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4RLL
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BU of 4rll by Molmil
Crystal structure of human CK2alpha in complex with the ATP-competitive inhibitor 4-[(E)-(fluoren-9-ylidenehydrazinylidene)-methyl] benzoate
Descriptor: 4-[(E)-(9H-fluoren-9-ylidenehydrazinylidene)methyl]benzoic acid, Casein kinase II subunit alpha, GLYCEROL
Authors:Guerra, B, Rasmussen, T.D.L, Schnitzler, A, Jensen, H.H, Boldyreff, B.S, Miyata, Y, Marcussen, N, Niefind, K, Issinger, O.G.
Deposit date:2014-10-17
Release date:2014-12-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Protein kinase CK2 inhibition is associated with the destabilization of HIF-1 alpha in human cancer cells.
Cancer Lett, 356, 2015
4RLK
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BU of 4rlk by Molmil
Crystal structure of Z. mays CK2alpha in complex with the ATP-competitive inhibitor 4-[(E)-(fluoren-9-ylidenehydrazinylidene)-methyl] benzoate
Descriptor: 4-[(E)-(9H-fluoren-9-ylidenehydrazinylidene)methyl]benzoic acid, ACETATE ION, Casein kinase II subunit alpha, ...
Authors:Guerra, B, Rasmussen, T.D.L, Schnitzler, A, Jensen, H.H, Boldyreff, B.S, Miyata, Y, Marcussen, N, Niefind, K, Issinger, O.G.
Deposit date:2014-10-17
Release date:2014-12-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Protein kinase CK2 inhibition is associated with the destabilization of HIF-1 alpha in human cancer cells.
Cancer Lett, 356, 2015
4UB7
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BU of 4ub7 by Molmil
High-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26) showing an extreme distortion of the ATP-binding loop combined with a pi-halogen bond
Descriptor: 4-(6,8-dibromo-3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid, CHLORIDE ION, Casein kinase II subunit alpha
Authors:Niefind, K, Bischoff, N, Guerra, B, Golub, A, Issinger, O.-G.
Deposit date:2014-08-12
Release date:2015-07-01
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2 alpha Complex Structures.
Acs Chem.Biol., 10, 2015
4UBA
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BU of 4uba by Molmil
Low-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26)
Descriptor: 4-(6,8-dibromo-3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid, Casein kinase II subunit alpha
Authors:Niefind, K, Bischoff, N, Guerra, B, Golub, A, Issinger, O.-G.
Deposit date:2014-08-12
Release date:2015-07-01
Method:X-RAY DIFFRACTION (2.995 Å)
Cite:A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2 alpha Complex Structures.
Acs Chem.Biol., 10, 2015
1DAY
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BU of 1day by Molmil
CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-GMPPNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, PROTEIN KINASE CK2
Authors:Niefind, K, Puetter, M, Guerra, B, Issinger, O.G, Schomburg, D.
Deposit date:1999-11-01
Release date:2000-05-03
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:GTP plus water mimic ATP in the active site of protein kinase CK2.
Nat.Struct.Biol., 6, 1999
1DAW
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BU of 1daw by Molmil
CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-AMPPNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PROTEIN KINASE CK2
Authors:Niefind, K, Puetter, M, Guerra, B, Issinger, O.G, Schomburg, D.
Deposit date:1999-11-01
Release date:2000-05-03
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:GTP plus water mimic ATP in the active site of protein kinase CK2.
Nat.Struct.Biol., 6, 1999
1LP4
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BU of 1lp4 by Molmil
Crystal structure of a binary complex of the catalytic subunit of protein kinase CK2 with Mg-AMPPNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Protein kinase CK2
Authors:Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D.
Deposit date:2002-05-07
Release date:2002-05-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
1LPU
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BU of 1lpu by Molmil
Low Temperature Crystal Structure of the Apo-form of the catalytic subunit of protein kinase CK2 from Zea mays
Descriptor: BENZAMIDINE, Protein kinase CK2
Authors:Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D.
Deposit date:2002-05-08
Release date:2002-05-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
1LR4
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BU of 1lr4 by Molmil
Room Temperature Crystal Structure of the Apo-form of the catalytic subunit of protein kinase CK2 from Zea mays
Descriptor: BENZAMIDINE, Protein kinase CK2
Authors:Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D.
