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1KG2
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CRYSTAL STRUCTURE OF THE CORE FRAGMENT OF MUTY FROM E.COLI AT 1.2A RESOLUTION
Descriptor:A/G-specific adenine glycosylase, SULFATE ION, IRON/SULFUR CLUSTER, ...
Authors:Gilboa, R., Kilshtein, A., Zharkov, D.O., Kycia, J.H., Gerchman, S.E., Grollman, A.P., Shoham, G.
Deposit date:2001-11-26
Release date:2002-11-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Analysis of the E.coli MutY DNA glycosylase structure and function by site-directed mutagenesis
To be Published
1KG3
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CRYSTAL STRUCTURE OF THE CORE FRAGMENT OF MUTY FROM E.COLI AT 1.55A RESOLUTION
Descriptor:A/G-specific adenine glycosylase, SULFATE ION, IRON/SULFUR CLUSTER, ...
Authors:Gilboa, R., Kilshtein, A., Zharkov, D.O., Kycia, J.H., Gerchman, S.E., Grollman, A.P., Shoham, G.
Deposit date:2001-11-26
Release date:2002-11-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Analysis of the E.coli MutY DNA glycosylase structure and function by site-directed mutagenesis
To be Published
1KG4
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CRYSTAL STRUCTURE OF THE K142A MUTANT OF E. COLI MUTY (CORE FRAGMENT)
Descriptor:A/G-specific adenine glycosylase, SULFATE ION, IRON/SULFUR CLUSTER, ...
Authors:Gilboa, R., Kilshtein, A., Zharkov, D.O., Kycia, J.H., Gerchman, S.E., Grollman, A.P., Shoham, G.
Deposit date:2001-11-26
Release date:2002-11-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Analysis of the E.coli MutY DNA glycosylase structure and function by site-directed mutagenesis
To be Published
1KG5
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CRYSTAL STRUCTURE OF THE K142Q MUTANT OF E.COLI MUTY (CORE FRAGMENT)
Descriptor:A/G-specific adenine glycosylase, SULFATE ION, IRON/SULFUR CLUSTER, ...
Authors:Gilboa, R., Kilshtein, A., Zharkov, D.O., Kycia, J.H., Gerchman, S.E., Grollman, A.P., Shoham, G.
Deposit date:2001-11-26
Release date:2002-11-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Analysis of the E.coli MutY DNA glycosylase structure and function by site-directed mutagenesis
To be Published
1KG6
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CRYSTAL STRUCTURE OF THE K142R MUTANT OF E.COLI MUTY (CORE FRAGMENT)
Descriptor:A/G-specific adenine glycosylase, SULFATE ION, IRON/SULFUR CLUSTER, ...
Authors:Gilboa, R., Kilshtein, A., Zharkov, D.O., Kycia, J.H., Gerchman, S.E., Grollman, A.P., Shoham, G.
Deposit date:2001-11-26
Release date:2002-11-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Analysis of the E.coli MutY DNA glycosylase structure and function by site-directed mutagenesis
To be Published
1KG7
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CRYSTAL STRUCTURE OF THE E161A MUTANT OF E.COLI MUTY (CORE FRAGMENT)
Descriptor:A/G-specific adenine glycosylase, SULFATE ION, IRON/SULFUR CLUSTER, ...
Authors:Gilboa, R., Kilshtein, A., Zharkov, D.O., Kycia, J.H., Gerchman, S.E., Grollman, A.P., Shoham, G.
Deposit date:2001-11-26
Release date:2002-11-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Analysis of the E.coli MutY DNA glycosylase structure and function by site-directed mutagenesis
To be Published
1B5K
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3,N4-ETHENO-2'-DEOXYCYTIDINE OPPOSITE THYMIDINE IN AN 11-MER DUPLEX, SOLUTION STRUCTURE FROM NMR AND MOLECULAR DYNAMICS
Descriptor:DNA (5'-D(*CP*GP*TP*AP*CP*EDCP*CP*AP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*TP*GP*TP*AP*CP*G)-3')
Authors:Cullinan, D., Korobka, A., Grollman, A.P., Patel, D.J., Eisenberg, M., De Santos, C.L.
Deposit date:1999-01-07
Release date:1999-01-13
Last modified:2017-02-01
Method:SOLUTION NMR
Cite:NMR solution structure of an oligodeoxynucleotide duplex containing the exocyclic lesion 3,N4-etheno-2'-deoxycytidine opposite thymidine: comparison with the duplex containing deoxyadenosine opposite the adduct.
