Author results

4NEY
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CRYSTAL STRUCTURE OF AN ENGINEERED PROTEIN WITH FERREDOXIN FOLD, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR277
Descriptor:Engineered protein OR277, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, tetrabutylphosphonium
Authors:Guan, R., Lin, Y.-R., Koga, N., Koga, R., Castellanos, J., Seetharaman, J., Maglaqui, M., Sahdev, S., Mao, L., Xiao, R., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-10-30
Release date:2014-01-15
Method:X-RAY DIFFRACTION (2.323 Å)
Cite:Northeast Structural Genomics Consortium Target OR277
To be published
4NEZ
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CRYSTAL STRUCTURE OF AN ENGINEERED PROTEIN WITH FERREDOXIN FOLD, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR276
Descriptor:Engineered protein OR276, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, tetrabutylphosphonium
Authors:Guan, R., Lin, Y.-R., Koga, N., Koga, R., Castellanos, J., Seetharaman, J., Maglaqui, M., Sahdev, S., Mao, L., Xiao, R., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-10-30
Release date:2014-01-15
Method:X-RAY DIFFRACTION (2.395 Å)
Cite:Northeast Structural Genomics Consortium Target OR276
To be published
3I1H
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CRYSTAL STRUCTURE OF HUMAN BFL-1 IN COMPLEX WITH BAK BH3 PEPTIDE
Descriptor:Protein BFL-1, Apoptosis regulator BAK
Authors:Guan, R., Xiao, R., Zhao, L., Acton, T., White, E., Gelinas, C., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2009-06-26
Release date:2009-07-14
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:crystal structure of human BFL-1 in complex with BAK BH3 peptide
To be Published
3MQP
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CRYSTAL STRUCTURE OF HUMAN BFL-1 IN COMPLEX WITH NOXA BH3 PEPTIDE, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR2930
Descriptor:Bcl-2-related protein A1, Phorbol-12-myristate-13-acetate-induced protein 1
Authors:Guan, R., Xiao, R., Zhao, L., Acton, T.B., Gelinas, C., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-04-28
Release date:2010-06-02
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Crystal Structure of human BFL-1 in complex with NOXA BH3 peptide
To be Published
3NNQ
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF MOLONEY MURINE LEUKEMIA VIRUS INTEGRASE, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET OR3
Descriptor:N-terminal domain of Moloney murine leukemia virus integrase, ZINC ION, ACETATE ION
Authors:Guan, R., Xiao, R., Acton, T., Jiang, M., Roth, M., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-06-24
Release date:2010-07-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.693 Å)
Cite:X-ray crystal structure of the N-terminal region of Moloney murine leukemia virus integrase and its implications for viral DNA recognition.
Proteins, 2017
4NE7
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CRYSTAL STRUCTURE OF ENGINEERED KUMAMOLISIN-AS FROM ALICYCLOBACILLUS SENDAIENSIS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR367
Descriptor:Kumamolisin-As, ZINC ION
Authors:Guan, R., Pultz, I.S., Siegel, J.B., Seetharaman, J., Kornhaber, G., Maglaqui, M., Mao, L., Xiao, R., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-10-28
Release date:2013-11-20
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Northeast Structural Genomics Consortium Target OR367
To be Published
4NZG
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF MOLONEY MURINE LEUKEMIA VIRUS INTEGRASE, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET OR3
Descriptor:Integrase p46, ZINC ION, ACETATE ION, ...
Authors:Guan, R., Jiang, M., Janjua, H., Maglaqui, M., Zhao, L., Xiao, R., Acton, T.B., Everett, J.K., Roth, M., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-12-12
Release date:2014-02-05
Last modified:2017-02-22
Method:X-RAY DIFFRACTION (2.152 Å)
Cite:X-ray crystal structure of the N-terminal region of Moloney murine leukemia virus integrase and its implications for viral DNA recognition.
