1ZSX | | CRYSTAL STRUCTURE OF HUMAN POTASSIUM CHANNEL KV BETA-SUBUNIT (KCNAB2) | | Descriptor: | Voltage-gated potassium channel beta-2 subunit, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Wennerstrand, P., Johannsson, I., Ugochukwu, E., Kavanagh, K., Edwards, A., Arrowsmith, C., Williams, L., Sundstrom, M., Guo, K., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-05-25 | | Release date: | 2005-06-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal Structure Of Human Potassium Channel Kv Beta-subunit (KCNAB2)
To be Published
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2FVL | | CRYSTAL STRUCTURE OF HUMAN 3-ALPHA HYDROXYSTEROID/DIHYDRODIOL DEHYDROGENASE (AKR1C4) COMPLEXED WITH NADP+ | | Descriptor: | Aldo-keto reductase family 1, member C4, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Ugochukwu, E., Smee, C., Guo, K., Lukacik, P., Kavanagh, K., Debreczeni, J.E., von Delft, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2006-01-31 | | Release date: | 2006-02-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of human 3-alpha hydroxysteroid/dihydrodiol dehydrogenase (AKR1C4) complexed with NADP+
To be Published
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2H63 | | CRYSTAL STRUCTURE OF HUMAN BILIVERDIN REDUCTASE A | | Descriptor: | Biliverdin reductase A, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Kavanagh, K., Elkins, J., Ugochukwu, E., Guo, K., Pilka, E., Lukacik, P., Smee, C., Papagrigoriou, E., Bunkoczi, G., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2006-05-30 | | Release date: | 2006-07-04 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal Structure of Human Biliverdin Reductase A
To be Published
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2IZZ | | CRYSTAL STRUCTURE OF HUMAN PYRROLINE-5-CARBOXYLATE REDUCTASE | | Descriptor: | PYRROLINE-5-CARBOXYLATE REDUCTASE 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1,2-ETHANEDIOL | | Authors: | Pike, A.C.W., Guo, K., Kavanagh, K., Pilka, E.S., Berridge, G., Colebrook, S., Bray, J., Salah, E., Savitsky, P., Papagrigoriou, E., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U. | | Deposit date: | 2006-07-31 | | Release date: | 2006-08-01 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal Structure of Human Pyrroline-5-Carboxylate Reductase
To be Published
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3K1Z | | CRYSTAL STRUCTURE OF HUMAN HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN CONTAINING 3 (HDHD3) | | Descriptor: | Haloacid dehalogenase-like hydrolase domain-containing protein 3, 1,2-ETHANEDIOL, GLYCEROL | | Authors: | Ugochukwu, E., Guo, K., Yue, W.W., Pilka, E., Picaud, S., Muniz, J., Pike, A.C.W., Krojer, T., Gomes, M., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Kavanagh, K., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2009-09-29 | | Release date: | 2009-11-03 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal Structure of Human Haloacid Dehalogenase-like Hydrolase Domain containing 3 (HDHD3)
To be Published
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3OOY | | CRYSTAL STRUCTURE OF HUMAN TRANSKETOLASE (TKT) | | Descriptor: | Transketolase, THIAMIN DIPHOSPHATE, CALCIUM ION, ... | | Authors: | Krojer, T., Krysztofinska, E., Guo, K., Pilka, E., Kochan, G., Chaikuad, A., Vollmar, M., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Kavanagh, K., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2010-08-31 | | Release date: | 2010-11-17 | | Last modified: | 2014-02-19 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystal structure of human Transketolase (TKT)
To be Published
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2GDZ | | CRYSTAL STRUCTURE OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE TYPE1, COMPLEXED WITH NAD+ | | Descriptor: | NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Pilka, E.S., Guo, K., Kavanagh, K., Von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2006-03-17 | | Release date: | 2006-04-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | High-Affinity Inhibitors of Human NAD-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships.
