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4B6L
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DISCOVERY OF ORAL POLO-LIKE KINASE (PLK) INHIBITORS WITH ENHANCED SELECTIVITY PROFILE USING RESIDUE TARGETED DRUG DESIGN
Descriptor:SERINE/THREONINE-PROTEIN KINASE PLK3, 4-[[(4R)-5-cyclopentyl-4-ethyl-3a,4-dihydro-3H-[1,2,4]triazolo[4,3-f]pteridin-7-yl]amino]-N-cyclopropyl-3-methoxy-benzamide, SULFATE ION
Authors:Brown, K., Charrier, J.D., Durrant, S., Griffiths, M., Hudson, C., Kay, D., Knegtel, R., ODonnell, M., Pierard, F., Twin, H., Weber, P., Young, S.
Deposit date:2012-08-14
Release date:2013-08-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of Oral Polo-Like Kinase (Plk) Inhibitors with Enhanced Selectivity Profile Using Residue Targeted Drug Design
To be Published
2FYG
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CRYSTAL STRUCTURE OF NSP10 FROM SARS CORONAVIRUS
Descriptor:Replicase polyprotein 1ab, ZINC ION, GLYCEROL
Authors:Joseph, J.S., Saikatendu, K.S., Subramanian, V., Neuman, B.W., Brooun, A., Griffith, M., Moy, K., Yadav, M.K., Velasquez, J., Buchmeier, M.J., Stevens, R.C., Kuhn, P.
Deposit date:2006-02-07
Release date:2006-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs.
J.Virol., 80, 2006
2M2D
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HUMAN PROGRAMMED CELL DEATH 1 RECEPTOR
Descriptor:Programmed cell death protein 1
Authors:Veverka, V., Cheng, X., Waters, L.C., Muskett, F.W., Morgan, S., Lesley, A., Griffiths, M., Stubberfield, C., Griffin, R., Henry, A.J., Robinson, M.K., Jansson, A., Ladbury, J.E., Ikemizu, S., Davis, S.J., Carr, M.D.
Deposit date:2012-12-18
Release date:2013-02-27
Last modified:2013-05-15
Method:SOLUTION NMR
Cite:Structure and interactions of the human programmed cell death 1 receptor.
J.Biol.Chem., 288, 2013
2ACF
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NMR STRUCTURE OF SARS-COV NON-STRUCTURAL PROTEIN NSP3A (SARS1) FROM SARS CORONAVIRUS
Descriptor:Replicase polyprotein 1ab, GLYCEROL
Authors:Saikatendu, K.S., Joseph, J.S., Subramanian, V., Neuman, B.W., Buchmeier, M.J., Stevens, R.C., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2005-07-18
Release date:2006-02-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3.
Structure, 13, 2005