Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
8A28
DownloadVisualize
BU of 8a28 by Molmil
Structure of the astacin zymogen of LAST-MAM from Limulus polyphemus
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, MAGNESIUM ION, ...
Authors:Guevara, T, Rodriguez Banqueri, A.
Deposit date:2022-06-02
Release date:2022-10-19
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Zymogenic latency in an ∼250-million-year-old astacin metallopeptidase.
Acta Crystallogr D Struct Biol, 78, 2022
3LQ0
DownloadVisualize
BU of 3lq0 by Molmil
Zymogen structure of crayfish astacin metallopeptidase
Descriptor: GLYCEROL, ProAstacin, SULFATE ION, ...
Authors:Guevara, T, Yiallouros, I, Kappelhoff, R, Bissdorf, S, Stocker, W, Gomis-Ruth, F.X.
Deposit date:2010-02-08
Release date:2010-02-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Proenzyme structure and activation of astacin metallopeptidase
J.Biol.Chem., 285, 2010
4IN9
DownloadVisualize
BU of 4in9 by Molmil
Structure of karilysin MMP-like catalytic domain in complex with inhibitory tetrapeptide SWFP
Descriptor: GLYCEROL, Karilysin protease, POTASSIUM ION, ...
Authors:Guevara, T, Ksiazek, M, Skottrup, P.D, Cerda-Costa, N, Trillo-Muyo, S, de Diego, I, Riise, E, Potempa, J, Gomis-Ruth, F.X.
Deposit date:2013-01-04
Release date:2013-05-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of the catalytic domain of the Tannerella forsythia matrix metallopeptidase karilysin in complex with a tetrapeptidic inhibitor.
Acta Crystallogr.,Sect.F, 69, 2013
2IWA
DownloadVisualize
BU of 2iwa by Molmil
Unbound glutaminyl cyclotransferase from Carica papaya.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLUTAMINE CYCLOTRANSFERASE, ...
Authors:Guevara, T, Mallorqui-Fernandez, N, Garcia-Castellanos, R, Petersen, G.E, Lauritzen, C, Pedersen, J, Arnau, J, Gomis-Ruth, F.X, Sola, M.
Deposit date:2006-06-27
Release date:2006-07-04
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Papaya Glutamine Cyclotransferase Shows a Singular Five-Fold Beta-Propeller Architecture that Suggests a Novel Reaction Mechanism.
Biol.Chem., 387, 2006
6SAZ
DownloadVisualize
BU of 6saz by Molmil
Cleaved human fetuin-b in complex with crayfish astacin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Astacin, ...
Authors:Gomis-Ruth, F.X, Guevara, T, Cuppari, A, Korschgen, H, Schmitz, C, Kuske, M, Yiallouros, I, Floehr, J, Jahnen-Dechent, W, Stocker, W.
Deposit date:2019-07-18
Release date:2019-10-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:The C-terminal region of human plasma fetuin-B is dispensable for the raised-elephant-trunk mechanism of inhibition of astacin metallopeptidases.
Sci Rep, 9, 2019
6I9A
DownloadVisualize
BU of 6i9a by Molmil
Porphyromonas gingivalis gingipain K (Kgp) in complex with inhibitor KYT-36
Descriptor: (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Gomis-Ruth, F.X, Guevara, T, Rofdriguez-Banqueri, A.
Deposit date:2018-11-22
Release date:2019-03-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor.
Sci Rep, 9, 2019
6R7U
DownloadVisualize
BU of 6r7u by Molmil
Selenomethionine variant of Tannerella forsythia promirolysin mutant E225A
Descriptor: BORIC ACID, CALCIUM ION, GLYCEROL, ...
Authors:Rodriguez-Banqueri, A, Guevara, T, Ksiazek, M, Potempa, J, Gomis-Ruth, F.X.
Deposit date:2019-03-29
Release date:2020-02-05
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases.
Iucrj, 7, 2020
6R7V
DownloadVisualize
BU of 6r7v by Molmil
Tannerella forsythia promirolysin mutant E225A
Descriptor: CALCIUM ION, GLYCEROL, Mirolysin, ...
Authors:Rodriguez-Banqueri, A, Guevara, T, Ksiazek, M, Potempa, J, Gomis-Ruth, F.X.
Deposit date:2019-03-29
Release date:2019-11-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases.
Iucrj, 7, 2020
6R7W
DownloadVisualize
BU of 6r7w by Molmil
Tannerella forsythia mature mirolysin in complex with a cleaved peptide.
Descriptor: CALCIUM ION, CITRIC ACID, ETHANOL, ...
Authors:Rodriguez-Banqueri, A, Guevara, T, Ksiazek, M, Potempa, J, Gomis-Ruth, F.X.
Deposit date:2019-03-29
Release date:2019-11-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases.
Iucrj, 7, 2020
5M11
DownloadVisualize
BU of 5m11 by Molmil
Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.
Descriptor: CACODYLATE ION, CALCIUM ION, CHLORIDE ION, ...
Authors:Lasica, A.M, Goulas, T, Mizgalska, D, Zhou, X, Ksiazek, M, Madej, M, Guo, Y, Guevara, T, Nowak, M, Potempa, B, Goel, A, Sztukowska, M, Prabhakar, A.T, Bzowska, M, Widziolek, M, Thogersen, I.B, Enghild, J.J, Simonian, M, Kulczyk, A.W, Nguyen, K.-A, Potempa, J, Gomis-Ruth, F.X.
Deposit date:2016-10-07
Release date:2016-11-09
Last modified:2022-03-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.
Sci Rep, 6, 2016
5MUN
DownloadVisualize
BU of 5mun by Molmil
Structural insight into zymogenic latency of gingipain K from Porphyromonas gingivalis.
Descriptor: AZIDE ION, Lys-gingipain W83
Authors:Pomowski, A, Uson, I, Nowakovska, Z, Veillard, F, Sztukowska, M.N, Guevara, T, Goulas, T, Mizgalska, D, Nowak, M, Potempa, B, Huntington, J.A, Potempa, J, Gomis-Ruth, F.X.
Deposit date:2017-01-13
Release date:2017-02-22
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome.
J. Biol. Chem., 292, 2017
6ZA2
DownloadVisualize
BU of 6za2 by Molmil
Crystal structure of dimeric latent PorU from Porphyromonas gingivalis
Descriptor: CALCIUM ION, Por secretion system protein porU
Authors:Gomis-Ruth, F.X, Goulas, T, Guevara, T, Rodriguez-Banqueri, A, Potempa, J.
Deposit date:2020-06-04
Release date:2021-09-29
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Intermolecular latency regulates the essential C-terminal signal peptidase and sortase of the Porphyromonas gingivalis type-IX secretion system.
Proc.Natl.Acad.Sci.USA, 118, 2021
3D4U
DownloadVisualize
BU of 3d4u by Molmil
Bovine thrombin-activatable fibrinolysis inhibitor (TAFIa) in complex with tick-derived carboxypeptidase inhibitor.
Descriptor: ACETATE ION, Carboxypeptidase B2, Carboxypeptidase inhibitor, ...
Authors:Sanglas, L, Valnickova, Z, Arolas, J.L, Pallares, I, Guevara, T, Sola, M, Kristensen, T, Enghild, J.J, Aviles, F.X, Gomis-Ruth, F.X.
Deposit date:2008-05-15
Release date:2008-08-19
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of activated thrombin-activatable fibrinolysis inhibitor, a molecular link between coagulation and fibrinolysis.
Mol.Cell, 31, 2008
3RAM
DownloadVisualize
BU of 3ram by Molmil
Crystal structure of HmrA
Descriptor: GLYCEROL, HmrA protein, ZINC ION
Authors:Botelho, T, Guevara, T, Marrero, A, Gomis-Ruth, F.X.
Deposit date:2011-03-28
Release date:2011-05-25
Last modified:2011-08-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Functional Analyses Reveal That Staphylococcus aureus Antibiotic Resistance Factor HmrA Is a Zinc-dependent Endopeptidase.
J.Biol.Chem., 286, 2011
7ZU8
DownloadVisualize
BU of 7zu8 by Molmil
Crystal Structure of the zymogen form of the glutamic-class prolyl-endopeptidase neprosin at 2.05 A resolution in presence of the crystallophore Lu-Xo4.
Descriptor: 12-oxidanyl-9,11$l^{3}-dioxa-1$l^{4},19$l^{4},22,27$l^{4},28$l^{4}-pentaza-10$l^{6}-lutetaoctacyclo[17.5.2.1^{3,7}.1^{10,13}.0^{1,10}.0^{10,19}.0^{10,28}.0^{17,27}]octacosa-3,5,7(28),11,13,15,17(27)-heptaen-8-one, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Del Amo-Maestro, L, Eckhard, U, Rodriguez-Banqueri, A, Mendes, S.R, Guevara, T, Gomis-Ruth, F.X.
Deposit date:2022-05-11
Release date:2022-08-10
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy.
Nat Commun, 13, 2022
7ZVB
DownloadVisualize
BU of 7zvb by Molmil
Crystal Structure of the mature form of the glutamic-class prolyl-endopeptidase neprosin at 2.35 A resolution.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, C-terminal peptidase, TRIETHYLENE GLYCOL, ...
Authors:Del Amo-Maestro, L, Eckhard, U, Rodriguez-Banqueri, A, Mendes, S.R, Guevara, T, Gomis-Ruth, F.X.
Deposit date:2022-05-14
Release date:2022-08-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy.
Nat Commun, 13, 2022
7ZVC
DownloadVisualize
BU of 7zvc by Molmil
Second crystal form of the mature glutamic-class prolyl-endopeptidase neprosin at 1.85 A resolution.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, C-terminal peptidase, GLY-GLY-GLY-GLY, ...
Authors:Rodriguez-Banqueri, A, Eckhard, U, Del Amo-Maestro, L, Mendes, S.R, Guevara, T, Gomis-Ruth, F.X.
Deposit date:2022-05-14
Release date:2022-08-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy.
Nat Commun, 13, 2022
7ZVA
DownloadVisualize
BU of 7zva by Molmil
Crystal Structure of the native zymogen form of the glutamic-class prolyl-endopeptidase neprosin at 1.80 A resolution.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, C-terminal peptidase, ...
Authors:Del Amo-Maestro, L, Eckhard, U, Rodriguez-Banqueri, A, Mendes, S.R, Guevara, T, Gomis-Ruth, F.X.
Deposit date:2022-05-14
Release date:2022-08-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy.
Nat Commun, 13, 2022
3H8T
DownloadVisualize
BU of 3h8t by Molmil
Structure of Porphyromonas gingivalis heme-binding protein HmuY in complex with Heme
Descriptor: GLYCEROL, HmuY, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Wojtowicz, H, Guevara, T, Tallant, C, Olczak, M, Sroka, A, Potempa, J, Sola, M, Olczak, T, Gomis-Ruth, F.X.
Deposit date:2009-04-29
Release date:2009-05-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Unique structure and stability of HmuY, a novel heme-binding protein of Porphyromonas gingivalis
Plos Pathog., 5, 2009
8B2Q
DownloadVisualize
BU of 8b2q by Molmil
Matrix-metallopeptidase inhibitor Potempin A (PotA) from Tannerella forsythia in complex with T. forsythia karilysin.
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ...
Authors:Potempa, J, Ksiazek, M, Goulas, T, Cuppari, A, Rodriguez-Banqueri, A, Arolas, J.L, Lopez-Pelegrin, M, Garcia-Ferrer, I, Guevara, T.
Deposit date:2022-09-14
Release date:2022-12-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia.
Chem Sci, 14, 2023
4YT9
DownloadVisualize
BU of 4yt9 by Molmil
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) substrate-unbound.
Descriptor: GLYCEROL, Peptidylarginine deiminase, SODIUM ION
Authors:Goulas, T, Mizgalska, D, Garcia-Ferrer, I, Kantyka, T, Guevara, T, Szmigielski, B, Sroka, A, Millan, C, Uson, I, Veillard, F, Potempa, B, Mydel, P, Sola, M, Potempa, J, Gomis-Ruth, F.X.
Deposit date:2015-03-17
Release date:2015-07-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase.
Sci Rep, 5, 2015
4YTB
DownloadVisualize
BU of 4ytb by Molmil
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) in complex with dipeptide Asp-Gln.
Descriptor: ASPARTIC ACID, AZIDE ION, CHLORIDE ION, ...
Authors:Goulas, T, Mizgalska, D, Garcia-Ferrer, I, Kantyka, T, Guevara, T, Szmigielski, B, Sroka, A, Millan, C, Uson, I, Veillard, F, Potempa, B, Mydel, P, Sola, M, Potempa, J, Gomis-Ruth, F.X.
Deposit date:2015-03-17
Release date:2015-07-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase.
Sci Rep, 5, 2015
4YTG
DownloadVisualize
BU of 4ytg by Molmil
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) mutant C351A in complex with dipeptide Met-Arg.
Descriptor: ARGININE, AZIDE ION, CHLORIDE ION, ...
Authors:Goulas, T, Mizgalska, D, Garcia-Ferrer, I, Kantyka, T, Guevara, T, Szmigielski, B, Sroka, A, Millan, C, Uson, I, Veillard, F, Potempa, B, Mydel, P, Sola, M, Potempa, J, Gomis-Ruth, F.X.
Deposit date:2015-03-17
Release date:2015-07-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase.
Sci Rep, 5, 2015
6TAV
DownloadVisualize
BU of 6tav by Molmil
Crystal structure of endopeptidase-induced alpha2-macroglobulin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
Authors:Gomis-Ruth, F.X, Duquerroy, S, Trapani, S, Marrero, A, Goulas, T, Guevara, T, Andersen, G.A, Sottrup-Jensen, L, Navaza, J.
Deposit date:2019-10-30
Release date:2021-05-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Cryo-EM structures shows the mechanistic basis of pan-peptidase inhibition by human alpha2-macroglobulin
Proc.Natl.Acad.Sci.USA, 2022
2XS4
DownloadVisualize
BU of 2xs4 by Molmil
Structure of karilysin catalytic MMP domain in complex with magnesium
Descriptor: CHLORIDE ION, KARILYSIN PROTEASE, MAGNESIUM ION, ...
Authors:Cerda-Costa, N, Guevara, T, Karim, A.Y, Ksiazek, M, Nguyen, K.-A, Arolas, J.L, Potempa, J, Gomis-Ruth, F.X.
Deposit date:2010-09-24
Release date:2010-11-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Structure of the Catalytic Domain of Tannerella Forsythia Karilysin Reveals It is a Bacterial Xenologue of Animal Matrix Metalloproteinases.
Mol.Microbiol., 79, 2011

 

123>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon