Author results

3SYN
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CRYSTAL STRUCTURE OF FLHF IN COMPLEX WITH ITS ACTIVATOR
Descriptor:Flagellar biosynthesis protein flhF, ATP-binding protein YlxH, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bange, G., Kuemmerer, N., Wild, K., Sinning, I.
Deposit date:2011-07-18
Release date:2011-11-09
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (3.063 Å)
Cite:Structural basis for the molecular evolution of SRP-GTPase activation by protein.
Nat.Struct.Mol.Biol., 18, 2011
4GR2
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STRUCTURE OF ATRBCX1 FROM ARABIDOPSIS THALIANA.
Descriptor:AtRbcX1
Authors:Golik, P., Grudnik, P., Kolesinski, P., Dubin, G., Szczepaniak, A.
Deposit date:2012-08-24
Release date:2013-01-30
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into eukaryotic Rubisco assembly - Crystal structures of RbcX chaperones from Arabidopsis thaliana.
Biochim.Biophys.Acta, 1830, 2013
4GR6
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CRYSTAL STRUCTURE OF ATRBCX2 FROM ARABIDOPSIS THALIANA
Descriptor:AtRbcX2, 1,2-ETHANEDIOL
Authors:Grudnik, P., Golik, P., Kolesinski, P., Dubin, G., Szczepaniak, A.
Deposit date:2012-08-24
Release date:2013-01-30
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into eukaryotic Rubisco assembly - Crystal structures of RbcX chaperones from Arabidopsis thaliana.
Biochim.Biophys.Acta, 1830, 2013
4U2W
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ATOMIC RESOLUTION CRYSTAL STRUCTURE OF HV-BBI PROTEASE INHIBITOR FROM AMPHIBIAN SKIN IN COMPLEX WITH BOVINE TRYPSIN
Descriptor:Bowman-Birk trypsin inhibitor, Cationic trypsin, CALCIUM ION, ...
Authors:Grudnik, P., Golik, P., Malicki, S., Debowski, D., Legowska, A., Rolka, K., Dubin, G.
Deposit date:2014-07-18
Release date:2015-01-14
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1 Å)
Cite:Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin.
Proteins, 83, 2015
4TRP
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CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY AGAINST NEUROBLASTOMA ASSOCIATED ANTIGEN.
Descriptor:Heavy chain of monoclonal antibody against neuroblastoma associated antigen, Light chain of monoclonal antibody against neuroblastoma associated antigen
Authors:Horwacik, I., Golik, P., Grudnik, P., Zdzalik, M., Rokita, H., Dubin, G.
Deposit date:2014-06-17
Release date:2015-07-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody.
Mol.Cell Proteomics, 14, 2015
4TUJ
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CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY AGAINST NEUROBLASTOMA ASSOCIATED ANTIGEN.
Descriptor:Heavy chain of monoclonal antibody against neuroblastoma associated antigen, Light chain of monoclonal antibody against neuroblastoma associated antigen, peptide1
Authors:Grudnik, P., Golik, P., Horwacik, I., Zdzalik, M., Rokita, H., Dubin, G.
Deposit date:2014-06-24
Release date:2015-07-15
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody.
Mol.Cell Proteomics, 14, 2015
4TUK
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CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY AGAINST NEUROBLASTOMA ASSOCIATED ANTIGEN.
Descriptor:Heavy chain of monoclonal antibody against neuroblastoma associated antigen, Light chain of monoclonal antibody against neuroblastoma associated antigen, peptide2, ...
Authors:Golik, P., Grudnik, P., Dubin, G., Horwacik, I., Zdzalik, M., Rokita, H.
Deposit date:2014-06-24
Release date:2015-07-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody.
Mol.Cell Proteomics, 14, 2015
4TUL
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CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY AGAINST NEUROBLASTOMA ASSOCIATED ANTIGEN.
Descriptor:Heavy chain of monoclonal antibody against neuroblastoma associated antigen, Light chain of monoclonal antibody against neuroblastoma associated antigen, peptide2, ...
Authors:Golik, P., Grudnik, P., Dubin, G., Zdzalik, M., Rokita, H., Horwacik, I.
Deposit date:2014-06-24
Release date:2015-07-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody.
Mol.Cell Proteomics, 14, 2015
4TUO
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CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY AGAINST NEUROBLASTOMA ASSOCIATED ANTIGEN.
Descriptor:Heavy chain of monoclonal antibody against neuroblastoma associated antigen, Light chain of monoclonal antibody against neuroblastoma associated antigen, SODIUM ION, ...
