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7QG0
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BU of 7qg0 by Molmil
Inhibitor-induced hSARM1 duplex
Descriptor: NAD(+) hydrolase SARM1
Authors:Zalk, R, Kahzma, T, Guez-Haddad, J.
Deposit date:2021-12-07
Release date:2022-12-21
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (4.02 Å)
Cite:A duplex structure of SARM1 octamers stabilized by a new inhibitor.
Cell.Mol.Life Sci., 80, 2022
6ZG0
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BU of 6zg0 by Molmil
SARM1 SAM1-2 domains
Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Dessau, M, Mim, C, Isupov, M.N, Zalk, R, Hons, M, Opatowsky, Y.
Deposit date:2020-06-18
Release date:2020-11-11
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (7.7 Å)
Cite:Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
6ZFX
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BU of 6zfx by Molmil
hSARM1 GraFix-ed
Descriptor: (~{E})-4-methylnon-4-enedial, NAD(+) hydrolase SARM1
Authors:Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Dessau, M, Mim, C, Isupov, M.N, Zalk, R, Hons, M, Opatowsky, Y.
Deposit date:2020-06-18
Release date:2020-11-18
Last modified:2022-11-09
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
6ZG1
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BU of 6zg1 by Molmil
SARM1 SAM1-2 domains
Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Dessau, M, Mim, C, Isupov, M.N, Zalk, R, Hons, M, Opatowsky, Y.
Deposit date:2020-06-18
Release date:2020-11-11
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (3.77 Å)
Cite:Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
7ANW
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BU of 7anw by Molmil
hSARM1 NAD+ complex
Descriptor: NAD(+) hydrolase SARM1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Mim, C, Isupov, M.N, Zalk, R, Dessau, M, Hons, M, Opatowsky, Y.
Deposit date:2020-10-13
Release date:2020-11-11
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (2.68 Å)
Cite:Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
5I6J
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BU of 5i6j by Molmil
Crystal Structure of SRGAP2 F-BARx
Descriptor: SLIT-ROBO Rho GTPase-activating protein 2
Authors:Sporny, M, Guez-Haddad, J, Isupov, M.N, Opatowsky, Y.
Deposit date:2016-02-16
Release date:2017-03-08
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural History of Human SRGAP2 Proteins.
Mol. Biol. Evol., 34, 2017
5I7D
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BU of 5i7d by Molmil
Crystal Structure of srGAP2 F-BARx WT Form-2
Descriptor: SLIT-ROBO Rho GTPase-activating protein 2
Authors:Sporny, M, Guez-Haddad, J, Isupov, M.N, Opatowsky, Y.
Deposit date:2016-02-17
Release date:2017-08-30
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:Structural Basis for srGAP2 Membrane Interactions, and Antagonism by the Human Specific Paralog srGAP2C
To Be Published
5I6R
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BU of 5i6r by Molmil
Crystal Structure of srGAP2 F-BARx WT Form-1
Descriptor: ACETATE ION, D-MALATE, SLIT-ROBO Rho GTPase-activating protein 2, ...
Authors:Sporny, M, Guez-Haddad, J, Isupov, M.N, Opatowsky, Y.
Deposit date:2016-02-16
Release date:2017-08-30
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Basis for srGAP2 Membrane Interactions, and Antagonism by the Human Specific Paralog srGAP2C
To Be Published
4RTT
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BU of 4rtt by Molmil
Cyrstal structure of SLIT-ROBO Rho GTPase-activating protein 2 fragment
Descriptor: SLIT-ROBO Rho GTPase-activating protein 2, SULFATE ION
Authors:Opatowsky, Y, Guez-Hadad, J.
Deposit date:2014-11-16
Release date:2015-11-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The Neuronal Migration Factor srGAP2 Achieves Specificity in Ligand Binding through a Two-Component Molecular Mechanism.
Structure, 23, 2015
4RUG
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BU of 4rug by Molmil
Cyrstal structure of SLIT-ROBO Rho GTPase-activating protein 2 fragment
Descriptor: SLIT-ROBO Rho GTPase-activating protein 2
Authors:Opatowsky, Y, Guez-Hadad, J.
Deposit date:2014-11-19
Release date:2015-11-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:The Neuronal Migration Factor srGAP2 Achieves Specificity in Ligand Binding through a Two-Component Molecular Mechanism.
Structure, 23, 2015
5NOI
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BU of 5noi by Molmil
human Robo2 extracellular domains 4-5
Descriptor: Roundabout homolog 2
Authors:Opatowsky, Y, Barak, R.
Deposit date:2017-04-12
Release date:2017-10-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Robo Ig4 Is a Dimerization Domain.
J. Mol. Biol., 429, 2017
6QWV
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BU of 6qwv by Molmil
SARM1 SAM1-2 domains
Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Sporny, M, Isupov, N.M, Opatowsky, Y.
Deposit date:2019-03-06
Release date:2019-07-03
Last modified:2019-09-18
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Structural Evidence for an Octameric Ring Arrangement of SARM1.
J.Mol.Biol., 431, 2019
8P2M
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BU of 8p2m by Molmil
C. elegans TIR-1 protein.
Descriptor: NAD(+) hydrolase tir-1
Authors:Isupov, M.N, Opatowsky, Y.
Deposit date:2023-05-16
Release date:2023-09-06
Method:ELECTRON MICROSCOPY (3.82 Å)
Cite:Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans.
Cell Rep, 42, 2023
8P2L
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BU of 8p2l by Molmil
A CHIMERA construct containing human SARM1 ARM and SAM domains and C. elegans TIR domain.
Descriptor: NAD(+) hydrolase SARM1,NAD(+) hydrolase tir-1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Isupov, M.N, Opatowsky, Y.
Deposit date:2023-05-16
Release date:2023-09-06
Method:ELECTRON MICROSCOPY (2.68 Å)
Cite:Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans.
Cell Rep, 42, 2023
6I9S
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BU of 6i9s by Molmil
hRobo2 Extracellular Domains 2-3
Descriptor: Roundabout homolog 2, SODIUM ION
Authors:Barak, R, Isupov, N.M, Opatowsky, Y.
Deposit date:2018-11-25
Release date:2019-03-13
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Structural Principles in Robo Activation and Auto-inhibition.
Cell, 177, 2019
6IAA
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BU of 6iaa by Molmil
hRobo2 ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Roundabout homolog 2, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Barak, R, Isupov, N.M, Opatowsky, Y.
Deposit date:2018-11-26
Release date:2019-03-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural Principles in Robo Activation and Auto-inhibition.
Cell, 177, 2019

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PDB entries from 2024-03-27

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