Author results

5Z3Q
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CRYSTAL STRUCTURE OF A SOLUBLE FRAGMENT OF POLIOVIRUS 2C ATPASE (2.55 ANGSTROM)
Descriptor:PV-2C, ZINC ION, PHOSPHATE ION
Authors:Guan, H., Tian, J., Zhang, C., Qin, B., Cui, S.
Deposit date:2018-01-08
Release date:2018-09-12
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.545 Å)
Cite:Crystal structure of a soluble fragment of poliovirus 2CATPase
PLoS Pathog., 14, 2018
5YAG
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CRYSTAL STRUCTURE OF MOSQUITO ARYLALKYLAMINE N-ACETYLTRANSFERASE LIKE 5B/SPERMINE N-ACETYLTRANSFERASE
Descriptor:AAEL004827-PA, GLYCEROL
Authors:Han, Q., Guan, H., Robinson, H., Li, J.
Deposit date:2017-08-31
Release date:2018-02-28
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Identification of aaNAT5b as a spermine N-acetyltransferase in the mosquito, Aedes aegypti.
PLoS ONE, 13, 2018
5GNB
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CRYSTAL STRUCTURE OF THE RECEPTOR BINDING DOMAIN OF THE SPIKE GLYCOPROTEIN OF HUMAN BETACORONAVIRUS HKU1 (HKU1 1A-CTD, 2.3 ANGSTROM, NATIVE-SAD PHASING)
Descriptor:Spike glycoprotein, N-ACETYL-D-GLUCOSAMINE
Authors:Guan, H., Wojdyla, J.A., Wang, M., Cui, S.
Deposit date:2016-07-20
Release date:2017-06-07
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1
Nat Commun, 8, 2017
5KWB
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CRYSTAL STRUCTURE OF THE RECEPTOR BINDING DOMAIN OF THE SPIKE GLYCOPROTEIN OF HUMAN BETACORONAVIRUS HKU1 (HKU1 1A-CTD, 1.9 ANGSTROM, MOLECULAR REPLACEMENT)
Descriptor:Spike glycoprotein, N-ACETYL-D-GLUCOSAMINE, SUCROSE, ...
Authors:Guan, H., Wojdyla, J.A., Wang, M., Cui, S.
Deposit date:2016-07-17
Release date:2017-06-07
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1
Nat Commun, 8, 2017
5YDH
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CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE CATALYTIC SUBUNITS OF THE MALARIA VECTOR ANOPHELES GAMBIAE, 3.2 A
Descriptor:Acetylcholinesterase, SULFATE ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Han, Q., Guan, H., Robinson, H., Ding, H., Liao, C., Li, J.
Deposit date:2017-09-13
Release date:2018-03-07
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Crystal structures of acetylcholinesterase of the malaria vector Anopheles gambiae reveal a polymerization interface, ligand binding residues and post translational modifications
To Be Published
5YDI
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CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE CATALYTIC SUBUNITS OF THE MALARIA VECTOR ANOPHELES GAMBIAE, NEW CRYSTAL PACKING
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, GLYCEROL, ...
Authors:Han, Q., Guan, H., Ding, H., Liao, C., Robinson, H., Li, J.
Deposit date:2017-09-13
Release date:2018-03-07
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Crystal structures of acetylcholinesterase of the malaria vector Anopheles gambiae reveal a polymerization interface, ligand binding residues and post translational modifications
To Be Published
5YDJ
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CRYSTAL STRUCTURE OF ANOPHELES GAMBIAE ACETYLCHOLINESTERASE IN COMPLEX WITH PMSF
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, SULFATE ION, ...
Authors:Han, Q., Guan, H., Ding, H., Liao, C., Robinson, H., Li, J.
Deposit date:2017-09-13
Release date:2018-03-07
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Crystal structures of acetylcholinesterase of the malaria vector Anopheles gambiae reveal a polymerization interface, ligand binding residues and post translational modifications
To Be Published
5IQL
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CRYSTAL STRUCTURE OF YEATS2 YEATS BOUND TO H3K27CR PEPTIDE
Descriptor:YEATS domain-containing protein 2, Histone H3.1
Authors:Li, H., Zhao, D., Guan, H.