Authors:Golik, P., Grudnik, P., Horwacik, I., Zdzalik, M., Rokita, H., Dubin, G.
Deposit date:2014-06-24
Release date:2015-07-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody.
Mol.Cell Proteomics, 14, 2015
4XOJ
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STRUCTURE OF BOVINE TRYPSIN IN COMPLEX WITH ANALOGUES OF SUNFLOWER INHIBITOR 1 (SFTI-1)
Descriptor:Cationic trypsin, Trypsin inhibitor 1, SULFATE ION, ...
Authors:Golik, P., Malicki, S., Grudnik, P., Karna, N., Debowski, D., Legowska, A., Wladyka, B., Gitlin, A., Brzozowski, K., Dubin, G., Rolka, K.
Deposit date:2015-01-16
Release date:2015-08-12
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (0.91 Å)
Cite:Investigation of Serine-Proteinase-Catalyzed Peptide Splicing in Analogues of Sunflower Trypsin Inhibitor 1 (SFTI-1).
Chembiochem, 16, 2015
4X6Z
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YEAST 20S PROTEASOME IN COMPLEX WITH PR-VI MODULATOR
Descriptor:Proteasome subunit beta type-6, Proteasome subunit beta type-7, Proteasome subunit alpha type-1, ...
Authors:Rostankowski, R., Witkowska, J., Borek, D., Otwinowski, Z., Jankowska, E.
Deposit date:2014-12-09
Release date:2015-12-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures revealed the common place of binding of low-molecular mass activators with the 20S proteasome
To Be Published
5J89
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STRUCTURE OF HUMAN PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) WITH LOW MOLECULAR MASS INHIBITOR
Descriptor:Programmed cell death 1 ligand 1, N-{2-[({2-methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]pyridin-3-yl}methyl)amino]ethyl}acetamide, 1,2-ETHANEDIOL
Authors:Zak, K.M., Grudnik, P., Guzik, K., Zieba, B.J., Musielak, B., Doemling, P., Dubin, G., Holak, T.A.
Deposit date:2016-04-07
Release date:2016-04-27
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).
Oncotarget, 7, 2016
5J8O
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STRUCTURE OF HUMAN PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) WITH LOW MOLECULAR MASS INHIBITOR
Descriptor:Programmed cell death 1 ligand 1, (2R)-1-({3-bromo-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl}methyl)piperidine-2-carboxylic acid
Authors:Zak, K.M., Grudnik, P., Guzik, K., Zieba, B.J., Musielak, B., Doemling, P., Dubin, G., Holak, T.A.
Deposit date:2016-04-08
Release date:2016-04-27
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).
Oncotarget, 7, 2016
4ZFI
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STRUCTURE OF MDM2 WITH LOW MOLECULAR WEIGHT INHIBITOR
Descriptor:E3 ubiquitin-protein ligase Mdm2, (5S)-3,5-bis(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-hydroxy-1-methyl-1,5-dihydro-2H-pyrrol-2-one
Authors:Zak, K.M., Twarda-Clapa, A., Wrona, E.M., Grudnik, P., Dubin, G., Holak, T.A.
Deposit date:2015-04-21
Release date:2016-10-19
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction.
ACS Chem. Biol., 11, 2016
4ZGK
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STRUCTURE OF MDM2 WITH LOW MOLECULAR WEIGHT INHIBITOR.
Descriptor:E3 ubiquitin-protein ligase Mdm2, (5R)-3,5-bis(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-hydroxyfuran-2(5H)-one
Authors:Twarda-Clapa, A., Zak, K.M., Wrona, E.M., Grudnik, P., Dubin, G., Holak, T.A.
Deposit date:2015-04-23
Release date:2016-10-19
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction.
ACS Chem. Biol., 11, 2016
5N2D
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STRUCTURE OF PD-L1/SMALL-MOLECULE INHIBITOR COMPLEX
Descriptor:Programmed cell death 1 ligand 1, ~{N}-[2-[[2,6-dimethoxy-4-[(2-methyl-3-phenyl-phenyl)methoxy]phenyl]methylamino]ethyl]ethanamide
Authors:Guzik, K., Zak, K.M., Grudnik, P., Dubin, G., Holak, T.A.
Deposit date:2017-02-07
Release date:2017-06-28
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1.
