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2H8N
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STRUCTURE OF A GLUTAMINE-RICH DOMAIN FROM HISTONE DEACETYLASE 4
分子名称:Histone deacetylase 4
著者Guo, L., Han, A., Bates, D.L., Chen, L.
登録日2006-06-07
公開日2007-02-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of a conserved N-terminal domain of histone deacetylase 4 reveals functional insights into glutamine-rich domains.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2O94
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THE 97H/F MUTANT STRUCTURE OF A GLUTAMINE-RICH DOMAIN FROM HISTONE DEACETYLASE 4
分子名称:Histone deacetylase 4
著者Guo, L., Han, A., Bates, D.L., Chen, L.
登録日2006-12-13
公開日2007-02-27
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of a conserved N-terminal domain of histone deacetylase 4 reveals functional insights into glutamine-rich domains.
Proc.Natl.Acad.Sci.Usa, 104, 2007
5YY8
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CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN NS1-BP
分子名称:Influenza virus NS1A-binding protein
著者Guo, L., Liu, Y., Liang, H.
登録日2017-12-08
公開日2018-03-14
実験手法X-RAY DIFFRACTION (1.979 Å)
主引用文献Crystal structure of the Kelch domain of human NS1-binding protein at 1.98 angstrom resolution.
Acta Crystallogr F Struct Biol Commun, 74, 2018
2JTM
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SOLUTION STRUCTURE OF SSO6901 FROM SULFOLOBUS SOLFATARICUS P2
分子名称:Putative uncharacterized protein
著者Feng, Y., Guo, L., Huang, L., Wang, J.
登録日2007-08-03
公開日2008-04-29
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Biochemical and structural characterization of Cren7, a novel chromatin protein conserved among Crenarchaea
Nucleic Acids Res., 36, 2008
5GT7
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CRYSTAL STRUCTURE OF ARG-BOUND CASTOR1
分子名称:GATS-like protein 3, ARGININE, MALONATE ION
著者Guo, L., Deng, D.
登録日2016-08-18
公開日2017-08-23
最終更新日2019-03-13
実験手法X-RAY DIFFRACTION (2.048 Å)
主引用文献Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states
Biochem. Biophys. Res. Commun., 508, 2019
5GT8
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CRYSTAL STRUCTURE OF APO-CASTOR1
分子名称:GATS-like protein 3
著者Guo, L., Deng, D.
登録日2016-08-18
公開日2017-08-23
最終更新日2019-03-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states
Biochem. Biophys. Res. Commun., 508, 2019
6JBT
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COMPLEX STRUCTURE OF TORIPALIMAB-FAB AND PD-1
分子名称:Programmed cell death protein 1, Heavy chain, Light chain, ...
著者Guo, L., Tan, S., Chai, Y., Qi, J., Gao, G.F., Yan, J.
登録日2019-01-26
公開日2019-06-19
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy.
Mabs, 11, 2019
2AS5
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STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT AND FOXP2 BOUND SPECIFICALLY TO DNA.
分子名称:5'-D(TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*GP*)-3', 5'-D(AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*TP*)-3', Nuclear factor of activated T-cells, ...
著者Wu, Y., Stroud, J.C., Borde, M., Bates, D.L., Guo, L., Han, A., Rao, A., Chen, L.
登録日2005-08-22
公開日2006-08-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT.
Cell(Cambridge,Mass.), 126, 2006
3DFV
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ADJACENT GATA DNA BINDING
分子名称:DNA (5'-D(*DTP*DTP*DCP*DTP*DGP*DAP*DTP*DAP*DAP*DGP*DAP*DCP*DTP*DTP*DAP*DTP*DCP*DTP*DGP*DC)-3'), DNA (5'-D(*DAP*DAP*DGP*DCP*DAP*DGP*DAP*DTP*DAP*DAP*DGP*DTP*DCP*DTP*DTP*DAP*DTP*DCP*DAP*DG)-3'), Trans-acting T-cell-specific transcription factor GATA-3, ...
著者Bates, D.L., Kim, G.K., Guo, L., Chen, L.
登録日2008-06-12
公開日2008-07-29
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA.
