Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
2FBE
DownloadVisualize
BU of 2fbe by Molmil
Crystal Structure of the PRYSPRY-domain
Descriptor: PREDICTED: similar to ret finger protein-like 1
Authors:Gruetter, C, Briand, C, Capitani, G, Mittl, P.R, Gruetter, M.G.
Deposit date:2005-12-09
Release date:2006-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Structure of the PRYSPRY-domain: Implications for autoinflammatory diseases
Febs Lett., 580, 2006
3TZ7
DownloadVisualize
BU of 3tz7 by Molmil
Kinase domain of cSrc in complex with RL103
Descriptor: N-(4-{[4-({[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]carbamoyl}amino)phenyl]amino}quinazolin-6-yl)-4-(dimethylamino)butanamide, Proto-oncogene tyrosine-protein kinase Src
Authors:Gruetter, C, Richters, A, Rauh, D.
Deposit date:2011-09-27
Release date:2012-10-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Overcoming Gatekeeper Mutations in cSrc and Abl by Hybrid Compound Design
To be Published
3TZ9
DownloadVisualize
BU of 3tz9 by Molmil
Kinase domain of cSrc in complex with RL130
Descriptor: 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-[4-(quinazolin-4-ylamino)phenyl]urea, Proto-oncogene tyrosine-protein kinase Src
Authors:Gruetter, C, Richters, A, Rauh, D.
Deposit date:2011-09-27
Release date:2012-10-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Overcoming Gatekeeper Mutations in cSrc and Abl by Hybrid Compound Design
To be Published
3TZ8
DownloadVisualize
BU of 3tz8 by Molmil
Kinase domain of cSrc in complex with RL104
Descriptor: N-(4-{[4-({[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]carbamoyl}amino)phenyl]amino}quinazolin-6-yl)-3-(4-methylpiperazin-1-yl)propanamide, Proto-oncogene tyrosine-protein kinase Src
Authors:Gruetter, C, Richters, A, Rauh, D.
Deposit date:2011-09-27
Release date:2012-10-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Overcoming Gatekeeper Mutations in cSrc and Abl by Hybrid Compound Design
To be Published
3IW6
DownloadVisualize
BU of 3iw6 by Molmil
Human p38 MAP Kinase in Complex with a Benzylpiperazin-Pyrrol
Descriptor: Mitogen-activated protein kinase 14, ethyl 4-[(4-benzylpiperazin-1-yl)carbonyl]-1-ethyl-3,5-dimethyl-1H-pyrrole-2-carboxylate, octyl beta-D-glucopyranoside
Authors:Gruetter, C, Simard, J.R, Rauh, D.
Deposit date:2009-09-02
Release date:2009-11-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha
J.Am.Chem.Soc., 131, 2009
3IW5
DownloadVisualize
BU of 3iw5 by Molmil
Human p38 MAP Kinase in Complex with an Indole Derivative
Descriptor: Mitogen-activated protein kinase 14, N-[2-(3-{[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]sulfanyl}-1H-indol-1-yl)ethyl]-3-(trifluoromethyl)benzamide, octyl beta-D-glucopyranoside
Authors:Gruetter, C, Simard, J.R, Rauh, D.
Deposit date:2009-09-02
Release date:2009-11-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha
J.Am.Chem.Soc., 131, 2009
3IW8
DownloadVisualize
BU of 3iw8 by Molmil
Structure of Inactive Human p38 MAP Kinase in Complex with a Thiazole-Urea
Descriptor: 1-{4-[(1S)-1-amino-2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-(3-chloro-4-fluorophenyl)urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside
Authors:Gruetter, C, Simard, J.R, Rauh, D.
Deposit date:2009-09-02
Release date:2009-11-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha
J.Am.Chem.Soc., 131, 2009
3IW7
DownloadVisualize
BU of 3iw7 by Molmil
Human p38 MAP Kinase in Complex with an Imidazo-pyridine
Descriptor: 2-({4-[(4-benzylpiperidin-1-yl)carbonyl]benzyl}sulfanyl)-3H-imidazo[4,5-c]pyridine, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside
Authors:Gruetter, C, Simard, J.R, Rauh, D.