J. Med. Chem., 60, 2017
5N2F
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STRUCTURE OF PD-L1/SMALL-MOLECULE INHIBITOR COMPLEX
Descriptor:Programmed cell death 1 ligand 1, 4-[[4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-phenyl]methoxy]-2,5-bis(fluoranyl)phenyl]methylamino]-3-oxidanylidene-butanoic acid
Authors:Guzik, K., Zak, K.M., Grudnik, P., Dubin, G., Holak, T.A.
Deposit date:2017-02-07
Release date:2017-06-28
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1.
J. Med. Chem., 60, 2017
5NIF
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YEAST 20S PROTEASOME IN COMPLEX WITH BLM-PEP ACTIVATOR
Descriptor:Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ...
Authors:Witkowska, J., Grudnik, P., Golik, P., Dubin, G., Jankowska, E.
Deposit date:2017-03-23
Release date:2017-08-02
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome - insights into the enzyme activation mechanism.
Sci Rep, 7, 2017
5O45
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STRUCTURE OF HUMAN PD-L1 IN COMPLEX WITH INHIBITOR
Descriptor:Programmed cell death 1 ligand 1, PHE-MEA-9KK-SAR-ASP-VAL-MEA-TYR-SAR-TRP-TYR-LEU-CCS-GLY-NH2
Authors:Magiera, K., Grudnik, P., Dubin, G., Holak, T.A.
Deposit date:2017-05-26
Release date:2017-09-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (0.99 Å)
Cite:Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint.
Angew. Chem. Int. Ed. Engl., 56, 2017
5O4Y
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STRUCTURE OF HUMAN PD-L1 IN COMPLEX WITH INHIBITOR
Descriptor:Programmed cell death 1 ligand 1, PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2
Authors:Magiera, K., Grudnik, P., Dubin, G., Holak, T.A.
Deposit date:2017-05-31
Release date:2017-09-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint.
Angew. Chem. Int. Ed. Engl., 56, 2017
5O11
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CRYSTAL STRUCTURE OF PIM1 KINASE IN COMPLEX WITH SMALL-MOLECULE INHIBITOR
Descriptor:Serine/threonine-protein kinase pim-1, 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, IMIDAZOLE, ...
Authors:Bogusz, J., Dubin, G.
Deposit date:2017-05-17
Release date:2017-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors.
Sci Rep, 7, 2017
5O12
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CRYSTAL STRUCTURE OF PIM1 KINASE IN COMPLEX WITH SMALL-MOLECULE INHIBITOR
Descriptor:Serine/threonine-protein kinase pim-1, (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, IMIDAZOLE
Authors:Dubin, G., Bogusz, J.
Deposit date:2017-05-17
Release date:2017-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors.
Sci Rep, 7, 2017
5O13
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CRYSTAL STRUCTURE OF PIM1 KINASE IN COMPLEX WITH SMALL-MOLECULE INHIBITOR
Descriptor:Serine/threonine-protein kinase pim-1, (3~{E})-5-chloranyl-3-[[5-[3-[(4-methyl-1,4-diazepan-1-yl)carbonyl]phenyl]furan-2-yl]methylidene]-1~{H}-indol-2-one, IMIDAZOLE, ...
Authors:Dubin, G., Bogusz, J.
Deposit date:2017-05-17
Release date:2017-11-01
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors.
Sci Rep, 7, 2017
5NIU
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STRUCTURE OF HUMAN PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) WITH LOW MOLECULAR MASS INHIBITOR
Descriptor:Programmed cell death 1 ligand 1, (2~{R})-2-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-phenyl]methoxy]-5-methyl-phenyl]methylamino]-3-oxidanyl-propanoic acid, 1,2-ETHANEDIOL
Authors:Zak, K.M., Grudnik, P., Skalniak, L., Dubin, G., Holak, T.A.
Deposit date:2017-03-27
Release date:2017-12-06
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.
Oncotarget, 8, 2017
5NIX
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STRUCTURE OF HUMAN PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) WITH LOW MOLECULAR MASS INHIBITOR
Descriptor:Programmed cell death 1 ligand 1, (2~{R},3~{R},5~{R})-2-[[2-[[3-(aminomethyl)phenyl]methoxy]-4-[[3-(1,4-benzodioxin-6-yl)-2-methyl-phenyl]methoxy]-5-chloranyl-phenyl]methyl]-5-oxidanyl-pyrrolidine-3-carboxylic acid, 1,2-ETHANEDIOL
Authors:Zak, K.M., Grudnik, P., Skalniak, L., Dubin, G., Holak, T.A.
Deposit date:2017-03-27
Release date:2017-12-06
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.
Oncotarget, 8, 2017
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