Deposit date:2002-05-14
Release date:2002-05-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
4IB5
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BU of 4ib5 by Molmil
Structure of human protein kinase CK2 catalytic subunit in complex with a CK2beta-competitive cyclic peptide
Descriptor: CHLORIDE ION, CK2beta-derived cyclic peptide, Casein kinase II subunit alpha, ...
Authors:Raaf, J, Guerra, B, Neundorf, I, Bopp, B, Issinger, O.-G, Jose, J, Pietsch, M, Niefind, K.
Deposit date:2012-12-08
Release date:2013-03-20
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:First structure of protein kinase CK2 catalytic subunit with an effective CK2 beta-competitive ligand
Acs Chem.Biol., 8, 2013
1JWH
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BU of 1jwh by Molmil
Crystal Structure of Human Protein Kinase CK2 Holoenzyme
Descriptor: Casein kinase II beta chain, Casein kinase II, alpha chain, ...
Authors:Niefind, K, Guerra, B, Ermakowa, I, Issinger, O.G.
Deposit date:2001-09-04
Release date:2002-03-04
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme.
EMBO J., 20, 2001
3FWQ
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BU of 3fwq by Molmil
Inactive conformation of human protein kinase CK2 catalytic subunit
Descriptor: CHLORIDE ION, Casein kinase II subunit alpha, GLYCEROL, ...
Authors:Niefind, K, Raaf, J, Issinger, O.G.
Deposit date:2009-01-19
Release date:2009-02-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:First inactive conformation of CK2 alpha, the catalytic subunit of protein kinase CK2
J.Mol.Biol., 386, 2009
3OFM
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BU of 3ofm by Molmil
Structure of a human CK2alpha prime, the paralog isoform of the catalytic subunit of protein kinase CK2 from Homo sapiens
Descriptor: 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol, CHLORIDE ION, Casein kinase II subunit alpha'
Authors:Bischoff, N, Olsen, B, Raaf, J, Bretner, M, Issinger, O.-G, Niefind, K.
Deposit date:2010-08-15
Release date:2011-01-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of the reduced affinity between the protein kinase CK2 subunits CK2alpha prime and CK2beta
J.Mol.Biol., 407, 2011
1F0Q
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BU of 1f0q by Molmil
CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF PROTEIN KINASE CK2 IN COMPLEX WITH THE NUCLEOTIDE COMPETITIVE INHIBITOR EMODIN
Descriptor: 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, PROTEIN KINASE CK2, ALPHA SUBUNIT
Authors:Battistutta, R, Sarno, S, De Moliner, E, Papinutto, E, Zanotti, G, Pinna, L.A.
Deposit date:2000-05-17
Release date:2001-05-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:The replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2.
J.Biol.Chem., 275, 2000
1DS5
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BU of 1ds5 by Molmil
DIMERIC CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT IN COMPLEX WITH TWO BETA PEPTIDES MIMICKING THE ARCHITECTURE OF THE TETRAMERIC PROTEIN KINASE CK2 HOLOENZYME.
Descriptor: ADENOSINE MONOPHOSPHATE, CASEIN KINASE, ALPHA CHAIN, ...
Authors:Battistutta, R, Sarno, S, De Moliner, E, Marin, O, Zanotti, G, Pinna, L.A.
Deposit date:2000-01-07
Release date:2001-01-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:The crystal structure of the complex of Zea mays alpha subunit with a fragment of human beta subunit provides the clue to the architecture of protein kinase CK2 holoenzyme.
Eur.J.Biochem., 267, 2000
3U87
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BU of 3u87 by Molmil
Structure of a chimeric construct of human CK2alpha and human CK2alpha' in complex with a non-hydrolysable ATP-analogue
Descriptor: CHLORIDE ION, Casein kinase II subunit alpha, GLYCEROL, ...
Authors:Niefind, K, Raaf, J, Issinger, O.-G, Olsen, B.
Deposit date:2011-10-16
Release date:2012-05-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Low-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing bias.
Acta Crystallogr.,Sect.D, 68, 2012
1PJK
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BU of 1pjk by Molmil
Crystal Structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit
Descriptor: CHLORIDE ION, Casein kinase II, alpha chain, ...