Deposit date:2009-09-02
Release date:2009-11-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha
J.Am.Chem.Soc., 131, 2009
3LFA
DownloadVisualize
BU of 3lfa by Molmil
Human p38 MAP Kinase in Complex with Dasatinib
Descriptor: Mitogen-activated protein kinase 14, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, octyl beta-D-glucopyranoside
Authors:Gruetter, C, Simard, J.R, Getlik, M, Rauh, D.
Deposit date:2010-01-16
Release date:2011-04-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha
To be Published
3LFD
DownloadVisualize
BU of 3lfd by Molmil
Human p38 MAP Kinase in Complex with RL113
Descriptor: 1-{4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside
Authors:Gruetter, C, Simard, J.R, Getlik, M, Rauh, D.
Deposit date:2010-01-16
Release date:2011-04-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha
To be Published
3PG3
DownloadVisualize
BU of 3pg3 by Molmil
Human p38 MAP Kinase in Complex with RL182
Descriptor: 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-{4-[2-(pyridin-3-ylmethoxy)ethyl]-1,3-thiazol-2-yl}urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside
Authors:Gruetter, C, Simard, J.R, Getlik, M, Rauh, D.
Deposit date:2010-10-29
Release date:2011-11-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-based design and synthesis of cell active N-pyrazole, N-thiazole urea inhibitors of the MAP kinase p38alpha
To be Published
3QBN
DownloadVisualize
BU of 3qbn by Molmil
Structure of Human Aurora A in Complex with a diaminopyrimidine
Descriptor: 5-chloro-N~4~-cyclopropyl-N~2~-[4-(2-methoxyethoxy)phenyl]pyrimidine-2,4-diamine, Serine/threonine-protein kinase 6
Authors:Gruetter, C, Simard, J.R, Rauh, D.
Deposit date:2011-01-13
Release date:2012-01-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Identification of Ustilago maydis Aurora kinase as a novel antifungal target.
Acs Chem.Biol., 6, 2011
3QUD
DownloadVisualize
BU of 3qud by Molmil
Human p38 MAP Kinase in Complex with 2-amino-phenylamino-benzophenone
Descriptor: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, {4-[(2-aminophenyl)amino]phenyl}(phenyl)methanone
Authors:Gruetter, C, Rauh, D.
Deposit date:2011-02-23
Release date:2012-04-11
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Resolving the selectivity problem for p38 mitogen activated protein (MAP) Kinase-inhibitors: Development of new highly potent inhibitors of p38 MAP kinase with an outstanding selectivity profile
To be Published
3LFC
DownloadVisualize
BU of 3lfc by Molmil
Human p38 MAP Kinase in Complex with RL99
Descriptor: (4-{5-[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}carbamoyl)amino]-3-tert-butyl-1H-pyrazol-1-yl}phenyl)acetic acid, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside
Authors:Gruetter, C, Simard, J.R, Getlik, M, Rauh, D.
Deposit date:2010-01-16
Release date:2011-04-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha
To be Published
3LOK
DownloadVisualize
BU of 3lok by Molmil
Drug resistant cSrc kinase domain in complex with covalent inhibitor PD168393
Descriptor: N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE, Proto-oncogene tyrosine-protein kinase Src
Authors:Gruetter, C, Rode, H.B, Rauh, D.
Deposit date:2010-02-04
Release date:2010-12-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Characterization of irreversible kinase inhibitors by directly detecting covalent bond formation: a tool for dissecting kinase drug resistance
Chembiochem, 11, 2010
3LFF
DownloadVisualize
BU of 3lff by Molmil
Human p38 MAP Kinase in Complex with RL166
Descriptor: (4-{3-tert-butyl-5-[(1,3-thiazol-2-ylcarbamoyl)amino]-1H-pyrazol-1-yl}phenyl)acetic acid, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside
Authors:Gruetter, C, Simard, J.R, Getlik, M, Rauh, D.