J.Mol.Biol., 381, 2008
3DFX
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OPPOSITE GATA DNA BINDING
分子名称:DNA (5'-D(*DTP*DTP*DGP*DAP*DTP*DAP*DAP*DAP*DTP*DCP*DAP*DGP*DAP*DGP*DAP*DTP*DAP*DAP*DCP*DC)-3'), DNA (5'-D(*DAP*DAP*DGP*DGP*DTP*DTP*DAP*DTP*DCP*DTP*DCP*DTP*DGP*DAP*DTP*DTP*DTP*DAP*DTP*DC)-3'), Trans-acting T-cell-specific transcription factor GATA-3, ...
著者Bates, D.L., Kim, G.K., Guo, L., Chen, L.
登録日2008-06-12
公開日2008-07-29
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA.
J.Mol.Biol., 381, 2008
3J9B
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ELECTRON CRYO-MICROSCOPY OF AN RNA POLYMERASE
分子名称:Polymerase, RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 2, ...
著者Chang, S.H., Sun, D.P., Liang, H.H., Wang, J., Li, J., Guo, L., Wang, X.L., Guan, C.C., Boruah, B.M., Yuan, L.M., Feng, F., Yang, M.R., Wojdyla, J., Wang, J.W., Wang, M.T., Wang, H.W., Liu, Y.F.
登録日2014-12-16
公開日2015-02-18
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 angstrom Resolution.
Mol.Cell, 2015
3LWH
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CRYSTAL STRUCTURE OF CREN7-DSDNA COMPLEX
分子名称:Chromatin protein Cren7, DNA (5'-D(*GP*TP*AP*AP*TP*TP*AP*C)-3')
著者Zhang, Z.F., Gong, Y., Guo, L., Jiang, T., Huang, L.
登録日2010-02-23
公開日2010-05-26
最終更新日2014-03-05
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural insights into the interaction of the crenarchaeal chromatin protein Cren7 with DNA
Mol.Microbiol., 76, 2010
3LWI
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CRYSTAL STRUCTURE OF CREN7-DSDNA COMPLEX
分子名称:Chromatin protein Cren7, DNA (5'-D(*GP*CP*GP*AP*TP*CP*GP*C)-3')
著者Zhang, Z.F., Gong, Y., Guo, L., Jiang, T., Huang, L.
登録日2010-02-23
公開日2010-05-26
最終更新日2014-03-05
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural insights into the interaction of the crenarchaeal chromatin protein Cren7 with DNA
Mol.Microbiol., 76, 2010
3TLQ
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CRYSTAL STRUCTURE OF EAL-LIKE DOMAIN PROTEIN YDIV
分子名称:Regulatory protein YdiV, PHOSPHATE ION, GLYCEROL
著者Li, B., Li, N., Wang, F., Guo, L., Liu, C., Zhu, D., Xu, S., Gu, L.
登録日2011-08-30
公開日2012-09-12
最終更新日2013-07-03
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Structural insight of a concentration-dependent mechanism by which YdiV inhibits Escherichia coli flagellum biogenesis and motility
Nucleic Acids Res., 40, 2012
5EGM
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DEVELOPMENT OF A NOVEL TRICYCLIC CLASS OF POTENT AND SELECTIVE FIXA INHIBITORS
分子名称:Coagulation factor IX, SODIUM ION, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ...
著者Meng, D., Andre, P., Bateman, T.J., Berger, R., Chen, Y., Desai, K., Dewnani, S., Ellsworth, K., Feng, D., Geissler, W.M., Guo, L., Hruza, A., Jian, T., Li, H., Parker, D.L., Reichert, P., Sherer, E.C., Smith, C.J., Sonatore, L.M., Tschirret-Guth, R., Wu, J., Xu, J., Zhang, T., Campeau, L., Orr, R., Poirier, M., McCabe-Dunn, j., Araki, K., Nishimura, T., Sakurada, I., Hirabayashi, T., Wood, H.B.
登録日2015-10-27
公開日2015-11-18
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.841 Å)
主引用文献Development of a novel tricyclic class of potent and selective FIXa inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
2AKE
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STRUCTURE OF HUMAN TRYPTOPHANYL-TRNA SYNTHETASE IN COMPLEX WITH TRNA(TRP)
分子名称:transfer RNA-Trp, Tryptophanyl-tRNA synthetase, SULFATE ION, ...
著者Shen, N., Guo, L., Yang, B., Jin, Y., Ding, J.
登録日2005-08-03
公開日2006-07-11
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of human tryptophanyl-tRNA synthetase in complex with tRNA(Trp) reveals the molecular basis of tRNA recognition and specificity
Nucleic Acids Res., 34, 2006
2DR2
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STRUCTURE OF HUMAN TRYPTOPHANYL-TRNA SYNTHETASE IN COMPLEX WITH TRNA(TRP)
分子名称:transfer RNA-Trp, Tryptophanyl-tRNA synthetase, SULFATE ION, ...
