1XJO | | STRUCTURE OF AMINOPEPTIDASE | | Descriptor: | AMINOPEPTIDASE, ZINC ION, PHOSPHATE ION, ... | | Authors: | Greenblatt, H.M., Barra, D., Blumberg, S., Shoham, G. | | Deposit date: | 1996-10-09 | | Release date: | 1997-04-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Streptomyces griseus aminopeptidase: X-ray crystallographic structure at 1.75 A resolution.
J.Mol.Biol., 265, 1997
|
|
1ARL | | CARBOXYPEPTIDASE A WITH ZN REMOVED | | Descriptor: | APO-CARBOXYPEPTIDASE A=ALPHA= (COX) | | Authors: | Greenblatt, H.M., Feinberg, H., Tucker, P.A., Shoham, G. | | Deposit date: | 1994-11-22 | | Release date: | 1996-08-01 | | Last modified: | 2019-08-14 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Carboxypeptidase A: native, zinc-removed and mercury-replaced forms.
Acta Crystallogr.,Sect.D, 54, 1998
|
|
1ARM | | CARBOXYPEPTIDASE A WITH ZN REPLACED BY HG | | Descriptor: | HG-CARBOXYPEPTIDASE A=ALPHA= (COX), MERCURY (II) ION, COPPER (II) ION, ... | | Authors: | Greenblatt, H.M., Feinberg, H., Tucker, P.A., Shoham, G. | | Deposit date: | 1994-11-22 | | Release date: | 1996-08-17 | | Last modified: | 2019-08-14 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Carboxypeptidase A: native, zinc-removed and mercury-replaced forms.
Acta Crystallogr.,Sect.D, 54, 1998
|
|
1DX6 | | STRUCTURE OF ACETYLCHOLINESTERASE COMPLEXED WITH (-)-GALANTHAMINE AT 2.3A RESOLUTION | | Descriptor: | ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, TETRAETHYLENE GLYCOL, ... | | Authors: | Greenblatt, H.M., Kryger, G., Lewis, T.T., Silman, I., Sussman, J.L. | | Deposit date: | 1999-12-21 | | Release date: | 2000-01-02 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of Acetylcholinesterase Complexed with (-)-Galanthamine at 2.3A Resolution
FEBS Lett., 463, 1999
|
|
1W4L | | COMPLEX OF TCACHE WITH BIS-ACTING GALANTHAMINE DERIVATIVE | | Descriptor: | ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Greenblatt, H.M., Guillou, C., Guenard, D., Badet, B., Thal, C., Silman, I., Sussman, J.L. | | Deposit date: | 2004-07-25 | | Release date: | 2004-11-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.
J.Am.Chem.Soc., 126, 2004
|
|
1W6R | | COMPLEX OF TCACHE WITH GALANTHAMINE DERIVATIVE | | Descriptor: | ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose, (-)-GALANTHAMINE, ... | | Authors: | Greenblatt, H.M., Guillou, C., Guenard, D., Badet, B., Thal, C., Silman, I., Sussman, J.L. | | Deposit date: | 2004-08-23 | | Release date: | 2004-11-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.
J.Am.Chem.Soc., 126, 2004
|
|
1W75 | | NATIVE ORTHORHOMBIC FORM OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE (ACHE) | | Descriptor: | ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Greenblatt, H.M., Botti, S., Argaman, A., Silman, I., Sussman, J.L. | | Deposit date: | 2004-08-29 | | Release date: | 2004-11-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.
J.Am.Chem.Soc., 126, 2004
|
|
1W76 | | ORTHORHOMBIC FORM OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE (ACHE) COMPLEXED WITH BIS-ACTING GALANTHAMINE DERIVATIVE | | Descriptor: | ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose, (-)-GALANTHAMINE | | Authors: | Greenblatt, H.M., Guillou, C., Guenard, D., Badet, B., Thal, C., Silman, I., Sussman, J.L. | | Deposit date: | 2004-08-30 | | Release date: | 2004-11-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.
J.Am.Chem.Soc., 126, 2004
|
|
1YME | | STRUCTURE OF CARBOXYPEPTIDASE | | Descriptor: | CARBOXYPEPTIDASE A ALPHA, ZINC ION | | Authors: | Greenblatt, H.M., Tucker, P.A., Shoham, G. | | Deposit date: | 1996-07-15 | | Release date: | 1997-02-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Carboxypeptidase A: native, zinc-removed and mercury-replaced forms.
Acta Crystallogr.,Sect.D, 54, 1998
|
|
4AB1 | | RECOMBINANT HUMAN CARBOXYLESTERASE 1 FROM WHOLE CABBAGE LOOPERS | | Descriptor: | LIVER CARBOXYLESTERASE 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, THIOCYANATE ION | | Authors: | Greenblatt, H.M., Otto, T.C., Cerasoli, D.M., Sussman, J.L. | | Deposit date: | 2011-12-06 | | Release date: | 2012-03-07 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of Recombinant Human Carboxylesterase 1 Isolated from Whole Cabbage Looper Larvae.