Deposit date:2010-01-16
Release date:2011-04-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha
To be Published
3LFE
DownloadVisualize
BU of 3lfe by Molmil
Human p38 MAP Kinase in Complex with RL116
Descriptor: 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-{4-[2-(pyridin-4-ylmethoxy)ethyl]-1,3-thiazol-2-yl}urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside
Authors:Gruetter, C, Simard, J.R, Getlik, M, Rauh, D.
Deposit date:2010-01-16
Release date:2011-04-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha
To be Published
3LFB
DownloadVisualize
BU of 3lfb by Molmil
Human p38 MAP Kinase in Complex with RL98
Descriptor: 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(1,3-thiazol-2-yl)urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside
Authors:Gruetter, C, Simard, J.R, Getlik, M, Rauh, D.
Deposit date:2010-01-16
Release date:2011-04-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha
To be Published
3EO1
DownloadVisualize
BU of 3eo1 by Molmil
Structure of the Fab Fragment of GC-1008 in Complex with Transforming Growth Factor-Beta 3
Descriptor: GC-1008 Fab Heavy Chain, GC-1008 Fab Light Chain, Transforming growth factor beta-3
Authors:Gruetter, C, Gruetter, M.G.
Deposit date:2008-09-26
Release date:2008-12-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions
Proc.Natl.Acad.Sci.Usa, 105, 2008
3EO0
DownloadVisualize
BU of 3eo0 by Molmil
Structure of the Transforming Growth Factor-Beta Neutralizing Antibody GC-1008
Descriptor: GC-1008 Fab Heavy Chain, GC-1008 Fab Light Chain, GLYCEROL
Authors:Gruetter, C, Gruetter, M.G.
Deposit date:2008-09-26
Release date:2008-12-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions
Proc.Natl.Acad.Sci.Usa, 105, 2008
3F3T
DownloadVisualize
BU of 3f3t by Molmil
Kinase domain of cSrc in complex with inhibitor RL38 (Type III)
Descriptor: 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea, Proto-oncogene tyrosine-protein kinase Src
Authors:Gruetter, C, Klueter, S, Getlik, M, Rauh, D.
Deposit date:2008-10-31
Release date:2009-03-03
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A new screening assay for allosteric inhibitors of cSrc
Nat.Chem.Biol., 5, 2009
3F3U
DownloadVisualize
BU of 3f3u by Molmil
Kinase domain of cSrc in complex with inhibitor RL37 (Type III)
Descriptor: 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea, Proto-oncogene tyrosine-protein kinase Src
Authors:Gruetter, C, Klueter, S, Getlik, M, Rauh, D.
Deposit date:2008-10-31
Release date:2009-03-03
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A new screening assay for allosteric inhibitors of cSrc
Nat.Chem.Biol., 5, 2009
4I94
DownloadVisualize
BU of 4i94 by Molmil
Structure of BSK8 in complex with AMP-PNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Probable serine/threonine-protein kinase At5g41260
Authors:Gruetter, C, Rauh, D.
Deposit date:2012-12-04
Release date:2013-08-14
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Characterization of the RLCK Family Member BSK8: A Pseudokinase with an Unprecedented Architecture
J.Mol.Biol., 425, 2013
4I93
DownloadVisualize
BU of 4i93 by Molmil
Structure of the BSK8 kinase domain (SeMet labeled)
Descriptor: Probable serine/threonine-protein kinase At5g41260
Authors:Gruetter, C, Rauh, D.
Deposit date:2012-12-04
Release date:2013-08-14
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Characterization of the RLCK Family Member BSK8: A Pseudokinase with an Unprecedented Architecture
J.Mol.Biol., 425, 2013
4I92
DownloadVisualize
BU of 4i92 by Molmil
Structure of the BSK8 kinase domain
Descriptor: CHLORIDE ION, Probable serine/threonine-protein kinase At5g41260
Authors:Gruetter, C, Rauh, D.
Deposit date:2012-12-04
Release date:2013-08-14
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Characterization of the RLCK Family Member BSK8: A Pseudokinase with an Unprecedented Architecture
J.Mol.Biol., 425, 2013

 

123>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon