Author results

2GPL
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TMC-95 BASED BIPHENYL-ETHER MACROCYCLES: SPECIFIC PROTEASOME INHIBITORS
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Goetz, M., Kaiser, M., Weyher, E., Moroder, M.
登録日2006-04-18
公開日2006-07-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献TMC-95-Based Inhibitor Design Provides Evidence for the Catalytic Versatility of the Proteasome.
Chem.Biol., 13, 2006
3NZJ
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CRYSTAL STRUCTURE OF YEAST 20S PROTEASOME IN COMPLEX WITH LIGAND 2A
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Gallastegui, N., Marechal, X., Le Ravalec, V., Basse, N., Richy, N., Genin, E., Huber, R., Moroder, M., Vidal, V., Reboud-Ravaux, M.
登録日2010-07-16
公開日2011-02-16
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
3NZW
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH 2B
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Gallastegui, N., Marechal, X., Le Ravalec, V., Basse, N., Richy, N., Genin, E., Huber, R., Moroder, M., Vidal, V., Reboud-Ravaux, M.
登録日2010-07-17
公開日2011-02-16
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
3NZX
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH LIGAND 2C
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Gallastegui, N., Marechal, X., Le Ravalec, V., Basse, N., Richy, N., Genin, E., Huber, R., Moroder, M., Vidal, V., Reboud-Ravaux, M.
登録日2010-07-17
公開日2011-02-16
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
1G0U
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A GATED CHANNEL INTO THE PROTEASOME CORE PARTICLE
分子名称:PROTEASOME COMPONENT Y7, PROTEASOME COMPONENT Y13, PROTEASOME COMPONENT PRE6, ...
著者Groll, M., Bajorek, M., Kohler, A., Moroder, L., Rubin, D.M., Huber, R., Glickman, M.H., Finley, D.
登録日2000-10-09
公開日2000-11-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A gated channel into the proteasome core particle.
Nat.Struct.Biol., 7, 2000
1RYP
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CRYSTAL STRUCTURE OF THE 20S PROTEASOME FROM YEAST AT 2.4 ANGSTROMS RESOLUTION
分子名称:20S PROTEASOME, MAGNESIUM ION
著者Groll, M., Ditzel, L., Loewe, J., Stock, D., Bochtler, M., Bartunik, H.D., Huber, R.
登録日1997-02-26
公開日1998-04-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of 20S proteasome from yeast at 2.4 A resolution.
Nature, 386, 1997
2ZCY
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YEAST 20S PROTEASOME:SYRINGOLIN A-COMPLEX
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Dudler, R., Kaiser, M.
登録日2007-11-15
公開日2008-04-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
Nature, 452, 2008
3BDM
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YEAST 20S PROTEASOME:GLIDOBACTIN A-COMPLEX
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Dudler, R., Kaiser, M.
登録日2007-11-15
公開日2008-04-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
Nature, 452, 2008
1G65
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CRYSTAL STRUCTURE OF EPOXOMICIN:20S PROTEASOME REVEALS A MOLECULAR BASIS FOR SELECTIVITY OF ALPHA,BETA-EPOXYKETONE PROTEASOME INHIBITORS
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Kim, K.B., Kairies, N., Huber, R., Crews, C.
登録日2000-11-03
公開日2000-11-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal Structure of Epoxomicin:20S Proteasome reveals a molecular basis for selectivity of alpha,beta-Epoxyketone Proteasome Inhibitors
J.Am.Chem.Soc., 122, 2000
1J2P
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ALPHA-RING FROM THE PROTEASOME FROM ARCHAEOGLOBUS FULGIDUS
分子名称:Proteasome alpha subunit
著者Groll, M., Brandstetter, H., Bartunik, H., Bourenkow, G., Huber, R.
登録日2003-01-08
公開日2003-03-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Investigations on the Maturation and Regulation of Archaebacterial Proteasomes
J.MOL.BIOL., 327, 2003
1J2Q
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20S PROTEASOME IN COMPLEX WITH CALPAIN-INHIBITOR I FROM ARCHAEOGLOBUS FULGIDUS
分子名称:Proteasome alpha subunit, Proteasome beta subunit, 2-ACETYLAMINO-4-METHYL-PENTANOIC ACID [1-(1-FORMYL-PENTYLCARBAMOYL)-3-METHYL-BUTYL]-AMIDE
著者Groll, M., Brandstetter, H., Bartunik, H., Bourenkow, G., Huber, R.
登録日2003-01-08
公開日2003-03-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Investigations on the Maturation and Regulation of Archaebacterial Proteasomes
J.MOL.BIOL., 327, 2003
1JD2
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME:TMC-95A COMPLEX: A NON-COVALENT PROTEASOME INHIBITOR
分子名称:PROTEASOME COMPONENT Y7, PROTEASOME COMPONENT Y13, PROTEASOME COMPONENT PRE6, ...
