Author results

4RLK
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CRYSTAL STRUCTURE OF Z. MAYS CK2ALPHA IN COMPLEX WITH THE ATP-COMPETITIVE INHIBITOR 4-[(E)-(FLUOREN-9-YLIDENEHYDRAZINYLIDENE)-METHYL] BENZOATE
Descriptor:Casein kinase II subunit alpha, GLYCEROL, ACETATE ION, ...
Authors:Guerra, B., Rasmussen, T.D.L., Schnitzler, A., Jensen, H.H., Boldyreff, B.S., Miyata, Y., Marcussen, N., Niefind, K., Issinger, O.G.
Deposit date:2014-10-17
Release date:2014-12-17
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Protein kinase CK2 inhibition is associated with the destabilization of HIF-1 alpha in human cancer cells.
Cancer Lett, 356, 2015
4RLL
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CRYSTAL STRUCTURE OF HUMAN CK2ALPHA IN COMPLEX WITH THE ATP-COMPETITIVE INHIBITOR 4-[(E)-(FLUOREN-9-YLIDENEHYDRAZINYLIDENE)-METHYL] BENZOATE
Descriptor:Casein kinase II subunit alpha, GLYCEROL, 4-[(E)-(9H-fluoren-9-ylidenehydrazinylidene)methyl]benzoic acid
Authors:Guerra, B., Rasmussen, T.D.L., Schnitzler, A., Jensen, H.H., Boldyreff, B.S., Miyata, Y., Marcussen, N., Niefind, K., Issinger, O.G.
Deposit date:2014-10-17
Release date:2014-12-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Protein kinase CK2 inhibition is associated with the destabilization of HIF-1 alpha in human cancer cells.
Cancer Lett, 356, 2015
4UB7
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HIGH-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT WITH 4'-CARBOXY-6,8-BROMO-FLAVONOL (FLC26) SHOWING AN EXTREME DISTORTION OF THE ATP-BINDING LOOP COMBINED WITH A PI-HALOGEN BOND
Descriptor:Casein kinase II subunit alpha, 4-(6,8-dibromo-3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid, CHLORIDE ION
Authors:Niefind, K., Bischoff, N., Guerra, B., Golub, A., Issinger, O.-G.
Deposit date:2014-08-12
Release date:2015-07-01
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2 alpha Complex Structures.
Acs Chem.Biol., 10, 2015
4UBA
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LOW-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT WITH 4'-CARBOXY-6,8-BROMO-FLAVONOL (FLC26)
Descriptor:Casein kinase II subunit alpha, 4-(6,8-dibromo-3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid
Authors:Niefind, K., Bischoff, N., Guerra, B., Golub, A., Issinger, O.-G.
Deposit date:2014-08-12
Release date:2015-07-01
Method:X-RAY DIFFRACTION (2.995 Å)
Cite:A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2 alpha Complex Structures.
Acs Chem.Biol., 10, 2015
1LP4
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CRYSTAL STRUCTURE OF A BINARY COMPLEX OF THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2 WITH MG-AMPPNP
Descriptor:Protein kinase CK2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Niefind, K., Puetter, M., Guerra, B., Issinger, O.-G., Schomburg, D.
Deposit date:2002-05-07
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
1LPU
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LOW TEMPERATURE CRYSTAL STRUCTURE OF THE APO-FORM OF THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2 FROM ZEA MAYS
Descriptor:Protein kinase CK2, BENZAMIDINE
Authors:Niefind, K., Puetter, M., Guerra, B., Issinger, O.-G., Schomburg, D.
Deposit date:2002-05-08
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
1LR4
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ROOM TEMPERATURE CRYSTAL STRUCTURE OF THE APO-FORM OF THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2 FROM ZEA MAYS
Descriptor:Protein kinase CK2, BENZAMIDINE
Authors:Niefind, K., Puetter, M., Guerra, B., Issinger, O.-G., Schomburg, D.
Deposit date:2002-05-14
Release date:2002-05-29
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
1DAW
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CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-AMPPNP
Descriptor:PROTEIN KINASE CK2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Niefind, K., Puetter, M., Guerra, B., Issinger, O.G., Schomburg, D.
Deposit date:1999-11-01
Release date:2000-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:GTP plus water mimic ATP in the active site of protein kinase CK2.
Nat.Struct.Biol., 6, 1999
1DAY
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CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-GMPPNP
Descriptor:PROTEIN KINASE CK2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Niefind, K., Puetter, M., Guerra, B., Issinger, O.G., Schomburg, D.