Proteins, 2017
4R80
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CRYSTAL STRUCTURE OF A DE NOVO DESIGNED BETA SHEET PROTEIN, CYSTATIN FOLD, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR486
Descriptor:OR486
Authors:Guan, R., Marcos, E., O'Connell, P., Seetharaman, J., Janjua, H., Xiao, R., Maglaqui, M., Acton, T.B., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2014-08-29
Release date:2014-09-24
Method:X-RAY DIFFRACTION (2.445 Å)
Cite:Crystal Structure of an engineered protein with denovo beta sheet design, Northeast Structural Genomics Consortium (NESG) Target OR486
To be Published
4ZEQ
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CRYSTAL STRUCTURE OF HUMAN BFL-1 IN COMPLEX WITH TBID BH3 PEPTIDE, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HX9247
Descriptor:Bcl-2-related protein A1, BH3-interacting domain death agonist
Authors:Guan, R., Xiao, R., Mao, L., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2015-04-20
Release date:2015-05-06
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of human BFL-1 in complex with tBid BH3 peptide
To Be Published
1SK3
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CRYSTAL STRUCTURE OF THE C-TERMINAL PEPTIDOGLYCAN-BINDING DOMAIN OF HUMAN PEPTIDOGLYCAN RECOGNITION PROTEIN IALPHA
Descriptor:Peptidoglycan recognition protein I-alpha, NICKEL (II) ION, SULFATE ION
Authors:Guan, R., Malchiodi, E.L., Qian, W., Schuck, P., Mariuzza, R.A.
Deposit date:2004-03-04
Release date:2004-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ialpha
J.Biol.Chem., 279, 2004
1SK4
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CRYSTAL STRUCTURE OF THE C-TERMINAL PEPTIDOGLYCAN-BINDING DOMAIN OF HUMAN PEPTIDOGLYCAN RECOGNITION PROTEIN IALPHA
Descriptor:Peptidoglycan recognition protein I-alpha, SODIUM ION
Authors:Guan, R., Malchiodi, E.L., Qian, W., Schuck, P., Mariuzza, R.A.
Deposit date:2004-03-04
Release date:2004-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ialpha
J.Biol.Chem., 279, 2004
1TWQ
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CRYSTAL STRUCTURE OF THE C-TERMINAL PGN-BINDING DOMAIN OF HUMAN PGRP-IALPHA IN COMPLEX WITH PGN ANALOG MURAMYL TRIPEPTIDE
Descriptor:peptidoglycan recognition protein-I-alpha, muramyl tripeptide, NICKEL (II) ION
Authors:Guan, R., Roychowdury, A., Boons, G.-A., Mariuzza, R.A.
Deposit date:2004-07-01
Release date:2004-12-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for peptidoglycan binding by peptidoglycan recognition proteins
Proc.Natl.Acad.Sci.USA, 101, 2004
1YCK
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CRYSTAL STRUCTURE OF HUMAN PEPTIDOGLYCAN RECOGNITION PROTEIN (PGRP-S)
Descriptor:Peptidoglycan recognition protein
Authors:Guan, R., Wang, Q., Sundberg, E.J., Mariuzza, R.A.
Deposit date:2004-12-22
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution.
J.Mol.Biol., 347, 2005
2APH
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CRYSTAL STRUCTURE OF HUMAN PGRP-IALPHAC IN COMPLEX WITH MURAMYL PENTAPEPTIDE
Descriptor:Peptidoglycan recognition protein I-alpha, muramyl pentapeptide, SULFATE ION
Authors:Guan, R., Roychowdjury, A., Boons, G., Mariuzza, R.A.
Deposit date:2005-08-16
Release date:2006-06-27
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human peptidoglycan recognition protein I alpha bound to a muramyl pentapeptide from Gram-positive bacteria.
Protein Sci., 15, 2006
2Q3X
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THE RIM1ALPHA C2B DOMAIN
Descriptor:Regulating synaptic membrane exocytosis protein 1, SULFATE ION, CHLORIDE ION, ...
Authors:Guan, R., Dai, H., Tomchick, D.R., Machius, M., Sudhof, T.C., Rizo, J.
Deposit date:2007-05-30
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Crystal Structure of the RIM1alpha C(2)B Domain at 1.7 A Resolution.
Biochemistry, 46, 2007
3R66
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CRYSTAL STRUCTURE OF HUMAN ISG15 IN COMPLEX WITH NS1 N-TERMINAL REGION FROM INFLUENZA VIRUS B, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET IDS HX6481, HR2873, AND OR2
Descriptor:Non-structural protein 1, Ubiquitin-like protein ISG15
Authors:Guan, R., Ma, L.C., Krug, R.M., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2011-03-21
Release date:2011-06-08
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Structure of the complex of ISG15 and Influenza B virus NS1 Protein: implications for the mechanism of SN1-mediated inhibition of ISG15 conjugation
To be Published
3SDL
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CRYSTAL STRUCTURE OF HUMAN ISG15 IN COMPLEX WITH NS1 N-TERMINAL REGION FROM INFLUENZA B VIRUS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET IDS HX6481, HR2873, AND OR2
Descriptor:Non-structural protein 1, Ubiquitin-like protein ISG15
Authors:Guan, R., Ma, L.-C., Krug, R.M., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2011-06-09
Release date:2011-07-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus.
