Author results

6K0X
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STRUCTURE OF N6AMT1-TRMT112 COMPLEX WITH SAM
Descriptor:Methyltransferase N6AMT1, Multifunctional methyltransferase subunit TRM112-like protein, S-ADENOSYLMETHIONINE
Authors:Guo, Q., Liao, S., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2019-05-07
Release date:2019-06-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of HEMK2-TRM112 Complex with SAM
To Be Published
6ICV
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STRUCTURE OF SETD3 BOUND TO SAH AND UNMODIFIED ACTIN
Descriptor:Histone-lysine N-methyltransferase setd3, Actin, cytoplasmic 1, ...
Authors:Guo, Q., Liao, S., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2018-09-07
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural insights into SETD3-mediated histidine methylation on beta-actin.
Elife, 8, 2019
6ICT
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STRUCTURE OF SETD3 BOUND TO SAH AND METHYLATED ACTIN
Descriptor:Histone-lysine N-methyltransferase setd3, Actin, cytoplasmic 1, ...
Authors:Guo, Q., Liao, S., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2018-09-07
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.952 Å)
Cite:Structural insights into SETD3-mediated histidine methylation on beta-actin.
Elife, 8, 2019
6EZ8
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HUMAN HUNTINGTIN-HAP40 COMPLEX STRUCTURE
Descriptor:Huntingtin, Factor VIII intron 22 protein
Authors:Guo, Q., Bin, H., Cheng, J., Pfeifer, G., Baumeister, W., Fernandez-Busnadiego, R., Kochanek, S.
Deposit date:2017-11-14
Release date:2018-02-21
Last modified:2018-03-28
Method:ELECTRON MICROSCOPY (4 Å)
Cite:The cryo-electron microscopy structure of huntingtin.
Nature, 555, 2018
6EPF
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GROUND STATE 26S PROTEASOME (GS1)
Descriptor:3, 6, 12, ...
Authors:Guo, Q., Lehmer, C., Martinez-Sanchez, A., Rudack, T., Beck, F., Hartmann, H., Hipp, M.S., Hartl, F.U., Edbauer, D., Baumeister, W., Fernandez-Busnadiego, R.
Deposit date:2017-10-11
Release date:2018-02-07
Last modified:2018-02-21
Method:ELECTRON MICROSCOPY (11.8 Å)
Cite:In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Cell, 172, 2018
6EPE
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SUBSTRATE PROCESSING STATE 26S PROTEASOME (SPS2)
Descriptor:3, 6, 12, ...
Authors:Guo, Q., Lehmer, C., Martinez-Sanchez, A., Rudack, T., Beck, F., Hartmann, H., Hipp, M.S., Hartl, F.U., Edbauer, D., Baumeister, W., Fernandez-Busnadiego, R.
Deposit date:2017-10-11
Release date:2018-02-07
Last modified:2018-02-21
Method:ELECTRON MICROSCOPY (12.8 Å)
Cite:In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Cell, 172, 2018
6EPD
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SUBSTRATE PROCESSING STATE 26S PROTEASOME (SPS1)
Descriptor:3, 6, 12, ...
Authors:Guo, Q., Lehmer, C., Martinez-Sanchez, A., Rudack, T., Beck, F., Hartmann, H., Hipp, M.S., Hartl, F.U., Edbauer, D., Baumeister, W., Fernandez-Busnadiego, R.
Deposit date:2017-10-11
Release date:2018-02-07
Last modified:2018-02-21
Method:ELECTRON MICROSCOPY (15.4 Å)
Cite:In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Cell, 172, 2018
6EPC
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GROUND STATE 26S PROTEASOME (GS2)
Descriptor:3, 6, 12, ...
Authors:Guo, Q., Lehmer, C., Martinez-Sanchez, A., Rudack, T., Beck, F., Hartmann, H., Hipp, M.S., Hartl, F.U., Edbauer, D., Baumeister, W., Fernandez-Busnadiego, R.