Plos One, 5, 2010
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1XWS | | CRYSTAL STRUCTURE OF THE HUMAN PIM1 KINASE DOMAIN | | Descriptor: | Proto-oncogene serine/threonine-protein kinase Pim-1, SULFATE ION, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE | | Authors: | Knapp, S., Debreczeni, J., Bullock, A., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Guo, K. | | Deposit date: | 2004-11-02 | | Release date: | 2004-11-16 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of human PIM1 kinase domain
To be Published
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1YQ7 | | HUMAN FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH RISEDRONATE | | Descriptor: | Farnesyl pyrophosphate synthetase, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Kavanagh, K.L., Guo, K., Von delft, F., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-02-01 | | Release date: | 2005-02-22 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Human farnesyl diphosphate complexed with clinical inhibitor risedronate
To be Published
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1YV5 | | HUMAN FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH MG AND RISEDRONATE | | Descriptor: | Farnesyl pyrophosphate synthetase, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Kavanagh, K.L., Guo, K., Von Delft, F., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-02-15 | | Release date: | 2005-03-01 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
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1Z57 | | CRYSTAL STRUCTURE OF HUMAN CLK1 IN COMPLEX WITH 10Z-HYMENIALDISINE | | Descriptor: | Dual specificity protein kinase CLK1, DEBROMOHYMENIALDISINE | | Authors: | Debreczeni, J., Das, S., Knapp, S., Bullock, A., Guo, K., Amos, A., Fedorov, O., Edwards, A., Sundstrom, M., von Delft, F., Niesen, F.H., Ball, L., Sobott, F., Arrowsmith, C., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-03-17 | | Release date: | 2005-04-12 | | Last modified: | 2012-08-29 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.
Structure, 17, 2009
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1ZSV | | CRYSTAL STRUCTURE OF HUMAN NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE | | Descriptor: | NADP-dependent leukotriene B4 12-hydroxydehydrogenase, CHLORIDE ION | | Authors: | Turnbull, A.P., Johansson, C., Savitsky, P., Guo, K., Edwards, A., Arrowsmith, C., Sundstrom, M., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-05-25 | | Release date: | 2005-06-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of human NADP-dependent leukotriene B4 12-hydroxydehydrogenase
To be Published
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1ZW5 | | X-RAY STRUCTURE OF FARNESYL DIPHOSPHATE SYNTHASE PROTEIN | | Descriptor: | farnesyl diphosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... | | Authors: | Kavanagh, K.L., Guo, K., Wu, X., von Delft, F., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-06-03 | | Release date: | 2005-06-28 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
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2BIK | | HUMAN PIM1 PHOSPHORYLATED ON SER261 | | Descriptor: | PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, CHLORIDE ION | | Authors: | Knapp, S., Debreczeni, J., Bullock, A., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Guo, K. | | Deposit date: | 2005-01-22 | | Release date: | 2005-02-07 | | Last modified: | 2019-10-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Human Pim1 Phosphorylated on Ser261
To be Published
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2BIL | | THE HUMAN PROTEIN KINASE PIM1 IN COMPLEX WITH ITS CONSENSUS PEPTIDE PIMTIDE | | Descriptor: | CONSENSUS PIM1 PEPTIDE PIMTIDE, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE | | Authors: | Knapp, S., Debreczeni, J., Bullock, A., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Guo, K. | | Deposit date: | 2005-01-22 | | Release date: | 2005-02-07 | | Last modified: | 2019-10-23 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | The Human Protein Kinase Pim1 in Complex with its Consensus Peptide Pimtide
To be Published
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2C0C | | STRUCTURE OF THE MGC45594 GENE PRODUCT | | Descriptor: | ZINC BINDING ALCOHOL DEHYDROGENASE, DOMAIN CONTAINING 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Bunkoczi, G., Shafqat, N., Guo, K., Smee, C., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Gileadi, O., von Delft, F., Oppermann, U. | | Deposit date: | 2005-08-30 | | Release date: | 2005-09-12 | | Last modified: | 2018-02-28 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | The Structure of Mgc45594 Gene Product
To be Published
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2F6Q | | THE CRYSTAL STRUCTURE OF HUMAN PEROXISOMAL DELTA3, DELTA2 ENOYL COA ISOMERASE (PECI) | | Descriptor: | Peroxisomal 3,2-trans-enoyl-CoA isomerase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | | Authors: | Turnbull, A., Lukacik, P., Shafqat, N., Smee, C., Berridge, G., Guo, K., von Delft, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Gileadi, O., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-11-29 | | Release date: | 2005-12-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)
To be Published
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2M27 | | MAJOR G-QUADRUPLEX STRUCTURE FORMED IN HUMAN VEGF PROMOTER, A MONOMERIC PARALLEL-STRANDED QUADRUPLEX | | Descriptor: | DNA_(5'-D(*CP*GP*GP*GP*GP*CP*GP*GP*GP*CP*CP*TP*TP*GP*GP*GP*CP*GP*GP*GP*GP*T)-3')_ | | Authors: | Agrawal, P., Hatzakis, E., Guo, K., Carver, M., Yang, D. | | Deposit date: | 2012-12-14 | | Release date: | 2013-09-18 | | Last modified: | 2014-09-17 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes.