Proc.Natl.Acad.Sci.USA, 108, 2011
3MTT
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CRYSTAL STRUCTURE OF ISH2 DOMAIN OF HUMAN P85BETA, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR5531C
Descriptor:Phosphatidylinositol 3-kinase regulatory subunit beta
Authors:Guan, R., Schauder, C., Ma, L.C., Krug, R.M., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-04-30
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the iSH2 domain of human phosphatidylinositol 3-kinase p85beta subunit reveals conformational plasticity in the interhelical turn region
Acta Crystallogr.,Sect.F, 66, 2010
3N0A
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CRYSTAL STRUCTURE OF AUXILIN (40-400)
Descriptor:Tyrosine-protein phosphatase auxilin, CALCIUM ION, CHLORIDE ION
Authors:Harrison, S.C., Guan, R., Dai, H., Kirchhausen, T.
Deposit date:2010-05-13
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the PTEN-like Region of Auxilin, a Detector of Clathrin-Coated Vesicle Budding.
Structure, 18, 2010
3OZB
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CRYSTAL STRUCTURE OF 5'-METHYLTHIOINOSINE PHOSPHORYLASE FROM PSEDOMONAS AERUGINOSA IN COMPLEX WITH HYPOXANTHINE
Descriptor:Methylthioadenosine phosphorylase, HYPOXANTHINE, SULFATE ION
Authors:Ho, M., Guan, R., Almo, S.C., Schramm, V.L.
Deposit date:2010-09-24
Release date:2011-08-10
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing.
Biochemistry, 50, 2011
4GBD
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CRYSTAL STRUCTURE OF ADENOSINE DEAMINASE FROM PSEUDOMONAS AERUGINOSA PAO1 WITH BOUND ZN AND METHYLTHIO-COFORMYCIN
Descriptor:Putative uncharacterized protein, (8R)-3-(5-S-methyl-5-thio-beta-D-ribofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, ZINC ION, ...
Authors:Ho, M., Guan, R., Almo, S.C., Schramm, V.L.
Deposit date:2012-07-27
Release date:2013-06-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.975 Å)
Cite:Methylthioadenosine deaminase in an alternative quorum sensing pathway in Pseudomonas aeruginosa.
Biochemistry, 51, 2012
5DIL
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CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF THE NS1 PROTEIN FROM INFLUENZA VIRUS B
Descriptor:Non-structural protein 1, IODIDE ION
Authors:Guan, R., Hamilton, K., Ma, L., Montelione, G.T.
Deposit date:2015-09-01
Release date:2016-08-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:A Second RNA-Binding Site in the NS1 Protein of Influenza B Virus.
Structure, 24, 2016
5X3E
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KINESIN 6
Descriptor:Kinesin-like protein, SULFATE ION, IODIDE ION
Authors:Chen, Z., Guan, R., Zhang, L.
Deposit date:2017-02-04
Release date:2017-04-19
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin
Nat Commun, 8, 2017
4RJV
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CRYSTAL STRUCTURE OF A DE NOVO DESIGNED FERREDOXIN FOLD, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR461
Descriptor:OR461
Authors:O'Connell, P.T., Lin, Y.-R., Guan, R., Koga, N., Koga, R., Seetharaman, J., Janjua, H., Xiao, R., Maglaqui, M., Everett, J.K., Acton, T.B., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2014-10-09
Release date:2014-10-22
Method:X-RAY DIFFRACTION (1.523 Å)
Cite:Northeast Structural Genomics Consortium Target OR461
To be published
1P4L
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CRYSTAL STRUCTURE OF NK RECEPTOR LY49C MUTANT WITH ITS MHC CLASS I LIGAND H-2KB
Descriptor:MHC CLASS I H-2KB HEAVY CHAIN, Beta-2-microglobulin, Ovalbumin peptide, ...
Authors:Dam, J., Guan, R., Natarajan, K., Dimasi, N., Mariuzza, R.A.
Deposit date:2003-04-23
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b).
Nat.Immunol., 4, 2003