Biochemistry, 35, 1996
1B6X
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3,N4-ETHENO-2'-DEOXYCYTIDINE OPPOSITE GUANINE IN AN 11-MER DUPLEX, SOLUTION STRUCTURE FROM NMR AND MOLECULAR DYNAMICS, 4 STRUCTURES
Descriptor:5'-D(*CP*GP*TP*AP*CP*(EDC)P*CP*AP*TP*GP*C)-3', 5'-D(*GP*CP*AP*TP*GP*GP*GP*TP*AP*CP*G)-3'
Authors:Cullinan, D., Johnson, F., Grollman, A.P., Eisenberg, M., De Los Santos, C.
Deposit date:1999-01-19
Release date:1999-01-27
Last modified:2012-01-18
Method:SOLUTION NMR
Cite:Solution structure of a DNA duplex containing the exocyclic lesion 3,N4-etheno-2'-deoxycytidine opposite 2'-deoxyguanosine.
Biochemistry, 36, 1997
1B6Y
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3,N4-ETHENO-2'-DEOXYCYTIDINE OPPOSITE ADENINE IN AN 11-MER DUPLEX, SOLUTION STRUCTURE FROM NMR AND MOLECULAR DYNAMICS, 2 STRUCTURES
Descriptor:5'-D(*CP*GP*TP*AP*CP*(EDC)P*CP*AP*TP*GP*C)-3', 5'-D(*GP*CP*AP*TP*GP*AP*GP*TP*AP*CP*G)-3'
Authors:Korobka, A., Cullinan, D., Cosman, M., Grollman, A.P., Patel, D.J., Eisenberg, M., De Los Santos, C.
Deposit date:1999-01-19
Release date:1999-01-27
Last modified:2012-01-18
Method:SOLUTION NMR
Cite:Solution structure of an oligodeoxynucleotide duplex containing the exocyclic lesion 3,N4-etheno-2'-deoxycytidine opposite 2'-deoxyadenosine, determined by NMR spectroscopy and restrained molecular dynamics.
Biochemistry, 35, 1996
1FJB
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NMR STUDY OF AN 11-MER DNA DUPLEX CONTAINING 7,8-DIHYDRO-8-OXOADENINE (AOXO) OPPOSITE THYMINE
Descriptor:DNA (5'-D(*GP*CP*AP*TP*GP*TP*GP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*AP*CP*(A38)P*CP*AP*TP*GP*C)-3')
Authors:Chen, H., Johnson, F., Grollman, A.P., Patel, D.J.
Deposit date:1995-12-15
Release date:1996-06-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Studies of the Ionizing Radiation Adduct 7,8-Dihydro-8-Oxoadenine (A Oxo) Positioned Opposite Thymine and Guanine in DNA Duplexes
MAGN.RESON.CHEM., 34, 1996
1K3W
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CRYSTAL STRUCTURE OF A TRAPPED REACTION INTERMEDIATE OF THE DNA REPAIR ENZYME ENDONUCLEASE VIII WITH DNA
Descriptor:5'-D(*GP*GP*CP*TP*TP*CP*AP*TP*CP*CP*TP*GP*G)-3', 5'-D(*CP*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', Endonuclease VIII, ...
Authors:Golan, G., Zharkov, D.O., Gilboa, R., Fernandes, A.S., Kycia, J.H., Gerchman, S.E., Rieger, R.A., Grollman, A.P., Shoham, G.
Deposit date:2001-10-04
Release date:2002-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Structural analysis of an Escherichia coli endonuclease VIII covalent reaction intermediate.
EMBO J., 21, 2002
1K3X
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CRYSTAL STRUCTURE OF A TRAPPED REACTION INTERMEDIATE OF THE DNA REPAIR ENZYME ENDONUCLEASE VIII WITH BROMINATED-DNA
Descriptor:5'-D(*GP*GP*CP*(BRU)P*(BRU)P*CP*AP*(BRU)P*CP*CP*(BRU)P*GP*G)-3', 5'-D(*CP*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', Endonuclease VIII, ...
Authors:Golan, G., Zharkov, D.O., Gilboa, R., Fernandes, A.S., Kycia, J.H., Gerchman, S.E., Rieger, R.A., Grollman, A.P., Shoham, G.
