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3LVP
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BU of 3lvp by Molmil
Crystal structure of bisphosphorylated IGF1-R Kinase domain (2P) in complex with a bis-azaindole inhibitor
Descriptor: 3-(4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Insulin-like growth factor 1 receptor, ...
Authors:Maignan, S, Marquette, J.P, Guilloteau, J.P.
Deposit date:2010-02-22
Release date:2010-07-21
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Design of Potent IGF1-R Inhibitors Related to Bis-azaindoles
Chem.Biol.Drug Des., 76, 2010
2BHJ
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BU of 2bhj by Molmil
murine iNO synthase with coumarin inhibitor
Descriptor: 7,8-DIHYDROBIOPTERIN, NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Mathieu, M, Guilloteau, J.P.
Deposit date:2005-01-12
Release date:2005-03-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Design, Synthesis and Characterization of a Novel Class of Coumarin-Based Inhibitors of Inducible Nitric Oxide Synthase
Bioorg.Med.Chem., 13, 2005
1BI4
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BU of 1bi4 by Molmil
CATALYTIC DOMAIN OF HIV-1 INTEGRASE
Descriptor: INTEGRASE
Authors:Maignan, S, Guilloteau, J.P, Zhou-Liu, Q, Clement-Mella, C, Mikol, V.
Deposit date:1998-06-22
Release date:1998-11-04
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases.
J.Mol.Biol., 282, 1998
1BHL
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BU of 1bhl by Molmil
CACODYLATED CATALYTIC DOMAIN OF HIV-1 INTEGRASE
Descriptor: HIV-1 INTEGRASE
Authors:Maignan, S, Guilloteau, J.P, Zhou-Liu, Q, Clement-Mella, C, Mikol, V.
Deposit date:1998-06-10
Release date:1998-10-14
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases.
J.Mol.Biol., 282, 1998
1BL3
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BU of 1bl3 by Molmil
CATALYTIC DOMAIN OF HIV-1 INTEGRASE
Descriptor: INTEGRASE, MAGNESIUM ION
Authors:Maignan, S, Guilloteau, J.P, Zhou-Liu, Q, Clement-Mella, C, Mikol, V.
Deposit date:1998-07-23
Release date:1998-09-30
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases.
J.Mol.Biol., 282, 1998
3O23
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BU of 3o23 by Molmil
Human unphosphorylated IGF1-R Kinase domain in complex with an hydantoin inhibitor
Descriptor: (5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifluoromethyl)sulfonyl]phenyl}imidazolidine-2,4-dione, Insulin-like growth factor 1 receptor
Authors:Maignan, S, Guilloteau, J.P, Dupuy, A.
Deposit date:2010-07-22
Release date:2011-05-04
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of the first non-ATP competitive IGF-1R kinase inhibitors: Advantages in comparison with competitive inhibitors
Bioorg.Med.Chem.Lett., 21, 2011
1NFX
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BU of 1nfx by Molmil
CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208944
Descriptor: 4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-1-{[1-(2-HYDROXYETHYL)-1H-PYRROLO[3,2-C]PYRIDIN-2-YL]METHYL}PIPERAZIN-2-ONE, CALCIUM ION, COAGULATION FACTOR XA, ...
Authors:Maignan, S, Guilloteau, J.P.
Deposit date:2002-12-16
Release date:2003-02-25
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Molecular structures of human Factor Xa complexed with ketopiperazine inhibitors: preference for a neutral group in the S1 pocket.
J.Med.Chem., 46, 2003
1NFU
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BU of 1nfu by Molmil
CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR132747
Descriptor: 3-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE, CALCIUM ION, COAGULATION FACTOR XA, ...
Authors:Maignan, S, Guilloteau, J.P.
Deposit date:2002-12-16
Release date:2003-02-25
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Molecular structures of human Factor Xa complexed with ketopiperazine inhibitors: preference for a neutral group in the S1 pocket.
J.Med.Chem., 46, 2003
1NFY
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BU of 1nfy by Molmil
CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR200095
Descriptor: 4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE, CALCIUM ION, Coagulation factor XA, ...
Authors:Maignan, S, Guilloteau, J.P.
Deposit date:2002-12-16
Release date:2003-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular structures of human Factor Xa complexed with ketopiperazine inhibitors: preference for a neutral group in the S1 pocket.