Nucleic Acids Res., 41, 2013
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2OME | | CRYSTAL STRUCTURE OF HUMAN CTBP2 DEHYDROGENASE COMPLEXED WITH NAD(H) | | Descriptor: | C-terminal-binding protein 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Pilka, E.S., Guo, K., Rojkova, A., Debreczeni, J.E., Kavanagh, K.L., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-01-22 | | Release date: | 2007-02-06 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)
To be Published
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2PD6 | | STRUCTURE OF HUMAN HYDROXYSTEROID DEHYDROGENASE TYPE 8, HSD17B8 | | Descriptor: | Estradiol 17-beta-dehydrogenase 8, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Turnbull, A.P., Salah, E., Gileadi, O., Savitsky, P., Guo, K., Bunkoczi, G., Pike, A.C.W., Ugochukwu, E., Umeano, C., von Delft, F., Weigelt, J., Arrowsmith, C.H., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-03-31 | | Release date: | 2007-05-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of human hydroxysteroid dehydrogenase type 8, HSD17B8
To be Published
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2R37 | | CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE PEROXIDASE 3 (SELENOCYSTEINE TO GLYCINE MUTANT) | | Descriptor: | Glutathione peroxidase 3, CHLORIDE ION, SODIUM ION | | Authors: | Pilka, E.S., Guo, K., Gileadi, O., Rojkowa, A., von Delft, F., Pike, A.C.W., Kavanagh, K.L., Johannson, C., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-08-29 | | Release date: | 2007-09-11 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal structure of human glutathione peroxidase 3 (selenocysteine to glycine mutant).
TO BE PUBLISHED
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2VN8 | | CRYSTAL STRUCTURE OF HUMAN RETICULON 4 INTERACTING PROTEIN 1 IN COMPLEX WITH NADPH | | Descriptor: | RETICULON-4-INTERACTING PROTEIN 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SODIUM ION, ... | | Authors: | Pike, A.C.W., Guo, K., Elkins, J., Ugochukwu, E., Roos, A.K., Filippakopoulos, P., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Oppermann, U. | | Deposit date: | 2008-01-31 | | Release date: | 2008-03-18 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of Human Reticulon 4 Interacting Protein 1 in Complex with Nadph
To be Published
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2VRE | | CRYSTAL STRUCTURE OF HUMAN PEROXISOMAL DELTA3,5,DELTA2,4-DIENOYL COA ISOMERASE | | Descriptor: | DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, CHLORIDE ION | | Authors: | Yue, W., Guo, K., von Delft, F., Pilka, E., Murray, J., Roos, A., Kochan, G., Bountra, C., Arrowsmith, C., Wikstrom, M., Edwards, A., Oppermann, U. | | Deposit date: | 2008-03-31 | | Release date: | 2008-04-15 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal Structure of Human Peroxisomal Delta3,5, Delta2,4-Dienoyl Coa Isomerase (Ech1)
To be Published
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2VWR | | CRYSTAL STRUCTURE OF THE SECOND PDZ DOMAIN OF NUMB-BINDING PROTEIN 2 | | Descriptor: | LIGAND OF NUMB PROTEIN X 2 | | Authors: | Roos, A.K., Guo, K., Burgess-Brown, N., Yue, W.W., Elkins, J.M., Pike, A.C.W., Filippakopoulos, P., Arrowsmith, C.H., Wikstom, M., Edwards, A., von Delft, F., Bountra, C., Doyle, D., Oppermann, U. | | Deposit date: | 2008-06-26 | | Release date: | 2008-09-16 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Crystal Structure of the Second Pdz Domain of the Human Numb-Binding Protein 2
To be Published
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2VX2 | | CRYSTAL STRUCTURE OF HUMAN ENOYL COENZYME A HYDRATASE DOMAIN- CONTAINING PROTEIN 3 (ECHDC3) | | Descriptor: | ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3 | | Authors: | Yue, W.W., Guo, K., Kochan, G., Pilka, E., Murray, J.W., Salah, E., Cocking, R., Sun, Z., Roos, A.K., Pike, A.C.W., Filippakopoulos, P., Arrowsmith, C., Wikstrom, M., Edwards, A., Bountra, C., Oppermann, U. | | Deposit date: | 2008-06-30 | | Release date: | 2008-10-14 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of Human Enoyl Coenzyme a Hydratase Domain-Containing Protein 3 (Echdc3)
To be Published
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