella, F., Boxue, T., Liu, H., Bhattacharya, P., Guo, S., Holton, J.M., Fletterick, R.J., Jacobson, M.P., England, P.M.
Deposit date:2018-05-09
Release date:2019-03-20
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite.
Cell Chem Biol, 26, 2019
6FM2
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CARP DOMAIN OF MOUSE CYCLASE-ASSOCIATED PROTEIN 1 (CAP1) BOUND TO ADP-ACTIN
Descriptor:Actin, alpha skeletal muscle, Adenylyl cyclase-associated protein 1, ...
Authors:Kotila, T.M., Kogan, K., Lappalainen, P.
Deposit date:2018-01-30
Release date:2018-05-16
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of actin monomer re-charging by cyclase-associated protein.
Nat Commun, 9, 2018
6F08
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14-3-3 ZETA IN COMPLEX WITH THE HUMAN SON OF SEVENLESS HOMOLOG 1 (SOS1)
Descriptor:14-3-3 protein zeta/delta, Son of sevenless homolog 1, PENTAETHYLENE GLYCOL
Authors:Ballone, A., Centorrino, F., Ottmann, C., Guo, S., Leysen, S.
Deposit date:2017-11-17
Release date:2018-02-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural characterization of 14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1).
J. Struct. Biol., 202, 2018
6F09
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BINARY COMPLEX OF 14-3-3 ZETA WITH UBIQUITIN SPECIFIC PROTEASE 8 (USP8) PSER718 PEPTIDE
Descriptor:14-3-3 protein zeta/delta, Ubiquitin carboxyl-terminal hydrolase 8
Authors:Centorrino, F., Ballone, A., Ottmann, C., Guo, S., Leysen, S.
Deposit date:2017-11-17
Release date:2018-03-07
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.594 Å)
Cite:Biophysical and structural insight into the USP8/14-3-3 interaction.
FEBS Lett., 592, 2018
5K8G
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CRYSTAL STRUCTURE OF A PUTATIVE PEPTIDE-BINDING DOMAIN OF MPAFP
Descriptor:Antifreeze protein, CALCIUM ION
Authors:Guo, S., Campbell, R., Davies, P.
Deposit date:2016-05-30
Release date:2017-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a 1.5-MDa adhesin that binds its Antarctic bacterium to diatoms and ice.
Sci Adv, 3, 2017
5JUH
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CRYSTAL STRUCTURE OF C-TERMINAL DOMAIN (RV) OF MPAFP
Descriptor:Antifreeze protein, CALCIUM ION
Authors:Guo, S.
Deposit date:2016-05-10
Release date:2017-07-19
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure of a 1.5-MDa adhesin that binds its Antarctic bacterium to diatoms and ice.
Sci Adv, 3, 2017
5J6Y
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CRYSTAL STRUCTURE OF PA14 DOMAIN OF MPAFP ANTIFREEZE PROTEIN
Descriptor:Antifreeze protein, CALCIUM ION, ALPHA-D-GLUCOSE, ...
Authors:Guo, S.
Deposit date:2016-04-05
Release date:2017-06-07
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.034 Å)
Cite:Structure of a 1.5-MDa adhesin that binds its Antarctic bacterium to diatoms and ice.
Sci Adv, 3, 2017
5IX9
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CELL SURFACE ANCHORING DOMAIN
Descriptor:Antifreeze protein
Authors:Guo, S., Langelaan, D.
Deposit date:2016-03-23
Release date:2017-06-28
Last modified:2017-09-20
Method:SOLUTION NMR
Cite:Structure of a 1.5-MDa adhesin that binds its Antarctic bacterium to diatoms and ice.
Sci Adv, 3, 2017
5IRB
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STRUCTURAL INSIGHT INTO HOST CELL SURFACE RETENTION OF A 1.5-MDA BACTERIAL ICE-BINDING ADHESIN
Descriptor:RTX-adhesin, CALCIUM ION, MAGNESIUM ION, ...
Authors:Guo, S., Phippen, S., Campbell, R., Davies, P.
Deposit date:2016-03-12
Release date:2017-07-19
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a 1.5-MDa adhesin that binds its Antarctic bacterium to diatoms and ice.
Sci Adv, 3, 2017
5C9C
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CRYSTAL STRUCTURE OF BRAF(V600E) IN COMPLEX WITH LY3009120 COMPND
Descriptor:Serine/threonine-protein kinase B-raf, 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea, CHLORIDE ION
Authors:Edwards, T., Abendroth, J., Chun, L.
Deposit date:2015-06-26
Release date:2015-07-15
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.
Cancer Cell, 28, 2015
4ZRD
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CRYSTAL STRUCTURE OF SMG1 F278N MUTANT
Descriptor:LIP1, secretory lipase (Family 3), N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xu, J., Xu, H., Hou, S., Liu, J.
Deposit date:2015-05-12
Release date:2015-09-23
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of product-bound SMG1 lipase: active site gating implications.
Febs J., 282, 2015
4ZRE
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CRYSTAL STRUCTURE OF SMG1 F278D MUTANT
Descriptor:LIP1, secretory lipase (Family 3), N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xu, J., Xu, H., Hou, S., Liu, J.
Deposit date:2015-05-12
Release date:2015-09-23
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of product-bound SMG1 lipase: active site gating implications.