Authors:Ermakova, I, Boldyreff, B, Issinger, O.-G, Niefind, K.
Deposit date:2003-06-03
Release date:2003-06-24
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit
J.Mol.Biol., 330, 2003
3EED
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BU of 3eed by Molmil
Crystal structure of human protein kinase CK2 regulatory subunit (CK2beta; mutant 1-193)
Descriptor: Casein kinase II subunit beta, SULFATE ION, ZINC ION
Authors:Niefind, K, Raaf, J, Issinger, O.-G.
Deposit date:2008-09-04
Release date:2008-09-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The interaction of CK2{alpha} and CK2{beta}, the subunits of protein kinase CK2, requires CK2{beta} in a preformed conformation and is enthalpically driven
Protein Sci., 17, 2008
2PVR
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BU of 2pvr by Molmil
Crystal structure of the catalytic subunit of protein kinase CK2 (C-terminal deletion mutant 1-335) in complex with two sulfate ions
Descriptor: Casein kinase II subunit alpha, catalytic subunit, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Niefind, K, Yde, C.W, Ermakova, I, Issinger, O.-G.
Deposit date:2007-05-10
Release date:2007-06-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.605 Å)
Cite:Evolved to Be Active: Sulfate Ions Define Substrate Recognition Sites of CK2alpha and Emphasise its Exceptional Role within the CMGC Family of Eukaryotic Protein Kinases
J.Mol.Biol., 370, 2007
3RPS
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BU of 3rps by Molmil
Structure of human CK2alpha in complex with the ATP-competitive inhibitor 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol
Descriptor: 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol, CHLORIDE ION, Casein kinase II subunit alpha, ...
Authors:Bischoff, N, Raaf, J, Olsen, B, Bretner, M, Issinger, O.-G, Niefind, K.
Deposit date:2011-04-27
Release date:2011-06-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Enzymatic activity with an incomplete catalytic spine - insights from a comparative structural analysis of human CK2alpha and its paralogous isoform CK2alpha'
Mol.Cell.Biochem., 356, 2011
4NH1
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BU of 4nh1 by Molmil
Crystal structure of a heterotetrameric CK2 holoenzyme complex carrying the Andante-mutation in CK2beta and consistent with proposed models of autoinhibition and trans-autophosphorylation
Descriptor: Casein kinase II subunit alpha, Casein kinase II subunit beta, GLYCEROL, ...
Authors:Schnitzler, A, Issinger, O.-G, Niefind, K.
Deposit date:2013-11-04
Release date:2014-03-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The Protein Kinase CK2(Andante) Holoenzyme Structure Supports Proposed Models of Autoregulation and Trans-Autophosphorylation
J.Mol.Biol., 426, 2014
1NA7
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BU of 1na7 by Molmil
Crystal structure of the catalytic subunit of human protein kinase CK2
Descriptor: Casein kinase II, alpha chain
Authors:Pechkova, E, Zanotti, G, Nicolini, C.
Deposit date:2002-11-27
Release date:2003-08-26
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.
Acta Crystallogr.,Sect.D, 59, 2003
5M56
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BU of 5m56 by Molmil
Monoclinic complex structure of human protein kinase CK2 catalytic subunit (isoform CK2alpha') with the inhibitor 4'-carboxy-6,8-chloro-flavonol (FLC21)
Descriptor: 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid, CHLORIDE ION, Casein kinase II subunit alpha', ...
Authors:Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O.
Deposit date:2016-10-20
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.237 Å)
Cite:Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
5M44
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BU of 5m44 by Molmil
Complex structure of human protein kinase CK2 catalytic subunit with a thieno[2,3-d]pyrimidin inhibitor crystallized under high-salt conditions
Descriptor: 3-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylpropanoic acid, CHLORIDE ION, Casein kinase II subunit alpha
Authors:Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O.
Deposit date:2016-10-18
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
5M4U
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BU of 5m4u by Molmil
ORTHORHOMBIC COMPLEX STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA') WITH THE INHIBITOR 4'-CARBOXY-6,8-CHLORO- FLAVONOL (FLC21)
Descriptor: 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid, ACETATE ION, CHLORIDE ION, ...
Authors:Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O.
Deposit date:2016-10-19
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.195 Å)
Cite:Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017

 

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