Author results

4PCO
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CRYSTAL STRUCTURE OF DOUBLE-STRANDED RNA WITH FOUR TERMINAL GU WOBBLE BASE PAIRS
Descriptor:RNA (5'-D(*GP*GP*UP*GP*GP*CP*UP*GP*UP*U)-3'), COBALT HEXAMMINE(III), CHLORIDE ION
Authors:Mooers, B.H.M.
Deposit date:2014-04-15
Release date:2015-10-14
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Structures and Energetics of Four Adjacent GU Pairs That Stabilize an RNA Helix.
J.Phys.Chem.B, 119, 2015
4ME2
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CRYSTAL STRUCTURE OF THA8 PROTEIN FROM BRACHYPODIUM DISTACHYON
Descriptor:Uncharacterized protein
Authors:Ke, J., Chen, R.Z., Ban, T., Brunzelle, J.S., Gu, X., Melcher, K., Xu, H.E.
Deposit date:2013-08-24
Release date:2013-10-30
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for RNA recognition by a dimeric PPR-protein complex.
Nat.Struct.Mol.Biol., 20, 2013
1YC1
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CRYSTAL STRUCTURES OF HUMAN HSP90ALPHA COMPLEXED WITH DIHYDROXYPHENYLPYRAZOLES
Descriptor:Heat shock protein HSP 90-alpha, 4-(1,3-BENZODIOXOL-5-YL)-5-(5-ETHYL-2,4-DIHYDROXYPHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID
Authors:Kreusch, A., Han, S., Brinker, A., Zhou, V., Choi, H., He, Y., Lesley, S.A., Caldwell, J., Gu, X.
Deposit date:2004-12-21
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.
Bioorg.Med.Chem.Lett., 15, 2005
2GEB
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CRYSTAL STRUCTURE OF THE THERMOANAEROBACTER TENGCONGENSIS HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE L160I MUTANT: INSIGHTS INTO THE INHIBITOR DESIGN
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, CALCIUM ION
Authors:Chen, Q., Luo, M.
Deposit date:2006-03-19
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant--insights into inhibitor design.
Febs J., 274, 2007
5CF8
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CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-10-ETHYL-7-[(3-METHOXYPROPYL)AMINO] -3-METHYL-3,5,8,10-TETRAAZATRICYCLO[7.3.0.0,6] DODECA-1(9),2(6),4,7,11-PENTAENE-11-CARBOXAMIDE
Descriptor:Tyrosine-protein kinase JAK2, N,N-dicyclopropyl-4-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide
Authors:Sack, J.S.
Deposit date:2015-07-08
Release date:2015-08-26
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms.
Acs Med.Chem.Lett., 6, 2015
1YC4
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CRYSTAL STRUCTURE OF HUMAN HSP90ALPHA COMPLEXED WITH DIHYDROXYPHENYLPYRAZOLES
Descriptor:Heat shock protein HSP 90-alpha, 4-(1H-IMIDAZOL-4-YL)-3-(5-ETHYL-2,4-DIHYDROXY-PHENYL)-1H-PYRAZOLE
Authors:Kreusch, A., Han, S., Brinker, A., Zhou, V., Choi, H., He, Y., Lesley, S.A., Caldwell, J., Gu, X.
Deposit date:2004-12-21
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.
Bioorg.Med.Chem.Lett., 15, 2005
4PW2
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CRYSTAL STRUCTURE OF D-GLUCURONYL C5 EPIMERASE
Descriptor:D-glucuronyl C5 epimerase B, CITRIC ACID
Authors:Ke, J., Qin, Y., Gu, X., Brunzelle, J.S., Xu, H.E., Ding, K.
Deposit date:2014-03-18
Release date:2015-01-14
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
1A4F
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BAR-HEADED GOOSE HEMOGLOBIN (OXY FORM)
Descriptor:HEMOGLOBIN (ALPHA CHAIN), HEMOGLOBIN (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Zhang, J., Gu, X.
Deposit date:1998-01-29
Release date:1998-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form).
J.Mol.Biol., 255, 1996
4LEU
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CRYSTAL STRUCTURE OF THA8-LIKE PROTEIN FROM ARABIDOPSIS THALIANA
Descriptor:Pentatricopeptide repeat-containing protein At3g46870
Authors:Ke, J., Chen, R.Z., Ban, T., Brunzelle, J.S., Gu, X., Kang, Y., Melcher, K., Zhu, J.K., Xu, H.E.
Deposit date:2013-06-26
Release date:2013-09-25
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a PLS-class Pentatricopeptide Repeat Protein Provides Insights into Mechanism of RNA Recognition.
J.Biol.Chem., 288, 2013
5JA5
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CRYSTAL STRUCTURE OF THE RICE TOPLESS RELATED PROTEIN 2 (TPR2) N-TERMINAL TOPLESS DOMAIN (1-209) L111A AND L130A MUTANT IN COMPLEX WITH RICE D53 REPRESSOR EAR PEPTIDE MOTIF
Descriptor:Protein TPR1, The rice D53 peptide (a.a. 794-808), ZINC ION
Authors:Ke, J., Ma, H., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2016-04-12
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
5JGC
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CRYSTAL STRUCTURE OF THE RICE TOPLESS RELATED PROTEIN 2 (TPR2) N-TERMINAL TOPLESS DOMAIN (1-209) L111A, L130A, L179A AND I195A MUTANT
Descriptor:Protein TPR1, ZINC ION
Authors:Ke, J., Ma, H., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2016-04-20
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
5J9F
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HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND (4-{[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)ETHYL]AMINO}BENZOYL)-L-GLUTAMIC ACID (AGF183)
Descriptor:Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid
Authors:Wong, J., Deis, S.M., Dann III, C.E.
Deposit date:2016-04-09
Release date:2016-08-10
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
J.Med.Chem., 59, 2016
1YC3
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CRYSTAL STRUCTURE OF HUMAN HSP90ALPHA COMPLEXED WITH DIHYDROXYPHENYLPYRAZOLES
Descriptor:Heat shock protein HSP 90-alpha, 4-(1,3-BENZODIOXOL-5-YL)-5-(5-ETHYL-2,4-DIHYDROXYPHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID
Authors:Kreusch, A., Han, S., Brinker, A., Zhou, V., Choi, H., He, Y., Lesley, S.A., Caldwell, J., Gu, X.
Deposit date:2004-12-21
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.
Bioorg.Med.Chem.Lett., 15, 2005
1YFZ
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NOVEL IMP BINDING IN FEEDBACK INHIBITION OF HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE FROM THERMOANAEROBACTER TENGCONGENSIS
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, ACETATE ION, MAGNESIUM ION, ...
Authors:Chen, Q., Liang, Y., Su, X., Gu, X., Zheng, X., Luo, M.
Deposit date:2005-01-04
Release date:2005-05-10
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Alternative IMP Binding in Feedback Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis.
J.Mol.Biol., 348, 2005
3D9H
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CRYSTAL STRUCTURE OF THE SPLICE VARIANT OF HUMAN ASB9 (HASB9-2), AN ANKYRIN REPEAT PROTEIN
Descriptor:cDNA FLJ77766, highly similar to Homo sapiens ankyrin repeat and SOCS box-containing 9 (ASB9), transcript variant 2, ...
Authors:Fei, X., Gu, X., Fan, S., Zhang, C., Ji, C.
Deposit date:2008-05-27
Release date:2009-06-02
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the Splice Variant of Human ASB9 (hASB9-2), an Ankyrin Repeat Protein
To be published
4PXQ
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CRYSTAL STRUCTURE OF D-GLUCURONYL C5-EPIMERASE IN COMPLEX WITH HEPARIN HEXASACCHARIDE
Descriptor:D-glucuronyl C5 epimerase B, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid, N,O6-DISULFO-GLUCOSAMINE, ...
Authors:Ke, J., Qin, Y., Gu, X., Tan, J., Brunzelle, J.S., Xu, H.E., Ding, K.
Deposit date:2014-03-24
Release date:2015-01-14
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
2EXX
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CRYSTAL STRUCTURE OF HSCARG FROM HOMO SAPIENS IN COMPLEX WITH NADP
Descriptor:HSCARG protein, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL
Authors:Dai, X., Chen, Q., Yao, D., Liang, Y., Dong, Y., Gu, X., Zheng, X., Luo, M.