Acta Crystallogr.,Sect.F, 68, 2012
|
|
1SOM | | TORPEDO CALIFORNICA ACETYLCHOLINESTERASE INHIBITED BY NERVE AGENT GD (SOMAN). | | Descriptor: | PROTEIN (ACETYLCHOLINESTERASE), 2-acetamido-2-deoxy-beta-D-glucopyranose, UNKNOWN ATOM OR ION, ... | | Authors: | Greenblatt, H.M., Millard, C.B., Sussman, J.L., Silman, I. | | Deposit date: | 1999-03-17 | | Release date: | 1999-06-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.
Biochemistry, 38, 1999
|
|
1HBJ | | X-RAY CRYSTAL STRUCTURE OF COMPLEX BETWEEN TORPEDO CALIFORNICA ACHE AND A REVERSIBLE INHIBITOR, 4-AMINO-5-FLUORO-2-METHYL-3-(3-TRIFLUOROACETYLBENZYLTHIOMETHYL)QUINOLINE | | Descriptor: | ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Greenblatt, H.M., Kryger, G., Lewis, T.L., Doucet, C., Viner, R., Silman, I., Sussman, J.L. | | Deposit date: | 2001-04-16 | | Release date: | 2001-09-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A Structure-Based Design Approach to the Development of Novel, Reversible Ache Inhibitors
J.Med.Chem., 44, 2001
|
|
1CP7 | | AMINOPEPTIDASE FROM STREPTOMYCES GRISEUS | | Descriptor: | AMINOPEPTIDASE, ZINC ION, CALCIUM ION | | Authors: | Gilboa, R., Greenblatt, H.M., Perach, M., Spungin-Bialik, A., Lessel, U., Schomburg, D., Blumberg, S., Shoham, G. | | Deposit date: | 1999-06-10 | | Release date: | 2000-05-03 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Interactions of Streptomyces griseus aminopeptidase with a methionine product analogue: a structural study at 1.53 A resolution.
Acta Crystallogr.,Sect.D, 56, 2000
|
|
1QQ9 | | STREPTOMYCES GRISEUS AMINOPEPTIDASE COMPLEXED WITH METHIONINE | | Descriptor: | AMINOPEPTIDASE, ZINC ION, CALCIUM ION, ... | | Authors: | Gilboa, R., Greenblatt, H.M., Perach, M., Spungin-Bialik, A., Lessel, U., Schomburg, D., Blumberg, S., Shoham, G. | | Deposit date: | 1999-06-12 | | Release date: | 2000-05-03 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Interactions of Streptomyces griseus aminopeptidase with a methionine product analogue: a structural study at 1.53 A resolution.
Acta Crystallogr.,Sect.D, 56, 2000
|
|
1ZGC | | CRYSTAL STRUCTURE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH AN (RS)-TACRINE(10)-HUPYRIDONE INHIBITOR. | | Descriptor: | Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, (5S)-5-{[10-(1,2,3,4-TETRAHYDROACRIDIN-9-YLAMINO)DECYL]AMINO}-5,6,7,8-TETRAHYDROQUINOLIN-2(1H)-ONE | | Authors: | Haviv, H., Wong, D.M., Greenblatt, H.M., Carlier, P.R., Pang, Y.P., Silman, I., Sussman, J.L., Israel Structural Proteomics Center (ISPC) | | Deposit date: | 2005-04-21 | | Release date: | 2005-08-16 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase
J.Am.Chem.Soc., 127, 2005
|
|
1ODC | | STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH N-4'-QUINOLYL-N'-9"-(1",2",3",4"-TETRAHYDROACRIDINYL)-1,8- DIAMINOOCTANE AT 2.2A RESOLUTION | | Descriptor: | ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-QUINOLIN-4-YL-N'-(1,2,3,4-TETRAHYDROACRIDIN-9-YL)OCTANE-1,8-DIAMINE | | Authors: | Wong, D.M., Greenblatt, H.M., Carlier, P.R., Han, Y.-F., Pang, Y.-P., Silman, I., Sussman, J.L. | | Deposit date: | 2003-02-15 | | Release date: | 2005-03-23 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Complexes of Alkylene-Linked Tacrine Dimers with Torpedo Californica Acetylcholinesterase: Binding of Bis(5)-Tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge.
J.Med.Chem., 49, 2006
|
|
1UT6 | | STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8- DIAMINOOCTANE AT 2.4 ANGSTROMS RESOLUTION. | | Descriptor: | ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8-DIAMINOOCTANE | | Authors: | Brumshtein, B., Wong, D.M., Greenblatt, H.M., Carlier, P.R., Pang, Y.-P., Silman, I., Sussman, J.L. | | Deposit date: | 2003-12-04 | | Release date: | 2005-04-21 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Complexes of Alkylene-Linked Tacrine Dimers with Torpedo Californica Acetylcholinesterase: Binding of Bis(5)-Tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge.