Deposit date:1999-11-01
Release date:2000-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:GTP plus water mimic ATP in the active site of protein kinase CK2.
Nat.Struct.Biol., 6, 1999
4IB5
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STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT IN COMPLEX WITH A CK2BETA-COMPETITIVE CYCLIC PEPTIDE
Descriptor:Casein kinase II subunit alpha, CK2beta-derived cyclic peptide, GLYCEROL, ...
Authors:Raaf, J., Guerra, B., Neundorf, I., Bopp, B., Issinger, O.-G., Jose, J., Pietsch, M., Niefind, K.
Deposit date:2012-12-08
Release date:2013-03-20
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:First structure of protein kinase CK2 catalytic subunit with an effective CK2 beta-competitive ligand
Acs Chem.Biol., 8, 2013
1JWH
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CRYSTAL STRUCTURE OF HUMAN PROTEIN KINASE CK2 HOLOENZYME
Descriptor:Casein kinase II, alpha chain, Casein kinase II beta chain, ...
Authors:Niefind, K., Guerra, B., Ermakowa, I., Issinger, O.G.
Deposit date:2001-09-04
Release date:2002-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme.
EMBO J., 20, 2001
3FWQ
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INACTIVE CONFORMATION OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT
Descriptor:Casein kinase II subunit alpha, GLYCEROL, SULFATE ION, ...
Authors:Niefind, K., Raaf, J., Issinger, O.G.
Deposit date:2009-01-19
Release date:2009-02-17
Last modified:2012-04-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:First inactive conformation of CK2 alpha, the catalytic subunit of protein kinase CK2
J.Mol.Biol., 386, 2009
3OFM
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STRUCTURE OF A HUMAN CK2ALPHA PRIME, THE PARALOG ISOFORM OF THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2 FROM HOMO SAPIENS
Descriptor:Casein kinase II subunit alpha', 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol, CHLORIDE ION
Authors:Bischoff, N., Olsen, B., Raaf, J., Bretner, M., Issinger, O.-G., Niefind, K.
Deposit date:2010-08-15
Release date:2011-01-19
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of the reduced affinity between the protein kinase CK2 subunits CK2alpha prime and CK2beta
J.Mol.Biol., 407, 2011
3U87
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STRUCTURE OF A CHIMERIC CONSTRUCT OF HUMAN CK2ALPHA AND HUMAN CK2ALPHA' IN COMPLEX WITH A NON-HYDROLYSABLE ATP-ANALOGUE
Descriptor:Casein kinase II subunit alpha, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Niefind, K., Raaf, J., Issinger, O.-G., Olsen, B.
Deposit date:2011-10-16
Release date:2012-05-30
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Low-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing bias.
Acta Crystallogr.,Sect.D, 68, 2012
1F0Q
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CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF PROTEIN KINASE CK2 IN COMPLEX WITH THE NUCLEOTIDE COMPETITIVE INHIBITOR EMODIN
Descriptor:PROTEIN KINASE CK2, ALPHA SUBUNIT, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE
Authors:Battistutta, R., Sarno, S., De Moliner, E., Papinutto, E., Zanotti, G., Pinna, L.A.
Deposit date:2000-05-17
Release date:2001-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:The replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2.
J.Biol.Chem., 275, 2000
3RPS
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STRUCTURE OF HUMAN CK2ALPHA IN COMPLEX WITH THE ATP-COMPETITIVE INHIBITOR 3-(4,5,6,7-TETRABROMO-1H-BENZOTRIAZOL-1-YL)PROPAN-1-OL
Descriptor:Casein kinase II subunit alpha, 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol, SULFATE ION, ...
Authors:Bischoff, N., Raaf, J., Olsen, B., Bretner, M., Issinger, O.-G., Niefind, K.
Deposit date:2011-04-27
Release date:2011-06-08
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Enzymatic activity with an incomplete catalytic spine - insights from a comparative structural analysis of human CK2alpha and its paralogous isoform CK2alpha'
Mol.Cell.Biochem., 356, 2011
1PJK
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CRYSTAL STRUCTURE OF A C-TERMINAL DELETION MUTANT OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT
Descriptor:Casein kinase II, alpha chain, CHLORIDE ION, ...
Authors:Ermakova, I., Boldyreff, B., Issinger, O.-G., Niefind, K.
Deposit date:2003-06-03
Release date:2003-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit
J.Mol.Biol., 330, 2003
2PVR
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CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2 (C-TERMINAL DELETION MUTANT 1-335) IN COMPLEX WITH TWO SULFATE IONS
Descriptor:Casein kinase II subunit alpha, catalytic subunit, SULFATE ION, ...