Deposit date:2016-03-11
Release date:2016-07-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:YEATS2 is a selective histone crotonylation reader.
Cell Res., 26, 2016
6JRL
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CRYSTAL STRUCTURE OF DROSOPHILA ALPHA METHYLDOPA-RESISTANT PROTEIN/3,4-DIHYDROXYPHENYLACETALDEHYDE SYNTHASE
Descriptor:3,4-dihydroxyphenylacetaldehyde synthase
Authors:Wei, S., Vavrick, C.J., Guan, H., Liao, C., Robinson, H., Liang, J., Wang, D., Han, Q., Li, J.
Deposit date:2019-04-04
Release date:2019-04-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for the bifunctional mechanism of Drosophila alpha methyldopa-resistant protein/3,4-dihydroxyphenylacetaldehyde synthase
To Be Published
3ZMM
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INHIBITORS OF JAK2 KINASE DOMAIN
Descriptor:TYROSINE-PROTEIN KINASE JAK2, 5-FLUORO-4-[(1S)-1-(5-FLUOROPYRIMIDIN-2-YL)ETHOXY]-N-(5-METHYL-1H-PYRAZOL-3-YL)-6-MORPHOLINO-PYRIMIDIN-2-AMINE, ACETYL GROUP
Authors:Read, J., Green, I., Pollard, H., Howard, T., Mott, R.
Deposit date:2013-02-11
Release date:2013-04-17
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Discovery of Novel Jak2-Stat Pathway Inhibitors with Extended Residence Time on Target.
Bioorg.Med.Chem.Lett., 23, 2013
5XNV
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CRYSTAL STRUCTURE OF YEATS2 YEATS BOUND TO H3K27AC PEPTIDE
Descriptor:YEATS domain-containing protein 2, ALA-ALA-ARG-ALY-SER-ALA-PRO-ALA, AMMONIUM ION, ...
Authors:Li, H.T., Guan, H.P., Zhao, D.
Deposit date:2017-05-24
Release date:2017-11-01
Method:X-RAY DIFFRACTION (2.696 Å)
Cite:YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.
Nat Commun, 8, 2017
6IG9
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TRA1 SUBUNIT FROM SACCHAROMYCES CEREVISIAE SAGA COMPLEX
Descriptor:Transcription-associated protein 1
Authors:Zheng, X.D., Liu, G.C., Guan, H.P., Li, H.T.
Deposit date:2018-09-25
Release date:2019-05-15
Last modified:2019-05-22
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Architecture ofSaccharomyces cerevisiaeSAGA complex.
Cell Discov, 5, 2019
5XTZ
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CRYSTAL STRUCTURE OF GAS41 YEATS BOUND TO H3K27AC PEPTIDE
Descriptor:YEATS domain-containing protein 4, THR-LYS-ALA-ALA-ARG-ALY-SER-ALA-PRO-ALA, ACETATE ION
Authors:Li, H.T., Zhao, D.
Deposit date:2017-06-21
Release date:2018-06-27
Method:X-RAY DIFFRACTION (2.105 Å)
Cite:Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity.
Cell Discov, 4, 2018
5EBT
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TANKYRASE 1 WITH PHTHALAZINONE 2
Descriptor:Tankyrase-1, (R,R)-2,3-BUTANEDIOL, 4-[bis(fluoranyl)-[3-[[(6~{S})-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5~{H}-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]carbonyl]phenyl]methyl]-2~{H}-phthalazin-1-one, ...
Authors:Kazmirski, S.L., Johannes, J.
Deposit date:2015-10-19
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.
Bioorg.Med.Chem.Lett., 25, 2015
5ECE
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TANKYRASE 1 WITH PHTHALAZINONE 1
Descriptor:Tankyrase-1, 1,2-ETHANEDIOL, 2-[4-[3-[(4-oxidanylidene-3~{H}-phthalazin-1-yl)methyl]phenyl]carbonylpiperazin-1-yl]pyridine-3-carbonitrile, ...
Authors:Kazmirski, S.L., Johannes, J., Read, J.A., Howard, T., Larsen, N.A., Ferguson, A.D.
Deposit date:2015-10-20
Release date:2015-11-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.
Bioorg.Med.Chem.Lett., 25, 2015