Deposit date:2001-10-04
Release date:2002-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural analysis of an Escherichia coli endonuclease VIII covalent reaction intermediate.
EMBO J., 21, 2002
1K82
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CRYSTAL STRUCTURE OF E.COLI FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE (FPG) COVALENTLY TRAPPED WITH DNA
Descriptor:5'-D(*GP*GP*CP*TP*TP*CP*CP*TP*CP*CP*TP*GP*G)-3', 5'-D(*CP*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', formamidopyrimidine-DNA glycosylase, ...
Authors:Gilboa, R., Zharkov, D.O., Golan, G., Fernandes, A.S., Gerchman, S.E., Matz, E., Kycia, J.H., Grollman, A.P., Shoham, G.
Deposit date:2001-10-22
Release date:2002-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of formamidopyrimidine-DNA glycosylase covalently complexed to DNA.
J.Biol.Chem., 277, 2002
1MQ2
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HUMAN DNA POLYMERASE BETA COMPLEXED WITH GAPPED DNA CONTAINING AN 8-OXO-7,8-DIHYDRO-GUANINE AND DAMP
Descriptor:5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(2DA))-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Krahn, J.M., Beard, W.A., Miller, H., Grollman, A.P., Wilson, S.H.
Deposit date:2002-09-13
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of DNA Polymerase beta with the Mutagenic DNA Lesion 8-oxodeoxyguanine Reveals Structural Insights into its Coding Potential
Structure, 11, 2003
1MQ3
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HUMAN DNA POLYMERASE BETA COMPLEXED WITH GAPPED DNA CONTAINING AN 8-OXO-7,8-DIHYDRO-GUANINE TEMPLATE PAIRED WITH DCTP
Descriptor:5'-D(*CP*CP*GP*AP*CP*(8OG)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Krahn, J.M., Beard, W.A., Miller, H., Grollman, A.P., Wilson, S.H.
Deposit date:2002-09-13
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of DNA Polymerase beta with the Mutagenic DNA Lesion 8-oxodeoxyguanine Reveals Structural Insights into its Coding Potential
Structure, 11, 2003
1N5C
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CRYSTAL STRUCTURE ANALYSIS OF THE B-DNA DODECAMER CGCGAATT(ETHENOC)GCG
Descriptor:5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*(EDC)P*GP*CP*G)-3', SODIUM ION
Authors:Freisinger, E., Fernandes, A., Grollman, A.P., Kisker, C.F.
Deposit date:2002-11-05
Release date:2003-06-03
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Crystallographic Characterization of an Exocyclic DNA Adduct: 3,N4-etheno-2'-deoxycytidine in the Dodecamer 5'-CGCGAATT(ethenoC)GCG-3'
J.Mol.Biol., 329, 2003
1Q39
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CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME ENDONUCLEASE-VIII (NEI) FROM E. COLI: THE WT ENZYME AT 2.8 RESOLUTION.
Descriptor:Endonuclease VIII, ZINC ION, CALCIUM ION
Authors:Golan, G., Zharkov, D.O., Feinberg, H., Fernandes, A.S., Zaika, E.I., Kycia, J.H., Grollman, A.P., Shoham, G.
Deposit date:2003-07-29
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the uncomplexed DNA repair enzyme endonuclease VIII indicates significant interdomain flexibility.
Nucleic Acids Res., 33, 2005
1Q3B
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CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME ENDONUCLEASE-VIII (NEI) FROM E. COLI: THE R252A MUTANT AT 2.05 RESOLUTION.
Descriptor:Endonuclease VIII, ZINC ION, MAGNESIUM ION, ...
Authors:Golan, G., Zharkov, D.O., Feinberg, H., Fernandes, A.S., Zaika, E.I., Kycia, J.H., Grollman, A.P., Shoham, G.
Deposit date:2003-07-29
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of the uncomplexed DNA repair enzyme endonuclease VIII indicates significant interdomain flexibility.
Nucleic Acids Res., 33, 2005
1Q3C
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CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME ENDONUCLEASE-VIII (NEI) FROM E. COLI: THE E2A MUTANT AT 2.3 RESOLUTION.
Descriptor:Endonuclease VIII, ZINC ION, MAGNESIUM ION, ...
Authors:Golan, G., Zharkov, D.O., Feinberg, H., Fernandes, A.S., Zaika, E.I., Kycia, J.H., Grollman, A.P., Shoham, G.