J.Med.Chem., 49, 2006
|
|
1ZGB | | CRYSTAL STRUCTURE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH AN (R)-TACRINE(10)-HUPYRIDONE INHIBITOR. | | Descriptor: | Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, (5R)-5-{[10-(1,2,3,4-TETRAHYDROACRIDIN-9-YLAMINO)DECYL]AMINO}-5,6,7,8-TETRAHYDROQUINOLIN-2(1H)-ONE | | Authors: | Haviv, H., Wong, D.M., Greenblatt, H.M., Carlier, P.R., Pang, Y.P., Silman, I., Sussman, J.L., Israel Structural Proteomics Center (ISPC) | | Deposit date: | 2005-04-21 | | Release date: | 2005-08-16 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase
J.Am.Chem.Soc., 127, 2005
|
|
1H22 | | STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH (S,S)-(-)-BIS(10)-HUPYRIDONE AT 2.15A RESOLUTION | | Descriptor: | ACETYLCHOLINESTERASE, (S,S)-(-)-N,N'-DI-5'-[5',6',7',8'-TETRAHYDRO- 2'(1'H)-QUINOLYNYL]-1,10-DIAMINODECANE DIHYDROCHLORIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Wong, D.M., Greenblatt, H.M., Carlier, P.R., Han, Y.-F., Pang, Y.-P., Silman, I., Sussman, J.L. | | Deposit date: | 2002-07-30 | | Release date: | 2002-12-23 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity
J.Am.Chem.Soc., 125, 2003
|
|
1H23 | | STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH (S,S)-(-)-BIS(12)-HUPYRIDONE AT 2.15A RESOLUTION | | Descriptor: | ACETYLCHOLINESTERASE, (S,S)-(-)-N,N'-DI-5'-[5',6',7',8'-TETRAHYDRO- 2'(1'H)-QUINOLYNYL]-1,12-DIAMINODODECANE DIHYDROCHLORIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Wong, D.M., Greenblatt, H.M., Carlier, P.R., Han, Y.F., Pang, Y.P., Silman, I., Sussman, J.L. | | Deposit date: | 2002-07-30 | | Release date: | 2002-12-23 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity
J.Am.Chem.Soc., 125, 2003
|
|
1M4L | | STRUCTURE OF NATIVE CARBOXYPEPTIDASE A AT 1.25 RESOLUTION | | Descriptor: | CARBOXYPEPTIDASE A, ZINC ION | | Authors: | Kilshtain-Vardi, A., Glick, M., Greenblatt, H.M., Goldblum, A., Shoham, G. | | Deposit date: | 2002-07-03 | | Release date: | 2003-01-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Refined structure of bovine carboxypeptidase A at 1.25 A resolution.
Acta Crystallogr.,Sect.D, 59, 2003
|
|
1Y7W | | CRYSTAL STRUCTURE OF A HALOTOLERANT CARBONIC ANHYDRASE FROM DUNALIELLA SALINA | | Descriptor: | Halotolerant alpha-type carbonic anhydrase (dCA II), SODIUM ION, ZINC ION, ... | | Authors: | Premkumar, L., Greenblatt, H.M., Bageshwar, U.K., Savchenko, T., Gokhman, I., Sussman, J.L., Zamir, A., Israel Structural Proteomics Center (ISPC) | | Deposit date: | 2004-12-10 | | Release date: | 2005-05-03 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Three-dimensional structure of a halotolerant algal carbonic anhydrase predicts halotolerance of a mammalian homolog.
Proc.Natl.Acad.Sci.Usa, 102, 2005
|
|
2C4H | | TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH 500MM ACETYLTHIOCHOLINE | | Descriptor: | ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose, TRIETHYLENE GLYCOL, ... | | Authors: | Colletier, J.P., Fournier, D., Greenblatt, H.M., Sussman, J.L., Zaccai, G., Silman, I., Weik, M. | | Deposit date: | 2005-10-19 | | Release date: | 2006-06-14 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural insights into substrate traffic and inhibition in acetylcholinesterase.
EMBO J., 25, 2006
|
|
2C58 | | TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH 20MM ACETYLTHIOCHOLINE | | Descriptor: | ACETYLCHOLINESTERASE, 2-(TRIMETHYLAMMONIUM)ETHYL THIOL, ACETYLTHIOCHOLINE, ... | | Authors: | Colletier, J.P., Fournier, D., Greenblatt, H.M., Sussman, J.L., Zaccai, G., Silman, I., Weik, M. | | Deposit date: | 2005-10-26 | | Release date: | 2006-06-14 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Insights Into Substrate Traffic and Inhibition in Acetylcholinesterase.
Embo J., 25, 2006
|
|
2C5F | | TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A NON HYDROLYSABLE SUBSTRATE ANALOGUE, 4-OXO-N,N,N-TRIMETHYLPENTANAMINIUM | | Descriptor: | ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose, TRIETHYLENE GLYCOL, ... | | Authors: | Colletier, J.P., Fournier, D., Greenblatt, H.M., Sussman, J.L., Zaccai, G., Silman, I., Weik, M. | | Deposit date: | 2005-10-27 | | Release date: | 2006-06-14 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural Insights Into Substrate Traffic and Inhibition in Acetylcholinesterase.
Embo J., 25, 2006
|
|