J.Med.Chem., 46, 2003
1NFW
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BU of 1nfw by Molmil
CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR209685
Descriptor: 4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1H-PYRROLO[3,2-C]PYRIDIN-2-YLMETHYL)PIPERAZIN-2-ONE, CALCIUM ION, COAGULATION FACTOR XA, ...
Authors:Maignan, S, Guilloteau, J.P.
Deposit date:2002-12-16
Release date:2003-02-25
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular structures of human Factor Xa complexed with ketopiperazine inhibitors: preference for a neutral group in the S1 pocket.
J.Med.Chem., 46, 2003
1F0R
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BU of 1f0r by Molmil
CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208815
Descriptor: CALCIUM ION, COAGULATION FACTOR XA, THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE
Authors:Maignan, S, Guilloteau, J.P, Pouzieux, S, Choi-Sledeski, Y.M, Becker, M.R, Klein, S.I, Ewing, W.R, Pauls, H.W, Spada, A.P, Mikol, V.
Deposit date:2000-05-17
Release date:2000-09-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of human factor Xa complexed with potent inhibitors.
J.Med.Chem., 43, 2000
1F0T
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BU of 1f0t by Molmil
BOVINE TRYPSIN COMPLEXED WITH RPR131247
Descriptor: 4-HYDROXY-3-[2-OXO-3-(THIENO[3,2-B]PYRIDINE-2-SULFONYLAMINO)-PYRROLIDIN-1-YLMETHYL]-BENZAMIDINE, CALCIUM ION, SULFATE ION, ...
Authors:Maignan, S, Guilloteau, J.P, Pouzieux, S, Choi-Sledeski, Y.M, Becker, M.R, Klein, S.I, Ewing, W.R, Pauls, H.W, Spada, A.P, Mikol, V.
Deposit date:2000-05-17
Release date:2000-09-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of human factor Xa complexed with potent inhibitors.
J.Med.Chem., 43, 2000
1EZQ
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BU of 1ezq by Molmil
CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR128515
Descriptor: 3-[(3'-AMINOMETHYL-BIPHENYL-4-CARBONYL)-AMINO]-2-(3-CARBAMIMIDOYL-BENZYL)-BUTYRIC ACID METHYL ESTER, CALCIUM ION, COAGULATION FACTOR XA
Authors:Maignan, S, Guilloteau, J.P, Pouzieux, S, Choi-Sledeski, Y.M, Becker, M.R, Klein, S.I, Ewing, W.R, Pauls, H.W, Spada, A.P, Mikol, V.
Deposit date:2000-05-11
Release date:2000-09-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of human factor Xa complexed with potent inhibitors.
J.Med.Chem., 43, 2000
1F0S
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BU of 1f0s by Molmil
Crystal Structure of Human Coagulation Factor XA Complexed with RPR208707
Descriptor: CALCIUM ION, COAGULATION FACTOR XA, THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [2-OXO-1-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)-PYRROLIDIN-3-YL]-AMIDE
Authors:Maignan, S, Guilloteau, J.P, Pouzieux, S, Choi-Sledeski, Y.M, Becker, M.R, Klein, S.I, Ewing, W.R, Pauls, H.W, Spada, A.P, Mikol, V.
Deposit date:2000-05-17
Release date:2000-09-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of human factor Xa complexed with potent inhibitors.
J.Med.Chem., 43, 2000
1F0U
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BU of 1f0u by Molmil
BOVINE TRYPSIN COMPLEXED WITH RPR128515
Descriptor: 3-[(3'-AMINOMETHYL-BIPHENYL-4-CARBONYL)-AMINO]-2-(3-CARBAMIMIDOYL-BENZYL)-BUTYRIC ACID METHYL ESTER, CALCIUM ION, SULFATE ION, ...
Authors:Maignan, S, Guilloteau, J.P, Pouzieux, S, Choi-Sledeski, Y.M, Becker, M.R, Klein, S.I, Ewing, W.R, Pauls, H.W, Spada, A.P, Mikol, V.
Deposit date:2000-05-17
Release date:2000-09-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of human factor Xa complexed with potent inhibitors.
J.Med.Chem., 43, 2000
1KSN
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BU of 1ksn by Molmil
Crystal Structure of Human Coagulation Factor XA Complexed with FXV673
Descriptor: CALCIUM ION, COAGULATION FACTOR XA, METHYL-3-(4'-N-OXOPYRIDYLPHENOYL)-3-METHYL-2-(M-AMIDINOBENZYL)-PROPIONATE
Authors:Maignan, S, Guilloteau, J.P.