Deposit date:2017-10-11
Release date:2018-02-07
Last modified:2018-02-21
Method:ELECTRON MICROSCOPY (12.3 Å)
Cite:In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Cell, 172, 2018
6D4C
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CRYSTAL STRUCTURE OF CANDIDA BOIDINII FORMATE DEHYDROGENASE V123G MUTANT COMPLEXED WITH NAD+ AND AZIDE
Descriptor:Formate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, AZIDE ION, ...
Authors:Guo, Q., Ye, H., Gakhar, L., Cheatum, C.M., Kohen, A.
Deposit date:2018-04-17
Release date:2019-04-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of Candida boidinii formate dehydrogenase V123G mutant complexed with NAD+ and azide
To Be Published
6D4B
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CRYSTAL STRUCTURE OF CANDIDA BOIDINII FORMATE DEHYDROGENASE V123A MUTANT COMPLEXED WITH NAD+ AND AZIDE
Descriptor:Formate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, AZIDE ION, ...
Authors:Guo, Q., Ye, H., Gakhar, L., Cheatum, C.M., Kohen, A.
Deposit date:2018-04-17
Release date:2019-04-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of Candida boidinii formate dehydrogenase V123A mutant complexed with NAD+ and azide
To Be Published
5YBV
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THE STRUCTURE OF THE KANK2 ANKYRIN DOMAIN WITH THE KIF21A PEPTIDE
Descriptor:KN motif and ankyrin repeat domain-containing protein 2, Kinesin-like protein KIF21A, SULFATE ION, ...
Authors:Guo, Q., Liao, S., Min, J., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2017-09-05
Release date:2017-12-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins.
J. Biol. Chem., 293, 2018
5YBU
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STRUCTURE OF THE KANK1 ANKYRIN DOMAIN IN COMPLEX WITH KIF21A PEPTIDE
Descriptor:KN motif and ankyrin repeat domain-containing protein 1, Kinesin-like protein KIF21A
Authors:Guo, Q., Liao, S., Min, J., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2017-09-05
Release date:2017-12-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins.
J. Biol. Chem., 293, 2018
5YBJ
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STRUCTURE OF APO KANK1 ANKYRIN DOMAIN
Descriptor:KN motif and ankyrin repeat domain-containing protein 1, GLYCEROL
Authors:Guo, Q., Liao, S., Min, J., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2017-09-05
Release date:2017-12-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.341 Å)
Cite:Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins.
J. Biol. Chem., 293, 2018
5XYI
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SMALL SUBUNIT OF TRICHOMONAS VAGINALIS RIBOSOME
Descriptor:18S, 40S ribosomal protein SA, Ribosomal protein S3Ae, ...
Authors:Li, Z., Guo, Q., Zheng, L., Ji, Y., Xie, Y., Lai, D., Lun, Z., Suo, X., Gao, N.
Deposit date:2017-07-08
Release date:2017-08-30
Last modified:2017-10-18
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Cell Res., 27, 2017
5XY3
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LARGE SUBUNIT OF TRICHOMONAS VAGINALIS RIBOSOME
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Li, Z., Guo, Q., Zheng, L., Ji, Y., Xie, Y., Lai, D., Lun, Z., Suo, X., Gao, N.
Deposit date:2017-07-06
Release date:2017-08-30
Last modified:2017-10-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Cell Res., 27, 2017
5XXU
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SMALL SUBUNIT OF TOXOPLASMA GONDII RIBOSOME
Descriptor:18S RNA, Ribosomal protein uS2, Ribosomal protein eS1, ...
Authors:LI, Z., Guo, Q., Zheng, L., Ji, Y., Xie, Y., Lai, D., Lun, Z., Suo, X., Gao, N.
Deposit date:2017-07-05
Release date:2017-08-30
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Cell Res., 27, 2017
5XXB
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LARGE SUBUNIT OF TOXOPLASMA GONDII RIBOSOME
Descriptor:25S RNA, 5S RNA, 5.8S RNA, ...
Authors:Li, Z., Guo, Q., Zheng, L., Ji, Y., Xie, Y., Lai, D., Lun, Z., Suo, X., Gao, N.