著者Shen, N., Guo, L., Yang, B., Jin, Y., Ding, J.
登録日2006-06-05
公開日2006-07-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of human tryptophanyl-tRNA synthetase in complex with tRNA(Trp) reveals the molecular basis of tRNA recognition and specificity
Nucleic Acids Res., 34, 2006
3M0E
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CRYSTAL STRUCTURE OF THE ATP-BOUND STATE OF WALKER B MUTANT OF NTRC1 ATPASE DOMAIN
分子名称:Transcriptional regulator (NtrC family), ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
著者Chen, B., Sysoeva, T.A., Chowdhury, S., Rusu, M., Birmanns, S., Guo, L., Hanson, J., Yang, H., Nixon, B.T.
登録日2010-03-02
公開日2010-11-03
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Engagement of Arginine Finger to ATP Triggers Large Conformational Changes in NtrC1 AAA+ ATPase for Remodeling Bacterial RNA Polymerase.
Structure, 18, 2010
3ODO
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CRYSTAL STRUCTURE OF THE DH/PH DOMAINS OF P115-RHOGEF
分子名称:Rho guanine nucleotide exchange factor 1
著者Chen, Z., Guo, L., Sprang, S.R., Sternweis, P.C.
登録日2010-08-11
公開日2011-01-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Protein Sci., 20, 2011
3ODW
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CRYSTAL STRUCTURE OF THE LINKER-DH/PH DOMAINS OF P115-RHOGEF
分子名称:Rho guanine nucleotide exchange factor 1
著者Chen, Z., Guo, L., Sprang, S.R., Sternweis, P.C.
登録日2010-08-11
公開日2011-01-05
最終更新日2014-02-19
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Protein Sci., 20, 2011
3ODX
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CRYSTAL STRUCTURE OF AN N-TERMINALLY TRUNCATED LINKER-DH/PH DOMAINS OF P115-RHOGEF
分子名称:Rho guanine nucleotide exchange factor 1
著者Chen, Z., Guo, L., Sprang, S.R., Sternweis, P.C.
登録日2010-08-12
公開日2011-01-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Protein Sci., 20, 2011
3P6A
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CRYSTAL STRUCTURE OF THE DH/PH DOMAINS OF P115-RHOGEF (R399E MUTANT)
分子名称:Rho guanine nucleotide exchange factor 1
著者Chen, Z., Guo, L., Sprang, S.R., Sternweis, P.C.
登録日2010-10-11
公開日2011-01-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Protein Sci., 20, 2011
3QZQ
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HUMAN ENTEROVIRUS 71 3C PROTEASE MUTANT E71D IN COMPLEX WITH RUPINTRIVIR
分子名称:3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER
著者Wang, J., Fan, T., Yao, X., Wu, Z., Guo, L., Lei, X., Wang, J., Wang, M., Jin, Q., Cui, S.
登録日2011-03-07
公開日2011-08-10
最終更新日2015-05-06
実験手法X-RAY DIFFRACTION (1.7001 Å)
主引用文献Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues.
J.Virol., 85, 2011
3QZR
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HUMAN ENTEROVIRUS 71 3C PROTEASE MUTANT E71A IN COMPLEX WITH RUPINTRIVIR
分子名称:3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER, 1,2-ETHANEDIOL
著者Wang, J., Fan, T., Yao, X., Wu, Z., Guo, L., Lei, X., Wang, J., Wang, M., Jin, Q., Cui, S.
登録日2011-03-07
公開日2011-08-10
最終更新日2015-05-06
実験手法X-RAY DIFFRACTION (1.039 Å)
主引用文献Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues.
J.Virol., 85, 2011
3R0F
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HUMAN ENTEROVIRUS 71 3C PROTEASE MUTANT H133G IN COMPLEX WITH RUPINTRIVIR
分子名称:3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER, 1,2-ETHANEDIOL
著者Wang, J., Fan, T., Yao, X., Wu, Z., Guo, L., Lei, X., Wang, J., Wang, M., Jin, Q., Cui, S.
登録日2011-03-08
公開日2011-08-10
最終更新日2015-05-06
実験手法X-RAY DIFFRACTION (1.3083 Å)
主引用文献Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues.
J.Virol., 85, 2011
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