Deposit date:2003-07-29
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the uncomplexed DNA repair enzyme endonuclease VIII indicates significant interdomain flexibility.
Nucleic Acids Res., 33, 2005
1Q9X
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CRYSTAL STRUCTURE OF ENTEROBACTERIA PHAGE RB69 GP43 DNA POLYMERASE COMPLEXED WITH TETRAHYDROFURAN CONTAINING DNA
Descriptor:5'-GCGGACTGCTTAC(dideoxycytidine)-3', 5'-AC(tetrahydrofuran)GGTAAGCAGTCCGCGG-3', DNA polymerase, ...
Authors:Freisinger, E., Grollman, A.P., Miller, H., Kisker, C.
Deposit date:2003-08-26
Release date:2004-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Lesion (in)tolerance reveals insights into DNA replication fidelity.
Embo J., 23, 2004
1Q9Y
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CRYSTAL STRUCTURE OF ENTEROBACTERIA PHAGE RB69 GP43 DNA POLYMERASE COMPLEXED WITH 8-OXOGUANOSINE CONTAINING DNA
Descriptor:5'-AC(8-OXOGUANOSINE)GGTAAGCAGTCCGCG-3', 5'-GCGGACTGCTTAC(DIDEOXYCYTIDINE)-3', DNA POLYMERASE, ...
Authors:Freisinger, E., Grollman, A.P., Miller, H., Kisker, C.
Deposit date:2003-08-26
Release date:2004-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Lesion (in)tolerance reveals insights into DNA replication fidelity.
Embo J., 23, 2004
2EA0
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CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME ENDONUCLEASE-VIII (NEI) FROM E. COLI IN COMPLEX WITH AP-SITE CONTAINING DNA SUBSTRATE
Descriptor:5'-D(P*GP*GP*CP*TP*TP*CP*AP*TP*CP*CP*TP*G)-3', 5'-D(P*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', Endonuclease VIII, ...
Authors:Golan, G., Zharov, D.O., Grollman, A.P., Shoham, G.
Deposit date:2007-01-29
Release date:2008-02-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Active site plasticity of endonuclease VIII: Conformational changes compensating for different substrate and mutations of critical residues
To be Published
2FCC
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CRYSTAL STRUCTURE OF T4 PYRIMIDINE DIMER GLYCOSYLASE (T4-PDG) COVALENTLY COMPLEXED WITH A DNA SUBSTRATE CONTAINING ABASIC SITE
Descriptor:DNA (5'-D(*CP*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*CP*(BRU)P*(BRU)P*CP*AP*(BRU)P*CP*CP*(BRU)P*GP*G)-3'), Endonuclease V, ...
Authors:Golan, G., Zharkov, D.O., Fernandes, A.S., Dodson, M.L., McCullough, A.K., Grollman, A.P., Lloyd, R.S., Shoham, G.
Deposit date:2005-12-12
Release date:2006-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of T4 Pyrimidine Dimer Glycosylase in a Reduced Imine Covalent Complex with Abasic Site-containing DNA.
J.Mol.Biol., 362, 2006
2OPF
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CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME ENDONUCLEASE-VIII (NEI) FROM E. COLI (R252A) IN COMPLEX WITH AP-SITE CONTAINING DNA SUBSTRATE
Descriptor:5'-D(*GP*GP*CP*TP*TP*CP*AP*TP*CP*CP*TP*G)-3', 5'-D(P*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', Endonuclease VIII, ...
Authors:Golan, G., Zharov, D.O., Grollman, A.P., Shoham, G.
Deposit date:2007-01-29
Release date:2008-02-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Active site plasticity of endonuclease VIII: Conformational changes compensating for different substrates and mutations of critical residues
To be Published
2OQ4
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CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME ENDONUCLEASE-VIII (NEI) FROM E. COLI (E2Q) IN COMPLEX WITH AP-SITE CONTAINING DNA SUBSTRATE
Descriptor:5'-D(*G*GP*CP*TP*TP*CP*AP*TP*CP*CP*TP*GP*G)-3', 5'-D(*C*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', Endonuclease VIII, ...
Authors:Golan, G., Zharkov, D.O., Grollman, A.P., Shoahm, G.
Deposit date:2007-01-31
Release date:2008-02-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Active site plasticity of endonuclease VIII: Conformational changes compensating for different substrates and mutations of critical residues
To be Published
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