Authors:Niefind, K., Yde, C.W., Ermakova, I., Issinger, O.-G.
Deposit date:2007-05-10
Release date:2007-06-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.605 Å)
Cite:Evolved to Be Active: Sulfate Ions Define Substrate Recognition Sites of CK2alpha and Emphasise its Exceptional Role within the CMGC Family of Eukaryotic Protein Kinases
J.Mol.Biol., 370, 2007
4NH1
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CRYSTAL STRUCTURE OF A HETEROTETRAMERIC CK2 HOLOENZYME COMPLEX CARRYING THE ANDANTE-MUTATION IN CK2BETA AND CONSISTENT WITH PROPOSED MODELS OF AUTOINHIBITION AND TRANS-AUTOPHOSPHORYLATION
Descriptor:Casein kinase II subunit alpha, Casein kinase II subunit beta, MAGNESIUM ION, ...
Authors:Schnitzler, A., Issinger, O.-G., Niefind, K.
Deposit date:2013-11-04
Release date:2014-03-12
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The Protein Kinase CK2(Andante) Holoenzyme Structure Supports Proposed Models of Autoregulation and Trans-Autophosphorylation
J.Mol.Biol., 426, 2014
1DS5
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DIMERIC CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT IN COMPLEX WITH TWO BETA PEPTIDES MIMICKING THE ARCHITECTURE OF THE TETRAMERIC PROTEIN KINASE CK2 HOLOENZYME.
Descriptor:CASEIN KINASE, ALPHA CHAIN, BETA CHAIN, ...
Authors:Battistutta, R., Sarno, S., De Moliner, E., Marin, O., Zanotti, G., Pinna, L.A.
Deposit date:2000-01-07
Release date:2001-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:The crystal structure of the complex of Zea mays alpha subunit with a fragment of human beta subunit provides the clue to the architecture of protein kinase CK2 holoenzyme.
Eur.J.Biochem., 267, 2000
1NA7
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CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF HUMAN PROTEIN KINASE CK2
Descriptor:Casein kinase II, alpha chain
Authors:Pechkova, E., Zanotti, G., Nicolini, C.
Deposit date:2002-11-27
Release date:2003-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.
Acta Crystallogr.,Sect.D, 59, 2003
3EED
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CRYSTAL STRUCTURE OF HUMAN PROTEIN KINASE CK2 REGULATORY SUBUNIT (CK2BETA; MUTANT 1-193)
Descriptor:Casein kinase II subunit beta, ZINC ION, SULFATE ION
Authors:Niefind, K., Raaf, J., Issinger, O.-G.
Deposit date:2008-09-04
Release date:2008-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The interaction of CK2{alpha} and CK2{beta}, the subunits of protein kinase CK2, requires CK2{beta} in a preformed conformation and is enthalpically driven
Protein Sci., 17, 2008
5M44
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COMPLEX STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT WITH A THIENO[2,3-D]PYRIMIDIN INHIBITOR CRYSTALLIZED UNDER HIGH-SALT CONDITIONS
Descriptor:Casein kinase II subunit alpha, 3-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylpropanoic acid, CHLORIDE ION
Authors:Niefind, K., Bischoff, N., Yarmoluk, S.M., Bdzhola, V.G., Golub, A.G., Balanda, A.O., Prykhod'ko, A.O.
Deposit date:2016-10-18
Release date:2017-01-18
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
5M4C
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COMPLEX STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT WITH A THIENO[2,3-D]PYRIMIDIN INHIBITOR CRYSTALLIZED UNDER LOW-SALT CONDITIONS
Descriptor:Casein kinase II subunit alpha, 3-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylpropanoic acid, CHLORIDE ION, ...
Authors:Niefind, K., Bischoff, N., Yarmoluk, S.M., Bdzhola, V.G., Golub, A.G., Balanda, A.O., Prykhod'ko, A.O.
Deposit date:2016-10-18
Release date:2017-01-18
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.935 Å)
Cite:Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
5M4F
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COMPLEX STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT WITH THE INHIBITOR 4'-CARBOXY-6,8-CHLORO-FLAVONOL (FLC21) CRYSTALLIZED UNDER LOW-SALT CONDITIONS
Descriptor:Casein kinase II subunit alpha, 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid, GLYCEROL, ...
Authors:Niefind, K., Bischoff, N., Yarmoluk, S.M., Bdzhola, V.G., Golub, A.G., Balanda, A.O., Prykhod'ko, A.O.
Deposit date:2016-10-18
Release date:2017-01-18
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.519 Å)
Cite:Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
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