Author results

6CNH
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HUMAN PRPF4B IN COMPLEX WITH REBASTINIB
Descriptor:Serine/threonine-protein kinase PRP4 homolog, 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, SULFATE ION
Authors:Godoi, P.H.C., Santiago, A.S., Ramos, P.Z., Fala, A.M., Salmazo, A.P.T., Counago, R.M., Righetto, G.L., Silva, P.N.B., Gileadi, O., Guimaraes, C.R.W., Massirer, K.B., Arruda, P., Elkins, J.M., Edwards, A.M., Structural Genomics Consortium (SGC)
Deposit date:2018-03-08
Release date:2018-03-28
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the human PRPF4B in complex with Rebastinib
To be Published
6PCW
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HUMAN PIM1 BOUND TO BENZOTHIOPHENE INHIBITOR 213
Descriptor:Serine/threonine-protein kinase pim-1, Peptide, 4-[5-(cyclopropylcarbamoyl)thiophen-2-yl]-1-benzothiophene-2-carboxamide, ...
Authors:Godoi, P.H.C., Santiago, A.S., Fala, A.M., Ramos, P.Z., Sriranganadane, D., Mascarello, A., Segretti, N., Azevedo, H., Guimaraes, C.R.W., Arruda, P., Elkins, J.M., Counago, R.M., Structural Genomics Consortium (SGC)
Deposit date:2019-06-18
Release date:2019-07-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:PIM1 bound to benzothiophene inhibitor
To Be Published
6PDI
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HUMAN PIM1 BOUND TO BENZOTHIOPHENE INHIBITOR 224
Descriptor:Serine/threonine-protein kinase pim-1, Peptide, 4-(5-{[(3-aminophenyl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide, ...
Authors:Godoi, P.H.C., Fala, A.M., Santiago, A.S., Ramos, P.Z., Sriranganadane, D., Mascarello, A., Segretti, N., Azevedo, H., Guimaraes, C.R.W., Arruda, P., Elkins, J.M., Counago, R.M., Structural Genomics Consortium (SGC)
Deposit date:2019-06-19
Release date:2019-07-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Human PIM1
To Be Published
6PDN
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HUMAN PIM1 BOUND TO BENZOTHIOPHENE INHIBITOR 292
Descriptor:Serine/threonine-protein kinase pim-1, peptide, 4-{5-[(3-aminopropyl)carbamoyl]thiophen-2-yl}-1-benzothiophene-2-carboxylic acid, ...
Authors:Godoi, P.H.C., Santiago, A.S., Fala, A.M., Ramos, P.Z., Sriranganadane, D., Mascarello, A., Segretti, N., Azevedo, H., Guimaraes, C.R.W., Arruda, P., Elkins, J.M., Counago, R.M., Structural Genomics Consortium (SGC)
Deposit date:2019-06-19
Release date:2019-07-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Human PIM1
To Be Published
6PDO
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HUMAN PIM1 BOUND TO BENZOTHIOPHENE INHIBITOR 354
Descriptor:Serine/threonine-protein kinase pim-1, Peptide, 4-{5-[(3-aminopropyl)carbamoyl]thiophen-2-yl}-1-benzothiophene-2-carboxamide
Authors:Godoi, P.H.C., Santiago, A.S., Fala, A.M., Ramos, P.Z., Sriranganadane, D., Mascarello, A., Segretti, N., Azevedo, H., Guimaraes, C.R.W., Arruda, P., Elkins, J.M., Counago, R.M., Structural Genomics Consortium (SGC)
Deposit date:2019-06-19
Release date:2019-07-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Human PIM1
To Be Published
6PDP
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HUMAN PIM1 BOUND TO BENZOTHIOPHENE INHIBITOR 379
Descriptor:Serine/threonine-protein kinase pim-1, Peptide, SULFATE ION, ...