Deposit date:2017-07-03
Release date:2017-08-30
Last modified:2017-10-18
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Cell Res., 27, 2017
5DNA
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CRYSTAL STRUCTURE OF CANDIDA BOIDINII FORMATE DEHYDROGENASE
Descriptor:FORMATE DEHYDROGENASE, SULFATE ION
Authors:Guo, Q., Gakhar, L., Wichersham, K., Francis, K., Vardi-Kilshtain, A., Major, D.T., Cheatum, C.M., Kohen, A.
Deposit date:2015-09-09
Release date:2016-05-04
Last modified:2016-05-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural and Kinetic Studies of Formate Dehydrogenase from Candida boidinii.
Biochemistry, 55, 2016
5DN9
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CRYSTAL STRUCTURE OF CANDIDA BOIDINII FORMATE DEHYDROGENASE COMPLEXED WITH NAD+ AND AZIDE
Descriptor:FDH, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, AZIDE ION, ...
Authors:Guo, Q., Gakhar, L., Wichersham, K., Francis, K., Vardi-Kilshtain, A., Major, D.T., Cheatum, C.M., Kohen, A.
Deposit date:2015-09-09
Release date:2016-05-04
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Kinetic Studies of Formate Dehydrogenase from Candida boidinii.
Biochemistry, 55, 2016
4RAL
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CRYSTAL STRUCTURE OF INSULIN DEGRADING ENZYME IN COMPLEX WITH MACROPHAGE INFLAMMATORY PROTEIN 1 BETA
Descriptor:Insulin-degrading enzyme, C-C motif chemokine 4, ZINC ION
Authors:Liang, W.G., Ren, M., Guo, Q., Tang, W.J.
Deposit date:2014-09-10
Release date:2015-05-13
Method:X-RAY DIFFRACTION (3.148 Å)
Cite:Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
4RA8
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STRUCTURE ANALYSIS OF THE MIP1A P8A MUTANT
Descriptor:C-C motif chemokine 3
Authors:Liang, W.G., Ren, M., Guo, Q., Tang, W.J.
Deposit date:2014-09-09
Release date:2014-09-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
4QIA
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH INHIBITOR N-BENZYL-N-(CARBOXYMETHYL)GLYCYL-L-HISTIDINE
Descriptor:Insulin-degrading enzyme, N-benzyl-N-(carboxymethyl)glycyl-L-histidine, ZINC ION
Authors:Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
Deposit date:2014-05-30
Release date:2015-05-13
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (3.202 Å)
Cite:Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.
Eur.J.Med.Chem., 90, 2015
4KR1
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CRYSTAL STRUCTURE OF THE KINETECHORE PROTEIN IML3 FROM BUDDING YEAST
Descriptor:Central kinetochore subunit IML3
Authors:Tao, Y., Guo, Q., Teng, M.
Deposit date:2013-05-16
Release date:2013-12-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into the role of the Chl4-Iml3 complex in kinetochore assembly
Acta Crystallogr.,Sect.D, 69, 2013
4IFH
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH COMPOUND BDM44619
Descriptor:Insulin-degrading enzyme, ZINC ION, N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)-4-methylbenzamide
Authors:Liang, W.G., Guo, Q., Deprez, R., Deprez, B., Tang, W.
Deposit date:2012-12-14
Release date:2013-12-18
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (3.286 Å)
Cite:Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015
4GSF
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THE STRUCTURE ANALYSIS OF CYSTEINE FREE INSULIN DEGRADING ENZYME (IDE) WITH (S)-2-{2-[CARBOXYMETHYL-(3-PHENYL-PROPIONYL)-AMINO]-ACETYLAMINO}-3-(3H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER
Descriptor:Insulin-degrading enzyme, methyl N-(carboxymethyl)-N-(3-phenylpropanoyl)glycyl-D-histidinate, ZINC ION
Authors:Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
Deposit date:2012-08-27
Release date:2013-08-28
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.
Eur.J.Med.Chem., 90, 2015