Febs J., 282, 2015
4PF7
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CRYSTAL STRUCTURE OF INSULIN DEGRADING ENZYME COMPLEXED WITH INHIBITOR
Descriptor:Insulin-degrading enzyme, (2S)-2-amino-N-{(1S)-1-cyclohexyl-2-[(4-methylphenyl)amino]-2-oxoethyl}-4-(methylselanyl)butanamide, ZINC ION
Authors:Wang, Y., Guo, S.
Deposit date:2014-04-28
Release date:2015-06-17
Last modified:2015-08-26
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J.Biol.Chem., 290, 2015
4PF9
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CRYSTAL STRUCTURE OF INSULIN DEGRADING ENZYME COMPLEXED WITH INHIBITOR
Descriptor:Insulin-degrading enzyme, methyl [(2S)-2-[4-({5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}oxy)phenyl]-3-(quinolin-3-yl)propyl]carbamate, ZINC ION
Authors:Wang, Y., Guo, S.
Deposit date:2014-04-28
Release date:2015-06-17
Last modified:2015-08-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J.Biol.Chem., 290, 2015
4PFC
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CRYSTAL STRUCTURE OF INSULIN DEGRADING ENZYME COMPLEXED WITH INHIBITOR
Descriptor:Insulin-degrading enzyme, methyl [(2S)-2-(5-{5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}-2-fluorophenyl)-3-(quinolin-3-yl)propyl]carbamate, ZINC ION
Authors:Wang, Y., Guo, S.
Deposit date:2014-04-28
Release date:2015-06-17
Last modified:2015-08-26
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J.Biol.Chem., 290, 2015
4PES
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CRYSTAL STRUCTURE OF INSULIN DEGRADING ENZYME COMPLEXED WITH INHIBITOR TERT-BUTYL [(2S)-2-(2,5-DIFLUOROPHENYL)-3-(QUINOLIN-3-YL)PROPYL]CARBAMATE
Descriptor:Insulin-degrading enzyme, Ala-Ala-Ala, tert-butyl [(2S)-2-(2,5-difluorophenyl)-3-(quinolin-3-yl)propyl]carbamate, ...
Authors:Wang, Y., Guo, S.
Deposit date:2014-04-24
Release date:2015-06-17
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Crystal structure of IDE complexed with an inhibitor
To Be Published
4Q2J
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A NOVEL STRUCTURE-BASED MECHANISM FOR DNA-BINDING OF SATB1
Descriptor:DNA-binding protein SATB1
Authors:Wang, Z., Long, J., Yang, X., Shen, Y.
Deposit date:2014-04-08
Release date:2015-03-11
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism.
J.Biol.Chem., 289, 2014
4P99
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CA2+-STABILIZED ADHESIN HELPS AN ANTARCTIC BACTERIUM REACH OUT AND BIND ICE
Descriptor:MpAFP_RII tetra-tandemer, CALCIUM ION, 1,2-ETHANEDIOL, ...
Authors:Guo, S., Vance, D.R.T., Campbell, R.L., Davies, P.L.
Deposit date:2014-04-02
Release date:2014-06-18
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ca2+-stabilized adhesin helps an Antarctic bacterium reach out and bind ice.
Biosci.Rep., 34, 2014
4NFE
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HUMAN KALLIKREIN-RELATED PEPTIDASE 2 IN COMPLEX WITH BENZAMIDINE
Descriptor:Kallikrein-2, BENZAMIDINE, SULFATE ION
Authors:Skala, W., Brandstetter, H., Magdolen, V., Goettig, P.
Deposit date:2013-10-31
Release date:2014-10-29
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity
J.Biol.Chem., 289, 2014
4NFF
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HUMAN KALLIKREIN-RELATED PEPTIDASE 2 IN COMPLEX WITH PPACK
Descriptor:Kallikrein-2, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide
Authors:Skala, W., Brandstetter, H., Magdolen, V., Goettig, P.
Deposit date:2013-10-31
Release date:2014-10-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity
J.Biol.Chem., 289, 2014
4KDV
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CRYSTAL STRUCTURE OF A BACTERIAL IMMUNOGLOBULIN-LIKE DOMAIN FROM THE M. PRIMORYENSIS ICE-BINDING ADHESIN
Descriptor:Antifreeze protein, CALCIUM ION
Authors:Guo, S., Garnham, C.P., Karunan, S.P., Campbell, R.L., Allingham, J.S., Davies, P.L.
Deposit date:2013-04-25
Release date:2013-10-02
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Role of Ca(2+) in folding the tandem beta-sandwich extender domains of a bacterial ice-binding adhesin.
Febs J., 280, 2013
4KDW
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CRYSTAL STRUCTURE OF A BACTERIAL IMMUNOGLOBULIN-LIKE DOMAIN FROM THE M. PRIMORYENSIS ICE-BINDING ADHESIN
Descriptor:Antifreeze protein, CALCIUM ION, GLYCEROL
Authors:Guo, S., Garnham, C.P., Karunan, S.P., Campbell, R.L., Allingham, J.S., Davies, P.L.
Deposit date:2013-04-25
Release date:2013-10-02
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Role of Ca(2+) in folding the tandem beta-sandwich extender domains of a bacterial ice-binding adhesin.
Febs J., 280, 2013
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