著者Groll, M., Koguchi, Y., Huber, R., Kohno, J.
登録日2001-06-12
公開日2002-02-13
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor.
J.Mol.Biol., 311, 2001
2F16
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH BORTEZOMIB
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M.
登録日2005-11-14
公開日2006-03-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome.
Structure, 14, 2006
2FAK
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CRYSTAL STRUCTURE OF SALINOSPORAMIDE A IN COMPLEX WITH THE YEAST 20S PROTEASOME
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Potts, B.C.
登録日2005-12-07
公開日2006-04-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of beta-Lactone Ring Opening and a Mechanism for Irreversible Binding.
J.Am.Chem.Soc., 128, 2006
3DY3
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CRYSTAL STRUCTURE OF YEAST 20S PROTEASOME IN COMPLEX WITH THE EPIMER FORM OF SPIROLACTACYSTIN
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Balskus, E., Jacobsen, E.
登録日2008-07-25
公開日2008-11-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Structural analysis of spiro beta-lactone proteasome inhibitors.
J.Am.Chem.Soc., 130, 2008
3DY4
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CRYSTAL STRUCTURE OF YEAST 20S PROTEASOME IN COMPLEX WITH SPIROLACTACYSTIN
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Balskus, E., Jacobsen, E.
登録日2008-07-25
公開日2008-11-04
最終更新日2014-08-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural analysis of spiro beta-lactone proteasome inhibitors.
J.Am.Chem.Soc., 130, 2008
3E47
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH HOMOBELACTOSIN C
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Larionov, O.V., de Meijere, A.
登録日2008-08-10
公開日2008-09-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Inhibitor-binding mode of homobelactosin C to proteasomes: new insights into class I MHC ligand generation
Proc.Natl.Acad.Sci.Usa, 103, 2006
3GPT
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH SALINOSPORAMIDE DERIVATIVES: SLOW SUBSTRATE LIGAND
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Macherla, V.R., Manam, R.R., Arthur, K.A.M., Potts, C.B.
登録日2009-03-23
公開日2009-09-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition
J.Med.Chem., 52, 2009
3GPW
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH SALINOSPORAMIDE DERIVATIVES: IRREVERSIBLE INHIBITOR LIGAND
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Macherla, V.R., Manam, R.R., Arthur, K.A.M., Potts, C.B.
登録日2009-03-23
公開日2009-09-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition
J.Med.Chem., 52, 2009
3HYE
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CRYSTAL STRUCTURE OF 20S PROTEASOME IN COMPLEX WITH HYDROXYLATED SALINOSPORAMIDE
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Arthur, K.A.M., Macherla, V.R., Manam, R.R., Potts, B.C.
登録日2009-06-22
公開日2009-09-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition
J.Med.Chem., 52, 2009
6GOP
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YEAST 20S PROTEASOME IN COMPLEX WITH HOMOSALINOSPORAMIDE A
分子名称:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
著者Groll, M., Romo, D.
登録日2018-06-01
公開日2018-08-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献(-)-Homosalinosporamide A and Its Mode of Proteasome Inhibition: An X-ray Crystallographic Study.
Mar Drugs, 16, 2018
3OKJ
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ALPHA-KETO-ALDEHYDE BINDING MECHANISM REVEALS A NOVEL LEAD STRUCTURE MOTIF FOR PROTEASOME INHIBITION
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Poynor, M., Gallastegui, P., Stein, M., Schmidt, B., Kloetzel, P.M., Huber, R.
登録日2010-08-25
公開日2011-06-08
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Elucidation of the alpha-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibition
Angew.Chem.Int.Ed.Engl., 50, 2011
2BHO
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CRYSTAL STRUCTURE OF THE YERSINIA ENTEROCOLITICA TYPE III SECRETION CHAPERONE SYCT
分子名称:CHAPERONE PROTEIN SYCT, PLATINUM (II) ION
著者Groll, M., Wilharm, G.
登録日2005-01-15
公開日2005-07-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of the Yersinia Enterocolitica Type III Secretion Chaperone Syct
J.Biol.Chem., 280, 2005
3D29
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PROTEASOME INHIBITION BY FELLUTAMIDE B
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Hines, J., Fahnestock, M., Crews, M.C.
登録日2008-05-07
公開日2008-06-10
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis
Chem.Biol., 15, 2008
3GPJ
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH SYRINGOLIN B
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Huber, R., Kaiser, M.
登録日2009-03-23
公開日2009-06-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition
Proc.Natl.Acad.Sci.USA, 106, 2009