Authors:Godoi, P.H.C., Sriranganadane, D., Santiago, A.S., Fala, A.M., Ramos, P.Z., Mascarello, A., Segretti, N., Azevedo, H., Guimaraes, C.R.W., Arruda, P., Elkins, J.M., Counago, R.M., Structural Genomics Consortium (SGC)
Deposit date:2019-06-19
Release date:2019-07-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Human PIM1
To Be Published
6PJJ
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HUMAN PRPF4B BOUND TO BENZOTHIOPHENE INHIBITOR 224
Descriptor:Serine/threonine-protein kinase PRP4 homolog, 4-(5-{[(3-aminophenyl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide, 1,2-ETHANEDIOL, ...
Authors:Godoi, P.H.C., Santiago, A.S., Fala, A.M., Ramos, P.Z., Sriranganadane, D., Mascarello, A., Segretti, N., Azevedo, H., Guimaraes, C.R.W., Arruda, P., Elkins, J.M., Counago, R.M., Structural Genomics Consortium (SGC)
Deposit date:2019-06-28
Release date:2019-08-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:to be published
To Be Published
6PK6
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HUMAN PRPF4B BOUND TO BENZOTHIOPHENE INHIBITOR 329
Descriptor:Serine/threonine-protein kinase PRP4 homolog, SULFATE ION, 4-(5-{[(2-aminophenyl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide
Authors:Godoi, P.H.C., Santiago, A.S., Fala, A.M., Ramos, P.Z., Sriranganadane, D., Mascarello, A., Segretti, N., Azevedo, H., Guimaraes, C.R.W., Arruda, P., Elkins, J.M., Counago, R.M., Structural Genomics Consortium (SGC)
Deposit date:2019-06-28
Release date:2019-08-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:to be published
To Be Published
3OP5
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HUMAN VACCINIA-RELATED KINASE 1
Descriptor:Serine/threonine-protein kinase VRK1, [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile, 1,2-ETHANEDIOL, ...
Authors:Allerston, C.K., Uttarkar, S., Savitsky, P., Elkins, J.M., Filippakopoulos, P., Krojer, T., Rellos, P., Fedorov, O., Eswaran, J., Brenner, B., Keates, T., Das, S., King, O., Chalk, R., Berridge, G., von Delft, F., Gileadi, O., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-08-31
Release date:2010-09-22
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.
Sci Rep, 7, 2017
5UKF
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CRYSTAL STRUCTURE OF THE HUMAN VACCINIA-RELATED KINASE 1 BOUND TO AN OXINDOLE INHIBITOR
Descriptor:Serine/threonine-protein kinase VRK1, 4-{[(Z)-(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}benzene-1-sulfonamide, PHOSPHATE ION, ...
Authors:Counago, R.M., Wells, C., Zuercher, W., Willson, T.M., Bountra, C., Edwards, A.M., Arruda, P., Gileadi, O., Structural Genomics Consortium (SGC)
Deposit date:2017-01-22
Release date:2017-03-29
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.
Sci Rep, 7, 2017
5UU1
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CRYSTAL STRUCTURE OF HUMAN VACCINIA-RELATED KINASE 2 (VRK-2) BOUND TO BI-D1870
Descriptor:Serine/threonine-protein kinase VRK2, (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one
Authors:Counago, R.M., Bountra, C., Arruda, P., Edwards, A.M., Gileadi, O., Structural Genomics Consortium (SGC)
Deposit date:2017-02-15
Release date:2017-03-01
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.
Sci Rep, 7, 2017
5UVF
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CRYSTAL STRUCTURE OF THE HUMAN VACCINIA-RELATED KINASE BOUND TO BI-D1870
Descriptor:Serine/threonine-protein kinase VRK1, (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one, PHOSPHATE ION, ...
Authors:Counago, R.M., Bountra, C., Arruda, P., Edwards, A.M., Gileadi, O., Structural Genomics Consortium (SGC)
Deposit date:2017-02-20
Release date:2017-03-22
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.
Sci Rep, 7, 2017