Deposit date:2002-01-14
Release date:2002-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Optimization of the beta-aminoester class of factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity.
Bioorg.Med.Chem.Lett., 12, 2002
1LRU
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BU of 1lru by Molmil
Crystal Structure of E.coli Peptide Deformylase Complexed with Antibiotic Actinonin
Descriptor: ACTINONIN, PEPTIDE DEFORMYLASE, SULFATE ION, ...
Authors:Guilloteau, J.-P, Mathieu, M, Giglione, C, Blanc, V, Dupuy, A, Chevrier, M, Gil, P, Famechon, A, Meinnel, T, Mikol, V.
Deposit date:2002-05-16
Release date:2002-07-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents.
J.Mol.Biol., 320, 2002
1LRY
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BU of 1lry by Molmil
Crystal Structure of P. aeruginosa Peptide Deformylase Complexed with Antibiotic Actinonin
Descriptor: ACTINONIN, PEPTIDE deformylase, ZINC ION
Authors:Guilloteau, J.-P, Mathieu, M, Giglione, C, Blanc, V, Dupuy, A, Chevrier, M, Gil, P, Famechon, A, Meinnel, T, Mikol, V.
Deposit date:2002-05-16
Release date:2002-07-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents.
J.Mol.Biol., 320, 2002
1LQW
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BU of 1lqw by Molmil
Crystal Structure of S.aureus Peptide Deformylase
Descriptor: PEPTIDE DEFORMYLASE PDF1, ZINC ION
Authors:Mikol, V.
Deposit date:2002-05-14
Release date:2002-07-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents.
J.Mol.Biol., 320, 2002
1LQY
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BU of 1lqy by Molmil
Crystal Structure of Bacillus stearothermophilus Peptide Deformylase Complexed with Antibiotic Actinonin
Descriptor: ACTINONIN, NICKEL (II) ION, PEPTIDE deformylase 2
Authors:Mathieu, M, Mikol, V.
Deposit date:2002-05-14
Release date:2002-07-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents.
J.Mol.Biol., 320, 2002
6EBX
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BU of 6ebx by Molmil
STRUCTURE DETERMINATION OF A DIMERIC FORM OF ERABUTOXIN B, CRYSTALLIZED FROM THIOCYANATE SOLUTION
Descriptor: ERABUTOXIN B, THIOCYANATE ION
Authors:Prange, T, Saludjian, P.
Deposit date:1991-05-31
Release date:1993-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure determination of a dimeric form of erabutoxin-b, crystallized from a thiocyanate solution.
Acta Crystallogr.,Sect.B, 48, 1992
1BHC
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BU of 1bhc by Molmil
BOVINE PANCREATIC TRYPSIN INHIBITOR CRYSTALLIZED FROM THIOCYANATE
Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR, THIOCYANATE ION
Authors:Hamiaux, C, Prange, T.
Deposit date:1998-06-05
Release date:1998-09-16
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The decameric structure of bovine pancreatic trypsin inhibitor (BPTI) crystallized from thiocyanate at 2.7 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
6PNW
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BU of 6pnw by Molmil
X-RAY STRUCTURE OF ERABUTOXIN C, A DIMERIC NEUROTOXIN
Descriptor: Erabutoxin c
Authors:Corfield, P.W.R, Low, B.W.
Deposit date:2019-07-03
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Structure Of Erabutoxin C At 2.1A Resolution
AM.CRYST.ASSOC.,ABSTR.PAPERS (ANNUAL MEETING), 1992
3ERA
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BU of 3era by Molmil
RECOMBINANT ERABUTOXIN A (S8T MUTANT)
Descriptor: ERABUTOXIN A, THIOCYANATE ION
Authors:Gaucher, J.F, Menez, R, Arnoux, B, Menez, A, Ducruix, A.
Deposit date:1997-06-25
Release date:1997-12-31
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:High resolution x-ray analysis of two mutants of a curaremimetic snake toxin
Eur.J.Biochem., 267, 2000
1GRI
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BU of 1gri by Molmil
GRB2
Descriptor: GROWTH FACTOR BOUND PROTEIN 2
Authors:Maignan, S, Arnoux, B, Ducruix, A.
Deposit date:1995-02-28
Release date:1996-03-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of the mammalian Grb2 adaptor.
Science, 268, 1995

 

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