Deposit date:2005-11-09
Release date:2006-11-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein.
Proc.Natl.Acad.Sci.USA, 104, 2007
3W1B
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CRYSTAL STRUCTURE OF HUMAN DNA LIGASE IV-ARTEMIS COMPLEX (MERCURY DERIVATIVE)
Descriptor:DNA ligase 4, Artemis-derived peptide, ADENOSINE MONOPHOSPHATE, ...
Authors:Ochi, T., Blundell, T.L.
Deposit date:2012-11-14
Release date:2013-04-03
Last modified:2013-08-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the catalytic region of DNA ligase IV in complex with an artemis fragment sheds light on double-strand break repair
Structure, 21, 2013
4MY2
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CRYSTAL STRUCTURE OF NORRIN IN FUSION WITH MALTOSE BINDING PROTEIN
Descriptor:Maltose-binding periplasmic protein, Norrin fusion protein, MALTOSE
Authors:Ke, J., Jurecky, C., Chen, C., Gu, X., Parker, N., Williams, B.O., Melcher, K., Xu, H.E.
Deposit date:2013-09-27
Release date:2013-11-13
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex.
Genes Dev., 27, 2013
5CM4
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CRYSTAL STRUCTURE OF HUMAN FRIZZLED 4 CYSTEINE-RICH DOMAIN (CRD)
Descriptor:Frizzled-4, N-ACETYL-D-GLUCOSAMINE
Authors:Ke, J., Parker, N., Gu, X., Zhang, C., Melcher, K., Xu, H.E.
Deposit date:2015-07-16
Release date:2015-08-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of the Norrin-Frizzled 4 interaction.
Cell Res., 25, 2015
5UBR
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CRYSTAL STRUCTURE OF PI3K ALPHA IN COMPLEX WITH A 7-(3-(PIPERAZIN-1-YL)PHENYL)PYRROLO[2,1-F][1,2,4] TRIAZIN-4-AMINE DERIVIATINE
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, 1-[4-(3-{4-amino-5-[1-(oxan-4-yl)-1H-pyrazol-5-yl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}phenyl)piperazin-1-yl]ethan-1-one
Authors:Sack, J.S.
Deposit date:2016-12-21
Release date:2017-02-08
Last modified:2017-02-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
4ZHE
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CRYSTAL STRUCTURE OF THE SEMET SUBSTITUTED TOPLESS RELATED PROTEIN 2 (TPR2) N-TERMINAL DOMAIN (1-209) FROM RICE
Descriptor:ASPR2 protein
Authors:Ke, J., Ma, H., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2015-04-24
Release date:2015-08-05
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors.
Sci Adv, 1, 2015
5TUC
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CRYSTAL STRUCTURE OF THE SUS TBC1D15 GAP DOMAIN
Descriptor:Sus TBC1D15 GAP Domain
Authors:Chen, Y.-N., Wang, W., Cheng, D., Ge, Y., Gu, X., Zhou, X.E., Ye, F., Xu, H.E., Lv, Z.
Deposit date:2016-11-05
Release date:2017-02-22
Last modified:2017-04-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases.
Protein Sci., 26, 2017
3W1G
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CRYSTAL STRUCTURE OF HUMAN DNA LIGASE IV-ARTEMIS COMPLEX (NATIVE)
Descriptor:DNA ligase 4, Artemis-derived peptide, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Ochi, T., Blundell, T.L.
Deposit date:2012-11-15
Release date:2013-04-03
Last modified:2013-08-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of the catalytic region of DNA ligase IV in complex with an artemis fragment sheds light on double-strand break repair
Structure, 21, 2013
5J9K
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CRYSTAL STRUCTURE OF THE RICE TOPLESS RELATED PROTEIN 2 (TPR2) N-TERMINAL TOPLESS DOMAIN (1-209) IN COMPLEX WITH RICE D53 REPRESSOR EAR PEPTIDE MOTIF
Descriptor:Protein TPR1, rice D53 peptide 794-808, ZINC ION
Authors:Ke, J., Ma, H., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2016-04-10
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
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